Formulation of Hydrogels

Applications / Formulation of Hydrogels

Hydrogels have been widely used in the biomedical field for developing bioengineered tissues and novel treatments such as wound dressings and drug delivery systems. They are composed of over 90% water and crosslinked polymeric chains and exhibit a pronounced viscoelastic behavior. The precise evaluation and control of their viscoelastic properties are often critical in terms of functionality and efficacy. When hydrogels are used as 3D cell culture environments, their viscoelasticity plays an important role in the cell differentiation, proliferation and remodeling. Similarly, mastering the gel formation kinetics and its final viscoelasticity is crucial for manufacturing processes such as biocasting, 3D bioprinting and electrospinning. Similarly, hydrogels degradation plays an important role in applications such as drug release and tissue engineering.
Hydrogel Viscoelasticity

ElastoSens™ Bio offers an extensive testing platform to formulate, compare, qualify and control the viscoelasticity of hydrogels used in multiple applications such as tissue engineering, 3D bioprinting, drug delivery and hemostatic applications. As the test is non-destructive and the gel is contained in a detachable sample holder, you can follow both short (crosslinking kinetics) and long-term (slow degradation or remodeling) evolutions of the same gel sample. In addition, the system has been designed to allow the application of specific external conditions: the sample can be tested in real time under controlled temperature, UV light and atmospheric inert gases, and exposed to physiological solutions.

Hydrogel results
In this example, the evolution of the shear elastic modulus of chitosan gels is measured using the ElastoSens™ Bio during the gel formation and the enzymatic (papain digestion solution) degradation phases. It clearly appears how the enzymes are affecting the gel formation compared to the control sample with no digestion solution.
The precise evaluation of hydrogels viscoelasticity can accelerate their formulation and the optimization of their functionality. Combined with the power of Soft Matter Analytics™, the ElastoSens™ Bio offers an unprecedented development and control platform for scientists and engineers creating hydrogel-based biosystems or devices.
ElastoSens Bio Tablet


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