{"id":71040,"date":"2025-09-16T11:17:48","date_gmt":"2025-09-16T15:17:48","guid":{"rendered":"https:\/\/rheolution.com\/?p=71040"},"modified":"2026-09-29T16:32:56","modified_gmt":"2026-09-29T20:32:56","slug":"medicao-das-propriedades-mecanicas-do-tecido-cardiaco","status":"publish","type":"post","link":"https:\/\/rheolution.com\/pt\/notas-de-aplicacao\/medicao-das-propriedades-mecanicas-do-tecido-cardiaco\/","title":{"rendered":"Medi\u00e7\u00e3o das propriedades mec\u00e2nicas do tecido card\u00edaco"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"71040\" class=\"elementor elementor-71040 elementor-61587\" data-elementor-post-type=\"post\">\n\t\t\t\t<div class=\"elementor-element elementor-element-8fd4dcf e-flex e-con-boxed e-con e-parent\" data-id=\"8fd4dcf\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-8c770e2 elementor-widget elementor-widget-heading\" data-id=\"8c770e2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h6 class=\"elementor-heading-title elementor-size-default\">Nota de Aplica\u00e7\u00e3o | ElastoSens\u2122 Bio<\/h6>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-760ae40 elementor-widget elementor-widget-heading\" data-id=\"760ae40\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Medi\u00e7\u00e3o das propriedades mec\u00e2nicas do tecido card\u00edaco utilizando o ElastoSens\u2122 Bio\n\n<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-97ac8de e-flex e-con-boxed e-con e-parent\" data-id=\"97ac8de\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-cbaa0e4 elementor-widget elementor-widget-heading\" data-id=\"cbaa0e4\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Introdu\u00e7\u00e3o<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-88d2925 elementor-widget elementor-widget-text-editor\" data-id=\"88d2925\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400;\">A capacidade do cora\u00e7\u00e3o de bombear sangue depende n\u00e3o apenas de sua atividade el\u00e9trica, mas tamb\u00e9m das propriedades mec\u00e2nicas de seu tecido. Essas propriedades \u2014 que v\u00e3o da elasticidade \u00e0 rigidez e \u00e0 viscoelasticidade \u2014 determinam como o mioc\u00e1rdio se distende, se contrai e se relaxa ao longo do ciclo card\u00edaco. Mudan\u00e7as sutis nessa mec\u00e2nica podem indicar o in\u00edcio de uma doen\u00e7a, enquanto altera\u00e7\u00f5es mais pronunciadas prejudicam a capacidade do cora\u00e7\u00e3o de encher-se e ejetar sangue. Ao estud\u00e1-las, cientistas e m\u00e9dicos podem compreender melhor como um cora\u00e7\u00e3o saud\u00e1vel funciona, detectar sinais precoces de doen\u00e7a e desenvolver terapias que restaurem ou preservem o desempenho.   <\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5fc8fde elementor-widget__width-initial elementor-widget-mobile__width-inherit elementor-widget elementor-widget-heading\" data-id=\"5fc8fde\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Principais propriedades mec\u00e2nicas do cora\u00e7\u00e3o<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-bd3468a elementor-widget elementor-widget-heading\" data-id=\"bd3468a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Elasticidade<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d61237b elementor-widget elementor-widget-text-editor\" data-id=\"d61237b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400;\">A elasticidade reflete a capacidade do mioc\u00e1rdio de retornar \u00e0 sua forma original ap\u00f3s a deforma\u00e7\u00e3o. Ela \u00e9 essencial para o enchimento diast\u00f3lico, permitindo que os ventr\u00edculos acomodem o sangue que chega e, em seguida, se recuperem de forma eficiente para a pr\u00f3xima contra\u00e7\u00e3o. <\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c984676 elementor-widget elementor-widget-heading\" data-id=\"c984676\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Rigidez<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d51523d elementor-widget elementor-widget-text-editor\" data-id=\"d51523d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400;\">A rigidez representa a resist\u00eancia \u00e0 deforma\u00e7\u00e3o, frequentemente quantificada por meio de par\u00e2metros como o m\u00f3dulo de elasticidade ou as rela\u00e7\u00f5es press\u00e3o-volume. Ela varia dinamicamente ao longo do ciclo card\u00edaco, com baixa rigidez durante a di\u00e1stole e maior rigidez durante a s\u00edstole. <\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-637b511 elementor-widget elementor-widget-heading\" data-id=\"637b511\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Conformidade<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-12ac0bd elementor-widget elementor-widget-text-editor\" data-id=\"12ac0bd\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400;\">A complac\u00eancia, o inverso da rigidez, descreve a capacidade do cora\u00e7\u00e3o de se expandir quando se enche. A complac\u00eancia reduzida limita a capacidade de enchimento e \u00e9 uma caracter\u00edstica marcante da disfun\u00e7\u00e3o diast\u00f3lica. <\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c8f3824 elementor-widget elementor-widget-heading\" data-id=\"c8f3824\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Viscoelasticidade<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-fcb70d7 elementor-widget elementor-widget-text-editor\" data-id=\"fcb70d7\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400;\">O cora\u00e7\u00e3o apresenta um comportamento tanto el\u00e1stico quanto viscoso, o que significa que sua resposta depende n\u00e3o apenas do grau de alongamento, mas tamb\u00e9m da taxa de deforma\u00e7\u00e3o. Essa viscoelasticidade influencia a forma como o mioc\u00e1rdio dissipa ou armazena energia durante a contra\u00e7\u00e3o e o relaxamento. <\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4b96c45 elementor-widget elementor-widget-heading\" data-id=\"4b96c45\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Anisotropia<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-bd7d10b elementor-widget elementor-widget-text-editor\" data-id=\"bd7d10b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400;\">Devido \u00e0 complexidade de sua arquitetura fibrosa, o mioc\u00e1rdio \u00e9 anisotr\u00f3pico \u2014 seu comportamento mec\u00e2nico varia de acordo com a dire\u00e7\u00e3o da for\u00e7a aplicada. Essa anisotropia contribui para o espessamento eficiente da parede e para o bombeamento coordenado. <\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5703c6a elementor-widget__width-initial elementor-widget-mobile__width-inherit elementor-widget elementor-widget-heading\" data-id=\"5703c6a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Rela\u00e7\u00e3o entre doen\u00e7as e propriedades mec\u00e2nicas do tecido card\u00edaco<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5a0b64a elementor-widget elementor-widget-heading\" data-id=\"5a0b64a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Insufici\u00eancia card\u00edaca com fra\u00e7\u00e3o de eje\u00e7\u00e3o preservada (HFpEF)<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-38524ee elementor-widget elementor-widget-text-editor\" data-id=\"38524ee\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400;\">A HFpEF est\u00e1 fortemente associada ao aumento da rigidez mioc\u00e1rdica e \u00e0 redu\u00e7\u00e3o da complac\u00eancia. Essas altera\u00e7\u00f5es prejudicam o enchimento diast\u00f3lico, limitando a capacidade do cora\u00e7\u00e3o de atender \u00e0s demandas circulat\u00f3rias, apesar da fra\u00e7\u00e3o de eje\u00e7\u00e3o normal. <\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-30981bc elementor-widget elementor-widget-heading\" data-id=\"30981bc\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Fibrose<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2e827a1 elementor-widget elementor-widget-text-editor\" data-id=\"2e827a1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400;\">A fibrose card\u00edaca, caracterizada pela deposi\u00e7\u00e3o excessiva de col\u00e1geno, torna a matriz extracelular mais r\u00edgida e altera a anisotropia. Essa remodela\u00e7\u00e3o perturba a mec\u00e2nica normal, contribuindo tanto para a disfun\u00e7\u00e3o sist\u00f3lica quanto para a diast\u00f3lica. <\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0959975 elementor-widget elementor-widget-heading\" data-id=\"0959975\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Les\u00e3o por isquemia\/reperfus\u00e3o<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-90cc644 elementor-widget elementor-widget-text-editor\" data-id=\"90cc644\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400;\">Durante a isquemia e a reperfus\u00e3o subsequente, a rigidez mioc\u00e1rdica sofre altera\u00e7\u00f5es din\u00e2micas. Estudos de elastografia por ondas de cisalhamento mostram altera\u00e7\u00f5es na rigidez sist\u00f3lica e diast\u00f3lica, refletindo comprometimento da contratilidade e do relaxamento no tecido lesionado. <\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-25ebf8f elementor-widget elementor-widget-heading\" data-id=\"25ebf8f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Cardiomiopatia dilatada<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3c011f7 elementor-widget elementor-widget-text-editor\" data-id=\"3c011f7\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400;\">Na cardiomiopatia dilatativa, altera\u00e7\u00f5es nas propriedades mec\u00e2nicas passivas e ativas \u2014 incluindo aumento da complac\u00eancia e altera\u00e7\u00e3o da viscoelasticidade \u2014 levam \u00e0 dilata\u00e7\u00e3o das c\u00e2maras, \u00e0 redu\u00e7\u00e3o da contratilidade e \u00e0 insufici\u00eancia card\u00edaca progressiva.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-28004d8 elementor-widget__width-initial elementor-widget-mobile__width-inherit elementor-widget elementor-widget-heading\" data-id=\"28004d8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Como \u00e9 avaliada a mec\u00e2nica do tecido card\u00edaco<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-06adff0 elementor-widget elementor-widget-heading\" data-id=\"06adff0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">T\u00e9cnicas in vivo (Cl\u00ednicas)<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ba2f1b1 elementor-widget elementor-widget-text-editor\" data-id=\"ba2f1b1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400;\">Clinicamente, a rigidez card\u00edaca pode ser avaliada por meio de t\u00e9cnicas invasivas e n\u00e3o invasivas. A an\u00e1lise do ciclo press\u00e3o-volume por meio de cateterismo continua sendo o padr\u00e3o-ouro para a avalia\u00e7\u00e3o da rigidez das c\u00e2maras card\u00edacas. As abordagens n\u00e3o invasivas s\u00e3o cada vez mais comuns, incluindo a elastografia por ondas de cisalhamento (SWE), que rastreia a propaga\u00e7\u00e3o das ondas no mioc\u00e1rdio, e ferramentas avan\u00e7adas de imagem, como a elastografia por resson\u00e2ncia magn\u00e9tica (MRE) e a imagem por impulso de for\u00e7a de radia\u00e7\u00e3o ac\u00fastica (ARFI). Esses m\u00e9todos fornecem informa\u00e7\u00f5es valiosas sobre a fun\u00e7\u00e3o diast\u00f3lica e sist\u00f3lica e s\u00e3o fundamentais para a detec\u00e7\u00e3o precoce de altera\u00e7\u00f5es relacionadas \u00e0 doen\u00e7a.   <\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d01f123 elementor-widget elementor-widget-heading\" data-id=\"d01f123\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">T\u00e9cnicas ex vivo (Pesquisa)<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-137d5ec elementor-widget elementor-widget-text-editor\" data-id=\"137d5ec\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400;\">Na pesquisa, os m\u00e9todos ex vivo permitem a caracteriza\u00e7\u00e3o detalhada da mec\u00e2nica do tecido card\u00edaco. Entre os instrumentos mais comuns est\u00e3o os ensaios de tra\u00e7\u00e3o, a reometria de cisalhamento e a indenta\u00e7\u00e3o (em escala nano a micro), aplicados desde c\u00e9lulas isoladas at\u00e9 amostras de cora\u00e7\u00e3o inteiro. Essas t\u00e9cnicas revelam a elasticidade, a viscosidade e o comportamento viscoel\u00e1stico sob condi\u00e7\u00f5es controladas, ajudando os pesquisadores a relacionar altera\u00e7\u00f5es moleculares \u00e0 mec\u00e2nica mioc\u00e1rdica como um todo.  <\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-892f73a elementor-widget__width-initial elementor-widget-mobile__width-inherit elementor-widget elementor-widget-heading\" data-id=\"892f73a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Estudo de caso: Caracteriza\u00e7\u00e3o mec\u00e2nica do tecido card\u00edaco com o ElastoSens\u2122 Bio<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-5a225c3 e-grid e-con-full e-con e-child\" data-id=\"5a225c3\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ce43e5b elementor-widget elementor-widget-text-editor\" data-id=\"ce43e5b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400;\">No campo da biomec\u00e2nica card\u00edaca, o <a href=\"https:\/\/rheolution.com\/pt\/produtos\/elastosens-bio\/instrumento\/\"><strong>ElastoSens\u2122 Bio<\/strong><\/a> oferece uma abordagem avan\u00e7ada para testes ex vivo. Esse instrumento permite a medi\u00e7\u00e3o cont\u00ednua e n\u00e3o destrutiva das propriedades viscoel\u00e1sticas, garantindo que a integridade do tecido seja mantida durante todo o experimento. Sua tecnologia proporciona uma caracteriza\u00e7\u00e3o precisa de amostras card\u00edacas moles e permite a realiza\u00e7\u00e3o de testes repetidos por longos per\u00edodos sob diferentes condi\u00e7\u00f5es ambientais, ampliando as informa\u00e7\u00f5es dispon\u00edveis al\u00e9m dos ensaios mec\u00e2nicos tradicionais.  <\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-045aef9 elementor-widget elementor-widget-image\" data-id=\"045aef9\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"968\" height=\"544\" src=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/elastosens2-1.webp?fit=968%2C544&amp;ssl=1\" class=\"attachment-large size-large wp-image-43562\" alt=\"\" srcset=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/elastosens2-1.webp?w=968&amp;ssl=1 968w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/elastosens2-1.webp?resize=300%2C169&amp;ssl=1 300w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/elastosens2-1.webp?resize=768%2C432&amp;ssl=1 768w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/elastosens2-1.webp?resize=133%2C75&amp;ssl=1 133w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/elastosens2-1.webp?resize=480%2C270&amp;ssl=1 480w\" sizes=\"(max-width:767px) 700px, (max-width:968px) 100vw, 968px\" data-attachment-id=\"43562\" data-permalink=\"https:\/\/rheolution.com\/pt\/elastosens2-4-2-2\/\" data-orig-file=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/elastosens2-1.webp?fit=968%2C544&amp;ssl=1\" data-orig-size=\"968,544\" data-comments-opened=\"1\" data-image-title=\"elastosens2\" data-image-description=\"\" data-image-caption=\"\" data-large-file=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/elastosens2-1.webp?fit=968%2C544&amp;ssl=1\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b87c673 elementor-widget elementor-widget-text-editor\" data-id=\"b87c673\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400;\">Para demonstrar as capacidades do ElastoSens\u2122 Bio, realizamos um estudo ex vivo com amostras de tecido card\u00edaco. A se\u00e7\u00e3o a seguir descreve os materiais e m\u00e9todos utilizados neste experimento, seguida dos resultados, apresentando um exemplo pr\u00e1tico da aplica\u00e7\u00e3o do instrumento. <\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4babf25 elementor-widget elementor-widget-heading\" data-id=\"4babf25\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Materiais e m\u00e9todos<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d118051 elementor-widget elementor-widget-text-editor\" data-id=\"d118051\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400;\">Cora\u00e7\u00f5es de su\u00ednos e ovinos foram obtidos em uma fazenda local. Amostras de tecido com formato aproximadamente cil\u00edndrico (23 mm de di\u00e2metro interno, altura vari\u00e1vel) foram extra\u00eddas por meio de um pun\u00e7\u00e3o semelhante ao utilizado em bi\u00f3psias. Cada amostra foi cuidadosamente posicionada no suporte macro do instrumento ElastoSens\u2122 Bio. As medi\u00e7\u00f5es foram realizadas \u00e0 temperatura ambiente, com cada amostra testada por um minuto.   <\/span><\/p><p><span style=\"font-weight: 400;\">O instrumento forneceu par\u00e2metros viscoel\u00e1sticos em tempo real, incluindo o m\u00f3dulo de armazenamento de cisalhamento (G\u2032) e o coeficiente de amortecimento (Tan\ud835\udeff). Para cada condi\u00e7\u00e3o, os resultados foram expressos como os valores m\u00e9dios obtidos a partir de cinco amostras independentes, extra\u00eddas do mesmo local anat\u00f4mico em cinco cora\u00e7\u00f5es diferentes (n=5). <\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-558712e elementor-widget__width-initial elementor-widget elementor-widget-image\" data-id=\"558712e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"688\" height=\"686\" src=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Heart-Tissue.png?fit=688%2C686&amp;ssl=1\" class=\"attachment-full size-full wp-image-61597\" alt=\"Heart tissue sample in the ElastoSens\u2122 Bio macro holder for non-destructive mechanical characterization.\" srcset=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Heart-Tissue.png?w=688&amp;ssl=1 688w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Heart-Tissue.png?resize=300%2C300&amp;ssl=1 300w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Heart-Tissue.png?resize=150%2C150&amp;ssl=1 150w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Heart-Tissue.png?resize=75%2C75&amp;ssl=1 75w\" sizes=\"(max-width:767px) 688px, 688px\" data-attachment-id=\"61597\" data-permalink=\"https:\/\/rheolution.com\/pt\/heart-tissue\/\" data-orig-file=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Heart-Tissue.png?fit=688%2C686&amp;ssl=1\" data-orig-size=\"688,686\" data-comments-opened=\"1\" data-image-title=\"Heart Tissue\" data-image-description=\"\" data-image-caption=\"\" data-large-file=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Heart-Tissue.png?fit=688%2C686&amp;ssl=1\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9f1b259 elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"9f1b259\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><b>Figura 1.<\/b><span style=\"font-weight: 400;\">  Amostra de tecido card\u00edaco no suporte ElastoSens\u2122 Bio macro para caracteriza\u00e7\u00e3o mec\u00e2nica n\u00e3o destrutiva.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-aa24bd0 elementor-widget elementor-widget-heading\" data-id=\"aa24bd0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Resultados e discuss\u00f5es<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-54513af elementor-widget elementor-widget-text-editor\" data-id=\"54513af\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400;\">Utilizando o sistema de ensaio n\u00e3o destrutivo ElastoSens\u2122 Bio, a Figura 2 mostra que o tecido card\u00edaco de porco apresentou um m\u00f3dulo de armazenamento de cisalhamento mais elevado (G\u2032 = 7,8 \u00b1 1,3 kPa) em compara\u00e7\u00e3o com o de ovelha (4,1 \u00b1 1,3 kPa), indicando maior rigidez e armazenamento de energia el\u00e1stica. Por outro lado, o tecido de ovelha apresentou um \u00edndice de amortecimento mais elevado (Tan\u03b4 = 0,42 \u00b1 0,05 vs. 0,36 \u00b1 0,05), refletindo maior dissipa\u00e7\u00e3o de energia viscosa. Essas propriedades viscoel\u00e1sticas espec\u00edficas de cada esp\u00e9cie destacam que o mioc\u00e1rdio su\u00edno \u00e9 mecanicamente mais r\u00edgido, enquanto o mioc\u00e1rdio ovino \u00e9 mais dissipativo.  <\/span><\/p><p><span style=\"font-weight: 400;\">Nossos valores para o cora\u00e7\u00e3o su\u00edno s\u00e3o consistentes com os relatados por Kolipaka et al. (2010) e Nenadic et al. (2009), que mediram o mioc\u00e1rdio su\u00edno por meio de elastografia por resson\u00e2ncia magn\u00e9tica e vibrometria de ondas de cisalhamento, relatando m\u00f3dulos de cisalhamento na faixa de 7,69 a 12,7 kPa. Para o mioc\u00e1rdio ovino, ensaios de tra\u00e7\u00e3o biaxial relataram m\u00f3dulos de armazenamento de cisalhamento equivalentes na faixa de 4,4 a 10,2 kPa, com uma m\u00e9dia de aproximadamente 6,5 kPa (Pandelani et al., 2025), refletindo varia\u00e7\u00f5es regionais e direcionais nos ventr\u00edculos. De modo geral, o ElastoSens\u2122 Bio permite medi\u00e7\u00f5es de tecido ex vivo com manuseio m\u00ednimo, sob condi\u00e7\u00f5es controladas de hidrata\u00e7\u00e3o e carga. Essa configura\u00e7\u00e3o controlada reduz fontes externas de variabilidade e captura a resposta viscoel\u00e1stica intr\u00ednseca do tecido mioc\u00e1rdico.   <\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-ea488a1 e-grid e-con-full e-con e-child\" data-id=\"ea488a1\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4582218 elementor-widget elementor-widget-image\" data-id=\"4582218\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"759\" height=\"763\" src=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/GSheep-Bar-Graph-sheep-and-pig-heart.png?fit=759%2C763&amp;ssl=1\" class=\"attachment-large size-large wp-image-61614\" alt=\"Viscoelastic properties of heart tissue for sheep and pig: shear storage modulus (G\u2032) obtained with the ElastoSens\u2122 Bio non-destructive testing system (mean \u00b1 SD, n=5).\" srcset=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/GSheep-Bar-Graph-sheep-and-pig-heart.png?w=759&amp;ssl=1 759w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/GSheep-Bar-Graph-sheep-and-pig-heart.png?resize=298%2C300&amp;ssl=1 298w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/GSheep-Bar-Graph-sheep-and-pig-heart.png?resize=150%2C150&amp;ssl=1 150w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/GSheep-Bar-Graph-sheep-and-pig-heart.png?resize=75%2C75&amp;ssl=1 75w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/GSheep-Bar-Graph-sheep-and-pig-heart.png?resize=700%2C704&amp;ssl=1 700w\" sizes=\"(max-width:767px) 700px, 759px\" data-attachment-id=\"61614\" data-permalink=\"https:\/\/rheolution.com\/pt\/gsheep-bar-graph-sheep-and-pig-heart\/\" data-orig-file=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/GSheep-Bar-Graph-sheep-and-pig-heart.png?fit=759%2C763&amp;ssl=1\" data-orig-size=\"759,763\" data-comments-opened=\"1\" data-image-title=\"G&amp;#8217;Sheep&amp;#8217; Bar Graph-sheep and pig heart\" data-image-description=\"\" data-image-caption=\"\" data-large-file=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/GSheep-Bar-Graph-sheep-and-pig-heart.png?fit=759%2C763&amp;ssl=1\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-97d02ec elementor-widget elementor-widget-image\" data-id=\"97d02ec\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"784\" height=\"767\" src=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/TanD-Bar-Graph-sheep-and-pig-heart.png?fit=784%2C767&amp;ssl=1\" class=\"attachment-large size-large wp-image-61606\" alt=\"Viscoelastic properties of heart tissue for sheep and pig: damping ratio (Tan\ud835\udeff) obtained with the ElastoSens\u2122 Bio non-destructive testing system (mean \u00b1 SD, n=5).\" srcset=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/TanD-Bar-Graph-sheep-and-pig-heart.png?w=784&amp;ssl=1 784w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/TanD-Bar-Graph-sheep-and-pig-heart.png?resize=300%2C293&amp;ssl=1 300w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/TanD-Bar-Graph-sheep-and-pig-heart.png?resize=768%2C751&amp;ssl=1 768w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/TanD-Bar-Graph-sheep-and-pig-heart.png?resize=77%2C75&amp;ssl=1 77w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/TanD-Bar-Graph-sheep-and-pig-heart.png?resize=700%2C685&amp;ssl=1 700w\" sizes=\"(max-width:767px) 700px, (max-width:784px) 100vw, 784px\" data-attachment-id=\"61606\" data-permalink=\"https:\/\/rheolution.com\/pt\/tand-bar-graph-sheep-and-pig-heart\/\" data-orig-file=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/TanD-Bar-Graph-sheep-and-pig-heart.png?fit=784%2C767&amp;ssl=1\" data-orig-size=\"784,767\" data-comments-opened=\"1\" data-image-title=\"TanD Bar Graph- sheep and pig heart\" data-image-description=\"\" data-image-caption=\"\" data-large-file=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/TanD-Bar-Graph-sheep-and-pig-heart.png?fit=784%2C767&amp;ssl=1\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-32a0d35 elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"32a0d35\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400;\"><strong>Figura 2:<\/strong> Propriedades viscoel\u00e1sticas do tecido card\u00edaco de ovelhas e porcos: m\u00f3dulo de armazenamento ao cisalhamento (G\u2032) (\u00e0 esquerda) e raz\u00e3o de amortecimento (Tan\ud835\udeff) (\u00e0 direita), obtidos com o sistema de testes n\u00e3o destrutivos ElastoSens\u2122 Bio (m\u00e9dia \u00b1 DP, n = 5).<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8ad5968 elementor-widget elementor-widget-heading\" data-id=\"8ad5968\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Conclus\u00f5es e perspectivas<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b7d7a98 elementor-widget elementor-widget-text-editor\" data-id=\"b7d7a98\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400;\">As propriedades mec\u00e2nicas do tecido card\u00edaco, incluindo elasticidade, rigidez, viscoelasticidade e anisotropia, s\u00e3o fundamentais para a compreens\u00e3o tanto da fun\u00e7\u00e3o fisiol\u00f3gica quanto da remodela\u00e7\u00e3o patol\u00f3gica. O presente estudo confirma que os testes viscoel\u00e1sticos n\u00e3o destrutivos com o ElastoSens\u2122 Bio permitem a medi\u00e7\u00e3o confi\u00e1vel da mec\u00e2nica do tecido card\u00edaco, captando par\u00e2metros-chave, como o m\u00f3dulo de armazenamento de cisalhamento (G\u2032) e a raz\u00e3o de amortecimento (Tan\ud835\udeff). Essa abordagem garante dados precisos e reproduz\u00edveis, proporcionando uma base s\u00f3lida para estudos comparativos entre esp\u00e9cies e condi\u00e7\u00f5es.  <\/span><\/p><p><span style=\"font-weight: 400;\">Al\u00e9m desses resultados, o ElastoSens\u2122 Bio oferece vantagens exclusivas para pesquisas nas \u00e1reas cardiovascular e de biomateriais:<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-aed2e2d elementor-widget elementor-widget-text-editor\" data-id=\"aed2e2d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">A prepara\u00e7\u00e3o e a montagem simples minimizam o manuseio e preservam a hidrata\u00e7\u00e3o e a arquitetura do mioc\u00e1rdio.<\/span><\/li><li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">A alta sensibilidade e repetibilidade garantem medi\u00e7\u00f5es consistentes em diferentes regi\u00f5es card\u00edacas (\u00e1trios, ventr\u00edculos, septo), captando a variabilidade intra-\u00f3rg\u00e2nica.<\/span><\/li><li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">A compara\u00e7\u00e3o entre esp\u00e9cies permite a realiza\u00e7\u00e3o de estudos translacionais por meio da compara\u00e7\u00e3o direta da mec\u00e2nica card\u00edaca em modelos animais e em seres humanos.<\/span><\/li><li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">A versatilidade da plataforma permite a realiza\u00e7\u00e3o de testes em diversos tecidos card\u00edacos e biomateriais em condi\u00e7\u00f5es id\u00eanticas, o que \u00e9 \u00fatil para o desenvolvimento de remendos card\u00edacos, arcabou\u00e7os ou substitutos valvares.<\/span><\/li><li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">As aplica\u00e7\u00f5es de tecido engenheirado se beneficiam de medi\u00e7\u00f5es n\u00e3o destrutivas e repetidas que capturam a evolu\u00e7\u00e3o din\u00e2mica de constru\u00e7\u00f5es mioc\u00e1rdicas bioengenheiradas.<\/span><\/li><li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">A incuba\u00e7\u00e3o controlada e a realiza\u00e7\u00e3o repetida de testes permitem monitorar as altera\u00e7\u00f5es nas propriedades viscoel\u00e1sticas ao longo do tempo, sejam elas decorrentes de isquemia, interven\u00e7\u00f5es farmacol\u00f3gicas ou evolu\u00e7\u00e3o da doen\u00e7a.<\/span><\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0f4db16 elementor-widget elementor-widget-text-editor\" data-id=\"0f4db16\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400;\">Em conjunto, essas capacidades posicionam o <strong>ElastoSens\u2122 Bio<\/strong> como uma ferramenta valiosa para o avan\u00e7o da pesquisa sobre tecido card\u00edaco, da fisiologia comparativa e do desenvolvimento de biomateriais de engenharia.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-794c36a elementor-widget elementor-widget-heading\" data-id=\"794c36a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Refer\u00eancias<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-27340c7 elementor-widget elementor-widget-text-editor\" data-id=\"27340c7\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400;\">Villalobos Lizardi, J. C., Baranger, J., Nguyen, M. B., Asnacios, A., Malik, A., Lumens, J., &#8230; &#038; Villemain, O. (2022). A guide for assessment of myocardial stiffness in health and disease.  <\/span>Nature Cardiovascular Research, 1(1), 8-22.<\/p><p><span style=\"font-weight: 400;\">Emig, R., Zgierski-Johnston, C. M., Timmermann, V., Taberner, A. J., Nash, M. P., Kohl, P., &#038; Peyronnet, R. (2021). Passive myocardial mechanical properties: meaning, measurement, models.  <\/span>Biophysical reviews, 13(5), 587-610.<\/p><p><span style=\"font-weight: 400;\">Caenen, A., Keijzer, L., B\u00e9zy, S., Duchenne, J., Orlowska, M., Van Der Steen, A. F., &#8230; &#038; Vos, H. J. (2023). Continuous shear wave measurements for dynamic cardiac stiffness evaluation in pigs.  <\/span>Scientific Reports, 13(1), 17660.<\/p><p><span style=\"font-weight: 400;\">Kolipaka, A., Araoz, P. A., McGee, K. P., Manduca, A., &#038; Ehman, R. L. (2010). Magnetic resonance elastography as a method for the assessment of effective myocardial stiffness throughout the cardiac cycle.  <\/span>Magnetic Resonance in Medicine, 64(3), 862\u2013870.<\/p><p><span style=\"font-weight: 400;\">Nenadic, I., Urban, M. W., &#038; Greenleaf, J. F. (2009). Ex vivo measurements of myocardial viscoelasticity using shearwave dispersion ultrasound vibrometry (SDUV).  <\/span>Proceedings of the IEEE Engineering in Medicine and Biology Society, 2895\u20132898.<\/p><p><span style=\"font-weight: 400;\">Pandelani, T., Mashosho, E., Walker, C., Scheffer, C., &#038; Franz, T. (2025). Passive biaxial mechanical and microstructural characterization of adult ovine heart ventricles.  <\/span>Frontiers in Bioengineering and Biotechnology, 13, 1500585.<span style=\"font-weight: 400;\"><br><\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9383078 elementor-widget__width-initial elementor-widget-mobile__width-inherit elementor--h-position-center elementor--v-position-middle elementor-arrows-position-inside elementor-widget elementor-widget-slides\" data-id=\"9383078\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;navigation&quot;:&quot;arrows&quot;,&quot;autoplay_speed&quot;:4000,&quot;transition_speed&quot;:4000,&quot;autoplay&quot;:&quot;yes&quot;,&quot;pause_on_hover&quot;:&quot;yes&quot;,&quot;pause_on_interaction&quot;:&quot;yes&quot;,&quot;infinite&quot;:&quot;yes&quot;,&quot;transition&quot;:&quot;slide&quot;}\" data-widget_type=\"slides.default\">\n\t\t\t\t<div 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data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Descubra como nossa tecnologia mede, de forma n\u00e3o destrutiva, as propriedades viscoel\u00e1sticas de biomateriais e tecidos moles utilizando microvolumes de amostras<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c4ce1d0 elementor-align-center elementor-widget elementor-widget-button\" data-id=\"c4ce1d0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/rheolution.com\/pt\/contato\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Entre em contato conosco para mais informa\u00e7\u00f5es<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-efbb293 elementor-widget elementor-widget-heading\" data-id=\"efbb293\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Posts Relacionados<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3f623a9 premium-blog-cta-full-yes premium-floating-effects-yes premium-disable-fe-yes elementor-widget__width-initial premium-blog-align-left elementor-widget elementor-widget-premium-addon-blog\" data-id=\"3f623a9\" data-element_type=\"widget\" data-e-type=\"widget\" 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href=\"https:\/\/rheolution.com\/pt\/notas-de-aplicacao\/medicao-das-propriedades-mecanicas-da-pele\/\" target=\"_blank\">\n\t\t\t\tMedi\u00e7\u00e3o das propriedades mec\u00e2nicas da pele\t\t\t<\/a>\n\t\t<\/h4>\n\t\t\t\t<div class=\"premium-blog-entry-meta\">\n\t\t\t\n\t\t\t\n\t\t\t\n\t\t\t\t\t<\/div>\n\t\t\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t<div class=\"premium-blog-content-inner-wrapper\">\n\t\t<p class=\"premium-blog-post-content\">A pele n\u00e3o \u00e9 apenas o maior \u00f3rg\u00e3o do corpo, mas tamb\u00e9m uma barreira mec\u00e2nica din\u00e2mica que protege contra o estresse ambiental, regula o equil\u00edbrio h\u00eddrico e contribui para a percep\u00e7\u00e3o sensorial. Sua fun\u00e7\u00e3o depende fortemente da organiza\u00e7\u00e3o estrutural do col\u00e1geno, da elastina e de outros componentes d\u00e9rmicos, que, juntos, d\u00e3o origem a comportamentos mec\u00e2nicos \u00fanicos, como elasticidade, rigidez e viscoelasticidade. A medi\u00e7\u00e3o dessas propriedades fornece informa\u00e7\u00f5es sobre como a pele responde \u00e0s for\u00e7as do dia a dia, desde o alongamento e a compress\u00e3o at\u00e9 o cisalhamento.<\/p><div class=\"premium-blog-excerpt-link-wrap\"><a href=\"https:\/\/rheolution.com\/pt\/notas-de-aplicacao\/medicao-das-propriedades-mecanicas-da-pele\/\" target=\"_blank\" class=\"premium-blog-excerpt-link elementor-button\">Leia Mais \u00bb<\/a><\/div>\t\t<\/div>\n\t\t\t\t\t\t\t\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\n\t\t\t\t<div class=\"premium-blog-post-outer-container\" data-total=\"2\">\n\t\t\t<div class=\"premium-blog-post-container premium-blog-skin-classic\">\n\t\t\t\t\t\t\t\t\t<div class=\"premium-blog-thumb-effect-wrapper\">\n\t\t\t\t\t\t<div class=\"premium-blog-thumbnail-container premium-blog-zoomin-effect\">\n\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"1200\" height=\"450\" src=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/web-banner-2.jpg?fit=1200%2C450&amp;ssl=1\" class=\"attachment-full size-full wp-image-70819\" alt=\"\" data-attachment-id=\"70819\" data-permalink=\"https:\/\/rheolution.com\/pt\/notas-de-aplicacao\/viscoelasticidade-da-gelomica-lunagel-ecm-fotoreticulavel\/attachment\/web-banner-2-4\/\" data-orig-file=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/web-banner-2.jpg?fit=1200%2C450&amp;ssl=1\" data-orig-size=\"1200,450\" data-comments-opened=\"1\" data-image-title=\"web-banner-2\" data-image-description=\"\" data-image-caption=\"\" data-large-file=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/web-banner-2.jpg?fit=1024%2C384&amp;ssl=1\" srcset=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/web-banner-2.jpg?w=1200&amp;ssl=1 1200w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/web-banner-2.jpg?resize=300%2C113&amp;ssl=1 300w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/web-banner-2.jpg?resize=1024%2C384&amp;ssl=1 1024w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/web-banner-2.jpg?resize=768%2C288&amp;ssl=1 768w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/web-banner-2.jpg?resize=260%2C98&amp;ssl=1 260w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/web-banner-2.jpg?resize=50%2C19&amp;ssl=1 50w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/web-banner-2.jpg?resize=150%2C56&amp;ssl=1 150w\" sizes=\"(max-width:767px) 700px, (max-width:1200px) 100vw, 1200px\" \/>\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"premium-blog-thumbnail-overlay\">\n\t\t\t\t\t\t\t\t<a class=\"elementor-icon\" href=\"https:\/\/rheolution.com\/pt\/notas-de-aplicacao\/viscoelasticidade-da-gelomica-lunagel-ecm-fotoreticulavel\/\" target=\"_blank\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-screen-only\">Ajuste da rigidez dos hidrog\u00e9is de ECM<\/span>\n\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"premium-blog-content-wrapper \">\n\n\t\t\t\t\t<div class=\"premium-blog-inner-container\">\n\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<h4 class=\"premium-blog-entry-title\">\n\t\t\t<a href=\"https:\/\/rheolution.com\/pt\/notas-de-aplicacao\/viscoelasticidade-da-gelomica-lunagel-ecm-fotoreticulavel\/\" target=\"_blank\">\n\t\t\t\tAjuste da rigidez dos hidrog\u00e9is de ECM\t\t\t<\/a>\n\t\t<\/h4>\n\t\t\t\t<div class=\"premium-blog-entry-meta\">\n\t\t\t\n\t\t\t\n\t\t\t\n\t\t\t\t\t<\/div>\n\t\t\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t<div class=\"premium-blog-content-inner-wrapper\">\n\t\t<p class=\"premium-blog-post-content\">Todas as c\u00e9lulas do corpo humano est\u00e3o expostas a for\u00e7as mec\u00e2nicas que regulam o funcionamento celular e o desenvolvimento dos tecidos, e cada tipo de c\u00e9lula est\u00e1 especificamente adaptado \u00e0s propriedades mec\u00e2nicas do tecido em que se encontra. As propriedades da matriz dos tecidos humanos tamb\u00e9m podem se alterar com a doen\u00e7a e, por sua vez, facilitar sua progress\u00e3o.<\/p><div class=\"premium-blog-excerpt-link-wrap\"><a href=\"https:\/\/rheolution.com\/pt\/notas-de-aplicacao\/viscoelasticidade-da-gelomica-lunagel-ecm-fotoreticulavel\/\" target=\"_blank\" class=\"premium-blog-excerpt-link elementor-button\">Leia Mais \u00bb<\/a><\/div>\t\t<\/div>\n\t\t\t\t\t\t\t\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\n\t\t\t\t<div class=\"premium-blog-post-outer-container\" data-total=\"2\">\n\t\t\t<div class=\"premium-blog-post-container premium-blog-skin-classic\">\n\t\t\t\t\t\t\t\t\t<div class=\"premium-blog-thumb-effect-wrapper\">\n\t\t\t\t\t\t<div class=\"premium-blog-thumbnail-container premium-blog-zoomin-effect\">\n\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"8448\" height=\"3166\" src=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Heart.jpg?fit=8448%2C3166&amp;ssl=1\" class=\"attachment-full size-full wp-image-71041\" alt=\"Measuring mechanical properties of heart tissue\" data-attachment-id=\"71041\" data-permalink=\"https:\/\/rheolution.com\/pt\/notas-de-aplicacao\/medicao-das-propriedades-mecanicas-do-tecido-cardiaco\/attachment\/heart-2\/\" data-orig-file=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Heart.jpg?fit=8448%2C3166&amp;ssl=1\" data-orig-size=\"8448,3166\" data-comments-opened=\"1\" data-image-title=\"Heart\" data-image-description=\"\" data-image-caption=\"\" data-large-file=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Heart.jpg?fit=1024%2C384&amp;ssl=1\" srcset=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Heart.jpg?w=8448&amp;ssl=1 8448w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Heart.jpg?resize=300%2C112&amp;ssl=1 300w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Heart.jpg?resize=1024%2C384&amp;ssl=1 1024w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Heart.jpg?resize=768%2C288&amp;ssl=1 768w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Heart.jpg?resize=1536%2C576&amp;ssl=1 1536w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Heart.jpg?resize=2048%2C768&amp;ssl=1 2048w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Heart.jpg?resize=150%2C56&amp;ssl=1 150w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Heart.jpg?resize=700%2C262&amp;ssl=1 700w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Heart.jpg?w=2440&amp;ssl=1 2440w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Heart.jpg?w=3660&amp;ssl=1 3660w\" sizes=\"(max-width:767px) 700px, (max-width:8448px) 100vw, 8448px\" \/>\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"premium-blog-thumbnail-overlay\">\n\t\t\t\t\t\t\t\t<a class=\"elementor-icon\" href=\"https:\/\/rheolution.com\/pt\/notas-de-aplicacao\/medicao-das-propriedades-mecanicas-do-tecido-cardiaco\/\" target=\"_blank\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-screen-only\">Medi\u00e7\u00e3o das propriedades mec\u00e2nicas do tecido card\u00edaco<\/span>\n\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"premium-blog-content-wrapper \">\n\n\t\t\t\t\t<div class=\"premium-blog-inner-container\">\n\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<h4 class=\"premium-blog-entry-title\">\n\t\t\t<a href=\"https:\/\/rheolution.com\/pt\/notas-de-aplicacao\/medicao-das-propriedades-mecanicas-do-tecido-cardiaco\/\" target=\"_blank\">\n\t\t\t\tMedi\u00e7\u00e3o das propriedades mec\u00e2nicas do tecido card\u00edaco\t\t\t<\/a>\n\t\t<\/h4>\n\t\t\t\t<div class=\"premium-blog-entry-meta\">\n\t\t\t\n\t\t\t\n\t\t\t\n\t\t\t\t\t<\/div>\n\t\t\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t<div class=\"premium-blog-content-inner-wrapper\">\n\t\t<p class=\"premium-blog-post-content\">O intestino \u00e9 um segmento altamente especializado do trato gastrointestinal, respons\u00e1vel pela absor\u00e7\u00e3o de nutrientes, pelo equil\u00edbrio h\u00eddrico e pela intera\u00e7\u00e3o cont\u00ednua com o microbioma. Sua fun\u00e7\u00e3o depende n\u00e3o apenas da atividade bioqu\u00edmica, mas tamb\u00e9m das propriedades mec\u00e2nicas da parede intestinal, que determinam como ela se expande, se contrai e transporta o conte\u00fado luminal. A parede intestinal \u00e9 uma estrutura em camadas composta por mucosa, submucosa, camada muscular e serosa, cada uma contribuindo com comportamentos mec\u00e2nicos distintos, como elasticidade, complac\u00eancia e anisotropia.<\/p><div class=\"premium-blog-excerpt-link-wrap\"><a href=\"https:\/\/rheolution.com\/pt\/notas-de-aplicacao\/medicao-das-propriedades-mecanicas-do-tecido-cardiaco\/\" target=\"_blank\" class=\"premium-blog-excerpt-link elementor-button\">Leia Mais \u00bb<\/a><\/div>\t\t<\/div>\n\t\t\t\t\t\t\t\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\n\t\t\t\t<div class=\"premium-blog-post-outer-container\" data-total=\"2\">\n\t\t\t<div class=\"premium-blog-post-container premium-blog-skin-classic\">\n\t\t\t\t\t\t\t\t\t<div class=\"premium-blog-thumb-effect-wrapper\">\n\t\t\t\t\t\t<div class=\"premium-blog-thumbnail-container premium-blog-zoomin-effect\">\n\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"1200\" height=\"450\" src=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2022\/05\/webbanner-1.jpg?fit=1200%2C450&amp;ssl=1\" class=\"attachment-full size-full wp-image-70837\" alt=\"\" data-attachment-id=\"70837\" data-permalink=\"https:\/\/rheolution.com\/pt\/artigos-rheolution\/bioimpressao-4d-utiliza-biomateriais-em-constante-evolucao\/attachment\/webbanner-6-4\/\" data-orig-file=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2022\/05\/webbanner-1.jpg?fit=1200%2C450&amp;ssl=1\" data-orig-size=\"1200,450\" data-comments-opened=\"1\" data-image-title=\"webbanner\" data-image-description=\"\" data-image-caption=\"\" data-large-file=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2022\/05\/webbanner-1.jpg?fit=1024%2C384&amp;ssl=1\" srcset=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2022\/05\/webbanner-1.jpg?w=1200&amp;ssl=1 1200w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2022\/05\/webbanner-1.jpg?resize=300%2C113&amp;ssl=1 300w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2022\/05\/webbanner-1.jpg?resize=1024%2C384&amp;ssl=1 1024w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2022\/05\/webbanner-1.jpg?resize=768%2C288&amp;ssl=1 768w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2022\/05\/webbanner-1.jpg?resize=260%2C98&amp;ssl=1 260w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2022\/05\/webbanner-1.jpg?resize=50%2C19&amp;ssl=1 50w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2022\/05\/webbanner-1.jpg?resize=150%2C56&amp;ssl=1 150w\" sizes=\"(max-width:767px) 700px, (max-width:1200px) 100vw, 1200px\" \/>\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"premium-blog-thumbnail-overlay\">\n\t\t\t\t\t\t\t\t<a class=\"elementor-icon\" href=\"https:\/\/rheolution.com\/pt\/artigos-rheolution\/bioimpressao-4d-utiliza-biomateriais-em-constante-evolucao\/\" target=\"_blank\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-screen-only\">O que \u00e9 Bioprinting 4D e sua import\u00e2ncia na Biomedicina<\/span>\n\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"premium-blog-content-wrapper \">\n\n\t\t\t\t\t<div class=\"premium-blog-inner-container\">\n\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<h4 class=\"premium-blog-entry-title\">\n\t\t\t<a href=\"https:\/\/rheolution.com\/pt\/artigos-rheolution\/bioimpressao-4d-utiliza-biomateriais-em-constante-evolucao\/\" target=\"_blank\">\n\t\t\t\tO que \u00e9 Bioprinting 4D e sua import\u00e2ncia na Biomedicina\t\t\t<\/a>\n\t\t<\/h4>\n\t\t\t\t<div class=\"premium-blog-entry-meta\">\n\t\t\t\n\t\t\t\n\t\t\t\n\t\t\t\t\t<\/div>\n\t\t\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t<div class=\"premium-blog-content-inner-wrapper\">\n\t\t<p class=\"premium-blog-post-content\">A bioimpress\u00e3o 4D introduz o \u201ctempo\u201d como a quarta dimens\u00e3o, permitindo que os objetos impressos sofram altera\u00e7\u00f5es ao longo do tempo. Est\u00edmulos f\u00edsicos, como luz, temperatura ou magnetismo, podem induzir essas transforma\u00e7\u00f5es. O processo de bioimpress\u00e3o tamb\u00e9m pode permitir a libera\u00e7\u00e3o direcionada de medicamentos por meio de mudan\u00e7as na temperatura ou no pH. Os nano-hidrog\u00e9is podem servir como transportadores de medicamentos, direcionados por campos magn\u00e9ticos, e podem ser rapidamente degradados por enzimas. Al\u00e9m disso, os hidrog\u00e9is podem reagir a sinais biol\u00f3gicos, auxiliando no tratamento de tumores ao liberar medicamentos e, posteriormente, se biodegradarem com o tempo.<\/p><div class=\"premium-blog-excerpt-link-wrap\"><a href=\"https:\/\/rheolution.com\/pt\/artigos-rheolution\/bioimpressao-4d-utiliza-biomateriais-em-constante-evolucao\/\" target=\"_blank\" class=\"premium-blog-excerpt-link elementor-button\">Leia Mais \u00bb<\/a><\/div>\t\t<\/div>\n\t\t\t\t\t\t\t\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\n\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div class=\"premium-blog-footer\">\n\t\t\t\t\t\t\t<nav class=\"premium-blog-pagination-container\" role=\"navigation\" aria-label=\"Pagina\u00e7\u00e3o\">\n\t\t\t\t<span aria-current=\"page\" class=\"page-numbers current\">1<\/span>\n<a class=\"page-numbers\" href=\"https:\/\/rheolution.com\/pt\/wp-json\/wp\/v2\/posts\/71040\/page\/2\/\">2<\/a>\n<a class=\"next page-numbers\" href=\"https:\/\/rheolution.com\/pt\/wp-json\/wp\/v2\/posts\/71040\/page\/2\/\">Pr\u00f3ximo \u00bb<\/a>\t\t\t<\/nav>\n\t\t\t\t\t\t<\/div>\n\t\t\n\t\t\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>O intestino \u00e9 um segmento altamente especializado do trato gastrointestinal, respons\u00e1vel pela absor\u00e7\u00e3o de nutrientes, pelo equil\u00edbrio h\u00eddrico e pela intera\u00e7\u00e3o cont\u00ednua com o microbioma. Sua fun\u00e7\u00e3o depende n\u00e3o apenas da atividade bioqu\u00edmica, mas tamb\u00e9m das propriedades mec\u00e2nicas da parede intestinal, que determinam como ela se expande, se contrai e transporta o conte\u00fado luminal. A parede intestinal \u00e9 uma estrutura em camadas composta por mucosa, submucosa, camada muscular e serosa, cada uma contribuindo com comportamentos mec\u00e2nicos distintos, como elasticidade, complac\u00eancia e anisotropia.  <\/p>\n","protected":false},"author":195401359,"featured_media":71041,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_wpcom_ai_launchpad_first_post":false,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_post_was_ever_published":false},"categories":[383,286],"tags":[89,124,88,100],"class_list":["post-71040","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-aplicacao-de-tecidos-nativos","category-notas-de-aplicacao","tag-elastosens-bio","tag-life-sciences","tag-mechanical-testing","tag-native-tissues"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ 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