Hydrogel degradation Archives

January 30, 2021

Gel formulation and long term mechanical stability analysis of cellularized gelatin-based hydrogel using ElastoSens™ Bio

Cellularized hydrogels have been widely investigated for producing in vitro models of tissues such as skin, blood vessels, bone, etc. These models can be a valuable alternative to animal models used in trials for studying physio/pathological processes and for testing new drugs and medical devices.

January 30, 2021

Thermal degradation analysis of 3D printed scaffolds using ElastoSens™ Bio

The thermoreversible behavior of some polymers relies on the large conformation changes in response to temperature. They have been investigated for a variety of clinical applications that demand an in situ gelation at physiological temperatures. In addition, these polymers have been widely studied for other biomedical applications such as drug delivery and tissue engineering in which the thermoresponsive behavior needs to be balanced with biocompatibility and degradation kinetics.

January 30, 2021

Degradation and drug release of hydrogel-based drug delivery systems

The controlled release of drugs at precise locations within the body can prevent systemic toxicity and deliver accurate dosages to patients. Hydrogels have recently been investigated as promising drug delivery systems due to their ability to provide spatial and temporal control over the release of a number of therapeutic agents. Furthermore, the easy tunability of their physicochemical and mechanical properties allows the design of application-specific release systems.

January 30, 2021

Real time digestion analysis of hydrogels using ElastoSens™ Bio

Biodegradable hydrogels are promising candidates as drug carriers due to their biocompatibility and tunable degradation. This is particularly valuable for oral delivery systems since the polymer should respond to pH or enzymatic changes in the gastrointestinal environment to achieve a controlled drug release.

January 30, 2021

Long term degradation analysis of chitosan hydrogel using ElastoSens™ Bio

Hydrogels exhibit a pronounced viscoelastic behavior similar to soft tissues. For this reason, they have been widely used in biomedical research for developing engineered tissues and novel treatments such as wound dressings and drug delivery systems.