Technical Note | NEPHEL.O™
Validation of low turbidity measurements
The NEPHEL.O™ nephelometer is a reliable instrument that performs comparably to established and commercially available nephelometers. It provides precise measurements of low turbidity solutions with good repeatability.
The determination of particle size is important in many fields, such as life sciences (nanomedicine, drug delivery, tissue engineering, bioanalysis), chemical, environmental sciences and industries. Turbidimetry is a quick and nondestructive method to estimate particle size following an easy-to-follow procedure. Curves of turbidity vs silica particle concentration in distilled water of various sizes were obtained with high precision using the TURBIDI.TTM. These curves can be used to build a reference curve for the determination of particle size.
A suspension is a mixture in which solid particles (organic or inorganic in nature) are dispersed in a liquid medium, but not dissolved. Suspensions are usually opaque or cloudy and can settle over time due to gravity. They have a broad range of applications and are present in various industrial processes, such as chemical, pharmaceutical, food and beverage, and environmental industries. During the production of pharmaceutical formulations for example, professionals may measure particle concentration to assess whether particles have aggregated or formed larger clusters to optimize the process and ensure product quality.
Determining the solubility point of compounds is key to optimizing performance, quality, and purity across various scientific fields and industries. Discover how we successfully determined the solubility point of sodium bicarbonate in distilled water using the innovative TURBIDI.T™ instrument.
The solubility of solid pharmaceutical compounds is a critical factor that their bioavailability, effectiveness, safety, and quality. Solubility determines how quickly and efficiently a drug can dissolve and be absorbed into the body, which can affect its bioavailability, therapeutic efficacy, and potential side effects. Therefore, understanding solubility is a crucial step in drug development, formulation, and dosage selection, as well as for ensuring the quality of medications throughout their shelf life.