March 17, 2022
How do hemostatic agents work ?
Hemostatic agents (HAs) can be absorbable, biological, or synthetic. Absorbable HAs, like gelatin or oxidized cellulose, speed up clotting and are naturally absorbed by the body. Biological HAs include thrombin, fibrinogen, and platelets which are key to blood clotting. Synthetic HAs, such as polyethylene glycol, form strong sealant matrices. The choice of HA depends on the type of bleeding, tissue interaction, and patient's coagulation profile. Instruments like the ElastoSens™ Bio provide valuable data on HA efficacy by measuring blood absorption and coagulation kinetics.
March 1, 2022
An inorganic biomaterial with great hemostatic potential
Scientists from Dalhousie University, led by Dr. Mark Joseph Filiaggi, investigated the sodium polyphosphate (NaPP) polymer as a potential hemostatic agent. They tested six formulations of the biomaterial, with varying degrees of polymerization and types of divalent cations. The hemostatic potential of these formulations was evaluated using various blood clotting assays. The biomaterial was mixed with coagulation reagents and recalcified blood or plasma in a tube, which was then shaken to visually assess blood or plasma flow. The clotting time was noted as the time required to achieve no flow. Surgifoam®, a commercial hemostatic agent, was used as a control.
December 20, 2020
Measuring the efficacy of hemostatic agents using ElastoSens™ Bio
Hemostatic agents (HA, e.g. powders, gauzes, adhesives and sealants) have been used for decades to control bleeding. The demand for these agents is growing due to two major trends in surgical practice: the expansion of minimally invasive surgery and complex reconstructive procedures that are more limited in their capacity to obtain hemostasis.