{"id":65563,"date":"2026-08-06T14:31:46","date_gmt":"2026-08-06T18:31:46","guid":{"rendered":"https:\/\/rheolution.com\/?p=65563"},"modified":"2026-08-14T09:39:17","modified_gmt":"2026-08-14T13:39:17","slug":"gelma-idrogel","status":"publish","type":"post","link":"https:\/\/rheolution.com\/it\/note-applicative\/gelma-idrogel\/","title":{"rendered":"Idrogel GelMA"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"65563\" class=\"elementor elementor-65563 elementor-62796\" data-elementor-post-type=\"post\">\n\t\t\t\t<div class=\"elementor-element elementor-element-8fd4dcf e-flex e-con-boxed e-con e-parent\" data-id=\"8fd4dcf\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-8c770e2 elementor-widget elementor-widget-heading\" data-id=\"8c770e2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h6 class=\"elementor-heading-title elementor-size-default\">Nota applicativa | ElastoSens\u2122 Bio<\/h6>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-760ae40 elementor-widget elementor-widget-heading\" data-id=\"760ae40\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Idrogel GelMA: propriet\u00e0, applicazioni e comportamento meccanico<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-16057f6 elementor-widget elementor-widget-text-editor\" data-id=\"16057f6\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>di <a href=\"https:\/\/www.linkedin.com\/in\/mayasalame\/\">Maya Salame<\/a> e <a href=\"https:\/\/www.linkedin.com\/in\/dimitria-camas%C3%A3o-049002a2\/\">Dimitria Camasao<\/a><\/p><p>Ricercatori applicativi<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-97ac8de e-flex e-con-boxed e-con e-parent\" data-id=\"97ac8de\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-5fc8fde elementor-widget__width-initial elementor-widget-mobile__width-inherit elementor-widget elementor-widget-heading\" data-id=\"5fc8fde\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Cos\u2019\u00e8 un idrogel GelMA?<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d61237b elementor-widget elementor-widget-text-editor\" data-id=\"d61237b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400\">La gelatina metacrililica (GelMA) \u00e8 un idrogel fotoreticolabile derivato dalla gelatina, a sua volta ottenuta dall\u2019idrolisi parziale del collagene, la principale proteina strutturale della matrice extracellulare (ECM). Il GelMA si ottiene facendo reagire la gelatina con l&#8217;anidride metacrilica, introducendo gruppi funzionali metacriloilici sui residui amminoacidici della gelatina e conservando al contempo la maggior parte dei suoi motivi bioattivi nativi. Questa modifica permette la reticolazione covalente sotto l&#8217;esposizione alla luce, mantenendo la biocompatibilit\u00e0 intrinseca della gelatina, la sua degradabilit\u00e0 enzimatica e le sequenze che interagiscono con le cellule. Grazie alla sua lavorabilit\u00e0 in ambiente acquoso, alle condizioni di reticolazione delicate e alla somiglianza strutturale con la MEC nativa, il GelMA \u00e8 diventato un biomateriale ampiamente utilizzato nella bioingegneria e nella ricerca biomedica.   <\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5703c6a elementor-widget__width-initial elementor-widget-mobile__width-inherit elementor-widget elementor-widget-heading\" data-id=\"5703c6a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Propriet\u00e0 principali degli idrogel a base di GelMA<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5a0b64a elementor-widget elementor-widget-heading\" data-id=\"5a0b64a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Caratteristiche fisico-chimiche<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-38524ee elementor-widget elementor-widget-text-editor\" data-id=\"38524ee\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400\">Gli idrogel GelMA si formano attraverso la polimerizzazione radicalica fotoindotta dei gruppi metacrililici, in presenza di un fotoiniziatore idrosolubile e sotto l&#8217;azione della luce. Questo processo produce una rete reticolata covalentemente in condizioni delicate e compatibili con le cellule. <\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e821974 elementor-widget elementor-widget-text-editor\" data-id=\"e821974\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400\">Tra le principali caratteristiche fisico-chimiche ci sono:<\/span><\/p><ul><li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Meccanismo di reticolazione: polimerizzazione radicalica indotta dalla luce dei sostituenti metacrililici.<\/span><\/li><li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Formulazione regolabile: la concentrazione di GelMA, il grado di metacrilazione, il contenuto di fotoiniziatore e la dose di luce determinano la densit\u00e0 della rete.<\/span><\/li><li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Doppio comportamento di gelificazione: gelificazione fisica a bassa temperatura dovuta alle catene di gelatina, seguita da una stabilizzazione chimica tramite reticolazione fotoindotta.<\/span><\/li><li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Sensibilit\u00e0 ambientale: la temperatura, il pH e la forza ionica influenzano la viscosit\u00e0 del prepolimero e la cinetica di gelificazione.<\/span><\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8842651 elementor-widget elementor-widget-text-editor\" data-id=\"8842651\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400\">Questi parametri permettono di controllare con precisione la struttura, la porosit\u00e0 e la stabilit\u00e0 dell&#8217;idrogel.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-30981bc elementor-widget elementor-widget-heading\" data-id=\"30981bc\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Propriet\u00e0 meccaniche<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2e827a1 elementor-widget elementor-widget-text-editor\" data-id=\"2e827a1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400\">Il comportamento meccanico degli idrogel GelMA \u00e8 altamente modulabile ed \u00e8 direttamente legato all&#8217;architettura della rete e alla densit\u00e0 di reticolazione. Il modulo elastico e la rigidit\u00e0 aumentano all&#8217;aumentare della concentrazione del polimero e del grado di sostituzione metacrililica. Al contrario, le reti con reticolazione pi\u00f9 lassa mostrano una maggiore compliance e rapporti di rigonfiamento pi\u00f9 elevati.  <\/span><\/p><p><span style=\"font-weight: 400\">Le caratteristiche meccaniche includono:<\/span><\/p><ul><li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Moduli elastici morbidi, simili a quelli dei tessuti, che vanno da pochi kilopascal a decine di kilopascal.<\/span><\/li><li style=\"font-weight: 400\"><span style=\"font-weight: 400\">La rigidit\u00e0 dipende fortemente dalla composizione e dalle condizioni di esposizione alla luce.<\/span><\/li><li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Un progressivo ammorbidimento meccanico durante la degradazione enzimatica, man mano che la rete viene rimodellata.<\/span><\/li><\/ul><p><span style=\"font-weight: 400\">Questa adattabilit\u00e0 permette agli idrogel GelMA di eguagliare le propriet\u00e0 meccaniche di diversi tessuti molli.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0959975 elementor-widget elementor-widget-heading\" data-id=\"0959975\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Interazioni biologiche<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-90cc644 elementor-widget elementor-widget-text-editor\" data-id=\"90cc644\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400\">Il GelMA favorisce naturalmente le interazioni tra cellule e materiale grazie ai motivi biochimici della gelatina che sono stati mantenuti. Le sequenze arginina-glicina-acido aspartico (RGD) favoriscono l&#8217;adesione cellulare, mentre i domini sensibili alle metalloproteinasi della matrice consentono il rimodellamento mediato dalle cellule. <\/span><\/p><p><span style=\"font-weight: 400\">Le caratteristiche biologiche includono:<\/span><\/p><ul><li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Elevata citocompatibilit\u00e0 e bassa immunogenicit\u00e0.<\/span><\/li><li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Favorisce l&#8217;adesione, l&#8217;espansione, la proliferazione e la migrazione delle cellule.<\/span><\/li><li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Degradabilit\u00e0 enzimatica indotta dalle proteasi secrete dalle cellule.<\/span><\/li><li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Compatibilit\u00e0 con l&#8217;incapsulamento cellulare durante la reticolazione fotochimica.<\/span><\/li><\/ul><p><span style=\"font-weight: 400\">Queste caratteristiche rendono GelMA particolarmente adatto ad ambienti dinamici e sensibili alle cellule.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-28004d8 elementor-widget__width-initial elementor-widget-mobile__width-inherit elementor-widget elementor-widget-heading\" data-id=\"28004d8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Applicazioni degli idrogel GelMA<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-06adff0 elementor-widget elementor-widget-heading\" data-id=\"06adff0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Ingegneria dei tessuti<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ba2f1b1 elementor-widget elementor-widget-text-editor\" data-id=\"ba2f1b1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400\">Gli idrogel GelMA sono ampiamente utilizzati come scaffold per l&#8217;ingegneria tissutale, ad esempio per la cartilagine, l&#8217;osso, il muscolo cardiaco, vascolare e scheletrico. Le loro propriet\u00e0 meccaniche regolabili, la degradabilit\u00e0 e la bioattivit\u00e0 permettono di creare matrici che guidano l&#8217;organizzazione cellulare, la differenziazione e la maturazione dei tessuti. <\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d01f123 elementor-widget elementor-widget-heading\" data-id=\"d01f123\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Coltura cellulare 3D e modelli di malattia<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-137d5ec elementor-widget elementor-widget-text-editor\" data-id=\"137d5ec\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400\">Nella coltura cellulare tridimensionale, il GelMA offre un ambiente che riproduce la matrice extracellulare (ECM) e favorisce un comportamento cellulare fisiologicamente rilevante. \u00c8 ampiamente utilizzato nei modelli organotipici, nei sistemi microfabbricati e nelle piattaforme \u201corgan-on-chip\u201d per studiare le interazioni cellula-matrice, la meccanobiologia e la progressione delle malattie. <\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c1cb3eb elementor-widget elementor-widget-heading\" data-id=\"c1cb3eb\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Somministrazione di farmaci, geni e cellule<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ff74672 elementor-widget elementor-widget-text-editor\" data-id=\"ff74672\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400\">Gli idrogel GelMA fungono da vettori per il rilascio di farmaci, geni e cellule terapeutiche. La struttura reticolare controllata permette di modulare i profili di diffusione e rilascio, mentre la degradazione enzimatica consente un rilascio localizzato e mediato dalle cellule del carico utile. <\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-892f73a elementor-widget__width-initial elementor-widget-mobile__width-inherit elementor-widget elementor-widget-heading\" data-id=\"892f73a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Perch\u00e9 la viscoelasticit\u00e0 degli idrogel GelMA \u00e8 importante<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-05c6bea elementor-widget elementor-widget-text-editor\" data-id=\"05c6bea\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400\">Gli idrogel GelMA mostrano un comportamento viscoelastico che assomiglia di pi\u00f9 ai tessuti biologici naturali rispetto ai materiali puramente elastici. La viscoelasticit\u00e0 influenza il modo in cui le cellule percepiscono e reagiscono al loro microambiente, influenzando l\u2019adesione, la migrazione, la differenziazione e il rimodellamento della matrice. Le risposte meccaniche dipendenti dal tempo regolano inoltre la dissipazione del carico, l\u2019integrit\u00e0 strutturale e le prestazioni a lungo termine in contesti biologici dinamici. Comprendere e controllare le propriet\u00e0 viscoelastiche \u00e8 quindi fondamentale per prevedere il comportamento in vitro e la funzionalit\u00e0 in vivo.   <\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-851f298 elementor-widget__width-initial elementor-widget-mobile__width-inherit elementor-widget elementor-widget-heading\" data-id=\"851f298\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Metodi per caratterizzare la viscoelasticit\u00e0 degli idrogel GelMA<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-171be53 elementor-widget elementor-widget-text-editor\" data-id=\"171be53\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400\">Le propriet\u00e0 meccaniche e viscoelastiche degli idrogel GelMA vengono solitamente caratterizzate tramite reometria in massa, prove di compressione e prove di trazione. Queste tecniche forniscono informazioni preziose sul modulo elastico, sui moduli di immagazzinamento e di perdita e sul comportamento a rottura delle reti completamente formate. Tuttavia, i metodi tradizionali spesso richiedono un contatto diretto, grandi deformazioni o una preparazione distruttiva dei campioni, e in genere non riescono a cogliere i rapidi cambiamenti meccanici che avvengono durante la reticolazione fotochimica. Di conseguenza, non sono molto adatti a monitorare la cinetica della fotogelificazione, a identificare il punto di transizione liquido-gel o a seguire lo sviluppo meccanico nelle prime fasi in condizioni sterili o in presenza di cellule.   <\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1961b9f elementor-widget__width-initial elementor-widget-mobile__width-inherit elementor-widget elementor-widget-heading\" data-id=\"1961b9f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Caso di studio: Caratterizzazione meccanica dell'idrogel GelMA con ElastoSens\u2122 Bio<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4babf25 elementor-widget__width-initial elementor-widget elementor-widget-heading\" data-id=\"4babf25\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">ElastoSens\u2122 Bio: uno strumento non distruttivo per misurare gli idrogel morbidi GelMA<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-5a225c3 e-grid e-con-full e-con e-child\" data-id=\"5a225c3\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ce43e5b elementor-widget elementor-widget-text-editor\" data-id=\"ce43e5b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Il <a href=\"https:\/\/rheolution.com\/instrument-elastosensbio\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400\"><strong>ElastoSens\u2122 Bio<\/strong><\/span><\/a> <span style=\"font-weight: 400\">permette di misurare in tempo reale e senza danneggiamento le propriet\u00e0 viscoelastiche degli idrogel GelMA morbidi e fotoreticolabili. Grazie a un\u2019eccitazione a bassa ampiezza e senza contatto, abbinata a un modulo di fotostimolazione integrato, permette di monitorare direttamente la cinetica della fotoreticolazione, identificare la transizione liquido-gel e quantificare con precisione la rigidit\u00e0 finale. Le misurazioni ripetute sullo stesso campione in condizioni sterili supportano studi longitudinali sulla formazione, la maturazione, la degradazione e il rimodellamento indotto dalle cellule del GelMA.  <\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-045aef9 elementor-widget elementor-widget-image\" data-id=\"045aef9\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"968\" height=\"544\" src=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/elastosens2-1.webp?fit=968%2C544&amp;ssl=1\" class=\"attachment-large size-large wp-image-43562\" alt=\"\" srcset=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/elastosens2-1.webp?w=968&amp;ssl=1 968w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/elastosens2-1.webp?resize=300%2C169&amp;ssl=1 300w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/elastosens2-1.webp?resize=768%2C432&amp;ssl=1 768w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/elastosens2-1.webp?resize=133%2C75&amp;ssl=1 133w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/elastosens2-1.webp?resize=480%2C270&amp;ssl=1 480w\" sizes=\"(max-width:767px) 700px, (max-width:968px) 100vw, 968px\" data-attachment-id=\"43562\" data-permalink=\"https:\/\/rheolution.com\/it\/elastosens2-4-2-2\/\" data-orig-file=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/elastosens2-1.webp?fit=968%2C544&amp;ssl=1\" data-orig-size=\"968,544\" data-comments-opened=\"1\" data-image-title=\"elastosens2\" data-image-description=\"\" data-image-caption=\"\" data-large-file=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/elastosens2-1.webp?fit=968%2C544&amp;ssl=1\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b87c673 elementor-widget elementor-widget-text-editor\" data-id=\"b87c673\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400\">Per dimostrare le potenzialit\u00e0 di ElastoSens\u2122 Bio, abbiamo eseguito una serie di test su idrogel a base di GelMA. La sezione seguente illustra i materiali e i metodi utilizzati, seguiti dai risultati, fornendo un esempio pratico della capacit\u00e0 dello strumento di monitorare in modo non distruttivo le propriet\u00e0 viscoelastiche nel tempo. <\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ed23fc9 elementor-widget elementor-widget-heading\" data-id=\"ed23fc9\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Materiali e metodi<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d118051 elementor-widget elementor-widget-text-editor\" data-id=\"d118051\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400\">La gelatina metacrilata (PhotoGel\u00ae, 5272; Advanced BioMatrix) \u00e8 stata preparata seguendo le istruzioni del produttore. Il fenil-2,4,6-trimetilbenzoilfosfinato di litio (LAP) \u00e8 stato preparato come soluzione madre a 17 mg\/mL in PBS e aggiunto alla formulazione di PhotoGel\u00ae come specificato dal produttore. Il PhotoGel\u00ae \u00e8 stato sciolto in PBS a 60 \u00b0C e preparato a concentrazioni del 5% e del 10% (p\/v). Per ogni condizione, sono stati versati 2 mL della soluzione precursore nel portacampioni ElastoSens\u2122 Bio macro e la misurazione \u00e8 stata avviata immediatamente. I campioni sono stati lasciati a equilibrio a 20 \u00b0C per 10 minuti (al buio). La fotoreticolazione \u00e8 stata poi eseguita sotto luce a 405 nm con un\u2019intensit\u00e0 di 8 mW\/cm\u00b2 per 20 minuti, mentre le misurazioni viscoelastiche sono state registrate ogni 5 secondi per tutta la durata dell\u2019esperimento.       <\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-aa24bd0 elementor-widget elementor-widget-heading\" data-id=\"aa24bd0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Risultati e discussione<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-54513af elementor-widget elementor-widget-text-editor\" data-id=\"54513af\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400\">Aumentando la concentrazione di PhotoGel\u00ae dal 5% al 10% (p\/v), il modulo di immagazzinamento di taglio finale (G\u2032) \u00e8 salito da 5398 \u00b1 106 Pa a 39 437 \u00b1 1251 Pa (***p &lt; 0,001). Allo stesso tempo, la velocit\u00e0 massima di gelificazione \u00e8 aumentata in modo significativo alle concentrazioni pi\u00f9 elevate, passando da 23,2 \u00b1 13,3 Pa\/s al 5% a 145,9 \u00b1 24,6 Pa\/s al 10% (**p &lt; 0,01), indicando uno sviluppo della rete notevolmente pi\u00f9 veloce a parit\u00e0 di condizioni di fotopolimerizzazione. Anche il tempo di inizio della gelificazione si \u00e8 ridotto notevolmente all\u2019aumentare della concentrazione di PhotoGel\u00ae, passando da 11,35 \u00b1 0,04 min al 5% a 5,36 \u00b1 0,34 min al 10% (***p &lt; 0,001), dimostrando un inizio pi\u00f9 precoce della gelificazione.  <\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-443aebb elementor-widget elementor-widget-text-editor\" data-id=\"443aebb\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400\">La forte dipendenza della G\u2032 dalla concentrazione riflette l\u2019aumento del contenuto di polimero e della disponibilit\u00e0 di gruppi fotoreticolabili. La riduzione del tempo di inizio e l\u2019aumento della velocit\u00e0 di gelificazione al 10% di PhotoGel\u00ae indicano che concentrazioni pi\u00f9 elevate di polimero non solo rafforzano la rete finale, ma accelerano anche sia l\u2019inizio che il proseguimento della fotopolimerizzazione. Nel complesso, questi risultati dimostrano che la concentrazione di PhotoGel\u00ae influisce sulla cinetica di gelificazione e sulle propriet\u00e0 meccaniche finali.  <\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-fa8e7e9 e-grid e-con-full e-con e-child\" data-id=\"fa8e7e9\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-1ea1d19 elementor-widget__width-initial elementor-widget elementor-widget-image\" data-id=\"1ea1d19\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"871\" height=\"750\" src=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/PhotoGel_G.png?fit=871%2C750&amp;ssl=1\" class=\"attachment-large size-large wp-image-62828\" alt=\"\" srcset=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/PhotoGel_G.png?w=871&amp;ssl=1 871w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/PhotoGel_G.png?resize=300%2C258&amp;ssl=1 300w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/PhotoGel_G.png?resize=768%2C661&amp;ssl=1 768w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/PhotoGel_G.png?resize=87%2C75&amp;ssl=1 87w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/PhotoGel_G.png?resize=700%2C603&amp;ssl=1 700w\" sizes=\"(max-width:767px) 700px, (max-width:871px) 100vw, 871px\" data-attachment-id=\"62828\" data-permalink=\"https:\/\/rheolution.com\/it\/photogel_g-2\/\" data-orig-file=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/PhotoGel_G.png?fit=871%2C750&amp;ssl=1\" data-orig-size=\"871,750\" data-comments-opened=\"1\" data-image-title=\"PhotoGel_G&amp;#8217;\" data-image-description=\"\" data-image-caption=\"\" data-large-file=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/PhotoGel_G.png?fit=871%2C750&amp;ssl=1\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d420ba6 elementor-widget__width-initial elementor-widget elementor-widget-image\" data-id=\"d420ba6\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"746\" height=\"817\" src=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/PhotoGel_Start.png?fit=746%2C817&amp;ssl=1\" class=\"attachment-large size-large wp-image-62812\" alt=\"\" srcset=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/PhotoGel_Start.png?w=746&amp;ssl=1 746w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/PhotoGel_Start.png?resize=274%2C300&amp;ssl=1 274w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/PhotoGel_Start.png?resize=68%2C75&amp;ssl=1 68w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/PhotoGel_Start.png?resize=700%2C767&amp;ssl=1 700w\" sizes=\"(max-width:767px) 700px, 746px\" data-attachment-id=\"62812\" data-permalink=\"https:\/\/rheolution.com\/it\/photogel_start-2\/\" data-orig-file=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/PhotoGel_Start.png?fit=746%2C817&amp;ssl=1\" data-orig-size=\"746,817\" data-comments-opened=\"1\" data-image-title=\"PhotoGel_Start\" data-image-description=\"\" data-image-caption=\"\" data-large-file=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/PhotoGel_Start.png?fit=746%2C817&amp;ssl=1\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2cc63de elementor-widget__width-initial elementor-widget elementor-widget-image\" data-id=\"2cc63de\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"780\" height=\"759\" src=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/PhotoGel_Speed.png?fit=780%2C759&amp;ssl=1\" class=\"attachment-large size-large wp-image-62804\" alt=\"\" srcset=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/PhotoGel_Speed.png?w=780&amp;ssl=1 780w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/PhotoGel_Speed.png?resize=300%2C292&amp;ssl=1 300w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/PhotoGel_Speed.png?resize=768%2C747&amp;ssl=1 768w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/PhotoGel_Speed.png?resize=77%2C75&amp;ssl=1 77w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/PhotoGel_Speed.png?resize=700%2C681&amp;ssl=1 700w\" sizes=\"(max-width:767px) 700px, (max-width:780px) 100vw, 780px\" data-attachment-id=\"62804\" data-permalink=\"https:\/\/rheolution.com\/it\/photogel_speed-2\/\" data-orig-file=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/PhotoGel_Speed.png?fit=780%2C759&amp;ssl=1\" data-orig-size=\"780,759\" data-comments-opened=\"1\" data-image-title=\"PhotoGel_Speed\" data-image-description=\"\" data-image-caption=\"\" data-large-file=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/PhotoGel_Speed.png?fit=780%2C759&amp;ssl=1\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-069025e elementor-widget elementor-widget-text-editor\" data-id=\"069025e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><em><b>Figura 1.<\/b><span style=\"font-weight: 400\">  Modulo di immagazzinamento di taglio finale (G\u2032, a sinistra), tempo di inizio (al centro, min) e velocit\u00e0 massima di gelificazione (a destra; Pa\/s) confrontando PhotoGel\u00ae al 5% e al 10% (p\/v) con polimerizzazione a 405 nm. Media \u00b1 deviazione standard (n = 3). **p &lt; 0,01, ***p &lt; 0,001.  <\/span><\/em><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a19c2ed elementor-widget__width-initial elementor-widget elementor-widget-image\" data-id=\"a19c2ed\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"875\" height=\"627\" src=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/GelMA-Hydrogel.jpeg?fit=875%2C627&amp;ssl=1\" class=\"attachment-large size-large wp-image-62820\" alt=\"\" srcset=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/GelMA-Hydrogel.jpeg?w=875&amp;ssl=1 875w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/GelMA-Hydrogel.jpeg?resize=300%2C215&amp;ssl=1 300w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/GelMA-Hydrogel.jpeg?resize=768%2C550&amp;ssl=1 768w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/GelMA-Hydrogel.jpeg?resize=105%2C75&amp;ssl=1 105w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/GelMA-Hydrogel.jpeg?resize=700%2C502&amp;ssl=1 700w\" sizes=\"(max-width:767px) 700px, (max-width:875px) 100vw, 875px\" data-attachment-id=\"62820\" data-permalink=\"https:\/\/rheolution.com\/it\/gelma-hydrogel-2\/\" data-orig-file=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/GelMA-Hydrogel.jpeg?fit=875%2C627&amp;ssl=1\" data-orig-size=\"875,627\" data-comments-opened=\"1\" data-image-title=\"GelMA Hydrogel\" data-image-description=\"\" data-image-caption=\"\" data-large-file=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/GelMA-Hydrogel.jpeg?fit=875%2C627&amp;ssl=1\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6327b34 elementor-widget elementor-widget-text-editor\" data-id=\"6327b34\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><em><b>Figura 2.<\/b><span style=\"font-weight: 400\">  PhotoGel\u00ae dopo la reticolazione fotochimica nell\u2019ElastoSens\u2122 Bio.  <\/span><\/em><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8ad5968 elementor-widget elementor-widget-heading\" data-id=\"8ad5968\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Conclusioni e prospettive<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b7d7a98 elementor-widget elementor-widget-text-editor\" data-id=\"b7d7a98\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400\">Il comportamento meccanico degli idrogel GelMA \u2014 determinato dalla cinetica di reticolazione fotoindotta, dalla densit\u00e0 della rete e dalla viscoelasticit\u00e0 dipendente dal tempo \u2014 \u00e8 un fattore chiave per le loro prestazioni biologiche e funzionali. Essendo materiali morbidi, idratati e sensibili alla luce, i sistemi GelMA richiedono metodi di caratterizzazione in grado di rilevare l\u2019evoluzione meccanica senza alterare la rete o le condizioni sperimentali. <\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-aed2e2d elementor-widget elementor-widget-text-editor\" data-id=\"aed2e2d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400\">La caratterizzazione viscoelastica non distruttiva con ElastoSens\u2122 Bio permette di:<\/span><\/p><ul><li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Misurazione accurata e ripetibile della cinetica di gelificazione del GelMA.<\/span><span style=\"font-weight: 400\"><br><\/span><\/li><li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Identificazione in tempo reale della transizione liquido-gel durante la fotoreticolazione.<\/span><span style=\"font-weight: 400\"><br><\/span><\/li><li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Quantificazione della rigidit\u00e0 finale in condizioni rilevanti per l&#8217;applicazione.<\/span><span style=\"font-weight: 400\"><br><\/span><\/li><li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Monitoraggio longitudinale dello stesso campione per valutare la maturazione o il degrado.<\/span><span style=\"font-weight: 400\"><br><\/span><\/li><li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Misurazioni in condizioni sterili e con illuminazione controllata grazie al modulo di fotostimolazione integrato.<\/span><span style=\"font-weight: 400\"><br><\/span><\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-afd54d4 elementor-widget elementor-widget-text-editor\" data-id=\"afd54d4\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400\">Tutte queste caratteristiche, nel loro insieme, consentono di comprendere meglio le relazioni tra struttura e propriet\u00e0, migliorano la riproducibilit\u00e0 sperimentale e rendono pi\u00f9 affidabile l&#8217;applicazione degli idrogel GelMA nei campi della biofabbricazione, dell&#8217;ingegneria tissutale e delle applicazioni biomediche.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-794c36a elementor-widget elementor-widget-heading\" data-id=\"794c36a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Riferimenti<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-27340c7 elementor-widget elementor-widget-text-editor\" data-id=\"27340c7\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400\">Yue, K., Trujillo-de Santiago, G., Alvarez, M. M., Tamayol, A., Annabi, N., &amp; Khademhosseini, A. (2015). Synthesis, properties, and biomedical applications of gelatin methacryloyl (GelMA) hydrogels.  <\/span>Biomaterials, 73, 254-271.<\/p><p><span style=\"font-weight: 400\">Bupphathong, S., Quiroz, C., Huang, W., Chung, P. F., Tao, H. Y., &amp; Lin, C. H. (2022). Gelatin methacrylate hydrogel for tissue engineering applications\u2014a review on material modifications.  <\/span>Pharmaceuticals, 15(2), 171.<\/p><p><span style=\"font-weight: 400\">Das, S., Jegadeesan, J. T., &amp; Basu, B. (2024). Gelatin methacryloyl (GelMA)-based biomaterial inks: process science for 3D\/4D printing and current status.  <\/span>Biomacromolecules, 25(4), 2156-2221.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9383078 elementor-widget__width-initial elementor-widget-mobile__width-inherit elementor--h-position-center elementor--v-position-middle elementor-arrows-position-inside elementor-widget elementor-widget-slides\" data-id=\"9383078\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;navigation&quot;:&quot;arrows&quot;,&quot;autoplay_speed&quot;:4000,&quot;transition_speed&quot;:4000,&quot;autoplay&quot;:&quot;yes&quot;,&quot;pause_on_hover&quot;:&quot;yes&quot;,&quot;pause_on_interaction&quot;:&quot;yes&quot;,&quot;infinite&quot;:&quot;yes&quot;,&quot;transition&quot;:&quot;slide&quot;}\" data-widget_type=\"slides.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-swiper\">\n\t\t\t\t\t<div class=\"elementor-slides-wrapper elementor-main-swiper swiper\" role=\"region\" aria-roledescription=\"carousel\" aria-label=\"Slides\" dir=\"ltr\" data-animation=\"fadeInUp\">\n\t\t\t\t<div class=\"swiper-wrapper elementor-slides\">\n\t\t\t\t\t\t\t\t\t\t<div class=\"elementor-repeater-item-c97f30c swiper-slide\" role=\"group\" aria-roledescription=\"slide\"><div class=\"swiper-slide-bg\" role=\"img\" aria-label=\"elastosens2\"><\/div><div class=\"swiper-slide-inner\" ><div class=\"swiper-slide-contents\"><\/div><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8cce0c6 elementor-widget__width-initial elementor-widget-mobile__width-inherit elementor-widget elementor-widget-text-editor\" data-id=\"8cce0c6\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Scopri come la nostra tecnologia misura in modo non distruttivo le propriet\u00e0 viscoelastiche dei biomateriali morbidi e dei tessuti utilizzando microvolumi di campioni<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c4ce1d0 elementor-align-center elementor-widget elementor-widget-button\" data-id=\"c4ce1d0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/rheolution.com\/contact\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Contattaci per saperne di pi\u00f9<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-efbb293 elementor-widget elementor-widget-heading\" data-id=\"efbb293\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Articoli correlati<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3f623a9 premium-blog-cta-full-yes premium-floating-effects-yes premium-disable-fe-yes elementor-widget__width-initial premium-blog-align-left elementor-widget elementor-widget-premium-addon-blog\" data-id=\"3f623a9\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;force_height&quot;:&quot;true&quot;,&quot;premium_blog_grid&quot;:&quot;yes&quot;,&quot;premium_blog_layout&quot;:&quot;even&quot;,&quot;premium_blog_columns_number&quot;:&quot;50%&quot;,&quot;premium_blog_columns_number_tablet&quot;:&quot;50%&quot;,&quot;premium_blog_columns_number_mobile&quot;:&quot;100%&quot;,&quot;scroll_to_offset&quot;:&quot;yes&quot;,&quot;premium_fe_trigger&quot;:&quot;load&quot;,&quot;premium_fe_direction&quot;:&quot;alternate&quot;,&quot;premium_fe_loop&quot;:&quot;default&quot;,&quot;premium_fe_easing&quot;:&quot;easeInOutSine&quot;}\" data-widget_type=\"premium-addon-blog.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\n\t\t\n\n\t\t\t\t<div class=\"premium-blog-wrap  premium-blog-even\" data-page=\"65563\" data-pagination=\"true\">\n\t\t\t\t\t\t\t\t\t<div class=\"premium-blog-post-outer-container\" data-total=\"3\">\n\t\t\t<div class=\"premium-blog-post-container premium-blog-skin-classic\">\n\t\t\t\t\t\t\t\t\t<div class=\"premium-blog-thumb-effect-wrapper\">\n\t\t\t\t\t\t<div class=\"premium-blog-thumbnail-container premium-blog-zoomin-effect\">\n\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"7000\" height=\"2322\" src=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/FIBRIN.jpg?fit=7000%2C2322&amp;ssl=1\" class=\"attachment-full size-full wp-image-63002\" alt=\"\" data-attachment-id=\"63002\" data-permalink=\"https:\/\/rheolution.com\/it\/fibrin-2\/\" data-orig-file=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/FIBRIN.jpg?fit=7000%2C2322&amp;ssl=1\" data-orig-size=\"7000,2322\" data-comments-opened=\"1\" data-image-title=\"FIBRIN\" data-image-description=\"\" data-image-caption=\"\" data-large-file=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/FIBRIN.jpg?fit=1024%2C340&amp;ssl=1\" srcset=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/FIBRIN.jpg?w=7000&amp;ssl=1 7000w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/FIBRIN.jpg?resize=300%2C100&amp;ssl=1 300w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/FIBRIN.jpg?resize=1024%2C340&amp;ssl=1 1024w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/FIBRIN.jpg?resize=768%2C255&amp;ssl=1 768w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/FIBRIN.jpg?resize=1536%2C510&amp;ssl=1 1536w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/FIBRIN.jpg?resize=2048%2C679&amp;ssl=1 2048w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/FIBRIN.jpg?resize=150%2C50&amp;ssl=1 150w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/FIBRIN.jpg?resize=700%2C232&amp;ssl=1 700w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/FIBRIN.jpg?w=2440&amp;ssl=1 2440w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/FIBRIN.jpg?w=3660&amp;ssl=1 3660w\" sizes=\"(max-width:767px) 700px, (max-width:7000px) 100vw, 7000px\" \/>\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"premium-blog-thumbnail-overlay\">\n\t\t\t\t\t\t\t\t<a class=\"elementor-icon\" href=\"https:\/\/rheolution.com\/it\/note-applicative\/idrogel-di-fibrina\/\" target=\"_blank\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-screen-only\">Idrogel di fibrina<\/span>\n\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"premium-blog-content-wrapper \">\n\n\t\t\t\t\t<div class=\"premium-blog-inner-container\">\n\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<h4 class=\"premium-blog-entry-title\">\n\t\t\t<a href=\"https:\/\/rheolution.com\/it\/note-applicative\/idrogel-di-fibrina\/\" target=\"_blank\">\n\t\t\t\tIdrogel di fibrina\t\t\t<\/a>\n\t\t<\/h4>\n\t\t\t\t<div class=\"premium-blog-entry-meta\">\n\t\t\t\n\t\t\t\n\t\t\t\n\t\t\t\t\t<\/div>\n\t\t\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t<div class=\"premium-blog-content-inner-wrapper\">\n\t\t<p class=\"premium-blog-post-content\">Gli idrogel di fibrina sono biomateriali naturali a base proteica formati dalla fibrina, il polimero insolubile che si forma durante la coagulazione del sangue. La fibrina deriva dal fibrinogeno, una glicoproteina plasmatica composta da tre coppie di catene polipeptidiche che, una volta attivate enzimaticamente, si assemblano in una rete fibrosa. In condizioni fisiologiche, la formazione della fibrina \u00e8 innescata dalla scissione del fibrinogeno mediata dalla trombina, che espone i siti di polimerizzazione che guidano l\u2019autoassemblaggio spontaneo in una matrice idratata e porosa.<\/p><div class=\"premium-blog-excerpt-link-wrap\"><a href=\"https:\/\/rheolution.com\/it\/note-applicative\/idrogel-di-fibrina\/\" target=\"_blank\" class=\"premium-blog-excerpt-link elementor-button\">Leggi di pi\u00f9 \u00bb<\/a><\/div>\t\t<\/div>\n\t\t\t\t\t\t\t\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\n\t\t\t\t<div class=\"premium-blog-post-outer-container\" data-total=\"3\">\n\t\t\t<div class=\"premium-blog-post-container premium-blog-skin-classic\">\n\t\t\t\t\t\t\t\t\t<div class=\"premium-blog-thumb-effect-wrapper\">\n\t\t\t\t\t\t<div class=\"premium-blog-thumbnail-container premium-blog-zoomin-effect\">\n\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"7000\" height=\"2322\" src=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/ALGINATE-1.jpg?fit=7000%2C2322&amp;ssl=1\" class=\"attachment-full size-full wp-image-63130\" alt=\"\" data-attachment-id=\"63130\" data-permalink=\"https:\/\/rheolution.com\/it\/alginate-2-2\/\" data-orig-file=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/ALGINATE-1.jpg?fit=7000%2C2322&amp;ssl=1\" data-orig-size=\"7000,2322\" data-comments-opened=\"1\" data-image-title=\"ALGINATE\" data-image-description=\"\" data-image-caption=\"\" data-large-file=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/ALGINATE-1.jpg?fit=1024%2C340&amp;ssl=1\" srcset=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/ALGINATE-1.jpg?w=7000&amp;ssl=1 7000w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/ALGINATE-1.jpg?resize=300%2C100&amp;ssl=1 300w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/ALGINATE-1.jpg?resize=1024%2C340&amp;ssl=1 1024w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/ALGINATE-1.jpg?resize=768%2C255&amp;ssl=1 768w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/ALGINATE-1.jpg?resize=1536%2C510&amp;ssl=1 1536w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/ALGINATE-1.jpg?resize=2048%2C679&amp;ssl=1 2048w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/ALGINATE-1.jpg?resize=150%2C50&amp;ssl=1 150w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/ALGINATE-1.jpg?resize=700%2C232&amp;ssl=1 700w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/ALGINATE-1.jpg?w=2440&amp;ssl=1 2440w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/ALGINATE-1.jpg?w=3660&amp;ssl=1 3660w\" sizes=\"(max-width:767px) 700px, (max-width:7000px) 100vw, 7000px\" \/>\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"premium-blog-thumbnail-overlay\">\n\t\t\t\t\t\t\t\t<a class=\"elementor-icon\" href=\"https:\/\/rheolution.com\/it\/note-applicative\/idrogel-di-alginato\/\" target=\"_blank\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-screen-only\">Idrogel di alginato<\/span>\n\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"premium-blog-content-wrapper \">\n\n\t\t\t\t\t<div class=\"premium-blog-inner-container\">\n\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<h4 class=\"premium-blog-entry-title\">\n\t\t\t<a href=\"https:\/\/rheolution.com\/it\/note-applicative\/idrogel-di-alginato\/\" target=\"_blank\">\n\t\t\t\tIdrogel di alginato\t\t\t<\/a>\n\t\t<\/h4>\n\t\t\t\t<div class=\"premium-blog-entry-meta\">\n\t\t\t\n\t\t\t\n\t\t\t\n\t\t\t\t\t<\/div>\n\t\t\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t<div class=\"premium-blog-content-inner-wrapper\">\n\t\t<p class=\"premium-blog-post-content\">Gli idrogel di alginato sono reti polimeriche tridimensionali ricche d'acqua, derivate dall'alginato, un polisaccaride anionico presente in natura. L'alginato viene estratto principalmente dalle pareti cellulari delle alghe brune appartenenti alla classe delle Phaeophyceae, anche se pu\u00f2 essere biosintetizzato da alcune specie batteriche come l'Azotobacter e lo Pseudomonas. Dal punto di vista strutturale, l\u2019alginato \u00e8 un copolimero lineare composto da acido \u03b2-D-mannuronico (unit\u00e0 M) e acido \u03b1-L-guluronico (unit\u00e0 G) collegati tramite legami glicosidici 1\u21924.<\/p><div class=\"premium-blog-excerpt-link-wrap\"><a href=\"https:\/\/rheolution.com\/it\/note-applicative\/idrogel-di-alginato\/\" target=\"_blank\" class=\"premium-blog-excerpt-link elementor-button\">Leggi di pi\u00f9 \u00bb<\/a><\/div>\t\t<\/div>\n\t\t\t\t\t\t\t\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\n\t\t\t\t<div class=\"premium-blog-post-outer-container\" data-total=\"3\">\n\t\t\t<div class=\"premium-blog-post-container premium-blog-skin-classic\">\n\t\t\t\t\t\t\t\t\t<div class=\"premium-blog-thumb-effect-wrapper\">\n\t\t\t\t\t\t<div class=\"premium-blog-thumbnail-container premium-blog-zoomin-effect\">\n\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"7875\" height=\"2612\" src=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Gelatin-Methacrylate-1.jpg?fit=7875%2C2612&amp;ssl=1\" class=\"attachment-full size-full wp-image-63422\" alt=\"\" data-attachment-id=\"63422\" data-permalink=\"https:\/\/rheolution.com\/it\/gelatin-methacrylate-2-2\/\" data-orig-file=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Gelatin-Methacrylate-1.jpg?fit=7875%2C2612&amp;ssl=1\" data-orig-size=\"7875,2612\" data-comments-opened=\"1\" data-image-title=\"Gelatin Methacrylate\" data-image-description=\"\" data-image-caption=\"\" data-large-file=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Gelatin-Methacrylate-1.jpg?fit=1024%2C340&amp;ssl=1\" srcset=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Gelatin-Methacrylate-1.jpg?w=7875&amp;ssl=1 7875w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Gelatin-Methacrylate-1.jpg?resize=300%2C100&amp;ssl=1 300w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Gelatin-Methacrylate-1.jpg?resize=1024%2C340&amp;ssl=1 1024w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Gelatin-Methacrylate-1.jpg?resize=768%2C255&amp;ssl=1 768w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Gelatin-Methacrylate-1.jpg?resize=1536%2C509&amp;ssl=1 1536w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Gelatin-Methacrylate-1.jpg?resize=2048%2C679&amp;ssl=1 2048w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Gelatin-Methacrylate-1.jpg?resize=150%2C50&amp;ssl=1 150w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Gelatin-Methacrylate-1.jpg?resize=700%2C232&amp;ssl=1 700w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Gelatin-Methacrylate-1.jpg?w=2440&amp;ssl=1 2440w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Gelatin-Methacrylate-1.jpg?w=3660&amp;ssl=1 3660w\" sizes=\"(max-width:767px) 700px, (max-width:7875px) 100vw, 7875px\" \/>\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"premium-blog-thumbnail-overlay\">\n\t\t\t\t\t\t\t\t<a class=\"elementor-icon\" href=\"https:\/\/rheolution.com\/it\/note-applicative\/gelma-idrogel\/\" target=\"_blank\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-screen-only\">Idrogel GelMA<\/span>\n\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"premium-blog-content-wrapper \">\n\n\t\t\t\t\t<div class=\"premium-blog-inner-container\">\n\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<h4 class=\"premium-blog-entry-title\">\n\t\t\t<a href=\"https:\/\/rheolution.com\/it\/note-applicative\/gelma-idrogel\/\" target=\"_blank\">\n\t\t\t\tIdrogel GelMA\t\t\t<\/a>\n\t\t<\/h4>\n\t\t\t\t<div class=\"premium-blog-entry-meta\">\n\t\t\t\n\t\t\t\n\t\t\t\n\t\t\t\t\t<\/div>\n\t\t\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t<div class=\"premium-blog-content-inner-wrapper\">\n\t\t<p class=\"premium-blog-post-content\">La gelatina metacrililica (GelMA) \u00e8 un idrogel fotoreticolabile derivato dalla gelatina, a sua volta ottenuta dall\u2019idrolisi parziale del collagene, la principale proteina strutturale della matrice extracellulare (ECM). Il GelMA si ottiene facendo reagire la gelatina con l'anidride metacrilica, introducendo gruppi funzionali metacriloilici sui residui amminoacidici della gelatina e conservando al contempo la maggior parte dei suoi motivi bioattivi nativi.<\/p><div class=\"premium-blog-excerpt-link-wrap\"><a href=\"https:\/\/rheolution.com\/it\/note-applicative\/gelma-idrogel\/\" target=\"_blank\" class=\"premium-blog-excerpt-link elementor-button\">Leggi di pi\u00f9 \u00bb<\/a><\/div>\t\t<\/div>\n\t\t\t\t\t\t\t\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\n\t\t\t\t<div class=\"premium-blog-post-outer-container\" data-total=\"3\">\n\t\t\t<div class=\"premium-blog-post-container premium-blog-skin-classic\">\n\t\t\t\t\t\t\t\t\t<div class=\"premium-blog-thumb-effect-wrapper\">\n\t\t\t\t\t\t<div class=\"premium-blog-thumbnail-container premium-blog-zoomin-effect\">\n\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"7875\" height=\"2612\" src=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/PMMA-1.jpg?fit=7875%2C2612&amp;ssl=1\" class=\"attachment-full size-full wp-image-63430\" alt=\"\" data-attachment-id=\"63430\" data-permalink=\"https:\/\/rheolution.com\/it\/pmma-2-2\/\" data-orig-file=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/PMMA-1.jpg?fit=7875%2C2612&amp;ssl=1\" data-orig-size=\"7875,2612\" data-comments-opened=\"1\" data-image-title=\"PMMA\" data-image-description=\"\" data-image-caption=\"\" data-large-file=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/PMMA-1.jpg?fit=1024%2C340&amp;ssl=1\" srcset=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/PMMA-1.jpg?w=7875&amp;ssl=1 7875w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/PMMA-1.jpg?resize=300%2C100&amp;ssl=1 300w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/PMMA-1.jpg?resize=1024%2C340&amp;ssl=1 1024w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/PMMA-1.jpg?resize=768%2C255&amp;ssl=1 768w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/PMMA-1.jpg?resize=1536%2C509&amp;ssl=1 1536w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/PMMA-1.jpg?resize=2048%2C679&amp;ssl=1 2048w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/PMMA-1.jpg?resize=150%2C50&amp;ssl=1 150w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/PMMA-1.jpg?resize=700%2C232&amp;ssl=1 700w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/PMMA-1.jpg?w=2440&amp;ssl=1 2440w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/PMMA-1.jpg?w=3660&amp;ssl=1 3660w\" sizes=\"(max-width:767px) 700px, (max-width:7875px) 100vw, 7875px\" \/>\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"premium-blog-thumbnail-overlay\">\n\t\t\t\t\t\t\t\t<a class=\"elementor-icon\" href=\"https:\/\/rheolution.com\/it\/note-applicative\/polimeri-pmma\/\" target=\"_blank\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-screen-only\">Polimeri PMMA<\/span>\n\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"premium-blog-content-wrapper \">\n\n\t\t\t\t\t<div class=\"premium-blog-inner-container\">\n\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<h4 class=\"premium-blog-entry-title\">\n\t\t\t<a href=\"https:\/\/rheolution.com\/it\/note-applicative\/polimeri-pmma\/\" target=\"_blank\">\n\t\t\t\tPolimeri PMMA\t\t\t<\/a>\n\t\t<\/h4>\n\t\t\t\t<div class=\"premium-blog-entry-meta\">\n\t\t\t\n\t\t\t\n\t\t\t\n\t\t\t\t\t<\/div>\n\t\t\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t<div class=\"premium-blog-content-inner-wrapper\">\n\t\t<p class=\"premium-blog-post-content\">Il polimetilmetacrilato (PMMA) \u00e8 un polimero sintetico termoplastico che fa parte della famiglia delle resine acriliche. Si ottiene tramite la polimerizzazione radicalica dei monomeri di metilmetacrilato (MMA), dando origine a un polimero lineare e amorfo caratterizzato da un\u2019elevata trasparenza ottica e rigidit\u00e0 strutturale. Il PMMA \u00e8 interamente prodotto industrialmente: l\u2019MMA viene sintetizzato a partire da materie prime petrolchimiche e polimerizzato tramite un processo di innesco termico, chimico o fotochimico controllato.<\/p><div class=\"premium-blog-excerpt-link-wrap\"><a href=\"https:\/\/rheolution.com\/it\/note-applicative\/polimeri-pmma\/\" target=\"_blank\" class=\"premium-blog-excerpt-link elementor-button\">Leggi di pi\u00f9 \u00bb<\/a><\/div>\t\t<\/div>\n\t\t\t\t\t\t\t\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\n\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div class=\"premium-blog-footer\">\n\t\t\t\t\t\t\t<nav class=\"premium-blog-pagination-container\" role=\"navigation\" aria-label=\"Pagination\">\n\t\t\t\t<span aria-current=\"page\" class=\"page-numbers current\">1<\/span>\n<a class=\"page-numbers\" href=\"https:\/\/rheolution.com\/it\/wp-json\/wp\/v2\/posts\/65563\/page\/2\/\">2<\/a>\n<a class=\"page-numbers\" href=\"https:\/\/rheolution.com\/it\/wp-json\/wp\/v2\/posts\/65563\/page\/3\/\">3<\/a>\n<a class=\"next page-numbers\" href=\"https:\/\/rheolution.com\/it\/wp-json\/wp\/v2\/posts\/65563\/page\/2\/\">Avanti \u00bb<\/a>\t\t\t<\/nav>\n\t\t\t\t\t\t<\/div>\n\t\t\n\t\t\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>La gelatina metacrililica (GelMA) \u00e8 un idrogel fotoreticolabile derivato dalla gelatina, a sua volta ottenuta dall\u2019idrolisi parziale del collagene, la principale proteina strutturale della matrice extracellulare (ECM). Il GelMA si ottiene facendo reagire la gelatina con l&#8217;anidride metacrilica, introducendo gruppi funzionali metacriloilici sui residui amminoacidici della gelatina e conservando al contempo la maggior parte dei suoi motivi bioattivi nativi.   <\/p>\n","protected":false},"author":195401359,"featured_media":63422,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_wpcom_ai_launchpad_first_post":false,"_jetpack_hide_featured_image":false,"_jetpack_featured_image_duplicate_dismissed":0,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_post_was_ever_published":false},"categories":[289,336],"tags":[89,124,88,261],"class_list":["post-65563","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-note-applicative","category-polymer-library","tag-elastosens-bio","tag-life-sciences","tag-mechanical-testing","tag-polymer"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Idrogel GelMA: Propriet\u00e0, Applicazioni e Caratteristiche Meccaniche<\/title>\n<meta name=\"description\" content=\"Scopri gli idrogel GelMA: dalla struttura e dalla gelificazione al comportamento meccanico, alla viscoelasticit\u00e0 e alle principali applicazioni nell&#039;ingegneria tissutale e nel rilascio di farmaci.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rheolution.com\/it\/note-applicative\/gelma-idrogel\/\" \/>\n<meta property=\"og:locale\" content=\"it_IT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Idrogel GelMA: Propriet\u00e0, Applicazioni e Caratteristiche Meccaniche\" \/>\n<meta property=\"og:description\" content=\"Scopri gli idrogel GelMA: dalla struttura e dalla gelificazione al comportamento meccanico, alla viscoelasticit\u00e0 e alle principali applicazioni nell&#039;ingegneria tissutale e nel rilascio di farmaci.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/rheolution.com\/it\/note-applicative\/gelma-idrogel\/\" \/>\n<meta property=\"og:site_name\" content=\"Rheolution\" \/>\n<meta property=\"article:published_time\" content=\"2026-08-06T18:31:46+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-08-14T13:39:17+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Gelatin-Methacrylate-1.jpg?fit=7875%2C2612&ssl=1\" \/>\n\t<meta property=\"og:image:width\" content=\"7875\" \/>\n\t<meta property=\"og:image:height\" content=\"2612\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Ana Paula Knorst\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Scritto da\" \/>\n\t<meta name=\"twitter:data1\" content=\"Ana Paula Knorst\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tempo di lettura stimato\" \/>\n\t<meta name=\"twitter:data2\" content=\"10 minuti\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/rheolution.com\\\/it\\\/note-applicative\\\/gelma-idrogel\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/rheolution.com\\\/it\\\/note-applicative\\\/gelma-idrogel\\\/\"},\"author\":{\"name\":\"Ana Paula Knorst\",\"@id\":\"https:\\\/\\\/rheolution.com\\\/it\\\/#\\\/schema\\\/person\\\/0b0ff48d3b1e01ba6ba6b90def2868ce\"},\"headline\":\"Idrogel GelMA\",\"datePublished\":\"2026-08-06T18:31:46+00:00\",\"dateModified\":\"2026-08-14T13:39:17+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/rheolution.com\\\/it\\\/note-applicative\\\/gelma-idrogel\\\/\"},\"wordCount\":1974,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\\\/\\\/rheolution.com\\\/it\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/rheolution.com\\\/it\\\/note-applicative\\\/gelma-idrogel\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/i0.wp.com\\\/rheolution.com\\\/wp-content\\\/uploads\\\/Gelatin-Methacrylate-1.jpg?fit=7875%2C2612&ssl=1\",\"keywords\":[\"ElastoSens Bio\",\"Life Sciences\",\"Mechanical testing\",\"Polymer\"],\"articleSection\":[\"App-Notes\",\"Polymer Library\"],\"inLanguage\":\"it-IT\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/rheolution.com\\\/it\\\/note-applicative\\\/gelma-idrogel\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/rheolution.com\\\/it\\\/note-applicative\\\/gelma-idrogel\\\/\",\"url\":\"https:\\\/\\\/rheolution.com\\\/it\\\/note-applicative\\\/gelma-idrogel\\\/\",\"name\":\"Idrogel GelMA: Propriet\u00e0, Applicazioni e Caratteristiche Meccaniche\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/rheolution.com\\\/it\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/rheolution.com\\\/it\\\/note-applicative\\\/gelma-idrogel\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/rheolution.com\\\/it\\\/note-applicative\\\/gelma-idrogel\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/i0.wp.com\\\/rheolution.com\\\/wp-content\\\/uploads\\\/Gelatin-Methacrylate-1.jpg?fit=7875%2C2612&ssl=1\",\"datePublished\":\"2026-08-06T18:31:46+00:00\",\"dateModified\":\"2026-08-14T13:39:17+00:00\",\"description\":\"Scopri gli idrogel GelMA: dalla struttura e dalla gelificazione al comportamento meccanico, alla viscoelasticit\u00e0 e alle principali applicazioni nell'ingegneria tissutale e nel rilascio di farmaci.\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/rheolution.com\\\/it\\\/note-applicative\\\/gelma-idrogel\\\/#breadcrumb\"},\"inLanguage\":\"it-IT\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/rheolution.com\\\/it\\\/note-applicative\\\/gelma-idrogel\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"it-IT\",\"@id\":\"https:\\\/\\\/rheolution.com\\\/it\\\/note-applicative\\\/gelma-idrogel\\\/#primaryimage\",\"url\":\"https:\\\/\\\/i0.wp.com\\\/rheolution.com\\\/wp-content\\\/uploads\\\/Gelatin-Methacrylate-1.jpg?fit=7875%2C2612&ssl=1\",\"contentUrl\":\"https:\\\/\\\/i0.wp.com\\\/rheolution.com\\\/wp-content\\\/uploads\\\/Gelatin-Methacrylate-1.jpg?fit=7875%2C2612&ssl=1\",\"width\":7875,\"height\":2612},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/rheolution.com\\\/it\\\/note-applicative\\\/gelma-idrogel\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/rheolution.com\\\/it\\\/home-page\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Idrogel GelMA\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/rheolution.com\\\/it\\\/#website\",\"url\":\"https:\\\/\\\/rheolution.com\\\/it\\\/\",\"name\":\"Rheolution\",\"description\":\"Soft Matter Analytics for Life Sciences and Agri-Food.\",\"publisher\":{\"@id\":\"https:\\\/\\\/rheolution.com\\\/it\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/rheolution.com\\\/it\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"it-IT\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/rheolution.com\\\/it\\\/#organization\",\"name\":\"Rheolution\",\"url\":\"https:\\\/\\\/rheolution.com\\\/it\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"it-IT\",\"@id\":\"https:\\\/\\\/rheolution.com\\\/it\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/rheolution.com\\\/wp-content\\\/uploads\\\/2020\\\/12\\\/RHEOLUTION_smarter_logo_RGB_cropped.png\",\"contentUrl\":\"https:\\\/\\\/rheolution.com\\\/wp-content\\\/uploads\\\/2020\\\/12\\\/RHEOLUTION_smarter_logo_RGB_cropped.png\",\"width\":2850,\"height\":637,\"caption\":\"Rheolution\"},\"image\":{\"@id\":\"https:\\\/\\\/rheolution.com\\\/it\\\/#\\\/schema\\\/logo\\\/image\\\/\"},\"sameAs\":[\"https:\\\/\\\/www.linkedin.com\\\/company\\\/rheolution\\\/\"]},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/rheolution.com\\\/it\\\/#\\\/schema\\\/person\\\/0b0ff48d3b1e01ba6ba6b90def2868ce\",\"name\":\"Ana Paula Knorst\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"it-IT\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/281774e3d2b924704828e4303c303ea882aea52911c944bb7ee382b407bcefaf?s=96&d=identicon&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/281774e3d2b924704828e4303c303ea882aea52911c944bb7ee382b407bcefaf?s=96&d=identicon&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/281774e3d2b924704828e4303c303ea882aea52911c944bb7ee382b407bcefaf?s=96&d=identicon&r=g\",\"caption\":\"Ana Paula Knorst\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Idrogel GelMA: Propriet\u00e0, Applicazioni e Caratteristiche Meccaniche","description":"Scopri gli idrogel GelMA: dalla struttura e dalla gelificazione al comportamento meccanico, alla viscoelasticit\u00e0 e alle principali applicazioni nell'ingegneria tissutale e nel rilascio di farmaci.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/rheolution.com\/it\/note-applicative\/gelma-idrogel\/","og_locale":"it_IT","og_type":"article","og_title":"Idrogel GelMA: Propriet\u00e0, Applicazioni e Caratteristiche Meccaniche","og_description":"Scopri gli idrogel GelMA: dalla struttura e dalla gelificazione al comportamento meccanico, alla viscoelasticit\u00e0 e alle principali applicazioni nell'ingegneria tissutale e nel rilascio di farmaci.","og_url":"https:\/\/rheolution.com\/it\/note-applicative\/gelma-idrogel\/","og_site_name":"Rheolution","article_published_time":"2026-08-06T18:31:46+00:00","article_modified_time":"2026-08-14T13:39:17+00:00","og_image":[{"width":7875,"height":2612,"url":"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Gelatin-Methacrylate-1.jpg?fit=7875%2C2612&ssl=1","type":"image\/jpeg"}],"author":"Ana Paula Knorst","twitter_card":"summary_large_image","twitter_misc":{"Scritto da":"Ana Paula Knorst","Tempo di lettura stimato":"10 minuti"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/rheolution.com\/it\/note-applicative\/gelma-idrogel\/#article","isPartOf":{"@id":"https:\/\/rheolution.com\/it\/note-applicative\/gelma-idrogel\/"},"author":{"name":"Ana Paula Knorst","@id":"https:\/\/rheolution.com\/it\/#\/schema\/person\/0b0ff48d3b1e01ba6ba6b90def2868ce"},"headline":"Idrogel GelMA","datePublished":"2026-08-06T18:31:46+00:00","dateModified":"2026-08-14T13:39:17+00:00","mainEntityOfPage":{"@id":"https:\/\/rheolution.com\/it\/note-applicative\/gelma-idrogel\/"},"wordCount":1974,"commentCount":0,"publisher":{"@id":"https:\/\/rheolution.com\/it\/#organization"},"image":{"@id":"https:\/\/rheolution.com\/it\/note-applicative\/gelma-idrogel\/#primaryimage"},"thumbnailUrl":"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Gelatin-Methacrylate-1.jpg?fit=7875%2C2612&ssl=1","keywords":["ElastoSens Bio","Life Sciences","Mechanical testing","Polymer"],"articleSection":["App-Notes","Polymer Library"],"inLanguage":"it-IT","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/rheolution.com\/it\/note-applicative\/gelma-idrogel\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/rheolution.com\/it\/note-applicative\/gelma-idrogel\/","url":"https:\/\/rheolution.com\/it\/note-applicative\/gelma-idrogel\/","name":"Idrogel GelMA: Propriet\u00e0, Applicazioni e Caratteristiche Meccaniche","isPartOf":{"@id":"https:\/\/rheolution.com\/it\/#website"},"primaryImageOfPage":{"@id":"https:\/\/rheolution.com\/it\/note-applicative\/gelma-idrogel\/#primaryimage"},"image":{"@id":"https:\/\/rheolution.com\/it\/note-applicative\/gelma-idrogel\/#primaryimage"},"thumbnailUrl":"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Gelatin-Methacrylate-1.jpg?fit=7875%2C2612&ssl=1","datePublished":"2026-08-06T18:31:46+00:00","dateModified":"2026-08-14T13:39:17+00:00","description":"Scopri gli idrogel GelMA: dalla struttura e dalla gelificazione al comportamento meccanico, alla viscoelasticit\u00e0 e alle principali applicazioni nell'ingegneria tissutale e nel rilascio di farmaci.","breadcrumb":{"@id":"https:\/\/rheolution.com\/it\/note-applicative\/gelma-idrogel\/#breadcrumb"},"inLanguage":"it-IT","potentialAction":[{"@type":"ReadAction","target":["https:\/\/rheolution.com\/it\/note-applicative\/gelma-idrogel\/"]}]},{"@type":"ImageObject","inLanguage":"it-IT","@id":"https:\/\/rheolution.com\/it\/note-applicative\/gelma-idrogel\/#primaryimage","url":"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Gelatin-Methacrylate-1.jpg?fit=7875%2C2612&ssl=1","contentUrl":"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Gelatin-Methacrylate-1.jpg?fit=7875%2C2612&ssl=1","width":7875,"height":2612},{"@type":"BreadcrumbList","@id":"https:\/\/rheolution.com\/it\/note-applicative\/gelma-idrogel\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/rheolution.com\/it\/home-page\/"},{"@type":"ListItem","position":2,"name":"Idrogel GelMA"}]},{"@type":"WebSite","@id":"https:\/\/rheolution.com\/it\/#website","url":"https:\/\/rheolution.com\/it\/","name":"Rheolution","description":"Soft Matter Analytics for Life Sciences and Agri-Food.","publisher":{"@id":"https:\/\/rheolution.com\/it\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/rheolution.com\/it\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"it-IT"},{"@type":"Organization","@id":"https:\/\/rheolution.com\/it\/#organization","name":"Rheolution","url":"https:\/\/rheolution.com\/it\/","logo":{"@type":"ImageObject","inLanguage":"it-IT","@id":"https:\/\/rheolution.com\/it\/#\/schema\/logo\/image\/","url":"https:\/\/rheolution.com\/wp-content\/uploads\/2020\/12\/RHEOLUTION_smarter_logo_RGB_cropped.png","contentUrl":"https:\/\/rheolution.com\/wp-content\/uploads\/2020\/12\/RHEOLUTION_smarter_logo_RGB_cropped.png","width":2850,"height":637,"caption":"Rheolution"},"image":{"@id":"https:\/\/rheolution.com\/it\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.linkedin.com\/company\/rheolution\/"]},{"@type":"Person","@id":"https:\/\/rheolution.com\/it\/#\/schema\/person\/0b0ff48d3b1e01ba6ba6b90def2868ce","name":"Ana Paula Knorst","image":{"@type":"ImageObject","inLanguage":"it-IT","@id":"https:\/\/secure.gravatar.com\/avatar\/281774e3d2b924704828e4303c303ea882aea52911c944bb7ee382b407bcefaf?s=96&d=identicon&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/281774e3d2b924704828e4303c303ea882aea52911c944bb7ee382b407bcefaf?s=96&d=identicon&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/281774e3d2b924704828e4303c303ea882aea52911c944bb7ee382b407bcefaf?s=96&d=identicon&r=g","caption":"Ana Paula Knorst"}}]}},"jetpack_likes_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/pcuyPq-h3t","jetpack_sharing_enabled":true,"jetpack_featured_media_url":"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Gelatin-Methacrylate-1.jpg?fit=7875%2C2612&ssl=1","_links":{"self":[{"href":"https:\/\/rheolution.com\/it\/wp-json\/wp\/v2\/posts\/65563","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/rheolution.com\/it\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/rheolution.com\/it\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/rheolution.com\/it\/wp-json\/wp\/v2\/users\/195401359"}],"replies":[{"embeddable":true,"href":"https:\/\/rheolution.com\/it\/wp-json\/wp\/v2\/comments?post=65563"}],"version-history":[{"count":6,"href":"https:\/\/rheolution.com\/it\/wp-json\/wp\/v2\/posts\/65563\/revisions"}],"predecessor-version":[{"id":66804,"href":"https:\/\/rheolution.com\/it\/wp-json\/wp\/v2\/posts\/65563\/revisions\/66804"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/rheolution.com\/it\/wp-json\/wp\/v2\/media\/63422"}],"wp:attachment":[{"href":"https:\/\/rheolution.com\/it\/wp-json\/wp\/v2\/media?parent=65563"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/rheolution.com\/it\/wp-json\/wp\/v2\/categories?post=65563"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/rheolution.com\/it\/wp-json\/wp\/v2\/tags?post=65563"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}