{"id":65611,"date":"2026-08-06T15:14:23","date_gmt":"2026-08-06T19:14:23","guid":{"rendered":"https:\/\/rheolution.com\/?p=65611"},"modified":"2026-08-14T09:57:24","modified_gmt":"2026-08-14T13:57:24","slug":"hidrogeis-de-alginato","status":"publish","type":"post","link":"https:\/\/rheolution.com\/pt\/notas-de-aplicacao\/hidrogeis-de-alginato\/","title":{"rendered":"Hidrog\u00e9is de alginato"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"65611\" class=\"elementor elementor-65611 elementor-62717\" data-elementor-post-type=\"post\">\n\t\t\t\t<div class=\"elementor-element elementor-element-8fd4dcf e-flex e-con-boxed e-con e-parent\" data-id=\"8fd4dcf\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-8c770e2 elementor-widget elementor-widget-heading\" data-id=\"8c770e2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h6 class=\"elementor-heading-title elementor-size-default\">Nota de Aplica\u00e7\u00e3o | ElastoSens\u2122 Bio<\/h6>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-760ae40 elementor-widget elementor-widget-heading\" data-id=\"760ae40\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Hidrog\u00e9is de alginato: propriedades, aplica\u00e7\u00f5es e comportamento mec\u00e2nico\n<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-16057f6 elementor-widget elementor-widget-text-editor\" data-id=\"16057f6\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>por <a href=\"https:\/\/www.linkedin.com\/in\/mayasalame\/\">Maya Salame<\/a> e <a href=\"https:\/\/www.linkedin.com\/in\/dimitria-camas%C3%A3o-049002a2\/\">Dimitria Camasao<\/a><\/p><p>Cientistas de Aplica\u00e7\u00f5es<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-97ac8de e-flex e-con-boxed e-con e-parent\" data-id=\"97ac8de\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-5fc8fde elementor-widget__width-initial elementor-widget-mobile__width-inherit elementor-widget elementor-widget-heading\" data-id=\"5fc8fde\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">O que \u00e9 um hidrogel de alginato?<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d61237b elementor-widget elementor-widget-text-editor\" data-id=\"d61237b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400\">Os hidrog\u00e9is de alginato s\u00e3o redes polim\u00e9ricas tridimensionais ricas em \u00e1gua, derivadas do alginato, um polissacar\u00eddeo ani\u00f4nico de origem natural. O alginato \u00e9 extra\u00eddo principalmente das paredes celulares das algas marrons pertencentes \u00e0 classe Phaeophyceae, embora tamb\u00e9m possa ser biossintetizado por certas esp\u00e9cies bacterianas, tais como   <\/span><i><span style=\"font-weight: 400\">Azotobacter<\/span><\/i><span style=\"font-weight: 400\"> e <\/span><i><span style=\"font-weight: 400\">Pseudomonas<\/span><\/i><span style=\"font-weight: 400\">. Estruturalmente, o alginato \u00e9 um copol\u00edmero linear composto por \u00e1cido \u03b2-D-manur\u00f4nico (unidades M) e \u00e1cido \u03b1-L-gulur\u00f4nico (unidades G), ligados por liga\u00e7\u00f5es glicos\u00eddicas 1\u21924. Esses mon\u00f4meros est\u00e3o dispostos em blocos homopolim\u00e9ricos de M, blocos de G e blocos alternados de MG, sendo que a distribui\u00e7\u00e3o relativa dos blocos depende da fonte biol\u00f3gica e do processo de extra\u00e7\u00e3o. <\/span><\/p><p><span style=\"font-weight: 400\">A produ\u00e7\u00e3o industrial de alginato envolve, normalmente, a extra\u00e7\u00e3o alcalina a partir da biomassa de algas marinhas secas, seguida de purifica\u00e7\u00e3o e convers\u00e3o em alginato de s\u00f3dio sol\u00favel em \u00e1gua. Quando dissolvidas em ambientes aquosos e expostas a c\u00e1tions multivalentes, as cadeias de alginato se organizam rapidamente em hidrog\u00e9is reticulados fisicamente. Esse processo de gelifica\u00e7\u00e3o aquoso e suave preserva a compatibilidade biol\u00f3gica e torna os hidrog\u00e9is de alginato particularmente atraentes para aplica\u00e7\u00f5es biom\u00e9dicas e biotecnol\u00f3gicas.  <\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5703c6a elementor-widget__width-initial elementor-widget-mobile__width-inherit elementor-widget elementor-widget-heading\" data-id=\"5703c6a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Principais propriedades dos hidrog\u00e9is de alginato<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5a0b64a elementor-widget elementor-widget-heading\" data-id=\"5a0b64a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Caracter\u00edsticas f\u00edsico-qu\u00edmicas<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-38524ee elementor-widget elementor-widget-text-editor\" data-id=\"38524ee\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400\">A forma\u00e7\u00e3o do hidrogel de alginato \u00e9 regida pelas intera\u00e7\u00f5es i\u00f4nicas entre os grupos carboxilatos com carga negativa na cadeia principal do pol\u00edmero e os c\u00e1tions multivalentes. A gelifica\u00e7\u00e3o ocorre por meio da liga\u00e7\u00e3o cooperativa desses \u00edons a regi\u00f5es ricas em \u00e1cido gulur\u00f4nico, resultando em uma arquitetura da zona de jun\u00e7\u00e3o frequentemente descrita como uma estrutura do tipo \u201ccaixa de ovos\u201d. <\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e821974 elementor-widget elementor-widget-text-editor\" data-id=\"e821974\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400\">As principais caracter\u00edsticas que influenciam a forma\u00e7\u00e3o do hidrogel incluem:<\/span><\/p><ul><li style=\"font-weight: 400\"><strong>Mecanismos de reticula\u00e7\u00e3o<\/strong><ul><li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Reticula\u00e7\u00e3o i\u00f4nica com c\u00e1tions divalentes ou trivalentes (por exemplo, Ca\u00b2\u207a, Ba\u00b2\u207a, Sr\u00b2\u207a).<\/span><\/li><li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Reticula\u00e7\u00e3o covalente por meio de oxida\u00e7\u00e3o parcial e rea\u00e7\u00f5es subsequentes de base de Schiff com pol\u00edmeros contendo aminas.<\/span><\/li><li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Redes interpenetrantes ou h\u00edbridas formadas por pol\u00edmeros sint\u00e9ticos ou naturais.<\/span><\/li><\/ul><\/li><li style=\"font-weight: 400\"><strong>Fatores ambientais<\/strong><ul><li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Tipo e concentra\u00e7\u00e3o do c\u00e1tion.<\/span><\/li><li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Peso molecular do alginato e propor\u00e7\u00e3o de blocos G\/M.<\/span><\/li><li style=\"font-weight: 400\"><span style=\"font-weight: 400\">pH e for\u00e7a i\u00f4nica do meio circundante.<\/span><\/li><\/ul><\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8842651 elementor-widget elementor-widget-text-editor\" data-id=\"8842651\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400\">Esses par\u00e2metros, em conjunto, controlam a cin\u00e9tica de gelifica\u00e7\u00e3o, a densidade da rede, a porosidade e a capacidade de reten\u00e7\u00e3o de \u00e1gua.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-30981bc elementor-widget elementor-widget-heading\" data-id=\"30981bc\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Propriedades mec\u00e2nicas<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2e827a1 elementor-widget elementor-widget-text-editor\" data-id=\"2e827a1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400\">Os hidrog\u00e9is de alginato apresentam um comportamento mec\u00e2nico macio e viscoel\u00e1stico que se assemelha muito ao dos tecidos biol\u00f3gicos hidratados. Sua rigidez e elasticidade s\u00e3o altamente ajust\u00e1veis e dependem da concentra\u00e7\u00e3o do pol\u00edmero, da arquitetura molecular e da densidade de reticula\u00e7\u00e3o. <\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4476bec elementor-widget elementor-widget-text-editor\" data-id=\"4476bec\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400\">As caracter\u00edsticas relevantes do ponto de vista mec\u00e2nico incluem:<\/span><\/p><ul><li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Modula\u00e7\u00e3o do m\u00f3dulo de elasticidade por meio da sele\u00e7\u00e3o de c\u00e1tions e do teor de G-block.<\/span><\/li><li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Comportamento de relaxamento de tens\u00e3o decorrente de liga\u00e7\u00f5es cruzadas i\u00f4nicas revers\u00edveis.<\/span><\/li><li style=\"font-weight: 400\"><span style=\"font-weight: 400\">A evolu\u00e7\u00e3o mec\u00e2nica dependente do tempo, como a troca i\u00f4nica ou a oxida\u00e7\u00e3o parcial do pol\u00edmero, pode enfraquecer gradualmente a rede.<\/span><\/li><li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Maior resist\u00eancia mec\u00e2nica em sistemas compostos ou h\u00edbridos \u00e0 base de alginato que incorporam pol\u00edmeros secund\u00e1rios, nanopart\u00edculas ou liga\u00e7\u00f5es covalentes.<\/span><\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-fba9753 elementor-widget elementor-widget-text-editor\" data-id=\"fba9753\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400\">Essa adaptabilidade permite que os hidrog\u00e9is de alginato abranjam uma ampla gama de regimes mec\u00e2nicos, desde matrizes altamente flex\u00edveis para encapsulamento celular at\u00e9 arcabou\u00e7os refor\u00e7ados para modelos de tecidos capazes de suportar cargas.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0959975 elementor-widget elementor-widget-heading\" data-id=\"0959975\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Intera\u00e7\u00f5es biol\u00f3gicas<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-90cc644 elementor-widget elementor-widget-text-editor\" data-id=\"90cc644\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400\">Os hidrog\u00e9is de alginato s\u00e3o amplamente reconhecidos por sua biocompatibilidade e baixa citotoxicidade, especialmente quando altamente purificados. Seu desempenho biol\u00f3gico, no entanto, \u00e9 fortemente influenciado pela composi\u00e7\u00e3o qu\u00edmica e pelo hist\u00f3rico de processamento. <\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-62fefea elementor-widget elementor-widget-text-editor\" data-id=\"62fefea\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400\">As principais intera\u00e7\u00f5es biol\u00f3gicas incluem:<\/span><\/p><ul><li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Ades\u00e3o celular inerente m\u00ednima, devido \u00e0 aus\u00eancia de motivos nativos de liga\u00e7\u00e3o celular.<\/span><\/li><li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Imunogenicidade ajust\u00e1vel, influenciada pela rela\u00e7\u00e3o G\/M e pelas impurezas residuais.<\/span><\/li><li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Estabilidade enzim\u00e1tica em mam\u00edferos, uma vez que as enzimas degradadoras de alginato geralmente est\u00e3o ausentes.<\/span><\/li><li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Capacidade de funcionaliza\u00e7\u00e3o, permitindo a incorpora\u00e7\u00e3o de pept\u00eddeos bioativos, prote\u00ednas ou polissacar\u00eddeos para promover a ades\u00e3o, a migra\u00e7\u00e3o e a diferencia\u00e7\u00e3o celular.<\/span><\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-84ba0f0 elementor-widget elementor-widget-text-editor\" data-id=\"84ba0f0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400\">Por meio de modifica\u00e7\u00f5es qu\u00edmicas, os hidrog\u00e9is de alginato podem ser projetados para imitar melhor os ambientes da matriz extracelular, mantendo, ao mesmo tempo, perfis de degrada\u00e7\u00e3o controlados.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-28004d8 elementor-widget__width-initial elementor-widget-mobile__width-inherit elementor-widget elementor-widget-heading\" data-id=\"28004d8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Aplica\u00e7\u00f5es dos hidrog\u00e9is de alginato<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-06adff0 elementor-widget elementor-widget-heading\" data-id=\"06adff0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Engenharia de tecidos<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ba2f1b1 elementor-widget elementor-widget-text-editor\" data-id=\"ba2f1b1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400\">Os hidrog\u00e9is de alginato s\u00e3o amplamente utilizados como materiais de arcabou\u00e7o para a engenharia de tecidos devido ao seu alto teor de \u00e1gua, \u00e0s condi\u00e7\u00f5es moderadas de gelifica\u00e7\u00e3o e \u00e0 semelhan\u00e7a estrutural com as matrizes extracelulares nativas. Eles permitem o encapsulamento tridimensional de c\u00e9lulas e s\u00e3o amplamente aplicados na regenera\u00e7\u00e3o de cartilagem, osso, pele e tecidos moles. Os sistemas compostos de alginato s\u00e3o frequentemente projetados para superar limita\u00e7\u00f5es em termos de resist\u00eancia mec\u00e2nica ou ades\u00e3o celular.  <\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d01f123 elementor-widget elementor-widget-heading\" data-id=\"d01f123\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Cultura celular 3D e modelos de doen\u00e7as<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-137d5ec elementor-widget elementor-widget-text-editor\" data-id=\"137d5ec\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400\">In vitro, os hidrog\u00e9is de alginato proporcionam ambientes reproduz\u00edveis e fisiologicamente relevantes para a cultura celular tridimensional. Sua permeabilidade permite o transporte eficiente de nutrientes e res\u00edduos, enquanto sua rigidez ajust\u00e1vel possibilita a modelagem de nichos mec\u00e2nicos espec\u00edficos de cada tecido. Essas caracter\u00edsticas tornam os hidrog\u00e9is de alginato valiosos para o estudo do comportamento celular, da mecanobiologia e da progress\u00e3o de doen\u00e7as.  <\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c1cb3eb elementor-widget elementor-widget-heading\" data-id=\"c1cb3eb\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Administra\u00e7\u00e3o de Medicamentos, Genes e C\u00e9lulas<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ff74672 elementor-widget elementor-widget-text-editor\" data-id=\"ff74672\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400\">Os hidrog\u00e9is de alginato funcionam como plataformas vers\u00e1teis de libera\u00e7\u00e3o de pequenas mol\u00e9culas, prote\u00ednas, \u00e1cidos nucleicos e c\u00e9lulas vivas. O encapsulamento na rede do hidrogel permite uma libera\u00e7\u00e3o localizada e sustentada, impulsionada pela difus\u00e3o, pelo relaxamento da rede ou pela degrada\u00e7\u00e3o controlada. Os sistemas injet\u00e1veis \u00e0 base de alginato s\u00e3o particularmente vantajosos para a administra\u00e7\u00e3o terap\u00eautica minimamente invasiva.  <\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-892f73a elementor-widget__width-initial elementor-widget-mobile__width-inherit elementor-widget elementor-widget-heading\" data-id=\"892f73a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Por que a viscoelasticidade dos hidrog\u00e9is de alginato \u00e9 importante?<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-05c6bea elementor-widget elementor-widget-text-editor\" data-id=\"05c6bea\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400\">A natureza viscoel\u00e1stica dos hidrog\u00e9is de alginato \u00e9 fundamental para seu desempenho biol\u00f3gico e funcional. A viscoelasticidade determina como esses materiais dissipam energia, se adaptam \u00e0 deforma\u00e7\u00e3o e relaxam a tens\u00e3o ao longo do tempo \u2014 propriedades que influenciam fortemente a mecanotransdu\u00e7\u00e3o celular, a integra\u00e7\u00e3o tecidual e a estabilidade estrutural. Na medicina regenerativa e na cultura celular, demonstrou-se que o relaxamento da tens\u00e3o e a rigidez dependente do tempo afetam a dissemina\u00e7\u00e3o celular, a diferencia\u00e7\u00e3o e a remodela\u00e7\u00e3o da matriz, tornando o ajuste da viscoelasticidade um par\u00e2metro cr\u00edtico de projeto.  <\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-851f298 elementor-widget__width-initial elementor-widget-mobile__width-inherit elementor-widget elementor-widget-heading\" data-id=\"851f298\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">M\u00e9todos para caracterizar a viscoelasticidade de hidrog\u00e9is de alginato<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-171be53 elementor-widget elementor-widget-text-editor\" data-id=\"171be53\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400\">As propriedades mec\u00e2nicas do hidrogel de alginato s\u00e3o comumente avaliadas por meio de t\u00e9cnicas de ensaio mec\u00e2nico em massa, como reometria oscilat\u00f3ria, compress\u00e3o n\u00e3o confinada e ensaio de tra\u00e7\u00e3o. Esses m\u00e9todos fornecem informa\u00e7\u00f5es valiosas sobre os m\u00f3dulos el\u00e1stico e viscoso, mas muitas vezes exigem contato com a amostra, sua destrui\u00e7\u00e3o ou uma prepara\u00e7\u00e3o complexa. Os ensaios tradicionais tamb\u00e9m podem ter dificuldade em capturar altera\u00e7\u00f5es dependentes do tempo em materiais macios e hidratados ou em monitorar a evolu\u00e7\u00e3o mec\u00e2nica sob condi\u00e7\u00f5es fisiol\u00f3gicas e est\u00e9reis.  <\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1961b9f elementor-widget__width-initial elementor-widget-mobile__width-inherit elementor-widget elementor-widget-heading\" data-id=\"1961b9f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Estudo de caso: Caracteriza\u00e7\u00e3o mec\u00e2nica do hidrogel de alginato utilizando o ElastoSens\u2122 Bio<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4babf25 elementor-widget__width-initial elementor-widget elementor-widget-heading\" data-id=\"4babf25\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">ElastoSens\u2122 Bio: Uma ferramenta n\u00e3o destrutiva para medir hidrog\u00e9is de alginato macios<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-5a225c3 e-grid e-con-full e-con e-child\" data-id=\"5a225c3\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ce43e5b elementor-widget elementor-widget-text-editor\" data-id=\"ce43e5b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><a href=\"https:\/\/rheolution.com\/instrument-elastosensbio\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400\"><strong>ElastoSens\u2122 Bio<\/strong><\/span><\/a> <span style=\"font-weight: 400\">\u00e9 um instrumento sem contato, baseado em resson\u00e2ncia, projetado especificamente para caracterizar as propriedades viscoel\u00e1sticas de biomateriais macios, como os hidrog\u00e9is de alginato. Ao gerar vibra\u00e7\u00f5es mec\u00e2nicas suaves e monitorar as mudan\u00e7as na frequ\u00eancia de resson\u00e2ncia, ele permite a medi\u00e7\u00e3o em tempo real da rigidez e da evolu\u00e7\u00e3o viscoel\u00e1stica sem deformar fisicamente ou danificar a amostra. Essa abordagem \u00e9 particularmente adequada para redes de alginato fr\u00e1geis e altamente hidratadas, oferecendo vantagens importantes, incluindo testes n\u00e3o destrutivos, alta sensibilidade a materiais macios, medi\u00e7\u00f5es repet\u00edveis ao longo do tempo e compatibilidade com fluxos de trabalho est\u00e9reis.  <\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-045aef9 elementor-widget elementor-widget-image\" data-id=\"045aef9\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"968\" height=\"544\" src=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/elastosens2-1.webp?fit=968%2C544&amp;ssl=1\" class=\"attachment-large size-large wp-image-43562\" alt=\"\" srcset=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/elastosens2-1.webp?w=968&amp;ssl=1 968w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/elastosens2-1.webp?resize=300%2C169&amp;ssl=1 300w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/elastosens2-1.webp?resize=768%2C432&amp;ssl=1 768w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/elastosens2-1.webp?resize=133%2C75&amp;ssl=1 133w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/elastosens2-1.webp?resize=480%2C270&amp;ssl=1 480w\" sizes=\"(max-width:767px) 700px, (max-width:968px) 100vw, 968px\" data-attachment-id=\"43562\" data-permalink=\"https:\/\/rheolution.com\/pt\/elastosens2-4-2-2\/\" data-orig-file=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/elastosens2-1.webp?fit=968%2C544&amp;ssl=1\" data-orig-size=\"968,544\" data-comments-opened=\"1\" data-image-title=\"elastosens2\" data-image-description=\"\" data-image-caption=\"\" data-large-file=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/elastosens2-1.webp?fit=968%2C544&amp;ssl=1\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b87c673 elementor-widget elementor-widget-text-editor\" data-id=\"b87c673\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400\">Para demonstrar as capacidades do ElastoSens\u2122 Bio, realizamos uma s\u00e9rie de testes em hidrog\u00e9is \u00e0 base de alginato. A se\u00e7\u00e3o a seguir descreve os materiais e m\u00e9todos utilizados para caracterizar a gelifica\u00e7\u00e3o do alginato e sua evolu\u00e7\u00e3o mec\u00e2nica, seguida dos resultados, fornecendo um exemplo pr\u00e1tico da capacidade do instrumento de monitorar de forma n\u00e3o destrutiva as propriedades viscoel\u00e1sticas ao longo do tempo. <\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ed23fc9 elementor-widget elementor-widget-heading\" data-id=\"ed23fc9\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Materiais e m\u00e9todos<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d118051 elementor-widget elementor-widget-text-editor\" data-id=\"d118051\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400\">As solu\u00e7\u00f5es de alginato (1% p\/v) e cloreto de c\u00e1lcio (CaCl\u2082, 10 mM e 50 mM) foram adquiridas da CELLINK (Boston, EUA). Colocou-se 3 mL de alginato no suporte para amostras macro do ElastoSens\u2122 Bio, e 3 mL de solu\u00e7\u00e3o de CaCl\u2082 foram cuidadosamente adicionados por cima para iniciar a reticula\u00e7\u00e3o i\u00f4nica. A solu\u00e7\u00e3o de CaCl\u2082 foi ent\u00e3o removida, e as propriedades viscoel\u00e1sticas foram medidas utilizando o ElastoSens\u2122 Bio a 25 \u00b0C por 5 minutos (intervalo de amostragem: 10 s) ap\u00f3s 100 minutos. Os dados s\u00e3o apresentados como m\u00e9dia \u00b1 desvio-padr\u00e3o. As an\u00e1lises estat\u00edsticas foram realizadas utilizando o GraphPad Prism v9, com o teste t n\u00e3o pareado (GraphPad Software, La Jolla, CA, EUA).     <\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0f0a34f elementor-widget elementor-widget-image\" data-id=\"0f0a34f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"512\" height=\"356\" src=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Alginate-Hydrogel.jpg?fit=512%2C356&amp;ssl=1\" class=\"attachment-large size-large wp-image-62720\" alt=\"Alginate gel in the holder after testing.\" srcset=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Alginate-Hydrogel.jpg?w=512&amp;ssl=1 512w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Alginate-Hydrogel.jpg?resize=300%2C209&amp;ssl=1 300w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Alginate-Hydrogel.jpg?resize=108%2C75&amp;ssl=1 108w\" sizes=\"(max-width:767px) 512px, 512px\" data-attachment-id=\"62720\" data-permalink=\"https:\/\/rheolution.com\/pt\/alginate-hydrogel\/\" data-orig-file=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Alginate-Hydrogel.jpg?fit=512%2C356&amp;ssl=1\" data-orig-size=\"512,356\" data-comments-opened=\"1\" data-image-title=\"Alginate Hydrogel\" data-image-description=\"\" data-image-caption=\"\" data-large-file=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Alginate-Hydrogel.jpg?fit=512%2C356&amp;ssl=1\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-13da851 elementor-widget elementor-widget-text-editor\" data-id=\"13da851\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><em><b>Figura 1.<\/b><span style=\"font-weight: 400\">  Imagem representativa do gel de alginato no suporte ap\u00f3s o teste.<\/span><\/em><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-aa24bd0 elementor-widget elementor-widget-heading\" data-id=\"aa24bd0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Resultados e discuss\u00f5es<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-54513af elementor-widget elementor-widget-text-editor\" data-id=\"54513af\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400\">Ap\u00f3s 100 min de reticula\u00e7\u00e3o, os hidrog\u00e9is de alginato a 1% (p\/v) formados com CaCl\u2082 a 50 mM apresentaram um m\u00f3dulo de armazenamento ao cisalhamento (G\u2032) significativamente maior do que aqueles reticulados com CaCl\u2082 a 10 mM (2.832 \u00b1 53 Pa vs. 608 \u00b1 25 Pa, ****p &lt; 0,0001). O fator de amortecimento (tan \u03b4) tamb\u00e9m foi significativamente maior na condi\u00e7\u00e3o de 50 mM em compara\u00e7\u00e3o com 10 mM (0,195 \u00b1 0,085 vs. 0,161 \u00b1 0,013, ****p &lt; 0,0001), indicando um equil\u00edbrio viscoel\u00e1stico alterado entre as contribui\u00e7\u00f5es el\u00e1sticas e viscosas. O aumento acentuado em G\u2032 com o aumento da concentra\u00e7\u00e3o de CaCl\u2082 reflete uma maior densidade de reticula\u00e7\u00e3o, consistente com mais pontes i\u00f4nicas entre as cadeias de alginato. Embora ambas as condi\u00e7\u00f5es tenham formado redes predominantemente el\u00e1sticas (tan \u03b4 &lt; 0,5), o valor mais alto de tan \u03b4 observado com 50 mM de CaCl\u2082 sugere um aumento modesto na dissipa\u00e7\u00e3o viscosa. Em conjunto, esses resultados demonstram que a concentra\u00e7\u00e3o de CaCl\u2082 ajusta efetivamente tanto a rigidez quanto a resposta viscoel\u00e1stica dos hidrog\u00e9is de alginato.    <\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-04b5520 e-grid e-con-full e-con e-child\" data-id=\"04b5520\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-a2fe99a elementor-widget elementor-widget-image\" data-id=\"a2fe99a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"817\" height=\"834\" src=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Alginate-Hydrogel_-G-10-vs-50.png?fit=817%2C834&amp;ssl=1\" class=\"attachment-large size-large wp-image-62728\" alt=\"\" srcset=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Alginate-Hydrogel_-G-10-vs-50.png?w=817&amp;ssl=1 817w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Alginate-Hydrogel_-G-10-vs-50.png?resize=294%2C300&amp;ssl=1 294w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Alginate-Hydrogel_-G-10-vs-50.png?resize=768%2C784&amp;ssl=1 768w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Alginate-Hydrogel_-G-10-vs-50.png?resize=73%2C75&amp;ssl=1 73w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Alginate-Hydrogel_-G-10-vs-50.png?resize=700%2C715&amp;ssl=1 700w\" sizes=\"(max-width:767px) 700px, (max-width:817px) 100vw, 817px\" data-attachment-id=\"62728\" data-permalink=\"https:\/\/rheolution.com\/pt\/alginate-hydrogel_-g-10-vs-50\/\" data-orig-file=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Alginate-Hydrogel_-G-10-vs-50.png?fit=817%2C834&amp;ssl=1\" data-orig-size=\"817,834\" data-comments-opened=\"1\" data-image-title=\"Alginate Hydrogel_ G&amp;#8217; 10 vs 50\" data-image-description=\"\" data-image-caption=\"\" data-large-file=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Alginate-Hydrogel_-G-10-vs-50.png?fit=817%2C834&amp;ssl=1\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a351799 elementor-widget elementor-widget-image\" data-id=\"a351799\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"771\" height=\"834\" src=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Alginate-Hydrogel_-tanD-10-vs-50.png?fit=771%2C834&amp;ssl=1\" class=\"attachment-large size-large wp-image-62736\" alt=\"\" srcset=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Alginate-Hydrogel_-tanD-10-vs-50.png?w=771&amp;ssl=1 771w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Alginate-Hydrogel_-tanD-10-vs-50.png?resize=277%2C300&amp;ssl=1 277w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Alginate-Hydrogel_-tanD-10-vs-50.png?resize=768%2C831&amp;ssl=1 768w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Alginate-Hydrogel_-tanD-10-vs-50.png?resize=69%2C75&amp;ssl=1 69w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Alginate-Hydrogel_-tanD-10-vs-50.png?resize=700%2C757&amp;ssl=1 700w\" sizes=\"(max-width:767px) 700px, (max-width:771px) 100vw, 771px\" data-attachment-id=\"62736\" data-permalink=\"https:\/\/rheolution.com\/pt\/alginate-hydrogel_-tand-10-vs-50\/\" data-orig-file=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Alginate-Hydrogel_-tanD-10-vs-50.png?fit=771%2C834&amp;ssl=1\" data-orig-size=\"771,834\" data-comments-opened=\"1\" data-image-title=\"Alginate Hydrogel_ tanD 10 vs 50\" data-image-description=\"\" data-image-caption=\"\" data-large-file=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Alginate-Hydrogel_-tanD-10-vs-50.png?fit=771%2C834&amp;ssl=1\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-39e927a elementor-widget elementor-widget-text-editor\" data-id=\"39e927a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><em><b>Figura 2.<\/b><span style=\"font-weight: 400\">  M\u00f3dulo de armazenamento de cisalhamento (G\u2032, \u00e0 esquerda) e fator de amortecimento (tan\u03b4, \u00e0 direita) de alginato a 1% (p\/v) reticulado com CaCl\u2082 a 50 mM e 10 mM ap\u00f3s 100 minutos (m\u00e9dia \u00b1 DP). Diferen\u00e7a estat\u00edstica indicada por ****p &lt; 0,0001. <\/span><\/em><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8ad5968 elementor-widget elementor-widget-heading\" data-id=\"8ad5968\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Conclus\u00f5es e perspectivas<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b7d7a98 elementor-widget elementor-widget-text-editor\" data-id=\"b7d7a98\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400\">O comportamento mec\u00e2nico dos hidrog\u00e9is de alginato \u2014 determinado pela reticula\u00e7\u00e3o i\u00f4nica, pela arquitetura da rede e pela troca i\u00f4nica dependente do tempo \u2014 \u00e9 fundamental para seu desempenho em sistemas biom\u00e9dicos e de engenharia. Como os g\u00e9is de alginato s\u00e3o macios, altamente hidratados e em constante evolu\u00e7\u00e3o din\u00e2mica, suas propriedades viscoel\u00e1sticas devem ser caracterizadas sem alterar a estrutura ou a esterilidade. O monitoramento viscoel\u00e1stico n\u00e3o destrutivo com o ElastoSens\u2122 Bio permite uma avalia\u00e7\u00e3o confi\u00e1vel e longitudinal dos hidrog\u00e9is de alginato, desde a gelifica\u00e7\u00e3o at\u00e9 o uso.  <\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-aed2e2d elementor-widget elementor-widget-text-editor\" data-id=\"aed2e2d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400\">Principais vantagens dos hidrog\u00e9is de alginato:<\/span><\/p><ul><li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Tecnologia n\u00e3o destrutiva otimizada para materiais macios e altamente hidratados.<\/span><span style=\"font-weight: 400\"><br><\/span><\/li><li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Alta sensibilidade e repetibilidade para redes de baixa rigidez.<\/span><span style=\"font-weight: 400\"><br><\/span><\/li><li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Monitoramento em tempo real da cin\u00e9tica de gelifica\u00e7\u00e3o e da transi\u00e7\u00e3o l\u00edquido-gel.<\/span><span style=\"font-weight: 400\"><br><\/span><\/li><li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Medi\u00e7\u00e3o da rigidez terminal e estabiliza\u00e7\u00e3o mec\u00e2nica.<\/span><span style=\"font-weight: 400\"><br><\/span><\/li><li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Testes longitudinais da mesma amostra, inclusive em condi\u00e7\u00f5es est\u00e9reis.<\/span><\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-794c36a elementor-widget elementor-widget-heading\" data-id=\"794c36a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Refer\u00eancias<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-27340c7 elementor-widget elementor-widget-text-editor\" data-id=\"27340c7\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><a href=\"https:\/\/link.springer.com\/article\/10.1007\/s42452-020-04096-w\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400\">Sahoo, D. R., &amp; Biswal, T. (2021). Alginate and its application to tissue engineering.  <\/span>SN Applied Sciences, 3(1), 30.<\/a><\/p><p><a href=\"https:\/\/www.mdpi.com\/1996-1944\/6\/4\/1285\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400\">Sun, J., &amp; Tan, H. (2013). Alginate-based biomaterials for regenerative medicine applications.  <\/span>Materials, 6(4), 1285-1309.<\/a><\/p><p><a href=\"https:\/\/www.mdpi.com\/1660-3397\/21\/3\/189\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400\">Farshidfar, N., Iravani, S., &amp; Varma, R. S. (2023). Alginate-based biomaterials in tissue engineering and regenerative medicine.  <\/span>Marine Drugs, 21(3), 189.<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9383078 elementor-widget__width-initial elementor-widget-mobile__width-inherit elementor--h-position-center elementor--v-position-middle elementor-arrows-position-inside elementor-widget elementor-widget-slides\" data-id=\"9383078\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;navigation&quot;:&quot;arrows&quot;,&quot;autoplay_speed&quot;:4000,&quot;transition_speed&quot;:4000,&quot;autoplay&quot;:&quot;yes&quot;,&quot;pause_on_hover&quot;:&quot;yes&quot;,&quot;pause_on_interaction&quot;:&quot;yes&quot;,&quot;infinite&quot;:&quot;yes&quot;,&quot;transition&quot;:&quot;slide&quot;}\" data-widget_type=\"slides.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-swiper\">\n\t\t\t\t\t<div class=\"elementor-slides-wrapper elementor-main-swiper swiper\" role=\"region\" aria-roledescription=\"carousel\" aria-label=\"Slides\" dir=\"ltr\" data-animation=\"fadeInUp\">\n\t\t\t\t<div class=\"swiper-wrapper elementor-slides\">\n\t\t\t\t\t\t\t\t\t\t<div class=\"elementor-repeater-item-c97f30c swiper-slide\" role=\"group\" aria-roledescription=\"slide\"><div class=\"swiper-slide-bg\" role=\"img\" aria-label=\"elastosens2\"><\/div><div class=\"swiper-slide-inner\" ><div class=\"swiper-slide-contents\"><\/div><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8cce0c6 elementor-widget__width-initial elementor-widget-mobile__width-inherit elementor-widget elementor-widget-text-editor\" data-id=\"8cce0c6\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Descubra como nossa tecnologia mede, de forma n\u00e3o destrutiva, as propriedades viscoel\u00e1sticas de biomateriais e tecidos moles utilizando microvolumes de amostras<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c4ce1d0 elementor-align-center elementor-widget elementor-widget-button\" data-id=\"c4ce1d0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/rheolution.com\/contact\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Entre em contato conosco para obter mais informa\u00e7\u00f5es<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-efbb293 elementor-widget elementor-widget-heading\" data-id=\"efbb293\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Artigos relacionados<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3f623a9 premium-blog-cta-full-yes premium-floating-effects-yes premium-disable-fe-yes elementor-widget__width-initial premium-blog-align-left elementor-widget elementor-widget-premium-addon-blog\" data-id=\"3f623a9\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;force_height&quot;:&quot;true&quot;,&quot;premium_blog_grid&quot;:&quot;yes&quot;,&quot;premium_blog_layout&quot;:&quot;even&quot;,&quot;premium_blog_columns_number&quot;:&quot;50%&quot;,&quot;premium_blog_columns_number_tablet&quot;:&quot;50%&quot;,&quot;premium_blog_columns_number_mobile&quot;:&quot;100%&quot;,&quot;scroll_to_offset&quot;:&quot;yes&quot;,&quot;premium_fe_trigger&quot;:&quot;load&quot;,&quot;premium_fe_direction&quot;:&quot;alternate&quot;,&quot;premium_fe_loop&quot;:&quot;default&quot;,&quot;premium_fe_easing&quot;:&quot;easeInOutSine&quot;}\" data-widget_type=\"premium-addon-blog.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\n\t\t\n\n\t\t\t\t<div class=\"premium-blog-wrap  premium-blog-even\" data-page=\"65611\" data-pagination=\"true\">\n\t\t\t\t\t\t\t\t\t<div class=\"premium-blog-post-outer-container\" data-total=\"3\">\n\t\t\t<div class=\"premium-blog-post-container premium-blog-skin-classic\">\n\t\t\t\t\t\t\t\t\t<div class=\"premium-blog-thumb-effect-wrapper\">\n\t\t\t\t\t\t<div class=\"premium-blog-thumbnail-container premium-blog-zoomin-effect\">\n\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"7000\" height=\"2322\" src=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/FIBRIN.jpg?fit=7000%2C2322&amp;ssl=1\" class=\"attachment-full size-full wp-image-71010\" alt=\"Fibrin Hydrogel\" data-attachment-id=\"71010\" data-permalink=\"https:\/\/rheolution.com\/pt\/notas-de-aplicacao\/hidrogeis-de-fibrina\/attachment\/fibrin-2\/\" data-orig-file=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/FIBRIN.jpg?fit=7000%2C2322&amp;ssl=1\" data-orig-size=\"7000,2322\" data-comments-opened=\"1\" data-image-title=\"FIBRIN\" data-image-description=\"\" data-image-caption=\"\" data-large-file=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/FIBRIN.jpg?fit=1024%2C340&amp;ssl=1\" srcset=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/FIBRIN.jpg?w=7000&amp;ssl=1 7000w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/FIBRIN.jpg?resize=300%2C100&amp;ssl=1 300w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/FIBRIN.jpg?resize=1024%2C340&amp;ssl=1 1024w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/FIBRIN.jpg?resize=768%2C255&amp;ssl=1 768w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/FIBRIN.jpg?resize=1536%2C510&amp;ssl=1 1536w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/FIBRIN.jpg?resize=2048%2C679&amp;ssl=1 2048w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/FIBRIN.jpg?resize=150%2C50&amp;ssl=1 150w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/FIBRIN.jpg?resize=700%2C232&amp;ssl=1 700w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/FIBRIN.jpg?w=2440&amp;ssl=1 2440w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/FIBRIN.jpg?w=3660&amp;ssl=1 3660w\" sizes=\"(max-width:767px) 700px, (max-width:7000px) 100vw, 7000px\" \/>\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"premium-blog-thumbnail-overlay\">\n\t\t\t\t\t\t\t\t<a class=\"elementor-icon\" href=\"https:\/\/rheolution.com\/pt\/notas-de-aplicacao\/hidrogeis-de-fibrina\/\" target=\"_blank\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-screen-only\">Hidrog\u00e9is de fibrina<\/span>\n\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"premium-blog-content-wrapper \">\n\n\t\t\t\t\t<div class=\"premium-blog-inner-container\">\n\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<h4 class=\"premium-blog-entry-title\">\n\t\t\t<a href=\"https:\/\/rheolution.com\/pt\/notas-de-aplicacao\/hidrogeis-de-fibrina\/\" target=\"_blank\">\n\t\t\t\tHidrog\u00e9is de fibrina\t\t\t<\/a>\n\t\t<\/h4>\n\t\t\t\t<div class=\"premium-blog-entry-meta\">\n\t\t\t\n\t\t\t\n\t\t\t\n\t\t\t\t\t<\/div>\n\t\t\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t<div class=\"premium-blog-content-inner-wrapper\">\n\t\t<p class=\"premium-blog-post-content\">Os hidrog\u00e9is de fibrina s\u00e3o biomateriais naturais \u00e0 base de prote\u00ednas, formados a partir da fibrina, o pol\u00edmero insol\u00favel gerado durante a coagula\u00e7\u00e3o sangu\u00ednea. A fibrina tem origem no fibrinog\u00eanio, uma glicoprote\u00edna plasm\u00e1tica composta por tr\u00eas cadeias polipept\u00eddicas emparelhadas que se organizam em uma rede fibrosa ap\u00f3s ativa\u00e7\u00e3o enzim\u00e1tica. Em condi\u00e7\u00f5es fisiol\u00f3gicas, a forma\u00e7\u00e3o da fibrina \u00e9 desencadeada pela clivagem do fibrinog\u00eanio mediada pela trombina, expondo s\u00edtios de polimeriza\u00e7\u00e3o que impulsionam a auto-montagem espont\u00e2nea em uma matriz hidratada e porosa.<\/p><div class=\"premium-blog-excerpt-link-wrap\"><a href=\"https:\/\/rheolution.com\/pt\/notas-de-aplicacao\/hidrogeis-de-fibrina\/\" target=\"_blank\" class=\"premium-blog-excerpt-link elementor-button\">Leia mais \u00bb<\/a><\/div>\t\t<\/div>\n\t\t\t\t\t\t\t\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\n\t\t\t\t<div class=\"premium-blog-post-outer-container\" data-total=\"3\">\n\t\t\t<div class=\"premium-blog-post-container premium-blog-skin-classic\">\n\t\t\t\t\t\t\t\t\t<div class=\"premium-blog-thumb-effect-wrapper\">\n\t\t\t\t\t\t<div class=\"premium-blog-thumbnail-container premium-blog-zoomin-effect\">\n\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"7000\" height=\"2322\" src=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/ALGINATE-1.jpg?fit=7000%2C2322&amp;ssl=1\" class=\"attachment-full size-full wp-image-65612\" alt=\"Alginate Hydrogel\" data-attachment-id=\"65612\" data-permalink=\"https:\/\/rheolution.com\/pt\/notas-de-aplicacao\/hidrogeis-de-alginato\/attachment\/alginate-2-2\/\" data-orig-file=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/ALGINATE-1.jpg?fit=7000%2C2322&amp;ssl=1\" data-orig-size=\"7000,2322\" data-comments-opened=\"1\" data-image-title=\"ALGINATE\" data-image-description=\"\" data-image-caption=\"\" data-large-file=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/ALGINATE-1.jpg?fit=1024%2C340&amp;ssl=1\" srcset=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/ALGINATE-1.jpg?w=7000&amp;ssl=1 7000w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/ALGINATE-1.jpg?resize=300%2C100&amp;ssl=1 300w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/ALGINATE-1.jpg?resize=1024%2C340&amp;ssl=1 1024w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/ALGINATE-1.jpg?resize=768%2C255&amp;ssl=1 768w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/ALGINATE-1.jpg?resize=1536%2C510&amp;ssl=1 1536w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/ALGINATE-1.jpg?resize=2048%2C679&amp;ssl=1 2048w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/ALGINATE-1.jpg?resize=150%2C50&amp;ssl=1 150w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/ALGINATE-1.jpg?resize=700%2C232&amp;ssl=1 700w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/ALGINATE-1.jpg?w=2440&amp;ssl=1 2440w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/ALGINATE-1.jpg?w=3660&amp;ssl=1 3660w\" sizes=\"(max-width:767px) 700px, (max-width:7000px) 100vw, 7000px\" \/>\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"premium-blog-thumbnail-overlay\">\n\t\t\t\t\t\t\t\t<a class=\"elementor-icon\" href=\"https:\/\/rheolution.com\/pt\/notas-de-aplicacao\/hidrogeis-de-alginato\/\" target=\"_blank\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-screen-only\">Hidrog\u00e9is de alginato<\/span>\n\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"premium-blog-content-wrapper \">\n\n\t\t\t\t\t<div class=\"premium-blog-inner-container\">\n\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<h4 class=\"premium-blog-entry-title\">\n\t\t\t<a href=\"https:\/\/rheolution.com\/pt\/notas-de-aplicacao\/hidrogeis-de-alginato\/\" target=\"_blank\">\n\t\t\t\tHidrog\u00e9is de alginato\t\t\t<\/a>\n\t\t<\/h4>\n\t\t\t\t<div class=\"premium-blog-entry-meta\">\n\t\t\t\n\t\t\t\n\t\t\t\n\t\t\t\t\t<\/div>\n\t\t\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t<div class=\"premium-blog-content-inner-wrapper\">\n\t\t<p class=\"premium-blog-post-content\">Os hidrog\u00e9is de alginato s\u00e3o redes polim\u00e9ricas tridimensionais ricas em \u00e1gua, derivadas do alginato, um polissacar\u00eddeo ani\u00f4nico de origem natural. O alginato \u00e9 extra\u00eddo principalmente das paredes celulares das algas marrons pertencentes \u00e0 classe Phaeophyceae, embora tamb\u00e9m possa ser biossintetizado por certas esp\u00e9cies bacterianas, como Azotobacter e Pseudomonas. Estruturalmente, o alginato \u00e9 um copol\u00edmero linear composto por \u00e1cido \u03b2-D-manur\u00f4nico (unidades M) e \u00e1cido \u03b1-L-gulur\u00f4nico (unidades G), ligados por liga\u00e7\u00f5es glicos\u00eddicas 1\u21924.<\/p><div class=\"premium-blog-excerpt-link-wrap\"><a href=\"https:\/\/rheolution.com\/pt\/notas-de-aplicacao\/hidrogeis-de-alginato\/\" target=\"_blank\" class=\"premium-blog-excerpt-link elementor-button\">Leia mais \u00bb<\/a><\/div>\t\t<\/div>\n\t\t\t\t\t\t\t\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\n\t\t\t\t<div class=\"premium-blog-post-outer-container\" data-total=\"3\">\n\t\t\t<div class=\"premium-blog-post-container premium-blog-skin-classic\">\n\t\t\t\t\t\t\t\t\t<div class=\"premium-blog-thumb-effect-wrapper\">\n\t\t\t\t\t\t<div class=\"premium-blog-thumbnail-container premium-blog-zoomin-effect\">\n\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"7875\" height=\"2612\" src=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Gelatin-Methacrylate-1.jpg?fit=7875%2C2612&amp;ssl=1\" class=\"attachment-full size-full wp-image-65567\" alt=\"Gelatin Methacrylate - GelMa\" data-attachment-id=\"65567\" data-permalink=\"https:\/\/rheolution.com\/pt\/notas-de-aplicacao\/gelma-hidrogeis\/attachment\/gelatin-methacrylate-2-2\/\" data-orig-file=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Gelatin-Methacrylate-1.jpg?fit=7875%2C2612&amp;ssl=1\" data-orig-size=\"7875,2612\" data-comments-opened=\"1\" data-image-title=\"Gelatin Methacrylate\" data-image-description=\"\" data-image-caption=\"\" data-large-file=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Gelatin-Methacrylate-1.jpg?fit=1024%2C340&amp;ssl=1\" srcset=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Gelatin-Methacrylate-1.jpg?w=7875&amp;ssl=1 7875w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Gelatin-Methacrylate-1.jpg?resize=300%2C100&amp;ssl=1 300w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Gelatin-Methacrylate-1.jpg?resize=1024%2C340&amp;ssl=1 1024w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Gelatin-Methacrylate-1.jpg?resize=768%2C255&amp;ssl=1 768w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Gelatin-Methacrylate-1.jpg?resize=1536%2C509&amp;ssl=1 1536w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Gelatin-Methacrylate-1.jpg?resize=2048%2C679&amp;ssl=1 2048w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Gelatin-Methacrylate-1.jpg?resize=150%2C50&amp;ssl=1 150w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Gelatin-Methacrylate-1.jpg?resize=700%2C232&amp;ssl=1 700w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Gelatin-Methacrylate-1.jpg?w=2440&amp;ssl=1 2440w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Gelatin-Methacrylate-1.jpg?w=3660&amp;ssl=1 3660w\" sizes=\"(max-width:767px) 700px, (max-width:7875px) 100vw, 7875px\" \/>\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"premium-blog-thumbnail-overlay\">\n\t\t\t\t\t\t\t\t<a class=\"elementor-icon\" href=\"https:\/\/rheolution.com\/pt\/notas-de-aplicacao\/gelma-hidrogeis\/\" target=\"_blank\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-screen-only\">Hidrog\u00e9is GelMA<\/span>\n\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"premium-blog-content-wrapper \">\n\n\t\t\t\t\t<div class=\"premium-blog-inner-container\">\n\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<h4 class=\"premium-blog-entry-title\">\n\t\t\t<a href=\"https:\/\/rheolution.com\/pt\/notas-de-aplicacao\/gelma-hidrogeis\/\" target=\"_blank\">\n\t\t\t\tHidrog\u00e9is GelMA\t\t\t<\/a>\n\t\t<\/h4>\n\t\t\t\t<div class=\"premium-blog-entry-meta\">\n\t\t\t\n\t\t\t\n\t\t\t\n\t\t\t\t\t<\/div>\n\t\t\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t<div class=\"premium-blog-content-inner-wrapper\">\n\t\t<p class=\"premium-blog-post-content\">A gelatina metacril\u00f3il (GelMA) \u00e9 um hidrogel fotocrosslink\u00e1vel derivado da gelatina, que, por sua vez, \u00e9 obtida por hidr\u00f3lise parcial do col\u00e1geno, a principal prote\u00edna estrutural da matriz extracelular (MEC). A GelMA \u00e9 sintetizada por meio da rea\u00e7\u00e3o da gelatina com o anidrido metacr\u00edlico, introduzindo grupos funcionais metacril\u00f3is nos res\u00edduos de amino\u00e1cidos da gelatina, ao mesmo tempo em que preserva a maior parte de seus motivos bioativos nativos.<\/p><div class=\"premium-blog-excerpt-link-wrap\"><a href=\"https:\/\/rheolution.com\/pt\/notas-de-aplicacao\/gelma-hidrogeis\/\" target=\"_blank\" class=\"premium-blog-excerpt-link elementor-button\">Leia mais \u00bb<\/a><\/div>\t\t<\/div>\n\t\t\t\t\t\t\t\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\n\t\t\t\t<div class=\"premium-blog-post-outer-container\" data-total=\"3\">\n\t\t\t<div class=\"premium-blog-post-container premium-blog-skin-classic\">\n\t\t\t\t\t\t\t\t\t<div class=\"premium-blog-thumb-effect-wrapper\">\n\t\t\t\t\t\t<div class=\"premium-blog-thumbnail-container premium-blog-zoomin-effect\">\n\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"7875\" height=\"2612\" src=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Polydimethylsiloxane-PDMS-1.jpg?fit=7875%2C2612&amp;ssl=1\" class=\"attachment-full size-full wp-image-65405\" alt=\"Polydimethylsiloxane (PDMS)\" data-attachment-id=\"65405\" data-permalink=\"https:\/\/rheolution.com\/pt\/notas-de-aplicacao\/pdms-polimeros\/attachment\/polydimethylsiloxane-pdms-2-2\/\" data-orig-file=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Polydimethylsiloxane-PDMS-1.jpg?fit=7875%2C2612&amp;ssl=1\" data-orig-size=\"7875,2612\" data-comments-opened=\"1\" data-image-title=\"Polydimethylsiloxane (PDMS)\" data-image-description=\"\" data-image-caption=\"\" data-large-file=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Polydimethylsiloxane-PDMS-1.jpg?fit=1024%2C340&amp;ssl=1\" srcset=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Polydimethylsiloxane-PDMS-1.jpg?w=7875&amp;ssl=1 7875w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Polydimethylsiloxane-PDMS-1.jpg?resize=300%2C100&amp;ssl=1 300w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Polydimethylsiloxane-PDMS-1.jpg?resize=1024%2C340&amp;ssl=1 1024w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Polydimethylsiloxane-PDMS-1.jpg?resize=768%2C255&amp;ssl=1 768w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Polydimethylsiloxane-PDMS-1.jpg?resize=1536%2C509&amp;ssl=1 1536w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Polydimethylsiloxane-PDMS-1.jpg?resize=2048%2C679&amp;ssl=1 2048w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Polydimethylsiloxane-PDMS-1.jpg?resize=150%2C50&amp;ssl=1 150w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Polydimethylsiloxane-PDMS-1.jpg?resize=700%2C232&amp;ssl=1 700w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Polydimethylsiloxane-PDMS-1.jpg?w=2440&amp;ssl=1 2440w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Polydimethylsiloxane-PDMS-1.jpg?w=3660&amp;ssl=1 3660w\" sizes=\"(max-width:767px) 700px, (max-width:7875px) 100vw, 7875px\" \/>\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"premium-blog-thumbnail-overlay\">\n\t\t\t\t\t\t\t\t<a class=\"elementor-icon\" href=\"https:\/\/rheolution.com\/pt\/notas-de-aplicacao\/pdms-polimeros\/\" target=\"_blank\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-screen-only\">Pol\u00edmeros PDMS<\/span>\n\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"premium-blog-content-wrapper \">\n\n\t\t\t\t\t<div class=\"premium-blog-inner-container\">\n\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<h4 class=\"premium-blog-entry-title\">\n\t\t\t<a href=\"https:\/\/rheolution.com\/pt\/notas-de-aplicacao\/pdms-polimeros\/\" target=\"_blank\">\n\t\t\t\tPol\u00edmeros PDMS\t\t\t<\/a>\n\t\t<\/h4>\n\t\t\t\t<div class=\"premium-blog-entry-meta\">\n\t\t\t\n\t\t\t\n\t\t\t\n\t\t\t\t\t<\/div>\n\t\t\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t<div class=\"premium-blog-content-inner-wrapper\">\n\t\t<p class=\"premium-blog-post-content\">O polidimetilsiloxano (PDMS) \u00e9 um pol\u00edmero polissiloxano sint\u00e9tico composto por uma estrutura principal flex\u00edvel de siloxano inorg\u00e2nico (\u2013Si\u2013O\u2013Si\u2013) com grupos laterais metil. Essa arquitetura inorg\u00e2nico-org\u00e2nica \u00fanica confere ao PDMS excepcional mobilidade de cadeia, temperatura de transi\u00e7\u00e3o v\u00edtrea muito baixa e comportamento elastom\u00e9rico est\u00e1vel em uma ampla faixa de temperatura. O PDMS \u00e9 produzido exclusivamente por s\u00edntese industrial, envolvendo tipicamente a hidr\u00f3lise e a condensa\u00e7\u00e3o de clorosilanos, seguidas pela polimeriza\u00e7\u00e3o por abertura de anel de siloxanos c\u00edclicos.<\/p><div class=\"premium-blog-excerpt-link-wrap\"><a href=\"https:\/\/rheolution.com\/pt\/notas-de-aplicacao\/pdms-polimeros\/\" target=\"_blank\" class=\"premium-blog-excerpt-link elementor-button\">Leia mais \u00bb<\/a><\/div>\t\t<\/div>\n\t\t\t\t\t\t\t\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\n\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div class=\"premium-blog-footer\">\n\t\t\t\t\t\t\t<nav class=\"premium-blog-pagination-container\" role=\"navigation\" aria-label=\"Pagina\u00e7\u00e3o\">\n\t\t\t\t<span aria-current=\"page\" class=\"page-numbers current\">1<\/span>\n<a class=\"page-numbers\" href=\"https:\/\/rheolution.com\/pt\/wp-json\/wp\/v2\/posts\/65611\/page\/2\/\">2<\/a>\n<a class=\"page-numbers\" href=\"https:\/\/rheolution.com\/pt\/wp-json\/wp\/v2\/posts\/65611\/page\/3\/\">3<\/a>\n<a class=\"next page-numbers\" href=\"https:\/\/rheolution.com\/pt\/wp-json\/wp\/v2\/posts\/65611\/page\/2\/\">Pr\u00f3ximo \u00bb<\/a>\t\t\t<\/nav>\n\t\t\t\t\t\t<\/div>\n\t\t\n\t\t\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Os hidrog\u00e9is de alginato s\u00e3o redes polim\u00e9ricas tridimensionais ricas em \u00e1gua, derivadas do alginato, um polissacar\u00eddeo ani\u00f4nico de origem natural. O alginato \u00e9 extra\u00eddo principalmente das paredes celulares das algas marrons pertencentes \u00e0 classe Phaeophyceae, embora tamb\u00e9m possa ser biossintetizado por certas esp\u00e9cies bacterianas, como Azotobacter e Pseudomonas. Estruturalmente, o alginato \u00e9 um copol\u00edmero linear composto por \u00e1cido \u03b2-D-manur\u00f4nico (unidades M) e \u00e1cido \u03b1-L-gulur\u00f4nico (unidades G), ligados por liga\u00e7\u00f5es glicos\u00eddicas 1\u21924.    <\/p>\n","protected":false},"author":195401359,"featured_media":65612,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_wpcom_ai_launchpad_first_post":false,"_jetpack_hide_featured_image":false,"_jetpack_featured_image_duplicate_dismissed":0,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_post_was_ever_published":false},"categories":[286,332],"tags":[89,124,88,261],"class_list":["post-65611","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-notas-de-aplicacao","category-polymer-library","tag-elastosens-bio","tag-life-sciences","tag-mechanical-testing","tag-polymer"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.7 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