{"id":71016,"date":"2025-09-16T11:17:48","date_gmt":"2025-09-16T15:17:48","guid":{"rendered":"https:\/\/rheolution.com\/?p=71016"},"modified":"2026-09-29T16:51:58","modified_gmt":"2026-09-29T20:51:58","slug":"mesure-des-proprietes-mecaniques-du-tissu-cardiaque","status":"publish","type":"post","link":"https:\/\/rheolution.com\/fr\/notes-application\/mesure-des-proprietes-mecaniques-du-tissu-cardiaque\/","title":{"rendered":"Mesure des propri\u00e9t\u00e9s m\u00e9caniques du tissu cardiaque"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"71016\" class=\"elementor elementor-71016 elementor-61587\" data-elementor-post-type=\"post\">\n\t\t\t\t<div class=\"elementor-element elementor-element-8fd4dcf e-flex e-con-boxed e-con e-parent\" data-id=\"8fd4dcf\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-8c770e2 elementor-widget elementor-widget-heading\" data-id=\"8c770e2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h6 class=\"elementor-heading-title elementor-size-default\">Note d\u2019application | ElastoSens\u2122 Bio<\/h6>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-760ae40 elementor-widget elementor-widget-heading\" data-id=\"760ae40\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Mesure des propri\u00e9t\u00e9s m\u00e9caniques du tissu cardiaque \u00e0 l'aide d'ElastoSens\u2122 Bio\n\n<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-97ac8de e-flex e-con-boxed e-con e-parent\" data-id=\"97ac8de\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-cbaa0e4 elementor-widget elementor-widget-heading\" data-id=\"cbaa0e4\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Introduction<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-88d2925 elementor-widget elementor-widget-text-editor\" data-id=\"88d2925\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400;\">La capacit\u00e9 du c\u0153ur \u00e0 pomper le sang d\u00e9pend non seulement de son activit\u00e9 \u00e9lectrique, mais aussi des propri\u00e9t\u00e9s m\u00e9caniques de ses tissus. Ces propri\u00e9t\u00e9s \u2014 qui vont de l\u2019\u00e9lasticit\u00e9 \u00e0 la rigidit\u00e9 en passant par la visco\u00e9lasticit\u00e9 \u2014 r\u00e9gissent la mani\u00e8re dont le myocarde s\u2019\u00e9tire, se contracte et se rel\u00e2che tout au long du cycle cardiaque. De l\u00e9g\u00e8res modifications de ces propri\u00e9t\u00e9s m\u00e9caniques peuvent \u00eatre le signe d\u2019une maladie pr\u00e9coce, tandis que des alt\u00e9rations plus marqu\u00e9es alt\u00e8rent la capacit\u00e9 du c\u0153ur \u00e0 se remplir et \u00e0 \u00e9jecter le sang. En les \u00e9tudiant, les scientifiques et les cliniciens peuvent mieux comprendre le fonctionnement d\u2019un c\u0153ur sain, d\u00e9tecter les premiers signes de maladie et mettre au point des traitements visant \u00e0 restaurer ou \u00e0 pr\u00e9server ses performances.   <\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5fc8fde elementor-widget__width-initial elementor-widget-mobile__width-inherit elementor-widget elementor-widget-heading\" data-id=\"5fc8fde\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Principales propri\u00e9t\u00e9s m\u00e9caniques du c\u0153ur<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-bd3468a elementor-widget elementor-widget-heading\" data-id=\"bd3468a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">\u00c9lasticit\u00e9<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d61237b elementor-widget elementor-widget-text-editor\" data-id=\"d61237b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400;\">L&rsquo;\u00e9lasticit\u00e9 refl\u00e8te la capacit\u00e9 du myocarde \u00e0 retrouver sa forme initiale apr\u00e8s avoir subi une d\u00e9formation. Elle est essentielle au remplissage diastolique, car elle permet aux ventricules d&rsquo;accueillir le sang entrant, puis de se contracter efficacement en vue de la contraction suivante. <\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c984676 elementor-widget elementor-widget-heading\" data-id=\"c984676\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Rigidit\u00e9<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d51523d elementor-widget elementor-widget-text-editor\" data-id=\"d51523d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400;\">La rigidit\u00e9 correspond \u00e0 la r\u00e9sistance \u00e0 la d\u00e9formation ; elle est souvent quantifi\u00e9e \u00e0 l&rsquo;aide de param\u00e8tres tels que le module d&rsquo;\u00e9lasticit\u00e9 ou les relations pression-volume. Elle varie de mani\u00e8re dynamique tout au long du cycle cardiaque, avec une faible rigidit\u00e9 pendant la diastole et une rigidit\u00e9 plus \u00e9lev\u00e9e pendant la systole. <\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-637b511 elementor-widget elementor-widget-heading\" data-id=\"637b511\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Conformit\u00e9<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-12ac0bd elementor-widget elementor-widget-text-editor\" data-id=\"12ac0bd\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400;\">La compliance, qui est l&rsquo;inverse de la rigidit\u00e9, d\u00e9crit la capacit\u00e9 du c\u0153ur \u00e0 se dilater lorsqu&rsquo;il se remplit. Une compliance r\u00e9duite limite la capacit\u00e9 de remplissage et constitue un signe caract\u00e9ristique d&rsquo;un dysfonctionnement diastolique. <\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c8f3824 elementor-widget elementor-widget-heading\" data-id=\"c8f3824\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Visco\u00e9lasticit\u00e9<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-fcb70d7 elementor-widget elementor-widget-text-editor\" data-id=\"fcb70d7\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400;\">Le c\u0153ur pr\u00e9sente \u00e0 la fois un comportement \u00e9lastique et visqueux, ce qui signifie que sa r\u00e9ponse d\u00e9pend non seulement du degr\u00e9 d&rsquo;\u00e9tirement, mais \u00e9galement de la vitesse de d\u00e9formation. Cette visco\u00e9lasticit\u00e9 influe sur la mani\u00e8re dont le myocarde dissipe ou stocke l&rsquo;\u00e9nergie pendant la contraction et la relaxation. <\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4b96c45 elementor-widget elementor-widget-heading\" data-id=\"4b96c45\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Anisotropie<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-bd7d10b elementor-widget elementor-widget-text-editor\" data-id=\"bd7d10b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400;\">En raison de la complexit\u00e9 de son architecture fibreuse, le myocarde est anisotrope : son comportement m\u00e9canique varie en fonction de la direction de la force appliqu\u00e9e. Cette anisotropie contribue \u00e0 un \u00e9paississement efficace de la paroi et \u00e0 un pompage coordonn\u00e9. <\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5703c6a elementor-widget__width-initial elementor-widget-mobile__width-inherit elementor-widget elementor-widget-heading\" data-id=\"5703c6a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Lien entre les maladies et les propri\u00e9t\u00e9s m\u00e9caniques du tissu cardiaque<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5a0b64a elementor-widget elementor-widget-heading\" data-id=\"5a0b64a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Insuffisance cardiaque avec fraction d'\u00e9jection pr\u00e9serv\u00e9e (HFpEF)<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-38524ee elementor-widget elementor-widget-text-editor\" data-id=\"38524ee\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400;\">L&rsquo;HFpEF est \u00e9troitement associ\u00e9e \u00e0 une rigidit\u00e9 myocardique accrue et \u00e0 une compliance r\u00e9duite. Ces modifications alt\u00e8rent le remplissage diastolique, limitant ainsi la capacit\u00e9 du c\u0153ur \u00e0 r\u00e9pondre aux besoins circulatoires malgr\u00e9 une fraction d&rsquo;\u00e9jection normale. <\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-30981bc elementor-widget elementor-widget-heading\" data-id=\"30981bc\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Fibrose<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2e827a1 elementor-widget elementor-widget-text-editor\" data-id=\"2e827a1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400;\">La fibrose cardiaque, caract\u00e9ris\u00e9e par un d\u00e9p\u00f4t excessif de collag\u00e8ne, rigidifie la matrice extracellulaire et modifie son anisotropie. Ce remodelage perturbe la m\u00e9canique normale du c\u0153ur, contribuant ainsi \u00e0 un dysfonctionnement tant systolique que diastolique. <\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0959975 elementor-widget elementor-widget-heading\" data-id=\"0959975\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">L\u00e9sion d'isch\u00e9mie-reperfusion<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-90cc644 elementor-widget elementor-widget-text-editor\" data-id=\"90cc644\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400;\">Au cours de l&rsquo;isch\u00e9mie et de la reperfusion qui s&rsquo;ensuit, la rigidit\u00e9 myocardique \u00e9volue de mani\u00e8re dynamique. Les \u00e9tudes d&rsquo;\u00e9lastographie par ondes de cisaillement mettent en \u00e9vidence une modification de la rigidit\u00e9 systolique et diastolique, refl\u00e9tant une alt\u00e9ration de la contractilit\u00e9 et de la relaxation au niveau du tissu l\u00e9s\u00e9. <\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-25ebf8f elementor-widget elementor-widget-heading\" data-id=\"25ebf8f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Cardiomyopathie dilat\u00e9e<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3c011f7 elementor-widget elementor-widget-text-editor\" data-id=\"3c011f7\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400;\">Dans la cardiomyopathie dilat\u00e9e, les modifications des propri\u00e9t\u00e9s m\u00e9caniques passives et actives \u2014 notamment une compliance accrue et une visco\u00e9lasticit\u00e9 alt\u00e9r\u00e9e \u2014 entra\u00eenent une dilatation des cavit\u00e9s cardiaques, une diminution de la contractilit\u00e9 et une insuffisance cardiaque progressive.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-28004d8 elementor-widget__width-initial elementor-widget-mobile__width-inherit elementor-widget elementor-widget-heading\" data-id=\"28004d8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Comment \u00e9value-t-on la m\u00e9canique des tissus cardiaques ?<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-06adff0 elementor-widget elementor-widget-heading\" data-id=\"06adff0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Techniques in vivo (cliniques)<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ba2f1b1 elementor-widget elementor-widget-text-editor\" data-id=\"ba2f1b1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400;\">Sur le plan clinique, la rigidit\u00e9 cardiaque peut \u00eatre \u00e9valu\u00e9e \u00e0 l\u2019aide de techniques tant invasives que non invasives. L\u2019analyse de la boucle pression-volume par cath\u00e9t\u00e9risme reste la r\u00e9f\u00e9rence en mati\u00e8re d\u2019\u00e9valuation de la rigidit\u00e9 des cavit\u00e9s cardiaques. Les approches non invasives sont de plus en plus courantes, notamment l\u2019\u00e9lastographie par ondes de cisaillement (SWE), qui suit la propagation des ondes dans le myocarde, ainsi que des outils d\u2019imagerie avanc\u00e9s tels que l\u2019\u00e9lastographie par r\u00e9sonance magn\u00e9tique (MRE) et l\u2019imagerie par impulsions de force de rayonnement acoustique (ARFI). Ces m\u00e9thodes fournissent des informations pr\u00e9cieuses sur les fonctions diastolique et systolique et jouent un r\u00f4le essentiel dans la d\u00e9tection pr\u00e9coce des modifications li\u00e9es \u00e0 la maladie.   <\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d01f123 elementor-widget elementor-widget-heading\" data-id=\"d01f123\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Techniques ex vivo (recherche)<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-137d5ec elementor-widget elementor-widget-text-editor\" data-id=\"137d5ec\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400;\">Dans le domaine de la recherche, les m\u00e9thodes ex vivo permettent une caract\u00e9risation d\u00e9taill\u00e9e des propri\u00e9t\u00e9s m\u00e9caniques du tissu cardiaque. Parmi les techniques couramment utilis\u00e9es figurent les essais de traction, la rh\u00e9om\u00e9trie de cisaillement et l\u2019indentation (\u00e0 l\u2019\u00e9chelle nanom\u00e9trique et microm\u00e9trique), appliqu\u00e9es aussi bien \u00e0 des cellules isol\u00e9es qu\u2019\u00e0 des \u00e9chantillons de c\u0153ur entier. Ces techniques permettent de mettre en \u00e9vidence l\u2019\u00e9lasticit\u00e9, la viscosit\u00e9 et le comportement visco\u00e9lastique dans des conditions contr\u00f4l\u00e9es, aidant ainsi les chercheurs \u00e0 \u00e9tablir un lien entre les modifications mol\u00e9culaires et la m\u00e9canique globale du myocarde.  <\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-892f73a elementor-widget__width-initial elementor-widget-mobile__width-inherit elementor-widget elementor-widget-heading\" data-id=\"892f73a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">\u00c9tude de cas : Caract\u00e9risation m\u00e9canique du tissu cardiaque avec ElastoSens\u2122 Bio<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-5a225c3 e-grid e-con-full e-con e-child\" data-id=\"5a225c3\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ce43e5b elementor-widget elementor-widget-text-editor\" data-id=\"ce43e5b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400;\">Dans le domaine de la biom\u00e9canique cardiaque, le <a href=\"https:\/\/rheolution.com\/fr\/produits\/elastosens-bio\/instrument\/\"><strong>ElastoSens\u2122 Bio<\/strong><\/a> propose une approche de pointe pour les essais ex vivo. Cet instrument permet une mesure continue et non destructive des propri\u00e9t\u00e9s visco\u00e9lastiques, garantissant ainsi le maintien de l&rsquo;int\u00e9grit\u00e9 des tissus tout au long des exp\u00e9riences. Sa technologie permet une caract\u00e9risation pr\u00e9cise des \u00e9chantillons cardiaques mous et prend en charge la r\u00e9alisation d&rsquo;essais r\u00e9p\u00e9t\u00e9s sur de longues p\u00e9riodes dans diff\u00e9rentes conditions environnementales, \u00e9largissant ainsi les informations disponibles au-del\u00e0 des essais m\u00e9caniques traditionnels.  <\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-045aef9 elementor-widget elementor-widget-image\" data-id=\"045aef9\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"968\" height=\"544\" src=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/elastosens2-1.webp?fit=968%2C544&amp;ssl=1\" class=\"attachment-large size-large wp-image-50364\" alt=\"\" srcset=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/elastosens2-1.webp?w=968&amp;ssl=1 968w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/elastosens2-1.webp?resize=300%2C169&amp;ssl=1 300w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/elastosens2-1.webp?resize=768%2C432&amp;ssl=1 768w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/elastosens2-1.webp?resize=133%2C75&amp;ssl=1 133w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/elastosens2-1.webp?resize=480%2C270&amp;ssl=1 480w\" sizes=\"(max-width:767px) 700px, (max-width:968px) 100vw, 968px\" data-attachment-id=\"50364\" data-permalink=\"https:\/\/rheolution.com\/fr\/elastosens2-4-2-2-2\/\" data-orig-file=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/elastosens2-1.webp?fit=968%2C544&amp;ssl=1\" data-orig-size=\"968,544\" data-comments-opened=\"1\" data-image-title=\"elastosens2\" data-image-description=\"\" data-image-caption=\"\" data-large-file=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/elastosens2-1.webp?fit=968%2C544&amp;ssl=1\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b87c673 elementor-widget elementor-widget-text-editor\" data-id=\"b87c673\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400;\">Afin de d\u00e9montrer les capacit\u00e9s de l\u2019ElastoSens\u2122 Bio, nous avons men\u00e9 une \u00e9tude ex vivo sur des \u00e9chantillons de tissu cardiaque. La section suivante d\u00e9crit le mat\u00e9riel et les m\u00e9thodes utilis\u00e9s dans le cadre de cette exp\u00e9rience, puis pr\u00e9sente les r\u00e9sultats, illustrant ainsi un exemple concret d\u2019application de l\u2019appareil. <\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4babf25 elementor-widget elementor-widget-heading\" data-id=\"4babf25\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Mat\u00e9riel et m\u00e9thodes<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d118051 elementor-widget elementor-widget-text-editor\" data-id=\"d118051\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400;\">Les c\u0153urs de porc et de mouton provenaient d\u2019une exploitation agricole locale. Des \u00e9chantillons de tissu de forme approximativement cylindrique (diam\u00e8tre interne de 23 mm, hauteur variable) ont \u00e9t\u00e9 pr\u00e9lev\u00e9s \u00e0 l\u2019aide d\u2019un emporte-pi\u00e8ce de type biopsique. Chaque \u00e9chantillon a \u00e9t\u00e9 soigneusement plac\u00e9 dans le support macro de l\u2019instrument ElastoSens\u2122 Bio. Les mesures ont \u00e9t\u00e9 effectu\u00e9es \u00e0 temp\u00e9rature ambiante, chaque \u00e9chantillon ayant \u00e9t\u00e9 test\u00e9 pendant une minute.   <\/span><\/p><p><span style=\"font-weight: 400;\">L&rsquo;instrument fournissait des param\u00e8tres visco\u00e9lastiques en temps r\u00e9el, notamment le module de stockage en cisaillement (G\u2032) et le coefficient d&rsquo;amortissement (Tan\ud835\udeff). Pour chaque condition, les r\u00e9sultats ont \u00e9t\u00e9 exprim\u00e9s sous forme de valeurs moyennes obtenues \u00e0 partir de cinq \u00e9chantillons ind\u00e9pendants, pr\u00e9lev\u00e9s au m\u00eame niveau anatomique sur cinq c\u0153urs diff\u00e9rents (n = 5). <\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-558712e elementor-widget__width-initial elementor-widget elementor-widget-image\" data-id=\"558712e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"688\" height=\"686\" src=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Heart-Tissue.png?fit=688%2C686&amp;ssl=1\" class=\"attachment-full size-full wp-image-61600\" alt=\"\" srcset=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Heart-Tissue.png?w=688&amp;ssl=1 688w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Heart-Tissue.png?resize=300%2C300&amp;ssl=1 300w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Heart-Tissue.png?resize=150%2C150&amp;ssl=1 150w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Heart-Tissue.png?resize=75%2C75&amp;ssl=1 75w\" sizes=\"(max-width:767px) 688px, 688px\" data-attachment-id=\"61600\" data-permalink=\"https:\/\/rheolution.com\/fr\/heart-tissue-2\/\" data-orig-file=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Heart-Tissue.png?fit=688%2C686&amp;ssl=1\" data-orig-size=\"688,686\" data-comments-opened=\"1\" data-image-title=\"Heart Tissue\" data-image-description=\"\" data-image-caption=\"\" data-large-file=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Heart-Tissue.png?fit=688%2C686&amp;ssl=1\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9f1b259 elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"9f1b259\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><b>Figure 1.<\/b><span style=\"font-weight: 400;\">  \u00c9chantillon de tissu cardiaque plac\u00e9 dans le support ElastoSens\u2122 Bio macro en vue d&rsquo;une caract\u00e9risation m\u00e9canique non destructive.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-aa24bd0 elementor-widget elementor-widget-heading\" data-id=\"aa24bd0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">R\u00e9sultats et discussion<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-54513af elementor-widget elementor-widget-text-editor\" data-id=\"54513af\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400;\">\u00c0 l\u2019aide du syst\u00e8me de contr\u00f4le non destructif ElastoSens\u2122 Bio, la figure 2 montre que le tissu cardiaque de porc pr\u00e9sentait un module de stockage en cisaillement plus \u00e9lev\u00e9 (G\u2032 = 7,8 \u00b1 1,3 kPa) que celui de mouton (4,1 \u00b1 1,3 kPa), ce qui indique une plus grande rigidit\u00e9 et un stockage d\u2019\u00e9nergie \u00e9lastique plus important. \u00c0 l\u2019inverse, le tissu ovin pr\u00e9sentait un coefficient d\u2019amortissement plus \u00e9lev\u00e9 (Tan\u03b4 = 0,42 \u00b1 0,05 contre 0,36 \u00b1 0,05), ce qui traduit une plus grande dissipation d\u2019\u00e9nergie visqueuse. Ces propri\u00e9t\u00e9s visco\u00e9lastiques sp\u00e9cifiques \u00e0 chaque esp\u00e8ce soulignent que le myocarde porcin est m\u00e9caniquement plus rigide, tandis que le myocarde ovin est plus dissipatif.  <\/span><\/p><p><span style=\"font-weight: 400;\">Nos valeurs concernant le c\u0153ur de porc concordent avec celles rapport\u00e9es par Kolipaka et al. (2010) et Nenadic et al. (2009), qui ont mesur\u00e9 le myocarde porcin \u00e0 l\u2019aide de l\u2019\u00e9lastographie par r\u00e9sonance magn\u00e9tique et de la vibrom\u00e9trie par ondes de cisaillement, et ont rapport\u00e9 des modules de cisaillement compris entre 7,69 et 12,7 kPa. Pour le myocarde ovin, des essais de traction biaxiaux ont fait \u00e9tat de modules de stockage de cisaillement \u00e9quivalents compris entre 4,4 et 10,2 kPa, avec une moyenne d\u2019environ 6,5 kPa (Pandelani et al., 2025), refl\u00e9tant des variations r\u00e9gionales et directionnelles au sein des ventricules. Dans l\u2019ensemble, l\u2019ElastoSens\u2122 Bio permet d\u2019effectuer des mesures ex vivo sur des tissus avec une manipulation minimale, dans des conditions contr\u00f4l\u00e9es d\u2019hydratation et de charge. Ce dispositif contr\u00f4l\u00e9 r\u00e9duit les sources externes de variabilit\u00e9 et permet de saisir la r\u00e9ponse visco\u00e9lastique intrins\u00e8que du tissu myocardique.   <\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-ea488a1 e-grid e-con-full e-con e-child\" data-id=\"ea488a1\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4582218 elementor-widget elementor-widget-image\" data-id=\"4582218\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"759\" height=\"763\" src=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/GSheep-Bar-Graph-sheep-and-pig-heart.png?fit=759%2C763&amp;ssl=1\" class=\"attachment-large size-large wp-image-61617\" alt=\"\" srcset=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/GSheep-Bar-Graph-sheep-and-pig-heart.png?w=759&amp;ssl=1 759w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/GSheep-Bar-Graph-sheep-and-pig-heart.png?resize=298%2C300&amp;ssl=1 298w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/GSheep-Bar-Graph-sheep-and-pig-heart.png?resize=150%2C150&amp;ssl=1 150w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/GSheep-Bar-Graph-sheep-and-pig-heart.png?resize=75%2C75&amp;ssl=1 75w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/GSheep-Bar-Graph-sheep-and-pig-heart.png?resize=700%2C704&amp;ssl=1 700w\" sizes=\"(max-width:767px) 700px, 759px\" data-attachment-id=\"61617\" data-permalink=\"https:\/\/rheolution.com\/fr\/gsheep-bar-graph-sheep-and-pig-heart-2\/\" data-orig-file=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/GSheep-Bar-Graph-sheep-and-pig-heart.png?fit=759%2C763&amp;ssl=1\" data-orig-size=\"759,763\" data-comments-opened=\"1\" data-image-title=\"G&amp;rsquo;Sheep&amp;rsquo; Bar Graph-sheep and pig heart\" data-image-description=\"\" data-image-caption=\"\" data-large-file=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/GSheep-Bar-Graph-sheep-and-pig-heart.png?fit=759%2C763&amp;ssl=1\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-97d02ec elementor-widget elementor-widget-image\" data-id=\"97d02ec\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"784\" height=\"767\" src=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/TanD-Bar-Graph-sheep-and-pig-heart.png?fit=784%2C767&amp;ssl=1\" class=\"attachment-large size-large wp-image-61609\" alt=\"\" srcset=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/TanD-Bar-Graph-sheep-and-pig-heart.png?w=784&amp;ssl=1 784w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/TanD-Bar-Graph-sheep-and-pig-heart.png?resize=300%2C293&amp;ssl=1 300w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/TanD-Bar-Graph-sheep-and-pig-heart.png?resize=768%2C751&amp;ssl=1 768w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/TanD-Bar-Graph-sheep-and-pig-heart.png?resize=77%2C75&amp;ssl=1 77w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/TanD-Bar-Graph-sheep-and-pig-heart.png?resize=700%2C685&amp;ssl=1 700w\" sizes=\"(max-width:767px) 700px, (max-width:784px) 100vw, 784px\" data-attachment-id=\"61609\" data-permalink=\"https:\/\/rheolution.com\/fr\/tand-bar-graph-sheep-and-pig-heart-2\/\" data-orig-file=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/TanD-Bar-Graph-sheep-and-pig-heart.png?fit=784%2C767&amp;ssl=1\" data-orig-size=\"784,767\" data-comments-opened=\"1\" data-image-title=\"TanD Bar Graph- sheep and pig heart\" data-image-description=\"\" data-image-caption=\"\" data-large-file=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/TanD-Bar-Graph-sheep-and-pig-heart.png?fit=784%2C767&amp;ssl=1\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-32a0d35 elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"32a0d35\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400;\"><strong>Figure 2 :<\/strong> Propri\u00e9t\u00e9s visco\u00e9lastiques du tissu cardiaque chez le mouton et le porc : module de stockage en cisaillement (G\u2032) (\u00e0 gauche) et rapport d&rsquo;amortissement (Tan\ud835\udeff) (\u00e0 droite) obtenus \u00e0 l&rsquo;aide du syst\u00e8me d&rsquo;analyse non destructive ElastoSens\u2122 Bio (moyenne \u00b1 \u00e9cart-type, n = 5).<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8ad5968 elementor-widget elementor-widget-heading\" data-id=\"8ad5968\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Conclusions et perspectives<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b7d7a98 elementor-widget elementor-widget-text-editor\" data-id=\"b7d7a98\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400;\">Les propri\u00e9t\u00e9s m\u00e9caniques du tissu cardiaque, notamment l\u2019\u00e9lasticit\u00e9, la rigidit\u00e9, la visco\u00e9lasticit\u00e9 et l\u2019anisotropie, sont essentielles \u00e0 la compr\u00e9hension tant de la fonction physiologique que du remodelage pathologique. La pr\u00e9sente \u00e9tude confirme que les essais visco\u00e9lastiques non destructifs r\u00e9alis\u00e9s \u00e0 l\u2019aide de l\u2019ElastoSens\u2122 Bio permettent une mesure fiable des propri\u00e9t\u00e9s m\u00e9caniques du tissu cardiaque, en capturant des param\u00e8tres cl\u00e9s tels que le module de stockage de cisaillement (G\u2032) et le coefficient d\u2019amortissement (Tan\ud835\udeff). Cette approche garantit des donn\u00e9es pr\u00e9cises et reproductibles, offrant ainsi une base solide pour des \u00e9tudes comparatives entre diff\u00e9rentes esp\u00e8ces et dans diverses conditions.  <\/span><\/p><p><span style=\"font-weight: 400;\">Au-del\u00e0 de ces r\u00e9sultats, l&rsquo;ElastoSens\u2122 Bio offre des avantages uniques pour la recherche dans les domaines cardiovasculaire et des biomat\u00e9riaux :<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-aed2e2d elementor-widget elementor-widget-text-editor\" data-id=\"aed2e2d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">La simplicit\u00e9 de la pr\u00e9paration et de la mise en place r\u00e9duit au minimum les manipulations et pr\u00e9serve l&rsquo;hydratation et l&rsquo;architecture du myocarde.<\/span><\/li><li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">La haute sensibilit\u00e9 et la r\u00e9p\u00e9tabilit\u00e9 garantissent des mesures coh\u00e9rentes dans les diff\u00e9rentes r\u00e9gions cardiaques (oreillettes, ventricules, septum), permettant ainsi de rendre compte de la variabilit\u00e9 intra-organique.<\/span><\/li><li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">L&rsquo;analyse comparative interesp\u00e8ces permet de mener des \u00e9tudes translationnelles en comparant directement la m\u00e9canique cardiaque chez les mod\u00e8les animaux et chez l&rsquo;\u00eatre humain.<\/span><\/li><li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">La polyvalence de cette plateforme permet de tester divers tissus cardiaques et biomat\u00e9riaux dans des conditions identiques, ce qui s&rsquo;av\u00e8re utile pour la mise au point de patchs cardiaques, de matrices de soutien ou de proth\u00e8ses valvulaires.<\/span><\/li><li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Les applications li\u00e9es aux tissus artificiels tirent parti de mesures non destructives et r\u00e9p\u00e9t\u00e9es qui permettent de suivre l&rsquo;\u00e9volution dynamique des structures myocardiques issues de la bio-ing\u00e9nierie.<\/span><\/li><li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Une incubation contr\u00f4l\u00e9e et des tests r\u00e9p\u00e9t\u00e9s permettent de suivre l&rsquo;\u00e9volution des propri\u00e9t\u00e9s visco\u00e9lastiques au fil du temps, qu&rsquo;elle soit due \u00e0 une isch\u00e9mie, \u00e0 des interventions pharmacologiques ou \u00e0 la progression d&rsquo;une maladie.<\/span><\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0f4db16 elementor-widget elementor-widget-text-editor\" data-id=\"0f4db16\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400;\">Ensemble, ces capacit\u00e9s font d&rsquo;<strong>ElastoSens\u2122 Bio<\/strong> un outil pr\u00e9cieux pour faire progresser la recherche sur les tissus cardiaques, la physiologie comparative et le d\u00e9veloppement de biomat\u00e9riaux de synth\u00e8se.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-794c36a elementor-widget elementor-widget-heading\" data-id=\"794c36a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">R\u00e9f\u00e9rences<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-27340c7 elementor-widget elementor-widget-text-editor\" data-id=\"27340c7\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400;\">Villalobos Lizardi, J. C., Baranger, J., Nguyen, M. B., Asnacios, A., Malik, A., Lumens, J., &#8230; &#038; Villemain, O. (2022). A guide for assessment of myocardial stiffness in health and disease.  <\/span>Nature Cardiovascular Research, 1(1), 8-22.<\/p><p><span style=\"font-weight: 400;\">Emig, R., Zgierski-Johnston, C. M., Timmermann, V., Taberner, A. J., Nash, M. P., Kohl, P., &#038; Peyronnet, R. (2021). Passive myocardial mechanical properties: meaning, measurement, models.  <\/span>Biophysical reviews, 13(5), 587-610.<\/p><p><span style=\"font-weight: 400;\">Caenen, A., Keijzer, L., B\u00e9zy, S., Duchenne, J., Orlowska, M., Van Der Steen, A. F., &#8230; &#038; Vos, H. J. (2023). Continuous shear wave measurements for dynamic cardiac stiffness evaluation in pigs.  <\/span><i><span style=\"font-weight: 400;\">Scientific Reports<\/span><\/i><span style=\"font-weight: 400;\">, <\/span><i><span style=\"font-weight: 400;\">13<\/span><\/i><span style=\"font-weight: 400;\">(1), 17660.<\/span><\/p><p><span style=\"font-weight: 400;\">Kolipaka, A., Araoz, P. A., McGee, K. P., Manduca, A., &#038; Ehman, R. L. (2010). Magnetic resonance elastography as a method for the assessment of effective myocardial stiffness throughout the cardiac cycle.  <\/span><i><span style=\"font-weight: 400;\">Magnetic Resonance in Medicine, 64<\/span><\/i><span style=\"font-weight: 400;\">(3), 862\u2013870.<\/span><\/p><p><span style=\"font-weight: 400;\">Nenadic, I., Urban, M. W., &#038; Greenleaf, J. F. (2009). Ex vivo measurements of myocardial viscoelasticity using shearwave dispersion ultrasound vibrometry (SDUV).  <\/span>Proceedings of the IEEE Engineering in Medicine and Biology Society, 2895\u20132898.<\/p><p><span style=\"font-weight: 400;\">Pandelani, T., Mashosho, E., Walker, C., Scheffer, C., &#038; Franz, T. (2025). Passive biaxial mechanical and microstructural characterization of adult ovine heart ventricles.  <\/span>Frontiers in Bioengineering and Biotechnology, 13, 1500585.<span style=\"font-weight: 400;\"><br><\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9383078 elementor-widget__width-initial elementor-widget-mobile__width-inherit elementor--h-position-center elementor--v-position-middle elementor-arrows-position-inside elementor-widget elementor-widget-slides\" data-id=\"9383078\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;navigation&quot;:&quot;arrows&quot;,&quot;autoplay_speed&quot;:4000,&quot;transition_speed&quot;:4000,&quot;autoplay&quot;:&quot;yes&quot;,&quot;pause_on_hover&quot;:&quot;yes&quot;,&quot;pause_on_interaction&quot;:&quot;yes&quot;,&quot;infinite&quot;:&quot;yes&quot;,&quot;transition&quot;:&quot;slide&quot;}\" data-widget_type=\"slides.default\">\n\t\t\t\t<div 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data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>D\u00e9couvrez comment notre technologie mesure de mani\u00e8re non destructive les propri\u00e9t\u00e9s visco\u00e9lastiques des biomat\u00e9riaux mous et des tissus en utilisant des micro-volumes d\u2019\u00e9chantillons<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c4ce1d0 elementor-align-center elementor-widget elementor-widget-button\" data-id=\"c4ce1d0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/rheolution.com\/fr\/contact\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Contactez-nous pour plus d'informations<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-efbb293 elementor-widget elementor-widget-heading\" data-id=\"efbb293\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Articles connexes<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3f623a9 premium-blog-cta-full-yes premium-floating-effects-yes premium-disable-fe-yes elementor-widget__width-initial premium-blog-align-left elementor-widget elementor-widget-premium-addon-blog\" data-id=\"3f623a9\" data-element_type=\"widget\" data-e-type=\"widget\" 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\/>\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"premium-blog-thumbnail-overlay\">\n\t\t\t\t\t\t\t\t<a class=\"elementor-icon\" href=\"https:\/\/rheolution.com\/fr\/notes-application\/mesure-des-proprietes-mecaniques-de-la-peau\/\" target=\"_blank\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-screen-only\">Mesure des propri\u00e9t\u00e9s m\u00e9caniques de la peau<\/span>\n\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"premium-blog-content-wrapper \">\n\n\t\t\t\t\t<div class=\"premium-blog-inner-container\">\n\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<h4 class=\"premium-blog-entry-title\">\n\t\t\t<a href=\"https:\/\/rheolution.com\/fr\/notes-application\/mesure-des-proprietes-mecaniques-de-la-peau\/\" target=\"_blank\">\n\t\t\t\tMesure des propri\u00e9t\u00e9s m\u00e9caniques de la peau\t\t\t<\/a>\n\t\t<\/h4>\n\t\t\t\t<div class=\"premium-blog-entry-meta\">\n\t\t\t\n\t\t\t\n\t\t\t\n\t\t\t\t\t<\/div>\n\t\t\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t<div class=\"premium-blog-content-inner-wrapper\">\n\t\t<p class=\"premium-blog-post-content\">La peau n\u2019est pas seulement le plus grand organe du corps, mais \u00e9galement une barri\u00e8re m\u00e9canique dynamique qui prot\u00e8ge contre les agressions environnementales, r\u00e9gule l\u2019\u00e9quilibre hydrique et contribue \u00e0 la perception sensorielle. Son fonctionnement d\u00e9pend fortement de l\u2019organisation structurelle du collag\u00e8ne, de l\u2019\u00e9lastine et d\u2019autres composants dermiques, qui, ensemble, donnent lieu \u00e0 des comportements m\u00e9caniques uniques tels que l\u2019\u00e9lasticit\u00e9, la rigidit\u00e9 et la visco\u00e9lasticit\u00e9. La mesure de ces propri\u00e9t\u00e9s permet de mieux comprendre comment la peau r\u00e9agit aux forces exerc\u00e9es au quotidien, qu\u2019il s\u2019agisse d\u2019\u00e9tirement, de compression ou de cisaillement.<\/p><div class=\"premium-blog-excerpt-link-wrap\"><a href=\"https:\/\/rheolution.com\/fr\/notes-application\/mesure-des-proprietes-mecaniques-de-la-peau\/\" target=\"_blank\" class=\"premium-blog-excerpt-link elementor-button\">Lire la suite \u00bb<\/a><\/div>\t\t<\/div>\n\t\t\t\t\t\t\t\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\n\t\t\t\t<div class=\"premium-blog-post-outer-container\" data-total=\"2\">\n\t\t\t<div class=\"premium-blog-post-container premium-blog-skin-classic\">\n\t\t\t\t\t\t\t\t\t<div class=\"premium-blog-thumb-effect-wrapper\">\n\t\t\t\t\t\t<div class=\"premium-blog-thumbnail-container premium-blog-zoomin-effect\">\n\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"1200\" height=\"450\" src=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/web-banner-2.jpg?fit=1200%2C450&amp;ssl=1\" class=\"attachment-full size-full wp-image-44476\" alt=\"\" data-attachment-id=\"44476\" data-permalink=\"https:\/\/rheolution.com\/fr\/notes-application\/viscoelasticite-de-la-gelomique-lunagel-mec-photoreticulable\/attachment\/web-banner-2-4\/\" data-orig-file=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/web-banner-2.jpg?fit=1200%2C450&amp;ssl=1\" data-orig-size=\"1200,450\" data-comments-opened=\"1\" data-image-title=\"web-banner-2\" data-image-description=\"\" data-image-caption=\"\" data-large-file=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/web-banner-2.jpg?fit=1024%2C384&amp;ssl=1\" srcset=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/web-banner-2.jpg?w=1200&amp;ssl=1 1200w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/web-banner-2.jpg?resize=300%2C113&amp;ssl=1 300w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/web-banner-2.jpg?resize=1024%2C384&amp;ssl=1 1024w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/web-banner-2.jpg?resize=768%2C288&amp;ssl=1 768w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/web-banner-2.jpg?resize=260%2C98&amp;ssl=1 260w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/web-banner-2.jpg?resize=50%2C19&amp;ssl=1 50w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/web-banner-2.jpg?resize=150%2C56&amp;ssl=1 150w\" sizes=\"(max-width:767px) 700px, (max-width:1200px) 100vw, 1200px\" \/>\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"premium-blog-thumbnail-overlay\">\n\t\t\t\t\t\t\t\t<a class=\"elementor-icon\" href=\"https:\/\/rheolution.com\/fr\/notes-application\/viscoelasticite-de-la-gelomique-lunagel-mec-photoreticulable\/\" target=\"_blank\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-screen-only\">R\u00e9glage de la rigidit\u00e9 des hydrogels \u00e0 base d&rsquo;ECM<\/span>\n\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"premium-blog-content-wrapper \">\n\n\t\t\t\t\t<div class=\"premium-blog-inner-container\">\n\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<h4 class=\"premium-blog-entry-title\">\n\t\t\t<a href=\"https:\/\/rheolution.com\/fr\/notes-application\/viscoelasticite-de-la-gelomique-lunagel-mec-photoreticulable\/\" target=\"_blank\">\n\t\t\t\tR\u00e9glage de la rigidit\u00e9 des hydrogels \u00e0 base d&rsquo;ECM\t\t\t<\/a>\n\t\t<\/h4>\n\t\t\t\t<div class=\"premium-blog-entry-meta\">\n\t\t\t\n\t\t\t\n\t\t\t\n\t\t\t\t\t<\/div>\n\t\t\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t<div class=\"premium-blog-content-inner-wrapper\">\n\t\t<p class=\"premium-blog-post-content\">Toutes les cellules du corps humain sont expos\u00e9es \u00e0 des forces m\u00e9caniques qui r\u00e9gulent leur fonctionnement et le d\u00e9veloppement des tissus, et chaque type de cellule est sp\u00e9cifiquement adapt\u00e9 aux propri\u00e9t\u00e9s m\u00e9caniques du tissu dans lequel il se trouve. Les propri\u00e9t\u00e9s de la matrice des tissus humains peuvent \u00e9galement \u00e9voluer en cas de maladie et, \u00e0 leur tour, favoriser sa progression.<\/p><div class=\"premium-blog-excerpt-link-wrap\"><a href=\"https:\/\/rheolution.com\/fr\/notes-application\/viscoelasticite-de-la-gelomique-lunagel-mec-photoreticulable\/\" target=\"_blank\" class=\"premium-blog-excerpt-link elementor-button\">Lire la suite \u00bb<\/a><\/div>\t\t<\/div>\n\t\t\t\t\t\t\t\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\n\t\t\t\t<div class=\"premium-blog-post-outer-container\" data-total=\"2\">\n\t\t\t<div class=\"premium-blog-post-container premium-blog-skin-classic\">\n\t\t\t\t\t\t\t\t\t<div class=\"premium-blog-thumb-effect-wrapper\">\n\t\t\t\t\t\t<div class=\"premium-blog-thumbnail-container premium-blog-zoomin-effect\">\n\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"8448\" height=\"3166\" src=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Heart.jpg?fit=8448%2C3166&amp;ssl=1\" class=\"attachment-full size-full wp-image-61633\" alt=\"\" data-attachment-id=\"61633\" data-permalink=\"https:\/\/rheolution.com\/fr\/heart-3\/\" data-orig-file=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Heart.jpg?fit=8448%2C3166&amp;ssl=1\" data-orig-size=\"8448,3166\" data-comments-opened=\"1\" data-image-title=\"Heart\" data-image-description=\"\" data-image-caption=\"\" data-large-file=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Heart.jpg?fit=1024%2C384&amp;ssl=1\" srcset=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Heart.jpg?w=8448&amp;ssl=1 8448w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Heart.jpg?resize=300%2C112&amp;ssl=1 300w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Heart.jpg?resize=1024%2C384&amp;ssl=1 1024w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Heart.jpg?resize=768%2C288&amp;ssl=1 768w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Heart.jpg?resize=1536%2C576&amp;ssl=1 1536w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Heart.jpg?resize=2048%2C768&amp;ssl=1 2048w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Heart.jpg?resize=150%2C56&amp;ssl=1 150w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Heart.jpg?resize=700%2C262&amp;ssl=1 700w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Heart.jpg?w=2440&amp;ssl=1 2440w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Heart.jpg?w=3660&amp;ssl=1 3660w\" sizes=\"(max-width:767px) 700px, (max-width:8448px) 100vw, 8448px\" \/>\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"premium-blog-thumbnail-overlay\">\n\t\t\t\t\t\t\t\t<a class=\"elementor-icon\" href=\"https:\/\/rheolution.com\/fr\/notes-application\/mesure-des-proprietes-mecaniques-du-tissu-cardiaque\/\" target=\"_blank\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-screen-only\">Mesure des propri\u00e9t\u00e9s m\u00e9caniques du tissu cardiaque<\/span>\n\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"premium-blog-content-wrapper \">\n\n\t\t\t\t\t<div class=\"premium-blog-inner-container\">\n\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<h4 class=\"premium-blog-entry-title\">\n\t\t\t<a href=\"https:\/\/rheolution.com\/fr\/notes-application\/mesure-des-proprietes-mecaniques-du-tissu-cardiaque\/\" target=\"_blank\">\n\t\t\t\tMesure des propri\u00e9t\u00e9s m\u00e9caniques du tissu cardiaque\t\t\t<\/a>\n\t\t<\/h4>\n\t\t\t\t<div class=\"premium-blog-entry-meta\">\n\t\t\t\n\t\t\t\n\t\t\t\n\t\t\t\t\t<\/div>\n\t\t\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t<div class=\"premium-blog-content-inner-wrapper\">\n\t\t<p class=\"premium-blog-post-content\">L'intestin est un segment hautement sp\u00e9cialis\u00e9 du tube digestif, charg\u00e9 de l'absorption des nutriments, de l'\u00e9quilibre hydrique et d'une interaction continue avec le microbiome. Son fonctionnement d\u00e9pend non seulement de l'activit\u00e9 biochimique, mais \u00e9galement des propri\u00e9t\u00e9s m\u00e9caniques de la paroi intestinale, qui d\u00e9terminent la mani\u00e8re dont celle-ci se dilate, se contracte et transporte le contenu luminal. La paroi intestinale est une structure stratifi\u00e9e compos\u00e9e de la muqueuse, de la sous-muqueuse, de la couche musculaire et de la s\u00e9reuse, chacune apportant des comportements m\u00e9caniques distincts tels que l\u2019\u00e9lasticit\u00e9, la compliance et l\u2019anisotropie.<\/p><div class=\"premium-blog-excerpt-link-wrap\"><a href=\"https:\/\/rheolution.com\/fr\/notes-application\/mesure-des-proprietes-mecaniques-du-tissu-cardiaque\/\" target=\"_blank\" class=\"premium-blog-excerpt-link elementor-button\">Lire la suite \u00bb<\/a><\/div>\t\t<\/div>\n\t\t\t\t\t\t\t\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\n\t\t\t\t<div class=\"premium-blog-post-outer-container\" data-total=\"2\">\n\t\t\t<div class=\"premium-blog-post-container premium-blog-skin-classic\">\n\t\t\t\t\t\t\t\t\t<div class=\"premium-blog-thumb-effect-wrapper\">\n\t\t\t\t\t\t<div class=\"premium-blog-thumbnail-container premium-blog-zoomin-effect\">\n\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"1200\" height=\"450\" src=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2022\/05\/webbanner-1.jpg?fit=1200%2C450&amp;ssl=1\" class=\"attachment-full size-full wp-image-44572\" alt=\"\" data-attachment-id=\"44572\" data-permalink=\"https:\/\/rheolution.com\/fr\/articles-rheolution\/limpression-3d-biologique-utilise-des-biomateriaux-en-constante-evolution\/attachment\/webbanner-6-4\/\" data-orig-file=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2022\/05\/webbanner-1.jpg?fit=1200%2C450&amp;ssl=1\" data-orig-size=\"1200,450\" data-comments-opened=\"1\" data-image-title=\"webbanner\" data-image-description=\"\" data-image-caption=\"\" data-large-file=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2022\/05\/webbanner-1.jpg?fit=1024%2C384&amp;ssl=1\" srcset=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2022\/05\/webbanner-1.jpg?w=1200&amp;ssl=1 1200w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2022\/05\/webbanner-1.jpg?resize=300%2C113&amp;ssl=1 300w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2022\/05\/webbanner-1.jpg?resize=1024%2C384&amp;ssl=1 1024w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2022\/05\/webbanner-1.jpg?resize=768%2C288&amp;ssl=1 768w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2022\/05\/webbanner-1.jpg?resize=260%2C98&amp;ssl=1 260w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2022\/05\/webbanner-1.jpg?resize=50%2C19&amp;ssl=1 50w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2022\/05\/webbanner-1.jpg?resize=150%2C56&amp;ssl=1 150w\" sizes=\"(max-width:767px) 700px, (max-width:1200px) 100vw, 1200px\" \/>\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"premium-blog-thumbnail-overlay\">\n\t\t\t\t\t\t\t\t<a class=\"elementor-icon\" href=\"https:\/\/rheolution.com\/fr\/articles-rheolution\/limpression-3d-biologique-utilise-des-biomateriaux-en-constante-evolution\/\" target=\"_blank\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-screen-only\">Qu\u2019est-ce que la bio-impression 4D et son r\u00f4le en biom\u00e9decine ?<\/span>\n\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"premium-blog-content-wrapper \">\n\n\t\t\t\t\t<div class=\"premium-blog-inner-container\">\n\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<h4 class=\"premium-blog-entry-title\">\n\t\t\t<a href=\"https:\/\/rheolution.com\/fr\/articles-rheolution\/limpression-3d-biologique-utilise-des-biomateriaux-en-constante-evolution\/\" target=\"_blank\">\n\t\t\t\tQu\u2019est-ce que la bio-impression 4D et son r\u00f4le en biom\u00e9decine ?\t\t\t<\/a>\n\t\t<\/h4>\n\t\t\t\t<div class=\"premium-blog-entry-meta\">\n\t\t\t\n\t\t\t\n\t\t\t\n\t\t\t\t\t<\/div>\n\t\t\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t<div class=\"premium-blog-content-inner-wrapper\">\n\t\t<p class=\"premium-blog-post-content\">La bio-impression 4D introduit le \u00ab temps \u00bb comme quatri\u00e8me dimension, permettant ainsi aux objets imprim\u00e9s d\u2019\u00e9voluer au fil du temps. Des stimuli physiques tels que la lumi\u00e8re, la temp\u00e9rature ou le magn\u00e9tisme peuvent induire des transformations. Le processus de bio-impression peut \u00e9galement permettre une lib\u00e9ration cibl\u00e9e de m\u00e9dicaments gr\u00e2ce \u00e0 des variations de temp\u00e9rature ou de pH. Les nano-hydrogels peuvent servir de vecteurs de m\u00e9dicaments, guid\u00e9s par des champs magn\u00e9tiques, et se d\u00e9grader rapidement sous l'action d'enzymes. De plus, les hydrogels peuvent r\u00e9agir \u00e0 des signaux biologiques, contribuant ainsi au traitement des tumeurs en lib\u00e9rant des m\u00e9dicaments avant de se biod\u00e9grader progressivement.<\/p><div class=\"premium-blog-excerpt-link-wrap\"><a href=\"https:\/\/rheolution.com\/fr\/articles-rheolution\/limpression-3d-biologique-utilise-des-biomateriaux-en-constante-evolution\/\" target=\"_blank\" class=\"premium-blog-excerpt-link elementor-button\">Lire la suite \u00bb<\/a><\/div>\t\t<\/div>\n\t\t\t\t\t\t\t\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\n\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div class=\"premium-blog-footer\">\n\t\t\t\t\t\t\t<nav class=\"premium-blog-pagination-container\" role=\"navigation\" aria-label=\"Pagination\">\n\t\t\t\t<span aria-current=\"page\" class=\"page-numbers current\">1<\/span>\n<a class=\"page-numbers\" href=\"https:\/\/rheolution.com\/fr\/wp-json\/wp\/v2\/posts\/71016\/page\/2\/\">2<\/a>\n<a class=\"next page-numbers\" href=\"https:\/\/rheolution.com\/fr\/wp-json\/wp\/v2\/posts\/71016\/page\/2\/\">Suivant \u00bb<\/a>\t\t\t<\/nav>\n\t\t\t\t\t\t<\/div>\n\t\t\n\t\t\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>L&rsquo;intestin est un segment hautement sp\u00e9cialis\u00e9 du tube digestif, charg\u00e9 de l&rsquo;absorption des nutriments, de l&rsquo;\u00e9quilibre hydrique et d&rsquo;une interaction continue avec le microbiome. Son fonctionnement d\u00e9pend non seulement de l&rsquo;activit\u00e9 biochimique, mais \u00e9galement des propri\u00e9t\u00e9s m\u00e9caniques de la paroi intestinale, qui d\u00e9terminent la mani\u00e8re dont celle-ci se dilate, se contracte et transporte le contenu luminal. La paroi intestinale est une structure stratifi\u00e9e compos\u00e9e de la muqueuse, de la sous-muqueuse, de la couche musculaire et de la s\u00e9reuse, chacune apportant des comportements m\u00e9caniques distincts tels que l\u2019\u00e9lasticit\u00e9, la compliance et l\u2019anisotropie.  <\/p>\n","protected":false},"author":195401359,"featured_media":61633,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_wpcom_ai_launchpad_first_post":false,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_post_was_ever_published":false},"categories":[285,380],"tags":[89,124,88,100],"class_list":["post-71016","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-notes-application","category-utilisation-de-tissus-natifs","tag-elastosens-bio","tag-life-sciences","tag-mechanical-testing","tag-native-tissues"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Mesure des Propri\u00e9t\u00e9s M\u00e9caniques du Tissu Cardiaque<\/title>\n<meta name=\"description\" content=\"D\u00e9couvrez comment les maladies modifient les propri\u00e9t\u00e9s m\u00e9caniques du tissu cardiaque, telles que la rigidit\u00e9 et la compliance, et comment l&#039;ElastoSens\u2122 Bio permet de r\u00e9aliser des tests biom\u00e9caniques pr\u00e9cis.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rheolution.com\/fr\/notes-application\/mesure-des-proprietes-mecaniques-du-tissu-cardiaque\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Mesure des Propri\u00e9t\u00e9s M\u00e9caniques du Tissu Cardiaque\" \/>\n<meta property=\"og:description\" content=\"D\u00e9couvrez comment les maladies modifient les propri\u00e9t\u00e9s m\u00e9caniques du 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