November 17, 2021
Viscoelasticity characterization of Gelomics LunaGel™ Photocrosslinkable Extracellular Matrices using ElastoSens™ Bio and its effect on cancer cells invasiveness
All cells in the human body are exposed to mechanical forces which regulate cell function and tissue development, and each cell type is specifically adapted to the mechanical properties of the tissue it resides in. The matrix properties of human tissues can also change with disease and in turn facilitate its progression.
September 22, 2021
Controlling hydrogel’s properties with photocrosslinking
In September, we explored the applications of photostimulation in hydrogels. Light-induced reactions are commonly used in various fields, including dentistry, coatings, and beauty salons. In biomedical research, natural components like collagen and hyaluronic acid have been modified to react to light exposure. These modifications, along with the use of photoinitiators, allow for better control over the processability and viscoelastic properties of hydrogels. This control is essential for applications such as in vivo injection, 3D bioprinting, and matching the mechanical behavior of implantation sites.
September 14, 2021
Light exposure
The effect of light exposure and formulation on the photocrosslinking kinetics of modified gelatin and hyaluronic acid
Gelatin and hyaluronic acid (HA) are biomaterials widely used in the biomedical research field. HA is the most abundant glycosaminoglycan in the body and is an important component of several tissues. HA contributes to tissue hydrodynamics, movement and proliferation of cells, and participates in a number of cell surface receptor interactions.
September 8, 2021
Tunning the stiffness of hydrogels with photocrosslinking
In the context of dental treatments and other applications like surface coatings and 3D printing, the use of light to transform deformable resins into rigid materials is well-known. Similarly, in biomedical applications, photostimulation is used to modify the mechanical properties of hydrogels. Natural hydrogels have been chemically modified to allow precise control over their viscoelastic properties through light exposure. These photosensitive hydrogels can transition from a liquid to a gel state with varying levels of firmness based on formulation, light intensity, and exposure time. Matching the viscoelasticity of the hydrogel to the target organ is crucial in tissue engineering and regenerative medicine.
January 30, 2021
Analysis of UV crosslinked hydrogels using ElastoSens™ Bio
Hydrogels have been widely used in biomedical research for developing engineered tissues and novel treatments such as wound dressings and drug delivery systems. Photo-crosslinkable polymers are an interesting option in the field due to the possibility of tuning its microstructure by regulating the wavelength, intensity and duration of the applied light [1, 2, 3].