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ELASTOSENS™ BIO
NON-DESTRUCTIVE MECHANICAL TESTER FOR SOFT BIOMATERIALS

The ElastoSens™ Bio is a contract-free, non-destructive mechanical tester specifically designed for measuring the viscoelastic properties of soft biomaterials used in the life sciences and biomedical fields.

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HOW IT WORKS

The ElastoSens™ Bio uses vibrations to measure non-destructively and without contact the viscoelasticity of soft materials. At each measurement, a gentle vibration is transmitted to the material through a patented sample holder and the sample response is measured remotely using a laser optical probe. A built-in height probe simultaneously captures the sample height in real time. ElastoSens™ Bio’s software then processes the raw data and displays in real time the viscoelastic properties of the sample.

Trusted By

McGill University
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New Castle University
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Sastra University
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University of Victoria

APPLICATIONS OF THE ELASTOSENS™ BIO

EX VIVO MECHANICAL TESTING OF PERICARDIUM MEMBRANES

This study investigates the mechanical properties of bovine pericardium membranes using the ElastoSens™ Bio. The Membrane Sample Holder was specifically designed to facilitate the non-destructive testing of soft biological membranes, ensuring precise measurements. The elasticity of bovine pericardium was characterized both before and after crosslinking treatment, demonstrating the tool’s utility in soft tissue mechanical analysis.

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EFFECT OF HEMOSTATIC AGENTS ON THE COAGULATION OF BLOOD

The ElastoSens™ Bio measured real-time changes in blood viscoelastic properties with various hemostatic agents (HAs). It captured key descriptors like clotting time and stiffness. HAs reduced clotting time and increased clot stiffness, supporting the development of new HAs for effective bleeding management, even in coagulation disorders.

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ENZYMATIC DEGRADATION OF TISSUES AND ORGANS

The ElastoSens™ Bio measured viscoelastic properties of kidney tissue during enzymatic degradation with collagenase. The study showed higher enzyme concentrations accelerated tissue degradation. These precise measurements are crucial for optimizing cell extraction in regenerative medicine, where enzymes degrade native tissues or simulate in vivo conditions for biomaterials development.

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AI MODELING FOR HYDROGEL FORMULATION

An AI model was developed to predict the gelation kinetics and viscoelastic properties of PEGDA hydrogels, using data generated by the ElastoSens™ Bio. This model, validated with a 3% mean error and R²≥0.97, offers a highly accurate, data-driven approach to hydrogel development, advancing beyond traditional experimental methods.

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MEASURING THE CROSSLINKING OF HYDROGELS

Alginate, a natural biomaterial, crosslinks with calcium ions to form tunable hydrogels. Using the ElastoSens™ Bio, it was observed that lower calcium concentrations cause swelling and slower crosslinking, while higher concentrations result in faster crosslinking, gel shrinkage, and increased stiffness. Alginate hydrogels dissolve in calcium-free saline solutions like PBS.

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EX VIVO MECHANICAL TESTING OF SOFT ORGANS

Samples from native tissues and organs can be tested ex vivo in the ElastoSens™ Bio. Cylindrical samples can be cut from the organ and inserted into the sample holder. The viscoelastic properties of the tissue can be measured under controlled temperature. These results can be used to understand the mechanical behavior of native tissues and as a reference for the development of biomaterials and tissue engineering products.

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PHOTOCROSSLINKING OF HYDROGELS

Photostimulation can be applied in the ElastoSens™ Bio chamber during testing, capturing UV/visible light effects on biomaterials in real time. Wavelength (365-405 nm) and intensity (0-24 mW/cm²) are adjustable. This allows precise control of viscoelasticity and optimization of photocrosslinking parameters for 3D printing processes.

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CHARACTERIZATION OF SUPERABSORBENT POLYMERS (SAPs)

The ElastoSens™ Bio measures real-time absorption of superabsorbent polymers (SAP) by tracking the elastic modulus of the forming gel. It captures the absorption start time, swelling speed, and final gel stiffness. The device also analyzes SAP reactions to multiple intakes and tracks porosity changes at low absorption rates.

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MECHANICAL TESTING FOR TISSUE ENGINEERING

The ElastoSens™ Bio optimized gelatin-based hydrogels by measuring real-time shear storage modulus. A 5 U/mL transglutaminase and 20% gelatin concentration were selected for stability. The 20% gelatin hydrogel maintained integrity over 14 days, matching human skin’s modulus (40-60 kPa), and was used for an epidermis model with keratinocytes.

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MEASURING BLOOD COAGULATION

The ElastoSens™ Bio enables repeatable, sensitive measurement of blood viscoelastic properties during coagulation, which is challenging for conventional techniques. The concentration of CaCl 2 non-linearly affects coagulation initiation, with clot stiffness proportional to CaCl 2 levels. ElastoSens™ Bio results closely matched a rotational rheometer and showed better correlation than TEG.

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HYDROGEL-BASED DRUG RELEASE SYSTEMS

The ElastoSens™ Bio enables precise measurement of the mechanical properties of hydrogel-based drug delivery systems during degradation, which is challenging with conventional instruments. It was used to evaluate dye-loaded gelatin/alginate composite gels, showing temperature-dependent degradation of gelatin beads, which promoted dye release from the composite gels.

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MECHANICAL TESTING FOR BIOPRINTING

The ElastoSens™ Bio enables non-destructive, precise measurement of 3D printed scaffold viscoelastic properties, overcoming the limitations of conventional destructive techniques. It showed that volume fraction and printing pattern influence scaffold mechanics, preserving samples for further testing, making it ideal for tissue engineering and drug delivery applications.

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FORMULATION OF HYDROGELS

The ElastoSens™ Bio offers non-destructive, sensitive evaluation of hydrogel formation, distinguishing agar and collagen formulations based on viscoelastic properties. It provides comparable results to conventional rheometers, simplifying the traditionally complex and destructive testing process, making it ideal for optimizing hydrogels in bioengineering and life sciences applications.

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DEGRADATION OF HYDROGELS

The ElastoSens™ Bio non-destructively measured the viscoelastic properties of forming and then degrading chitosan hydrogels over 7 days. It provided sensitive, long-term measurements under simulated physiological conditions. A decrease in shear storage modulus confirmed degradation in a lysozyme solution, even without significant weight change, surpassing conventional testing methods.

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ELASTOSENS™ BIO FEATURES & SPECS

WHAT ARE THE DIFFERENCES BETWEEN ELASTOSENS™ BIO AND RHEOMETERS OR COMPRESSION TESTERS?

RHEOLUTION SUPPORT & SERVICES

Calibration & Qualification

We provide calibration services as well as Installation & Operation qualification services (IQ/OQ).

Installation & Training

We support users with instrument installation and provide training on the use of our instruments and software.

Extended Warranties

We offer extended warranties on top of the standard 12 months full warranty period.

Lifetime Support

We offer our users life time access to our application specialists for support.

Certification & Documentation

We provide certificates and documentation that comply with your industry regulations.

Methods & Protocols

We work with you and your team on the development of custom protocols and methods.

PRICING OF THE ELASTOSENS™ BIO

ElastoSens™ Bio

The First Non-Destructive Mechanical Tester of Soft Biomaterials for under

US$40,000

Contact us for more information

BOOK A CALL WITH OUR SCIENTISTS

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