February 23, 2023
Guidance to the optimal point for freeze-drying a hydrogel
Freeze-drying is a common method to produce porous scaffolds from a hydrogel composed of natural or synthetic polymers. In a number of cases, the polymeric solution is crosslinked (bonds or interactions are established among the polymeric chains) and the hydrogel is then freeze-dried to obtain the porous and dried scaffold (1-3).
June 29, 2022
Machine learning for gel time prediction of living hydrogels
The development of tissue engineering products faces challenges due to the variety of biomaterials available and their dynamic properties once implanted. A recent study used artificial intelligence (AI) to help address this problem. The researchers created a system that automates the prediction of gelation time (when a liquid solution becomes a hydrogel) for different formulations. The hydrogels were composed of silk, horseradish peroxidase (HRP), hydrogen peroxide, and bacterial cells. They utilized differential dynamic microscopy (DDM) to identify gelation time and machine learning (ML) to predict the gelation time of different hydrogel compositions. This allowed them to streamline the process of finding hydrogel formulations with specific properties.
June 16, 2022
AI-based prediction of hydrogel gelation kinetics and their mechanical properties
Hydrogels are biomaterials that are widely studied in the biomedical field. They are used, for example, to produce contact lenses and wound dressings, for drug release systems, or as scaffolds for tissue engineering. The design of such hydrogels is often multidimensional since multiple parameters related to their chemical composition and physical properties affect how they are going to behave in vivo.
November 17, 2021
Viscoelasticity characterization of Gelomics LunaGel™ Photocrosslinkable Extracellular Matrices using ElastoSens™ Bio and its effect on cancer cells invasiveness
All cells in the human body are exposed to mechanical forces which regulate cell function and tissue development, and each cell type is specifically adapted to the mechanical properties of the tissue it resides in. The matrix properties of human tissues can also change with disease and in turn facilitate its progression.
September 14, 2021
Light exposure
The effect of light exposure and formulation on the photocrosslinking kinetics of modified gelatin and hyaluronic acid
Gelatin and hyaluronic acid (HA) are biomaterials widely used in the biomedical research field. HA is the most abundant glycosaminoglycan in the body and is an important component of several tissues. HA contributes to tissue hydrodynamics, movement and proliferation of cells, and participates in a number of cell surface receptor interactions.
January 30, 2021
ElastoSens™ Bio: A tool for hydrogel formulation
Natural polymers such as collagen, fibrin, chitosan, and agarose exhibit superior biological activity when compared to synthetic materials and so, they are often used to entirely or partially compose hydrogels. The formation of a hydrogel is governed by the development of physical or chemical bonds between the polymeric chains and depends strongly on its formulation. The formulation of a hydrogel includes the selection and dosage of the polymer, solvent and crosslinking agent (when present).