{"id":65839,"date":"2022-01-26T11:44:31","date_gmt":"2022-01-26T16:44:31","guid":{"rendered":"https:\/\/rheolution.com\/?p=65839"},"modified":"2026-09-28T16:44:26","modified_gmt":"2026-09-28T20:44:26","slug":"metodos-para-imprimir-em-3d-estruturas-de-suporte-a-base-de-alginato","status":"publish","type":"post","link":"https:\/\/rheolution.com\/pt\/artigos-rheolution\/metodos-para-imprimir-em-3d-estruturas-de-suporte-a-base-de-alginato\/","title":{"rendered":"M\u00e9todos para impress\u00e3o 3D de arcabou\u00e7os \u00e0 base de alginato"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"65839\" class=\"elementor elementor-65839 elementor-20031\" data-elementor-post-type=\"post\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-e7c3228 elementor-section-stretched elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"e7c3228\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;stretch_section&quot;:&quot;section-stretched&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-de4109d\" data-id=\"de4109d\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-318c0cc elementor-widget elementor-widget-text-editor\" data-id=\"318c0cc\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Artigo da Rheolution<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6c2ce3f elementor-widget elementor-widget-heading\" data-id=\"6c2ce3f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">M\u00e9todos para impress\u00e3o 3D de arcabou\u00e7os \u00e0 base de alginato<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-123993b elementor-widget elementor-widget-text-editor\" data-id=\"123993b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"raw_components--panel--3IcXg inspect_panels--inspectionPanel--3Wboz\" tabindex=\"-1\"><div class=\"inspect_panels--copyableRow--2_PiZ inspect_panels--highlightRow--21P9S\"><div class=\"inspect_panels--propertyRowContent--7Y-mu inspect_panels--copyableRow--2_PiZ inspect_panels--highlightRow--21P9S\"><div class=\"inspect_panels--contentProperty--2Z1QI text--fontPos11--RSei3 text--_fontBase--YWDo0 ellipsis--ellipsisAfter8Lines--2rn32 ellipsis--_ellipsisAfterNLines--26JkZ\"><p>por <a href=\"https:\/\/www.linkedin.com\/in\/dimitria-camas\u00e3o-049002a2\/\" target=\"_blank\" rel=\"noopener\">Dra. Dimitria Bonizol Camasao,<\/a><br\/>Especialista S\u00eanior em Aplica\u00e7\u00f5es, Rheolution Inc.<\/p><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-8755f61 elementor-section-stretched elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"8755f61\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;stretch_section&quot;:&quot;section-stretched&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-33eebc5\" data-id=\"33eebc5\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-b732a0e elementor-widget elementor-widget-text-editor\" data-id=\"b732a0e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400;\">Durante o primeiro m\u00eas de 2022, nos concentramos nos hidrog\u00e9is de alginato utilizados em aplica\u00e7\u00f5es de engenharia de tecidos e administra\u00e7\u00e3o de medicamentos. Conforme j\u00e1 foi discutido no   <\/span><a href=\"https:\/\/rheolution.com\/2022\/01\/12\/tuning-the-mechanical-properties-of-cell-laden-alginate-constructs\/xtracellular-matrices-ecm\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">primeira publica\u00e7\u00e3o<\/span><\/a><span style=\"font-weight: 400;\"> sobre este tema, alginato <\/span> <span style=\"font-weight: 400;\">\u00e9 comumente utilizado como bio-tinta na bioimpress\u00e3o 3D para produzir estruturas 3D (esqueletos) contendo c\u00e9lulas ou mol\u00e9culas bioativas, dependendo da aplica\u00e7\u00e3o. Uma caracter\u00edstica espec\u00edfica das solu\u00e7\u00f5es de alginato \u00e9 sua capacidade de se reticular rapidamente (ter suas mol\u00e9culas ligadas entre si) na presen\u00e7a de \u00edons (por exemplo, Ca\u00b2\u207a), resultando em um hidrogel coeso que pode ser preparado em diferentes formas. Al\u00e9m disso, suas propriedades mec\u00e2nicas finais podem ser ajustadas (pelo menos at\u00e9 certo ponto) variando-se os componentes utilizados em sua prepara\u00e7\u00e3o.    <\/span><\/p><p><span style=\"font-weight: 400;\">Na <\/span><a href=\"https:\/\/rheolution.com\/2022\/01\/19\/viscoelasticity-characterization-of-cellink-alginate-gels-using-elastosens-bio\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">segunda publica\u00e7\u00e3o<\/span><\/a><span style=\"font-weight: 400;\">  Em janeiro de 2022, os hidrog\u00e9is de alginato foram reticulados com solu\u00e7\u00e3o de CaCl\u2082 em diferentes concentra\u00e7\u00f5es e tempos crescentes. Compreender o comportamento de uma formula\u00e7\u00e3o espec\u00edfica durante a reticula\u00e7\u00e3o \u2014 como o tempo de inicia\u00e7\u00e3o e a velocidade de gelifica\u00e7\u00e3o, bem como o potencial de incha\u00e7o e encolhimento relacionados a esse processo de gelifica\u00e7\u00e3o \u2014 \u00e9 essencial para projetar melhor os experimentos, especialmente para a impress\u00e3o 3D.   <\/span><\/p><p><span style=\"font-weight: 400;\">Para a t\u00e9cnica de impress\u00e3o 3D por extrus\u00e3o, foram desenvolvidos diversos m\u00e9todos para imprimir estruturas 3D de alginato. A solu\u00e7\u00e3o de alginato possui viscosidade relativamente baixa e, para que seja poss\u00edvel imprimi-la na forma pura e submet\u00ea-la \u00e0 reticula\u00e7\u00e3o posterior, \u00e9 necess\u00e1ria uma otimiza\u00e7\u00e3o trabalhosa do protocolo. Por exemplo, os fabricantes de bio-tintas disp\u00f5em de protocolos detalhados, desenvolvidos para a impress\u00e3o de suas bio-tintas em uma concentra\u00e7\u00e3o espec\u00edfica, dentro da faixa recomendada de velocidade de impress\u00e3o, press\u00e3o de extrus\u00e3o, tamanho do bico, temperatura, entre outros par\u00e2metros. Um exemplo \u00e9 o alginato utilizado em uma de nossas <a href=\"https:\/\/rheolution.com\/2022\/01\/19\/viscoelasticity-characterization-of-cellink-alginate-gels-using-elastosens-bio\/\" target=\"_blank\" rel=\"noopener\">notas de aplica\u00e7\u00e3o<\/a> publicadas   <\/span><span style=\"font-weight: 400;\">. A Cellink desenvolveu um detalhado  <\/span><a href=\"https:\/\/www.cellink.com\/store\/wp-content\/uploads\/sites\/18\/2020\/09\/Bioprinting-Protocol-Alginate-5_18-Dec-2020.pdf\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">protocolo<\/span><\/a><span style=\"font-weight: 400;\"> para a impress\u00e3o de sua bio-tinta em suas impressoras 3D de extrus\u00e3o. <\/span> <\/p><p><span style=\"font-weight: 400;\">Quando um protocolo para a impress\u00e3o de solu\u00e7\u00e3o de alginato puro n\u00e3o est\u00e1 prontamente dispon\u00edvel ou \u00e9 dif\u00edcil de se obter, tamb\u00e9m foram desenvolvidos diferentes m\u00e9todos para superar sua baixa viscosidade. Alguns m\u00e9todos relatados incluem (Se\u00e7\u00e3o A na Figura 1) a pr\u00e9-reticula\u00e7\u00e3o da solu\u00e7\u00e3o de alginato no cilindro da seringa com solu\u00e7\u00e3o de CaCl\u2082 por at\u00e9 30 minutos antes da impress\u00e3o [1,2], (Se\u00e7\u00e3o B da Figura 1) o uso de uma agulha coaxial com solu\u00e7\u00e3o de alginato e CaCl\u2082 no inv\u00f3lucro e no n\u00facleo, respectivamente, para reticula\u00e7\u00e3o r\u00e1pida assim que saem da agulha durante o processo de impress\u00e3o [3], e, muito comum, (Se\u00e7\u00e3o C na Figura 1) a mistura com outros biomateriais, como gelatina, \u00e1gar, PEG, entre outros, para melhorar a capacidade de impress\u00e3o imediata [4]. <\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-889b200 elementor-widget elementor-widget-image\" data-id=\"889b200\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"1150\" height=\"768\" src=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2022\/01\/Alginate_rheolution_article.jpg?fit=1150%2C768&amp;ssl=1\" class=\"attachment-full size-full wp-image-65840\" alt=\"Methods to enhance alginate solution printability, including pre-crosslinking and coaxial needle techniques\" srcset=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2022\/01\/Alginate_rheolution_article.jpg?w=1150&amp;ssl=1 1150w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2022\/01\/Alginate_rheolution_article.jpg?resize=300%2C200&amp;ssl=1 300w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2022\/01\/Alginate_rheolution_article.jpg?resize=1024%2C684&amp;ssl=1 1024w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2022\/01\/Alginate_rheolution_article.jpg?resize=768%2C513&amp;ssl=1 768w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2022\/01\/Alginate_rheolution_article.jpg?resize=219%2C146&amp;ssl=1 219w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2022\/01\/Alginate_rheolution_article.jpg?resize=50%2C33&amp;ssl=1 50w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2022\/01\/Alginate_rheolution_article.jpg?resize=112%2C75&amp;ssl=1 112w\" sizes=\"(max-width:767px) 700px, (max-width:1150px) 100vw, 1150px\" data-attachment-id=\"65840\" data-permalink=\"https:\/\/rheolution.com\/pt\/artigos-rheolution\/metodos-para-imprimir-em-3d-estruturas-de-suporte-a-base-de-alginato\/attachment\/alginate_rheolution_article-4\/\" data-orig-file=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2022\/01\/Alginate_rheolution_article.jpg?fit=1150%2C768&amp;ssl=1\" data-orig-size=\"1150,768\" data-comments-opened=\"1\" data-image-title=\"alginate solution printability\" data-image-description=\"\" data-image-caption=\"\" data-large-file=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2022\/01\/Alginate_rheolution_article.jpg?fit=1024%2C684&amp;ssl=1\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4fe8916 elementor-widget elementor-widget-text-editor\" data-id=\"4fe8916\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400;\">Al\u00e9m disso, um m\u00e9todo de impress\u00e3o relativamente novo, recomendado para melhorar a fidelidade da impress\u00e3o de biomateriais macios, conhecido como Freeform Reversible Embedding of Suspended Hydrogels (FRESH), tamb\u00e9m pode ser utilizado para imprimir estruturas de alginato puro [5]. Nessa t\u00e9cnica (Se\u00e7\u00e3o D na Figura 1), a bio-tinta \u00e9 extrudida em um banho de suporte composto por um hidrogel sacrificial que mant\u00e9m a bio-tinta no lugar at\u00e9 que ela se gelifique. No caso do alginato, o banho de suporte tamb\u00e9m deve conter cloreto de c\u00e1lcio para desencadear a reticula\u00e7\u00e3o. Em suma, a impress\u00e3o FRESH oferece uma combina\u00e7\u00e3o inigual\u00e1vel de recursos em termos de bio-tintas, resolu\u00e7\u00e3o, tamanho e complexidade geom\u00e9trica 3D que podem ser utilizados e\/ou alcan\u00e7ados.   <\/span><span style=\"font-weight: 400;\"> <\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-d84f04a elementor-section-stretched elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"d84f04a\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;stretch_section&quot;:&quot;section-stretched&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-556e26f\" data-id=\"556e26f\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-a6663a5 elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"a6663a5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; font-size: 16px; font-family: 'Red Hat Text', sans-serif;\">Al\u00e9m disso, um m\u00e9todo de impress\u00e3o relativamente novo, recomendado para melhorar a fidelidade da impress\u00e3o de biomateriais macios, conhecido como Freeform Reversible Embedding of Suspended Hydrogels (FRESH), tamb\u00e9m pode ser utilizado para imprimir estruturas de alginato puro [5]. Nessa t\u00e9cnica (Se\u00e7\u00e3o D na Figura 1), a bio-tinta \u00e9 extrudida em um banho de suporte composto por um hidrogel sacrificial que mant\u00e9m a bio-tinta no lugar at\u00e9 que ela se gelifique. No caso do alginato, o banho de suporte tamb\u00e9m deve conter cloreto de c\u00e1lcio para desencadear a reticula\u00e7\u00e3o. Em suma, a impress\u00e3o FRESH oferece uma combina\u00e7\u00e3o inigual\u00e1vel de recursos em termos de bio-tintas, resolu\u00e7\u00e3o, tamanho e complexidade geom\u00e9trica 3D que podem ser utilizados e\/ou alcan\u00e7ados.   <\/span><span style=\"font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; font-size: 16px; font-family: 'Red Hat Text', sans-serif;\"> <\/span><span style=\"font-family: 'Red Hat Text', sans-serif; font-size: 16px; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400;\"><br><\/span><\/p><p><span style=\"font-family: 'Red Hat Text', sans-serif; font-size: 16px; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: 0px;\">Seja na forma pura ou misturado com outros biomateriais, o alginato confere ao arcabou\u00e7o uma biocompatibilidade inerente, custo relativamente baixo, baixa toxicidade e gelifica\u00e7\u00e3o suave e ajust\u00e1vel com a adi\u00e7\u00e3o de c\u00e1tions divalentes \u2014 fatores importantes para o encapsulamento de c\u00e9lulas ou mol\u00e9culas bioativas.  <\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-361c805 elementor-hidden-mobile elementor-hidden-tablet elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"361c805\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-8baed44\" data-id=\"8baed44\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-f127809 elementor-cta--layout-image-left elementor-cta--valign-middle elementor-cta--skin-classic elementor-animated-content elementor-widget elementor-widget-call-to-action\" data-id=\"f127809\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"call-to-action.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-cta\">\n\t\t\t\t\t<div class=\"elementor-cta__bg-wrapper\">\n\t\t\t\t<div class=\"elementor-cta__bg elementor-bg\" style=\"background-image: url(https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/4-1.png?fit=1200%2C1200&#038;ssl=1);\" role=\"img\" aria-label=\"Instrument for mechanical testing of hydrogels and biomaterials.\"><\/div>\n\t\t\t\t<div class=\"elementor-cta__bg-overlay\"><\/div>\n\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-cta__content\">\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<h2 class=\"elementor-cta__title elementor-cta__content-item elementor-content-item\">\n\t\t\t\t\t\tElastoSens\u2122 Bio\t\t\t\t\t<\/h2>\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-cta__description elementor-cta__content-item elementor-content-item\">\n\t\t\t\t\t\tDescubra como nossa tecnologia mede, de forma n\u00e3o destrutiva, as propriedades viscoel\u00e1sticas de biomateriais e tecidos moles utilizando microvolumes de amostras\t\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-cta__button-wrapper elementor-cta__content-item elementor-content-item \">\n\t\t\t\t\t<a class=\"elementor-cta__button elementor-button elementor-size-\" href=\"https:\/\/rheolution.com\/pt\/produtos\/elastosens-bio\/instrumento\/\">\n\t\t\t\t\t\tSaiba mais\t\t\t\t\t<\/a>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-20134ff elementor-section-full_width elementor-section-stretched elementor-hidden-desktop elementor-section-height-default elementor-section-height-default\" data-id=\"20134ff\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;stretch_section&quot;:&quot;section-stretched&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-e1a8c18\" data-id=\"e1a8c18\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-92b15ca elementor-cta--layout-image-left elementor-cta--mobile-layout-image-above elementor-cta--valign-middle elementor-cta--skin-classic elementor-animated-content elementor-widget elementor-widget-call-to-action\" data-id=\"92b15ca\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"call-to-action.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-cta\">\n\t\t\t\t\t<div class=\"elementor-cta__bg-wrapper\">\n\t\t\t\t<div class=\"elementor-cta__bg elementor-bg\" style=\"background-image: url(https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/4-1.png?fit=1200%2C1200&#038;ssl=1);\" role=\"img\" aria-label=\"Instrument for mechanical testing of hydrogels and biomaterials.\"><\/div>\n\t\t\t\t<div class=\"elementor-cta__bg-overlay\"><\/div>\n\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-cta__content\">\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<h2 class=\"elementor-cta__title elementor-cta__content-item elementor-content-item\">\n\t\t\t\t\t\tElastoSens\u2122 Bio\t\t\t\t\t<\/h2>\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-cta__description elementor-cta__content-item elementor-content-item\">\n\t\t\t\t\t\tDescubra como nossa tecnologia mede, de forma n\u00e3o destrutiva, as propriedades viscoel\u00e1sticas de biomateriais e tecidos moles utilizando microvolumes de amostras\t\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-cta__button-wrapper elementor-cta__content-item elementor-content-item \">\n\t\t\t\t\t<a class=\"elementor-cta__button elementor-button elementor-size-\" href=\"https:\/\/rheolution.com\/pt\/produtos\/elastosens-bio\/instrumento\/\">\n\t\t\t\t\t\tSaiba mais\t\t\t\t\t<\/a>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-52ccb90 elementor-section-stretched elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"52ccb90\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;stretch_section&quot;:&quot;section-stretched&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-b745372\" data-id=\"b745372\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-06ea31a elementor-widget elementor-widget-text-editor\" data-id=\"06ea31a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p style=\"text-align: left;\"><b>Refer\u00eancias<\/b><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f9b1087 elementor-widget elementor-widget-text-editor\" data-id=\"f9b1087\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400;\">[1] <\/span><span style=\"font-weight: 400;\">Freeman, F. E., &#038; Kelly, D. J. (2017). <\/span><a href=\"https:\/\/www.nature.com\/articles\/s41598-017-17286-1\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Ajuste da rigidez e da composi\u00e7\u00e3o da bio-tinta de alginato para a libera\u00e7\u00e3o controlada de fatores de crescimento e para direcionar espacialmente o destino das MSCs em tecidos bioimpressos<\/span><\/a><span style=\"font-weight: 400;\">. <\/span><i><span style=\"font-weight: 400;\">Scientific Reports<\/span><\/i><span style=\"font-weight: 400;\">, <\/span><i><span style=\"font-weight: 400;\">7<\/span><\/i><span style=\"font-weight: 400;\">(1), 1-12.<\/span><\/p><p><span style=\"font-weight: 400;\">[2] <\/span><span style=\"font-weight: 400;\">Daly, A. C., Critchley, S. E., Rencsok, E. M., &#038; Kelly, D. J. (2016). <\/span><a href=\"https:\/\/iopscience.iop.org\/article\/10.1088\/1758-5090\/8\/4\/045002\/meta\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Uma compara\u00e7\u00e3o entre diferentes bio-tintas para a bioimpress\u00e3o 3D de fibrocartilagem e cartilagem hialina.<\/span><\/a> <i><span style=\"font-weight: 400;\">Biofabrica\u00e7\u00e3o<\/span><\/i><span style=\"font-weight: 400;\">, <\/span><i><span style=\"font-weight: 400;\">8<\/span><\/i><span style=\"font-weight: 400;\">(4), 045002.<\/span><\/p><p><span style=\"font-weight: 400;\">[3] Zhang, Y., Yu, Y., Chen, H., &#038; Ozbolat, I. T. (2013). <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23458889\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Caracteriza\u00e7\u00e3o de canais microflu\u00eddicos celulares imprim\u00edveis para engenharia de tecidos<\/span><\/a><span style=\"font-weight: 400;\">. <\/span><i><span style=\"font-weight: 400;\">Biofabrica\u00e7\u00e3o<\/span><\/i><span style=\"font-weight: 400;\">, <\/span><i><span style=\"font-weight: 400;\">5<\/span><\/i><span style=\"font-weight: 400;\">(2), 025004.<\/span><\/p><p><span style=\"font-weight: 400;\">[4] Mallakpour, S., Azadi, E. e Hussain, C. M. (2021). <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34023568\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Estado da arte da tecnologia de impress\u00e3o 3D de hidrog\u00e9is \u00e0 base de alginato \u2014 Uma t\u00e9cnica emergente para aplica\u00e7\u00f5es industriais<\/span><\/a><span style=\"font-weight: 400;\">. <\/span><i><span style=\"font-weight: 400;\">Avan\u00e7os na Ci\u00eancia Coloidal e de Interfaces<\/span><\/i><span style=\"font-weight: 400;\">, 102436.<\/span><\/p><p><span style=\"font-weight: 400;\">[5] Shiwarski, D. J., Hudson, A. R., Tashman, J. W., &#038; Feinberg, A. W. (2021). <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7889293\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">O surgimento da impress\u00e3o 3D FRESH como plataforma para a biofabrica\u00e7\u00e3o avan\u00e7ada de tecidos<\/span><\/a><span style=\"font-weight: 400;\">. <\/span><i><span style=\"font-weight: 400;\">APL Bioengineering<\/span><\/i><span style=\"font-weight: 400;\">, <\/span><i><span style=\"font-weight: 400;\">5<\/span><\/i><span style=\"font-weight: 400;\">(1), 010904.<\/span><\/p><p><br><br><br><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f407260 elementor-align-center elementor-widget elementor-widget-button\" data-id=\"f407260\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/rheolution.com\/pt\/contato\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Entre em contato conosco para saber mais<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-6518686 elementor-section-stretched animated-slow elementor-section-boxed elementor-section-height-default elementor-section-height-default elementor-invisible\" data-id=\"6518686\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;stretch_section&quot;:&quot;section-stretched&quot;,&quot;animation&quot;:&quot;fadeInUp&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-d39ed77\" data-id=\"d39ed77\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-337c350 elementor-widget elementor-widget-text-editor\" data-id=\"337c350\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p style=\"text-align: center;\">Artigos relacionados<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-60215db elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"60215db\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-65cf7cb\" data-id=\"65cf7cb\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-dbe85fb premium-blog-cta-full-yes premium-floating-effects-yes premium-disable-fe-yes premium-blog-align-left elementor-widget elementor-widget-premium-addon-blog\" data-id=\"dbe85fb\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;force_height&quot;:&quot;true&quot;,&quot;premium_blog_grid&quot;:&quot;yes&quot;,&quot;premium_blog_layout&quot;:&quot;even&quot;,&quot;premium_blog_columns_number&quot;:&quot;50%&quot;,&quot;premium_blog_columns_number_tablet&quot;:&quot;50%&quot;,&quot;premium_blog_columns_number_mobile&quot;:&quot;100%&quot;,&quot;scroll_to_offset&quot;:&quot;yes&quot;,&quot;premium_fe_trigger&quot;:&quot;load&quot;,&quot;premium_fe_direction&quot;:&quot;alternate&quot;,&quot;premium_fe_loop&quot;:&quot;default&quot;,&quot;premium_fe_easing&quot;:&quot;easeInOutSine&quot;}\" data-widget_type=\"premium-addon-blog.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\n\t\t\n\n\t\t\t\t<div class=\"premium-blog-wrap  premium-blog-even\" data-page=\"65839\">\n\t\t\t\t\t\t\t\t\t<div class=\"premium-blog-post-outer-container\" data-total=\"1\">\n\t\t\t<div class=\"premium-blog-post-container premium-blog-skin-classic\">\n\t\t\t\t\t\t\t\t\t<div class=\"premium-blog-thumb-effect-wrapper\">\n\t\t\t\t\t\t<div class=\"premium-blog-thumbnail-container premium-blog-zoomin-effect\">\n\t\t\t\t\t\t\t<img decoding=\"async\" width=\"1200\" height=\"450\" src=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2022\/12\/webcover2.jpg?fit=1200%2C450&amp;ssl=1\" class=\"attachment-full size-full wp-image-65203\" alt=\"Featured Image: Diagram of FRESH bioprinting process and its functionality\" data-attachment-id=\"65203\" data-permalink=\"https:\/\/rheolution.com\/pt\/artigos-rheolution\/o-potencial-do-fresh-na-bioimpressao\/attachment\/webcover2-3-4\/\" data-orig-file=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2022\/12\/webcover2.jpg?fit=1200%2C450&amp;ssl=1\" data-orig-size=\"1200,450\" data-comments-opened=\"1\" data-image-title=\"FRESH bioprinting process\" data-image-description=\"\" data-image-caption=\"\" data-large-file=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2022\/12\/webcover2.jpg?fit=1024%2C384&amp;ssl=1\" srcset=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2022\/12\/webcover2.jpg?w=1200&amp;ssl=1 1200w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2022\/12\/webcover2.jpg?resize=300%2C113&amp;ssl=1 300w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2022\/12\/webcover2.jpg?resize=1024%2C384&amp;ssl=1 1024w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2022\/12\/webcover2.jpg?resize=768%2C288&amp;ssl=1 768w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2022\/12\/webcover2.jpg?resize=260%2C98&amp;ssl=1 260w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2022\/12\/webcover2.jpg?resize=50%2C19&amp;ssl=1 50w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2022\/12\/webcover2.jpg?resize=150%2C56&amp;ssl=1 150w\" sizes=\"(max-width:767px) 700px, (max-width:1200px) 100vw, 1200px\" \/>\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"premium-blog-thumbnail-overlay\">\n\t\t\t\t\t\t\t\t<a class=\"elementor-icon\" href=\"https:\/\/rheolution.com\/pt\/artigos-rheolution\/o-potencial-do-fresh-na-bioimpressao\/\" target=\"_blank\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-screen-only\">O que \u00e9 bioimpress\u00e3o FRESH e como funciona?<\/span>\n\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"premium-blog-content-wrapper \">\n\n\t\t\t\t\t<div class=\"premium-blog-inner-container\">\n\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<h4 class=\"premium-blog-entry-title\">\n\t\t\t<a href=\"https:\/\/rheolution.com\/pt\/artigos-rheolution\/o-potencial-do-fresh-na-bioimpressao\/\" target=\"_blank\">\n\t\t\t\tO que \u00e9 bioimpress\u00e3o FRESH e como funciona?\t\t\t<\/a>\n\t\t<\/h4>\n\t\t\t\t<div class=\"premium-blog-entry-meta\">\n\t\t\t\n\t\t\t\n\t\t\t\n\t\t\t\t\t<\/div>\n\t\t\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t<div class=\"premium-blog-content-inner-wrapper\">\n\t\t<p class=\"premium-blog-post-content\">J\u00e1 imaginou aqueles tanques de cura de fic\u00e7\u00e3o cient\u00edfica? O princ\u00edpio da flutuabilidade neutra por tr\u00e1s deles inspirou uma solu\u00e7\u00e3o \u00fanica para a impress\u00e3o 3D com tintas macias, semelhantes a l\u00edquidos. A t\u00e9cnica de bioimpress\u00e3o Freeform Reversible Embedding of Suspended Hydrogels (FRESH) foi desenvolvida para viabilizar a impress\u00e3o desses materiais complexos, ideais para aplica\u00e7\u00f5es em engenharia de tecidos. O segredo est\u00e1 em um banho de suporte habilmente projetado, capaz de sustentar as estruturas macias enquanto permite o movimento da agulha da extrusora. Com versatilidade, alta viabilidade celular e potencial para a impress\u00e3o de grandes estruturas, a FRESH abre um mundo de possibilidades, aproximando-nos ainda mais da bioimpress\u00e3o 3D de tecidos espec\u00edficos para cada paciente com base em dados anat\u00f4micos.<\/p><div class=\"premium-blog-excerpt-link-wrap\"><a href=\"https:\/\/rheolution.com\/pt\/artigos-rheolution\/o-potencial-do-fresh-na-bioimpressao\/\" target=\"_blank\" class=\"premium-blog-excerpt-link elementor-button\">Leia mais \u00bb<\/a><\/div>\t\t<\/div>\n\t\t\t\t\t\t\t\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\n\t\t\t\t<div class=\"premium-blog-post-outer-container\" data-total=\"1\">\n\t\t\t<div class=\"premium-blog-post-container premium-blog-skin-classic\">\n\t\t\t\t\t\t\t\t\t<div class=\"premium-blog-thumb-effect-wrapper\">\n\t\t\t\t\t\t<div class=\"premium-blog-thumbnail-container premium-blog-zoomin-effect\">\n\t\t\t\t\t\t\t<img decoding=\"async\" width=\"1200\" height=\"450\" src=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2022\/05\/webbanner-1.jpg?fit=1200%2C450&amp;ssl=1\" class=\"attachment-full size-full wp-image-70837\" alt=\"\" data-attachment-id=\"70837\" data-permalink=\"https:\/\/rheolution.com\/pt\/artigos-rheolution\/bioimpressao-4d-utiliza-biomateriais-em-constante-evolucao\/attachment\/webbanner-6-4\/\" data-orig-file=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2022\/05\/webbanner-1.jpg?fit=1200%2C450&amp;ssl=1\" data-orig-size=\"1200,450\" data-comments-opened=\"1\" data-image-title=\"webbanner\" data-image-description=\"\" data-image-caption=\"\" data-large-file=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2022\/05\/webbanner-1.jpg?fit=1024%2C384&amp;ssl=1\" srcset=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2022\/05\/webbanner-1.jpg?w=1200&amp;ssl=1 1200w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2022\/05\/webbanner-1.jpg?resize=300%2C113&amp;ssl=1 300w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2022\/05\/webbanner-1.jpg?resize=1024%2C384&amp;ssl=1 1024w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2022\/05\/webbanner-1.jpg?resize=768%2C288&amp;ssl=1 768w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2022\/05\/webbanner-1.jpg?resize=260%2C98&amp;ssl=1 260w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2022\/05\/webbanner-1.jpg?resize=50%2C19&amp;ssl=1 50w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2022\/05\/webbanner-1.jpg?resize=150%2C56&amp;ssl=1 150w\" sizes=\"(max-width:767px) 700px, (max-width:1200px) 100vw, 1200px\" \/>\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"premium-blog-thumbnail-overlay\">\n\t\t\t\t\t\t\t\t<a class=\"elementor-icon\" href=\"https:\/\/rheolution.com\/pt\/artigos-rheolution\/bioimpressao-4d-utiliza-biomateriais-em-constante-evolucao\/\" target=\"_blank\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-screen-only\">O que \u00e9 Bioprinting 4D e sua import\u00e2ncia na Biomedicina<\/span>\n\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"premium-blog-content-wrapper \">\n\n\t\t\t\t\t<div class=\"premium-blog-inner-container\">\n\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<h4 class=\"premium-blog-entry-title\">\n\t\t\t<a href=\"https:\/\/rheolution.com\/pt\/artigos-rheolution\/bioimpressao-4d-utiliza-biomateriais-em-constante-evolucao\/\" target=\"_blank\">\n\t\t\t\tO que \u00e9 Bioprinting 4D e sua import\u00e2ncia na Biomedicina\t\t\t<\/a>\n\t\t<\/h4>\n\t\t\t\t<div class=\"premium-blog-entry-meta\">\n\t\t\t\n\t\t\t\n\t\t\t\n\t\t\t\t\t<\/div>\n\t\t\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t<div class=\"premium-blog-content-inner-wrapper\">\n\t\t<p class=\"premium-blog-post-content\">A bioimpress\u00e3o 4D introduz o \u201ctempo\u201d como a quarta dimens\u00e3o, permitindo que os objetos impressos sofram altera\u00e7\u00f5es ao longo do tempo. Est\u00edmulos f\u00edsicos, como luz, temperatura ou magnetismo, podem induzir essas transforma\u00e7\u00f5es. O processo de bioimpress\u00e3o tamb\u00e9m pode permitir a libera\u00e7\u00e3o direcionada de medicamentos por meio de mudan\u00e7as na temperatura ou no pH. Os nano-hidrog\u00e9is podem servir como transportadores de medicamentos, direcionados por campos magn\u00e9ticos, e podem ser rapidamente degradados por enzimas. Al\u00e9m disso, os hidrog\u00e9is podem reagir a sinais biol\u00f3gicos, auxiliando no tratamento de tumores ao liberar medicamentos e, posteriormente, se biodegradarem com o tempo.<\/p><div class=\"premium-blog-excerpt-link-wrap\"><a href=\"https:\/\/rheolution.com\/pt\/artigos-rheolution\/bioimpressao-4d-utiliza-biomateriais-em-constante-evolucao\/\" target=\"_blank\" class=\"premium-blog-excerpt-link elementor-button\">Leia mais \u00bb<\/a><\/div>\t\t<\/div>\n\t\t\t\t\t\t\t\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\n\t\t\t\t\t\t\t<\/div>\n\n\t\t\n\t\t\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Em janeiro de 2022, estudamos os hidrog\u00e9is de alginato na engenharia de tecidos e na administra\u00e7\u00e3o de f\u00e1rmacos. O alginato, frequentemente utilizado como bio-tinta na bioimpress\u00e3o 3D, forma hidrog\u00e9is com propriedades ajust\u00e1veis. Analisamos os efeitos da varia\u00e7\u00e3o da concentra\u00e7\u00e3o de CaCl\u2082 na reticula\u00e7\u00e3o do alginato, processo crucial para a impress\u00e3o 3D. Devido \u00e0 baixa viscosidade do alginato, os m\u00e9todos de impress\u00e3o incluem a pr\u00e9-reticula\u00e7\u00e3o com CaCl\u2082, o uso de uma agulha coaxial para reticula\u00e7\u00e3o imediata ou a mistura do alginato com outros biomateriais para melhorar a imprimibilidade.   <\/p>\n","protected":false},"author":195401338,"featured_media":65841,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_wpcom_ai_launchpad_first_post":false,"_jetpack_hide_featured_image":false,"_jetpack_featured_image_duplicate_dismissed":0,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_post_was_ever_published":false},"categories":[309],"tags":[98,91,124],"class_list":["post-65839","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-artigos-rheolution","tag-3d-bioprinting","tag-hydrogels","tag-life-sciences"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ 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tecidos.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/rheolution.com\/pt\/artigos-rheolution\/metodos-para-imprimir-em-3d-estruturas-de-suporte-a-base-de-alginato\/","og_locale":"pt_BR","og_type":"article","og_title":"M\u00e9todos para Impress\u00e3o 3D de Arcabou\u00e7os \u00e0 Base de Alginato","og_description":"O alginato \u00e9 um material natural de baixa viscosidade amplamente utilizado na impress\u00e3o 3D para aplica\u00e7\u00f5es em engenharia de 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