{"id":70781,"date":"2026-09-29T11:58:48","date_gmt":"2026-09-29T15:58:48","guid":{"rendered":"https:\/\/rheolution.com\/?p=70781"},"modified":"2026-09-29T11:58:48","modified_gmt":"2026-09-29T15:58:48","slug":"viscoelasticite-de-la-gelomique-lunagel-mec-photoreticulable","status":"publish","type":"post","link":"https:\/\/rheolution.com\/fr\/notes-application\/viscoelasticite-de-la-gelomique-lunagel-mec-photoreticulable\/","title":{"rendered":"R\u00e9glage de la rigidit\u00e9 des hydrogels \u00e0 base d&rsquo;ECM"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"70781\" class=\"elementor elementor-70781 elementor-19680\" data-elementor-post-type=\"post\">\n\t\t\t\t<div class=\"elementor-element elementor-element-9926633 e-flex e-con-boxed e-con e-parent\" data-id=\"9926633\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-2aa8b2e elementor-widget elementor-widget-heading\" data-id=\"2aa8b2e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h6 class=\"elementor-heading-title elementor-size-default\">Note d\u2019application | ElastoSens\u2122 Bio<\/h6>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b490e4b elementor-widget elementor-widget-heading\" data-id=\"b490e4b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">R\u00e9glage de la rigidit\u00e9 des hydrogels ECM \u00e0 l'aide d'ElastoSens\u2122 Bio<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ed01f46 elementor-widget__width-initial elementor-widget elementor-widget-heading\" data-id=\"ed01f46\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">En collaboration avec<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-989a838 elementor-widget elementor-widget-image\" data-id=\"989a838\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.gelomics.com\">\n\t\t\t\t\t\t\t<img decoding=\"async\" width=\"300\" height=\"80\" src=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Gelomics_Logo_Horizontal_with_Claim_Full-colour_181002-01.png?fit=300%2C80&amp;ssl=1\" class=\"attachment-medium size-medium wp-image-44468\" alt=\"\" srcset=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Gelomics_Logo_Horizontal_with_Claim_Full-colour_181002-01.png?w=9178&amp;ssl=1 9178w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Gelomics_Logo_Horizontal_with_Claim_Full-colour_181002-01.png?resize=300%2C80&amp;ssl=1 300w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Gelomics_Logo_Horizontal_with_Claim_Full-colour_181002-01.png?resize=1024%2C272&amp;ssl=1 1024w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Gelomics_Logo_Horizontal_with_Claim_Full-colour_181002-01.png?resize=768%2C204&amp;ssl=1 768w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Gelomics_Logo_Horizontal_with_Claim_Full-colour_181002-01.png?resize=1536%2C407&amp;ssl=1 1536w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Gelomics_Logo_Horizontal_with_Claim_Full-colour_181002-01.png?resize=2048%2C543&amp;ssl=1 2048w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Gelomics_Logo_Horizontal_with_Claim_Full-colour_181002-01.png?resize=1200%2C318&amp;ssl=1 1200w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Gelomics_Logo_Horizontal_with_Claim_Full-colour_181002-01.png?resize=260%2C69&amp;ssl=1 260w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Gelomics_Logo_Horizontal_with_Claim_Full-colour_181002-01.png?resize=50%2C13&amp;ssl=1 50w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Gelomics_Logo_Horizontal_with_Claim_Full-colour_181002-01.png?resize=150%2C40&amp;ssl=1 150w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Gelomics_Logo_Horizontal_with_Claim_Full-colour_181002-01.png?w=2440&amp;ssl=1 2440w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Gelomics_Logo_Horizontal_with_Claim_Full-colour_181002-01.png?w=3660&amp;ssl=1 3660w\" sizes=\"(max-width:767px) 300px, 300px\" data-attachment-id=\"44468\" data-permalink=\"https:\/\/rheolution.com\/fr\/notes-application\/viscoelasticite-de-la-gelomique-lunagel-mec-photoreticulable\/attachment\/gelomics_logo_horizontal_with_claim_full-colour_181002-01-4\/\" data-orig-file=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Gelomics_Logo_Horizontal_with_Claim_Full-colour_181002-01.png?fit=9178%2C2434&amp;ssl=1\" data-orig-size=\"9178,2434\" data-comments-opened=\"1\" data-image-title=\"Gelomics_Logo_Horizontal_with_Claim_Full-colour_181002-01\" data-image-description=\"\" data-image-caption=\"\" data-large-file=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Gelomics_Logo_Horizontal_with_Claim_Full-colour_181002-01.png?fit=1024%2C272&amp;ssl=1\" \/>\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9026f26 elementor-widget__width-initial elementor-widget elementor-widget-heading\" data-id=\"9026f26\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Avis<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d3db1a2 elementor-widget__width-initial elementor-widget-mobile__width-inherit elementor-widget elementor-widget-text-editor\" data-id=\"d3db1a2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Cette \u00e9tude est le fruit d&rsquo;une collaboration entre <a href=\"https:\/\/rheolution.com\/life-sciences\/\">Rheolution<\/a> (Qu\u00e9bec, Canada) et <a href=\"https:\/\/www.gelomics.com\/hydrogels\">Gelomics<\/a> (Queensland, Australie).<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3ef1a56 elementor-widget elementor-widget-text-editor\" data-id=\"3ef1a56\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"raw_components--panel--3IcXg inspect_panels--inspectionPanel--3Wboz\" tabindex=\"-1\"><div class=\"inspect_panels--copyableRow--2_PiZ inspect_panels--highlightRow--21P9S\"><div class=\"inspect_panels--propertyRowContent--7Y-mu inspect_panels--copyableRow--2_PiZ inspect_panels--highlightRow--21P9S\"><div class=\"inspect_panels--contentProperty--2Z1QI text--fontPos11--RSei3 text--_fontBase--YWDo0 ellipsis--ellipsisAfter8Lines--2rn32 ellipsis--_ellipsisAfterNLines--26JkZ\"><p>par <a href=\"https:\/\/www.linkedin.com\/in\/gloriapinilla\/\" target=\"_blank\" rel=\"noopener\">Gloria Pinilla, M.Sc.<\/a>, sp\u00e9cialiste senior des applications,<br\/>Rheolution Inc.<\/p><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-29c9a4e elementor-widget__width-initial elementor-widget elementor-widget-heading\" data-id=\"29c9a4e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">R\u00e9sum\u00e9<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-23a78fe elementor-widget__width-initial elementor-widget-mobile__width-inherit elementor-widget elementor-widget-text-editor\" data-id=\"23a78fe\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li>La rigidit\u00e9 initiale des syst\u00e8mes de culture en 3D peut \u00eatre modul\u00e9e afin d&rsquo;\u00e9tudier des processus physiologiques et pathologiques in vitro.<\/li><li>Les hydrogels photor\u00e9ticulables constituent d&rsquo;excellents candidats pour les syst\u00e8mes de culture en 3D en raison de leur similitude avec la matrice extracellulaire naturelle et de la facilit\u00e9 avec laquelle il est possible de contr\u00f4ler leur rigidit\u00e9 finale.<\/li><li>Les produits LunaGel\u2122 \u00e0 base de matrice extracellulaire de Gelomics ont \u00e9t\u00e9 photor\u00e9ticul\u00e9s avec succ\u00e8s \u00e0 la lumi\u00e8re visible et leur cin\u00e9tique de r\u00e9ticulation a \u00e9t\u00e9 mesur\u00e9e en temps r\u00e9el \u00e0 l&rsquo;aide de <a href=\"https:\/\/rheolution.com\/fr\/produits\/elastosens-bio\/instrument\/\" target=\"_blank\" rel=\"noopener\">l&rsquo;ElastoSens\u2122 Bio<\/a>.<\/li><li>Les r\u00e9actions de photor\u00e9ticulation se sont d\u00e9roul\u00e9es rapidement, tant avec le kit LunaGel\u2122 \u00e0 faible rigidit\u00e9 qu&rsquo;avec celui \u00e0 haute rigidit\u00e9.<\/li><li>Les kits LunaGel\u2122 \u00e0 haute rigidit\u00e9 ont permis d&rsquo;obtenir une rigidit\u00e9 sup\u00e9rieure \u00e0 celle des kits \u00e0 faible rigidit\u00e9.<\/li><li>La rigidit\u00e9 des matrices LunaGel\u2122 augmentait avec la dur\u00e9e de la photor\u00e9ticulation.<\/li><li>Le caract\u00e8re invasif des cellules canc\u00e9reuses du sein augmentait consid\u00e9rablement avec la rigidit\u00e9 de la matrice extracellulaire.<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-a11b72f e-flex e-con-boxed e-con e-parent\" data-id=\"a11b72f\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ff67a5f elementor-widget__width-initial elementor-widget-mobile__width-inherit elementor-widget elementor-widget-heading\" data-id=\"ff67a5f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Le r\u00f4le de la rigidit\u00e9 de l'hydrogel dans le comportement cellulaire\n<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ddf558e elementor-widget elementor-widget-heading\" data-id=\"ddf558e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Introduction<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-dcef2a1 elementor-widget elementor-widget-text-editor\" data-id=\"dcef2a1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Toutes les cellules du corps humain sont soumises \u00e0 des forces m\u00e9caniques qui r\u00e9gulent leur fonctionnement et le d\u00e9veloppement des tissus, et chaque type de cellule est sp\u00e9cifiquement adapt\u00e9 aux propri\u00e9t\u00e9s m\u00e9caniques du tissu dans lequel elle se trouve. Les propri\u00e9t\u00e9s de la matrice des tissus humains peuvent \u00e9galement \u00e9voluer en cas de maladie et, \u00e0 leur tour, favoriser la progression de celle-ci. Par exemple, la croissance, la survie, la diff\u00e9renciation et la morphogen\u00e8se des cellules \u00e9pith\u00e9liales mammaires normales sont largement favoris\u00e9es par l&rsquo;interaction avec une matrice souple dont la rigidit\u00e9 est similaire \u00e0 celle du tissu mammaire normal. Cependant, \u00e0 la suite de la transformation survenant lors d\u2019un cancer du sein, le tissu devient progressivement plus rigide [1] et les cellules tumorales acqui\u00e8rent une contractilit\u00e9 nettement accrue ainsi qu\u2019une hyperr\u00e9activit\u00e9 aux signaux m\u00e9caniques de la matrice, ce qui conduit finalement \u00e0 la transition \u00e9pith\u00e9lio-m\u00e9senchymateuse (TEM) et \u00e0 la m\u00e9tastase [2,3]. L\u2019\u00e9tude m\u00e9canistique de l\u2019interaction complexe entre les propri\u00e9t\u00e9s du substrat et le comportement cellulaire n\u00e9cessite des m\u00e9thodologies avanc\u00e9es de culture cellulaire qui surmontent les limites associ\u00e9es aux approches de culture traditionnelles [4].    <\/p><p>Les matrices extracellulaires (MEC) LunaGel\u2122 de Gelomics sont des hydrogels photor\u00e9ticulables qui offrent un syst\u00e8me de culture cellulaire en 3D contr\u00f4l\u00e9 permettant d\u2019\u00e9tudier <i>in vitro<\/i> des processus pathologiques et physiologiques. Compos\u00e9es d\u2019\u00e9l\u00e9ments de la matrice extracellulaire (MEC) tels que les collag\u00e8nes de types I, III, IV et V, ainsi que des glycoprot\u00e9ines et des prot\u00e9oglycanes du tissu conjonctif, ces MEC reproduisent fid\u00e8lement la matrice extracellulaire naturelle entourant les cellules du corps humain et facilitent l\u2019adh\u00e9sion, la prolif\u00e9ration, la diff\u00e9renciation et la migration cellulaires, ainsi que la d\u00e9gradation prot\u00e9olytique de la MEC. De plus, le processus de photor\u00e9ticulation permet aux scientifiques de mieux contr\u00f4ler la rigidit\u00e9 finale du gel. En modifiant simplement la dur\u00e9e de la photor\u00e9ticulation, la rigidit\u00e9 du gel peut \u00eatre ajust\u00e9e avec pr\u00e9cision pour imiter des tissus mous et durs tels que le cerveau, le foie, le sein ou le cartilage, entre autres, tant dans des conditions saines que pathologiques. Pour ces raisons, ils constituent des substrats id\u00e9aux pour la culture et la diff\u00e9renciation d\u2019un large \u00e9ventail de types cellulaires et facilitent l\u2019\u00e9tude des modifications du comportement cellulaire induites par la rigidit\u00e9 de la matrice.      <\/p><p><a href=\"https:\/\/rheolution.com\/fr\/produits\/elastosens-bio\/instrument\/\" target=\"_blank\" rel=\"noopener\">ElastoSens\u2122 Bio<\/a> mesure sans contact les propri\u00e9t\u00e9s visco\u00e9lastiques des mat\u00e9riaux souples. En appliquant de l\u00e9g\u00e8res vibrations \u00e0 l\u2019\u00e9chantillon, l\u2019instrument est capable d\u2019enregistrer la cin\u00e9tique de photor\u00e9ticulation \u00e0 la longueur d\u2019onde souhait\u00e9e. Dans cette note d\u2019application, des ECM LunaGel\u2122 \u00e0 base de g\u00e9latine de peau porcine et d\u2019os bovin chimiquement modifi\u00e9es ont \u00e9t\u00e9 toutes deux photor\u00e9ticul\u00e9es, tandis que leur cin\u00e9tique de r\u00e9ticulation a \u00e9t\u00e9 \u00e9valu\u00e9e en temps r\u00e9el \u00e0 l\u2019aide de <a href=\"https:\/\/rheolution.com\/fr\/produits\/elastosens-bio\/instrument\/\" target=\"_blank\" rel=\"noopener\">l\u2019ElastoSens\u2122 Bio<\/a>. Afin d\u2019\u00e9tudier la capacit\u00e9 des MEC LunaGel\u2122 \u00e0 reproduire les modifications physiopathologiques de la rigidit\u00e9 tissulaire et leurs effets sur la progression du cancer, des sph\u00e9ro\u00efdes de cancer du sein ont \u00e9t\u00e9 cultiv\u00e9s sur des substrats de rigidit\u00e9 variable, et leurs morphologies ont \u00e9t\u00e9 observ\u00e9es.   <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-cc16549 elementor-widget__width-initial elementor-widget-mobile__width-inherit elementor-widget elementor-widget-heading\" data-id=\"cc16549\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">R\u00e9ticulation par exposition \u00e0 la lumi\u00e8re des hydrogels LunaGel\u2122 par Gelomics<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-cae21bc elementor-widget elementor-widget-heading\" data-id=\"cae21bc\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Mat\u00e9riel et m\u00e9thodes<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-dfb4356 elementor-widget elementor-widget-text-editor\" data-id=\"dfb4356\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Les ECM LunaGel\u2122 \u00e0 base de g\u00e9latine de peau porcine modifi\u00e9e chimiquement, de type A (<a href=\"https:\/\/www.gelomics.com\/product-page\/porcine-skin-gelatin\">LunaGel\u2122 \u2013 G\u00e9latine de peau porcine \u2013 faible et haute rigidit\u00e9, Gelomics<\/a>) et de g\u00e9latine d&rsquo;os bovin, de type B (<a href=\"https:\/\/www.gelomics.com\/product-page\/bovine-bone-gelatin\">LunaGel\u2122 \u2013 G\u00e9latine d&rsquo;os bovin \u2013 faible et haute rigidit\u00e9, Gelomics<\/a>), ont \u00e9t\u00e9 pr\u00e9par\u00e9s conform\u00e9ment aux instructions du fabricant. En bref, les flacons de photo-initiateur ont \u00e9t\u00e9 dissous dans du PBS et m\u00e9lang\u00e9s aux solutions d\u2019ECM photor\u00e9ticulables \u00e0 37 \u00b0C. 2 ml des produits ont \u00e9t\u00e9 pipet\u00e9s dans le porte-\u00e9chantillon de <a href=\"https:\/\/rheolution.com\/fr\/produits\/elastosens-bio\/instrument\/\" target=\"_blank\" rel=\"noopener\">l\u2019ElastoSens\u2122 Bio<\/a> et l\u2019essai de visco\u00e9lasticit\u00e9 a \u00e9t\u00e9 imm\u00e9diatement lanc\u00e9 \u00e0 37 \u00b0C en utilisant les s\u00e9quences de mesure suivantes :  <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3665319 elementor-widget__width-initial elementor-widget elementor-widget-image\" data-id=\"3665319\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"1024\" height=\"304\" src=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Screen-Shot-2021-11-18-at-10.26.59-AM.png?fit=1024%2C304&amp;ssl=1\" class=\"attachment-large size-large wp-image-44477\" alt=\"\" srcset=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Screen-Shot-2021-11-18-at-10.26.59-AM.png?w=2778&amp;ssl=1 2778w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Screen-Shot-2021-11-18-at-10.26.59-AM.png?resize=300%2C89&amp;ssl=1 300w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Screen-Shot-2021-11-18-at-10.26.59-AM.png?resize=1024%2C304&amp;ssl=1 1024w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Screen-Shot-2021-11-18-at-10.26.59-AM.png?resize=768%2C228&amp;ssl=1 768w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Screen-Shot-2021-11-18-at-10.26.59-AM.png?resize=1536%2C456&amp;ssl=1 1536w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Screen-Shot-2021-11-18-at-10.26.59-AM.png?resize=2048%2C607&amp;ssl=1 2048w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Screen-Shot-2021-11-18-at-10.26.59-AM.png?resize=1200%2C356&amp;ssl=1 1200w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Screen-Shot-2021-11-18-at-10.26.59-AM.png?resize=260%2C77&amp;ssl=1 260w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Screen-Shot-2021-11-18-at-10.26.59-AM.png?resize=50%2C15&amp;ssl=1 50w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Screen-Shot-2021-11-18-at-10.26.59-AM.png?resize=150%2C44&amp;ssl=1 150w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Screen-Shot-2021-11-18-at-10.26.59-AM.png?w=2440&amp;ssl=1 2440w\" sizes=\"(max-width:767px) 700px, (max-width:1024px) 100vw, 1024px\" data-attachment-id=\"44477\" data-permalink=\"https:\/\/rheolution.com\/fr\/notes-application\/viscoelasticite-de-la-gelomique-lunagel-mec-photoreticulable\/attachment\/screen-shot-2021-11-18-at-10-26-59-am-4\/\" data-orig-file=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Screen-Shot-2021-11-18-at-10.26.59-AM.png?fit=2778%2C824&amp;ssl=1\" data-orig-size=\"2778,824\" data-comments-opened=\"1\" data-image-title=\"crossover of G\u2019 and G\u2019\u2019\" data-image-description=\"\" data-image-caption=\"\" data-large-file=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Screen-Shot-2021-11-18-at-10.26.59-AM.png?fit=1024%2C304&amp;ssl=1\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-10b03f2 elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"10b03f2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Le module d&rsquo;\u00e9lasticit\u00e9 de cisaillement (G\u2019) et la tangente de \u03b4 (tan(\u03b4)) ont \u00e9t\u00e9 obtenus directement \u00e0 partir de l\u2019ElastoSens\u2122 Bio. Le temps de r\u00e9ticulation initial a \u00e9t\u00e9 d\u00e9termin\u00e9 \u00e0 partir du point d&rsquo;intersection entre G\u2019 et G\u2019\u2019 (tan(\u03b4) = 1). <\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0205664 elementor-widget__width-initial elementor-widget-mobile__width-inherit elementor-widget elementor-widget-heading\" data-id=\"0205664\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">La rigidit\u00e9 de l'hydrogel influence le comportement des cellules<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d2fcdb2 elementor-widget elementor-widget-heading\" data-id=\"d2fcdb2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">R\u00e9sultats et discussion<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8b37e89 elementor-widget elementor-widget-text-editor\" data-id=\"8b37e89\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Les ECM LunaGel\u2122 photor\u00e9ticulables ont tout d\u2019abord \u00e9t\u00e9 \u00e9valu\u00e9es en termes de propri\u00e9t\u00e9s visco\u00e9lastiques, qui peuvent \u00eatre d\u00e9crites par le module de stockage en cisaillement (G\u2019 \u2014 composante \u00e9lastique du comportement visco\u00e9lastique) et le module de perte en cisaillement (G\u2019\u2019 \u2014 composante visqueuse du comportement visco\u00e9lastique). Le rapport entre G\u2019\u2019 et G\u2019 (facteur d\u2019amortissement ou tan(\u03b4)) est \u00e9galement g\u00e9n\u00e9ralement d\u00e9termin\u00e9 afin de mettre en \u00e9vidence quel comportement est pr\u00e9dominant.   <\/p><p><b>La figure 1<\/b> illustre l\u2019\u00e9volution du module de stockage en cisaillement (G\u2019) en fonction du temps de r\u00e9ticulation pour des MEC LunaGel\u2122 photor\u00e9ticulables de faible et de forte rigidit\u00e9, d\u2019origine porcine (\u00e0 gauche) et bovine (\u00e0 droite). Les mesures ont \u00e9t\u00e9 effectu\u00e9es sans exposition \u00e0 la lumi\u00e8re pendant les deux premi\u00e8res minutes de l\u2019essai. L\u2019allumage de la lumi\u00e8re a ensuite \u00e9t\u00e9 programm\u00e9 par l\u2019instrument <a href=\"https:\/\/rheolution.com\/fr\/produits\/elastosens-bio\/instrument\/\" target=\"_blank\" rel=\"noopener\">ElastoSens\u2122 Bio<\/a> \u00e0 2 minutes, et son effet a \u00e9t\u00e9 clairement observ\u00e9 par l\u2019augmentation de G\u2019 apr\u00e8s ce moment, jusqu\u2019\u00e0 12 minutes (lorsque la lumi\u00e8re a \u00e9t\u00e9 \u00e9teinte). Les mesures se sont poursuivies pendant environ 15 minutes afin de d\u00e9terminer les propri\u00e9t\u00e9s visco\u00e9lastiques finales du gel. Les \u00e9chantillons pr\u00e9sentaient une r\u00e9ticulation homog\u00e8ne \u00e0 l\u2019issue de l\u2019essai (<b>Fig. 2<\/b>).    <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e04bd87 elementor-widget__width-initial elementor-widget elementor-widget-image\" data-id=\"e04bd87\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"861\" height=\"426\" src=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Fig1_Gelomics_ECM.jpg?fit=861%2C426&amp;ssl=1\" class=\"attachment-large size-large wp-image-44470\" alt=\"\" srcset=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Fig1_Gelomics_ECM.jpg?w=861&amp;ssl=1 861w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Fig1_Gelomics_ECM.jpg?resize=300%2C148&amp;ssl=1 300w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Fig1_Gelomics_ECM.jpg?resize=768%2C380&amp;ssl=1 768w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Fig1_Gelomics_ECM.jpg?resize=260%2C129&amp;ssl=1 260w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Fig1_Gelomics_ECM.jpg?resize=50%2C25&amp;ssl=1 50w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Fig1_Gelomics_ECM.jpg?resize=150%2C75&amp;ssl=1 150w\" sizes=\"(max-width:767px) 700px, (max-width:861px) 100vw, 861px\" data-attachment-id=\"44470\" data-permalink=\"https:\/\/rheolution.com\/fr\/notes-application\/viscoelasticite-de-la-gelomique-lunagel-mec-photoreticulable\/attachment\/fig1_gelomics_ecm-4\/\" data-orig-file=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Fig1_Gelomics_ECM.jpg?fit=861%2C426&amp;ssl=1\" data-orig-size=\"861,426\" data-comments-opened=\"1\" data-image-title=\"G\u2019 over time\" data-image-description=\"\" data-image-caption=\"\" data-large-file=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Fig1_Gelomics_ECM.jpg?fit=861%2C426&amp;ssl=1\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d3a0f6a elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"d3a0f6a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Fig. 1:  <\/strong>Module de stockage en cisaillement (G\u2019, Pa) en fonction du temps pour les produits ECM LunaGel\u2122 d\u2019origine porcine (\u00e0 gauche) et bovine (\u00e0 droite).<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f58da9e elementor-widget__width-initial elementor-widget elementor-widget-image\" data-id=\"f58da9e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"825\" height=\"371\" src=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Image-2.jpg?fit=825%2C371&amp;ssl=1\" class=\"attachment-large size-large wp-image-44471\" alt=\"\" srcset=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Image-2.jpg?w=825&amp;ssl=1 825w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Image-2.jpg?resize=300%2C135&amp;ssl=1 300w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Image-2.jpg?resize=768%2C345&amp;ssl=1 768w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Image-2.jpg?resize=260%2C117&amp;ssl=1 260w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Image-2.jpg?resize=50%2C22&amp;ssl=1 50w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Image-2.jpg?resize=150%2C67&amp;ssl=1 150w\" sizes=\"(max-width:767px) 700px, (max-width:825px) 100vw, 825px\" data-attachment-id=\"44471\" data-permalink=\"https:\/\/rheolution.com\/fr\/notes-application\/viscoelasticite-de-la-gelomique-lunagel-mec-photoreticulable\/attachment\/image-2-5\/\" data-orig-file=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Image-2.jpg?fit=825%2C371&amp;ssl=1\" data-orig-size=\"825,371\" data-comments-opened=\"1\" data-image-title=\"Crosslinked LunaGel\u2122\" data-image-description=\"\" data-image-caption=\"\" data-large-file=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Image-2.jpg?fit=825%2C371&amp;ssl=1\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b3cbd35 elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"b3cbd35\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Fig. 2:  <\/strong>Exemple repr\u00e9sentatif d&rsquo;un \u00e9chantillon de LunaGel\u2122 apr\u00e8s l&rsquo;essai.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ade62a3 elementor-widget elementor-widget-text-editor\" data-id=\"ade62a3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>La photor\u00e9ticulation a commenc\u00e9 apr\u00e8s environ 0,5 minute d\u2019exposition \u00e0 la lumi\u00e8re pour les hydrogels \u00e0 haute rigidit\u00e9 et apr\u00e8s environ 1,5 minute pour ceux \u00e0 faible rigidit\u00e9 (<b>fig. 3<\/b>). La valeur finale de G\u2019 \u00e9tait environ 8 fois plus \u00e9lev\u00e9e pour les formulations \u00e0 haute rigidit\u00e9 que pour celles \u00e0 faible rigidit\u00e9. Les formulations \u00e0 faible rigidit\u00e9 ont form\u00e9 des gels souples pr\u00e9sentant un G\u2019 d\u2019environ 550 Pa, tandis que les hydrogels \u00e0 haute rigidit\u00e9 ont atteint environ 4 500 Pa ; aucune diff\u00e9rence statistiquement significative n\u2019a \u00e9t\u00e9 constat\u00e9e entre les sources porcine et bovine. Toutefois, des diff\u00e9rences significatives entre les formulations \u00e0 faible et \u00e0 haute rigidit\u00e9 ont \u00e9t\u00e9 observ\u00e9es pour les deux types de g\u00e9latine. En effet, les produits LunaGel\u2122 \u00e0 faible et \u00e0 haute rigidit\u00e9 contiennent des concentrations diff\u00e9rentes des composants de g\u00e9latine modifi\u00e9e afin de permettre un contr\u00f4le pr\u00e9cis sur une large plage de rigidit\u00e9. La valeur finale de tan(\u03b4) \u00e9tait toujours inf\u00e9rieure \u00e0 0,1, ce qui montre que le comportement \u00e9lastique (li\u00e9 au module de stockage en cisaillement, G\u2019\u2019) est nettement plus pr\u00e9dominant que le comportement visqueux (li\u00e9 au module de perte en cisaillement, G\u2019\u2019) dans ces hydrogels.     <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f87206d elementor-widget__width-initial elementor-widget elementor-widget-image\" data-id=\"f87206d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"1020\" height=\"401\" src=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Fig3_Gelomics_ECM.jpg?fit=1020%2C401&amp;ssl=1\" class=\"attachment-large size-large wp-image-44472\" alt=\"\" srcset=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Fig3_Gelomics_ECM.jpg?w=1020&amp;ssl=1 1020w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Fig3_Gelomics_ECM.jpg?resize=300%2C118&amp;ssl=1 300w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Fig3_Gelomics_ECM.jpg?resize=768%2C302&amp;ssl=1 768w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Fig3_Gelomics_ECM.jpg?resize=260%2C102&amp;ssl=1 260w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Fig3_Gelomics_ECM.jpg?resize=50%2C20&amp;ssl=1 50w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Fig3_Gelomics_ECM.jpg?resize=150%2C59&amp;ssl=1 150w\" sizes=\"(max-width:767px) 700px, (max-width:1020px) 100vw, 1020px\" data-attachment-id=\"44472\" data-permalink=\"https:\/\/rheolution.com\/fr\/notes-application\/viscoelasticite-de-la-gelomique-lunagel-mec-photoreticulable\/attachment\/fig3_gelomics_ecm-4\/\" data-orig-file=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Fig3_Gelomics_ECM.jpg?fit=1020%2C401&amp;ssl=1\" data-orig-size=\"1020,401\" data-comments-opened=\"1\" data-image-title=\"crosslinking time\" data-image-description=\"\" data-image-caption=\"\" data-large-file=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Fig3_Gelomics_ECM.jpg?fit=1020%2C401&amp;ssl=1\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a66f9b4 elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"a66f9b4\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Fig. 3:<\/strong>  Dur\u00e9e initiale de r\u00e9ticulation (min), valeur finale de G\u2019 (Pa) et valeur finale de tan(\u03b4) des gels photor\u00e9ticul\u00e9s.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-df11603 elementor-widget elementor-widget-text-editor\" data-id=\"df11603\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Tant pour les formulations \u00e0 faible rigidit\u00e9 que pour celles \u00e0 haute rigidit\u00e9, la dur\u00e9e d\u2019exposition \u00e0 la lumi\u00e8re peut \u00eatre modifi\u00e9e afin d\u2019atteindre les rigidit\u00e9s cibles souhait\u00e9es, qui sont inf\u00e9rieures ou \u00e9gales \u00e0 la valeur finale de G\u2019. <b>La figure 4<\/b> illustre l\u2019\u00e9volution du module de stockage en cisaillement (G\u2019, Pa) en fonction du temps pour le LunaGel\u2122 porcin \u00e0 haute rigidit\u00e9, r\u00e9ticul\u00e9 \u00e0 une puissance de 9,0 mW\/cm\u00b2 pendant respectivement 2, 4, 8 et 10 minutes. De m\u00eame, la lumi\u00e8re a \u00e9t\u00e9 programm\u00e9e pour s\u2019allumer apr\u00e8s 2 minutes d\u2019essai, avec les dur\u00e9es mentionn\u00e9es. Comme pr\u00e9vu, les courbes \u00e9taient pratiquement identiques au cours des 4 premi\u00e8res minutes. Pass\u00e9 ce moment, le G\u2019 a continu\u00e9 \u00e0 augmenter de mani\u00e8re substantielle au fil du temps pour les \u00e9chantillons soumis \u00e0 une exposition \u00e0 la lumi\u00e8re plus longue.   <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a255815 elementor-widget__width-initial elementor-widget elementor-widget-image\" data-id=\"a255815\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"431\" height=\"401\" src=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Fig4_Gelomics_ECM.jpg?fit=431%2C401&amp;ssl=1\" class=\"attachment-large size-large wp-image-44473\" alt=\"\" srcset=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Fig4_Gelomics_ECM.jpg?w=431&amp;ssl=1 431w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Fig4_Gelomics_ECM.jpg?resize=300%2C279&amp;ssl=1 300w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Fig4_Gelomics_ECM.jpg?resize=157%2C146&amp;ssl=1 157w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Fig4_Gelomics_ECM.jpg?resize=50%2C47&amp;ssl=1 50w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Fig4_Gelomics_ECM.jpg?resize=81%2C75&amp;ssl=1 81w\" sizes=\"(max-width:767px) 431px, 431px\" data-attachment-id=\"44473\" data-permalink=\"https:\/\/rheolution.com\/fr\/notes-application\/viscoelasticite-de-la-gelomique-lunagel-mec-photoreticulable\/attachment\/fig4_gelomics_ecm-4\/\" data-orig-file=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Fig4_Gelomics_ECM.jpg?fit=431%2C401&amp;ssl=1\" data-orig-size=\"431,401\" data-comments-opened=\"1\" data-image-title=\"G\u2019 over time\" data-image-description=\"\" data-image-caption=\"\" data-large-file=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Fig4_Gelomics_ECM.jpg?fit=431%2C401&amp;ssl=1\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0635d67 elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"0635d67\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Fig. 4:  <\/strong>Module de stockage en cisaillement (G\u2019, Pa) en fonction du temps pour le LunaGel\u2122 porcin \u00e0 haute rigidit\u00e9, r\u00e9ticul\u00e9 par une lumi\u00e8re de 405 nm (9,0 mW\/cm\u00b2) pendant 2, 4, 8 et 10 minutes.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9ca4a98 elementor-widget elementor-widget-text-editor\" data-id=\"9ca4a98\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Afin d\u2019\u00e9tudier les effets de la rigidit\u00e9 de la MEC LunaGel sur le comportement des cellules canc\u00e9reuses du sein, des sph\u00e9ro\u00efdes MDA-MB-231 ont \u00e9t\u00e9 ensemenc\u00e9s sur des MEC pr\u00e9sentant un module de stockage en cisaillement (G\u2019) d\u2019environ 110, 220 et 440 kPa, respectivement. Au bout de 7 jours de culture, des diff\u00e9rences notables dans les morphologies cellulaires ont \u00e9t\u00e9 observ\u00e9es entre les diff\u00e9rentes rigidit\u00e9s de la MEC (<b>fig. 5<\/b>). Le caract\u00e8re invasif des cellules canc\u00e9reuses du sein augmentait en fonction de la rigidit\u00e9 de la MEC, ce qui corrobore les donn\u00e9es cliniques sugg\u00e9rant une survenue pr\u00e9f\u00e9rentielle de m\u00e9tastases dans les cancers du sein pr\u00e9sentant une plus grande rigidit\u00e9 tissulaire. Une \u00e9volution vers des morphologies cellulaires plus migratrices, associ\u00e9es aux m\u00e9tastases (fig. 5, encarts agrandis), a \u00e9t\u00e9 observ\u00e9e \u00e0 mesure que la rigidit\u00e9 de la MEC LunaGel augmentait.   <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-292155c elementor-widget__width-initial elementor-widget elementor-widget-image\" data-id=\"292155c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"355\" src=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Figure-5_web.jpg?fit=1024%2C355&amp;ssl=1\" class=\"attachment-large size-large wp-image-44474\" alt=\"\" srcset=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Figure-5_web.jpg?w=1415&amp;ssl=1 1415w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Figure-5_web.jpg?resize=300%2C104&amp;ssl=1 300w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Figure-5_web.jpg?resize=1024%2C355&amp;ssl=1 1024w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Figure-5_web.jpg?resize=768%2C266&amp;ssl=1 768w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Figure-5_web.jpg?resize=1200%2C416&amp;ssl=1 1200w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Figure-5_web.jpg?resize=260%2C90&amp;ssl=1 260w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Figure-5_web.jpg?resize=50%2C17&amp;ssl=1 50w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Figure-5_web.jpg?resize=150%2C52&amp;ssl=1 150w\" sizes=\"(max-width:767px) 700px, (max-width:1024px) 100vw, 1024px\" data-attachment-id=\"44474\" data-permalink=\"https:\/\/rheolution.com\/fr\/notes-application\/viscoelasticite-de-la-gelomique-lunagel-mec-photoreticulable\/attachment\/figure-5_web-4\/\" data-orig-file=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Figure-5_web.jpg?fit=1415%2C491&amp;ssl=1\" data-orig-size=\"1415,491\" data-comments-opened=\"1\" data-image-title=\"Breast cancer cell\" data-image-description=\"\" data-image-caption=\"\" data-large-file=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Figure-5_web.jpg?fit=1024%2C355&amp;ssl=1\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-201a0a6 elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"201a0a6\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Fig. 5:  <\/strong>Le caract\u00e8re invasif des cellules canc\u00e9reuses du sein augmente avec la rigidit\u00e9 de la matrice extracellulaire (MEC). Les images montrent des sph\u00e9ro\u00efdes MDA-MB-231 ensemenc\u00e9s sur des MEC \u00e0 base de g\u00e9latine bovine LunaGel pr\u00e9sentant un module de stockage en cisaillement de (A) 110 Pa, (B) 220 Pa et (C) 440 Pa, respectivement, apr\u00e8s 7 jours de culture. Les cellules\/sph\u00e9ro\u00efdes ont \u00e9t\u00e9 color\u00e9s pour mettre en \u00e9vidence les noyaux cellulaires (bleu), l&rsquo;int\u00e9grine \u03b21 (vert), la membrane cellulaire (orange) et l&rsquo;actine (magenta).     <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-298788a elementor-widget elementor-widget-heading\" data-id=\"298788a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Conclusions<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a5f8f67 elementor-widget elementor-widget-text-editor\" data-id=\"a5f8f67\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>L\u2019\u00e9volution visco\u00e9lastique des produits ECM LunaGel\u2122 de Gelomics au cours de la photor\u00e9ticulation a \u00e9t\u00e9 mesur\u00e9e avec succ\u00e8s en temps r\u00e9el \u00e0 l\u2019aide <a href=\"https:\/\/rheolution.com\/fr\/?p=70781\">d\u2019ElastoSens\u2122<\/a><a href=\"https:\/\/rheolution.com\/fr\/?p=70781\"> Bio.<\/a> La valeur finale de G\u2019 \u00e9tait environ 8 fois plus \u00e9lev\u00e9e pour les formulations \u00e0 haute rigidit\u00e9 que pour celles \u00e0 faible rigidit\u00e9. Les propri\u00e9t\u00e9s visco\u00e9lastiques finales de ces hydrogels ont \u00e9t\u00e9 facilement ajust\u00e9es en modifiant la dur\u00e9e d\u2019exposition \u00e0 la lumi\u00e8re pendant la r\u00e9ticulation (405 nm). L\u2019invasivit\u00e9 des cellules canc\u00e9reuses du sein a augment\u00e9 de mani\u00e8re significative avec la rigidit\u00e9 de l\u2019ECM, d\u00e9montrant ainsi la capacit\u00e9 du syst\u00e8me LunaGel\u2122 \u00e0 reproduire fid\u00e8lement les conditions tissulaires physiologiques et physiopathologiques.  <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-afd817a elementor-widget elementor-widget-heading\" data-id=\"afd817a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">R\u00e9sum\u00e9<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d936ff2 elementor-widget elementor-widget-text-editor\" data-id=\"d936ff2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul class=\"bullets\"><li class=\"bullets\">Les produits LunaGel\u2122 permettent de mettre au point des hydrogels pr\u00e9sentant la rigidit\u00e9 souhait\u00e9e.<\/li><li class=\"bullets\"><a href=\"https:\/\/rheolution.com\/fr\/?p=70781\">ElastoSens\u2122 Bio<\/a> est capable d&rsquo;appliquer de la lumi\u00e8re (\u00e0 diff\u00e9rentes longueurs d&rsquo;onde) pendant la mesure de la visco\u00e9lasticit\u00e9 des hydrogels, ce qui permet d&rsquo;obtenir en temps r\u00e9el la cin\u00e9tique de leur photor\u00e9ticulation.<\/li><li class=\"bullets\">Les intensit\u00e9s lumineuses et les dur\u00e9es d&rsquo;exposition lors de la photor\u00e9ticulation des hydrogels peuvent \u00eatre facilement combin\u00e9es dans <a href=\"https:\/\/rheolution.com\/fr\/?p=70781\">l&rsquo;ElastoSens\u2122 Bio<\/a> afin d&rsquo;atteindre la visco\u00e9lasticit\u00e9 souhait\u00e9e pour l&rsquo;application concern\u00e9e.<\/li><li class=\"bullets\">Les ECM LunaGel\u2122 facilitent l&rsquo;\u00e9tude du comportement cellulaire en fonction de la rigidit\u00e9 de la matrice extracellulaire.<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-650fa95 elementor-widget elementor-widget-heading\" data-id=\"650fa95\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">R\u00e9f\u00e9rences<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ec1a35b elementor-widget elementor-widget-text-editor\" data-id=\"ec1a35b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>[1] Keely, P., &#038; Nain, A. (2015). <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4754037\/\" target=\"_blank\" rel=\"noopener\">Capturing relevant extracellular matrices for investigating cell migration<\/a>. F1000Research, 4.<\/p><p>[2] Wei, S. C., Fattet, L., Tsai, J. H., Guo, Y., Pai, V. H., Majeski, H. E., &#8230; &#038; Yang, J. (2015).<a href=\"https:\/\/www.nature.com\/articles\/ncb3157\" target=\"_blank\" rel=\"noopener\"> Matrix stiffness drives epithelial\u2013mesenchymal transition and tumour metastasis through a TWIST1\u2013G3BP2 mechanotransduction pathway<\/a>. Nature cell biology, 17(5), 678-688.<\/p><p>[3] Paszek, M. J., Zahir, N., Johnson, K. R., Lakins, J. N., Rozenberg, G. I., Gefen, A., &#8230; &#038; Weaver, V. M. (2005). <a href=\"https:\/\/www.cell.com\/cancer-cell\/fulltext\/S1535-6108(05)00268-0\" target=\"_blank\" rel=\"noopener\">Tensional homeostasis and the malignant phenotype<\/a>. Cancer cell, 8(3), 241-254.<\/p><p>[4] Caliari, S. R., &#038; Burdick, J. A. (2016). <a href=\"https:\/\/www.nature.com\/articles\/nmeth.3839.pdf\" target=\"_blank\" rel=\"noopener\">A practical guide to hydrogels for cell culture<\/a>. Nature methods, 13(5), 405-414.<br\/><\/p><p> <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-93251b6 elementor-align-center elementor-widget elementor-widget-button\" data-id=\"93251b6\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/rheolution.com\/wp-content\/uploads\/Viscoelasticity-of-Gelomics-LunaGel-Photocrosslinkable-ECM.pdf\" target=\"_blank\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Consultez la note d'application compl\u00e8te (PDF) <\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element 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micro-volumes d\u2019\u00e9chantillons<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ca42a8b elementor-align-center elementor-widget elementor-widget-button\" data-id=\"ca42a8b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/rheolution.com\/fr\/contact\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Contactez-nous pour plus d'informations<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8418b6a elementor-widget elementor-widget-heading\" data-id=\"8418b6a\" data-element_type=\"widget\" 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class=\"premium-blog-thumbnail-overlay\">\n\t\t\t\t\t\t\t\t<a class=\"elementor-icon\" href=\"https:\/\/rheolution.com\/fr\/notes-application\/viscoelasticite-de-la-gelomique-lunagel-mec-photoreticulable\/\" target=\"_blank\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-screen-only\">R\u00e9glage de la rigidit\u00e9 des hydrogels \u00e0 base d&rsquo;ECM<\/span>\n\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"premium-blog-content-wrapper \">\n\n\t\t\t\t\t<div class=\"premium-blog-inner-container\">\n\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<h4 class=\"premium-blog-entry-title\">\n\t\t\t<a href=\"https:\/\/rheolution.com\/fr\/notes-application\/viscoelasticite-de-la-gelomique-lunagel-mec-photoreticulable\/\" target=\"_blank\">\n\t\t\t\tR\u00e9glage de la rigidit\u00e9 des hydrogels \u00e0 base d&rsquo;ECM\t\t\t<\/a>\n\t\t<\/h4>\n\t\t\t\t<div class=\"premium-blog-entry-meta\">\n\t\t\t\n\t\t\t\n\t\t\t\n\t\t\t\t\t<\/div>\n\t\t\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t<div class=\"premium-blog-content-inner-wrapper\">\n\t\t<p class=\"premium-blog-post-content\">Toutes les cellules du corps humain sont expos\u00e9es \u00e0 des forces m\u00e9caniques qui r\u00e9gulent leur fonctionnement et le d\u00e9veloppement des tissus, et chaque type de cellule est sp\u00e9cifiquement adapt\u00e9 aux propri\u00e9t\u00e9s m\u00e9caniques du tissu dans lequel il se trouve. Les propri\u00e9t\u00e9s de la matrice des tissus humains peuvent \u00e9galement \u00e9voluer en cas de maladie et, \u00e0 leur tour, favoriser sa progression.<\/p><div class=\"premium-blog-excerpt-link-wrap\"><a href=\"https:\/\/rheolution.com\/fr\/notes-application\/viscoelasticite-de-la-gelomique-lunagel-mec-photoreticulable\/\" target=\"_blank\" class=\"premium-blog-excerpt-link elementor-button\">Lire la suite \u00bb<\/a><\/div>\t\t<\/div>\n\t\t\t\t\t\t\t\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\n\t\t\t\t\t\t\t<\/div>\n\n\t\t\n\t\t\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Toutes les cellules du corps humain sont expos\u00e9es \u00e0 des forces m\u00e9caniques qui r\u00e9gulent leur fonctionnement et le d\u00e9veloppement des tissus, et chaque type de cellule est sp\u00e9cifiquement adapt\u00e9 aux propri\u00e9t\u00e9s m\u00e9caniques du tissu dans lequel il se trouve. Les propri\u00e9t\u00e9s de la matrice des tissus humains peuvent \u00e9galement \u00e9voluer en cas de maladie et, \u00e0 leur tour, favoriser sa progression.   <\/p>\n","protected":false},"author":195401338,"featured_media":44476,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_wpcom_ai_launchpad_first_post":false,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_post_was_ever_published":false},"categories":[285,370,296,371],"tags":[89,92,94,91,124,88,146,99,105,87],"class_list":["post-70781","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-notes-application","category-application-ingenierie-tissulaire","category-application-formulation-of-hydrogels","category-reticulation-par-exposition-a-la-lumiere","tag-elastosens-bio","tag-hydrogel-formation","tag-hydrogel-with-cells","tag-hydrogels","tag-life-sciences","tag-mechanical-testing","tag-natural-polymer","tag-photocrosslinking","tag-tissue-engineering","tag-viscoelasticity"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>R\u00e9glage de la Rigidit\u00e9 des Hydrogels d&#039;ECM pour la Culture Cellulaire<\/title>\n<meta name=\"description\" content=\"Mesurez en temps r\u00e9el la visco\u00e9lasticit\u00e9 et la photor\u00e9ticulation des hydrogels de la matrice extracellulaire (MEC) \u00e0 l&#039;aide d&#039;ElastoSens\u2122 Bio. 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