{"id":65395,"date":"2026-08-06T11:55:00","date_gmt":"2026-08-06T15:55:00","guid":{"rendered":"https:\/\/rheolution.com\/?p=65395"},"modified":"2026-08-13T15:55:21","modified_gmt":"2026-08-13T19:55:21","slug":"polymeres-pdms","status":"publish","type":"post","link":"https:\/\/rheolution.com\/fr\/notes-application\/polymeres-pdms\/","title":{"rendered":"Polym\u00e8res PDMS"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"65395\" class=\"elementor elementor-65395 elementor-63235\" data-elementor-post-type=\"post\">\n\t\t\t\t<div class=\"elementor-element elementor-element-8fd4dcf e-flex e-con-boxed e-con e-parent\" data-id=\"8fd4dcf\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-8c770e2 elementor-widget elementor-widget-heading\" data-id=\"8c770e2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h6 class=\"elementor-heading-title elementor-size-default\">Note d\u2019application | ElastoSens\u2122 Bio<\/h6>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-760ae40 elementor-widget elementor-widget-heading\" data-id=\"760ae40\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Polym\u00e8res PDMS : propri\u00e9t\u00e9s, applications et comportement m\u00e9canique<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-16057f6 elementor-widget elementor-widget-text-editor\" data-id=\"16057f6\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>par <a href=\"https:\/\/www.linkedin.com\/in\/mayasalame\/\">Maya Salame<\/a> et <a href=\"https:\/\/www.linkedin.com\/in\/dimitria-camas%C3%A3o-049002a2\/\">Dimitria Camasao<\/a><\/p><p>Scientifiques d\u2019application<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-97ac8de e-flex e-con-boxed e-con e-parent\" data-id=\"97ac8de\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-5fc8fde elementor-widget__width-initial elementor-widget-mobile__width-inherit elementor-widget elementor-widget-heading\" data-id=\"5fc8fde\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Qu'est-ce que le PDMS ?<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d61237b elementor-widget elementor-widget-text-editor\" data-id=\"d61237b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400\">Le polydim\u00e9thylsiloxane (PDMS) est un polym\u00e8re polysiloxane synth\u00e9tique compos\u00e9 d\u2019un squelette siloxane inorganique souple (\u2013Si\u2013O\u2013Si\u2013) comportant des groupes lat\u00e9raux m\u00e9thyle. Cette architecture inorganique-organique unique conf\u00e8re au PDMS une mobilit\u00e9 de cha\u00eene exceptionnelle, une tr\u00e8s basse temp\u00e9rature de transition vitreuse et un comportement \u00e9lastom\u00e8re stable sur une large plage de temp\u00e9ratures. Le PDMS est produit exclusivement par synth\u00e8se industrielle, impliquant g\u00e9n\u00e9ralement l\u2019hydrolyse et la condensation de chlorosilanes, suivies d\u2019une polym\u00e9risation par ouverture de cycle de siloxanes cycliques.  <\/span><\/p><p><span style=\"font-weight: 400\">Le PDMS est intrins\u00e8quement <\/span><b>hydrophobe<\/b><span style=\"font-weight: 400\">  et n&rsquo;absorbe pas l&rsquo;eau ni ne gonfle au contact de celle-ci. Par cons\u00e9quent,   <\/span><b>Le PDMS n&rsquo;est pas en soi un hydrogel<\/b><span style=\"font-weight: 400\">, mais plut\u00f4t un <\/span><b>\u00e9lastom\u00e8re de silicone<\/b><span style=\"font-weight: 400\">. Cependant, le PDMS est souvent incorpor\u00e9 dans  <\/span><b>syst\u00e8mes polym\u00e8res hybrides<\/b><span style=\"font-weight: 400\">, tels que les r\u00e9seaux polym\u00e8res interp\u00e9n\u00e9trants ou les hydrogels de silicone, dans lesquels une phase polym\u00e8re hydrophile permet l\u2019absorption d\u2019eau tandis que le PDMS apporte \u00e9lasticit\u00e9, perm\u00e9abilit\u00e9 et stabilit\u00e9 m\u00e9canique \u00e0 long terme.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5703c6a elementor-widget__width-initial elementor-widget-mobile__width-inherit elementor-widget elementor-widget-heading\" data-id=\"5703c6a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Propri\u00e9t\u00e9s essentielles des polym\u00e8res PDMS<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5a0b64a elementor-widget elementor-widget-heading\" data-id=\"5a0b64a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Caract\u00e9ristiques physico-chimiques<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-38524ee elementor-widget elementor-widget-text-editor\" data-id=\"38524ee\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400\">Le comportement physico-chimique du PDMS r\u00e9sulte de la souplesse et du caract\u00e8re partiellement ionique de la liaison siloxane.<\/span><\/p><ul><li style=\"font-weight: 400\"><b>M\u00e9canismes de polym\u00e9risation :<\/b><span style=\"font-weight: 400\"> Les cha\u00eenes de PDMS se forment par polym\u00e9risation par ouverture de cycle \u00e0 partir de siloxanes cycliques.<\/span><span style=\"font-weight: 400\"><br><\/span><\/li><li style=\"font-weight: 400\"><b>Strat\u00e9gies de r\u00e9ticulation :<\/b><b><br><\/b><ul><li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Durcissement par condensation via des r\u00e9actions de silanol.<\/span><span style=\"font-weight: 400\"><br><\/span><\/li><li style=\"font-weight: 400\"><span style=\"font-weight: 400\">R\u00e9ticulation par addition via une hydrosilylation entre des siloxanes \u00e0 fonction vinylique et \u00e0 fonction hydrure.<\/span><span style=\"font-weight: 400\"><br><\/span><\/li><li style=\"font-weight: 400\"><span style=\"font-weight: 400\">R\u00e9ticulation radicalaire ou photo-initi\u00e9e, y compris les r\u00e9actions thiol-\u00e8ne.<\/span><span style=\"font-weight: 400\"><br><\/span><\/li><\/ul><\/li><li style=\"font-weight: 400\"><b>Formation de mat\u00e9riaux hybrides :<\/b><span style=\"font-weight: 400\"> Le PDMS peut \u00eatre associ\u00e9 \u00e0 des polym\u00e8res hydrophiles pour former des hydrogels de silicone ou des r\u00e9seaux polym\u00e8res interp\u00e9n\u00e9trants capables d\u2019absorber l\u2019eau.<\/span><span style=\"font-weight: 400\"><br><\/span><\/li><\/ul><p><span style=\"font-weight: 400\">La densit\u00e9 de r\u00e9ticulation, le choix du catalyseur et l&rsquo;architecture du r\u00e9seau influencent fortement l&rsquo;\u00e9lasticit\u00e9, la perm\u00e9abilit\u00e9 et le comportement visco\u00e9lastique.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-30981bc elementor-widget elementor-widget-heading\" data-id=\"30981bc\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Propri\u00e9t\u00e9s m\u00e9caniques<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2e827a1 elementor-widget elementor-widget-text-editor\" data-id=\"2e827a1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400\">Les polym\u00e8res PDMS pr\u00e9sentent des propri\u00e9t\u00e9s m\u00e9caniques souples, semblables \u00e0 celles du caoutchouc, caract\u00e9ris\u00e9es par des comportements \u00e9lastiques et visco\u00e9lastiques.<\/span><\/p><ul><li style=\"font-weight: 400\"><b>\u00c9lasticit\u00e9 :<\/b><span style=\"font-weight: 400\"> La cha\u00eene principale flexible en siloxane permet d\u2019importantes d\u00e9formations r\u00e9versibles avec une hyst\u00e9r\u00e9sis minimale.<\/span><span style=\"font-weight: 400\"><br><\/span><\/li><li style=\"font-weight: 400\"><b>Rigidit\u00e9 r\u00e9glable :<\/b><span style=\"font-weight: 400\"> Les propri\u00e9t\u00e9s m\u00e9caniques peuvent \u00eatre ajust\u00e9es sur une large plage en modifiant la densit\u00e9 de r\u00e9ticulation, le poids mol\u00e9culaire entre les liaisons de r\u00e9ticulation ou en incorporant des r\u00e9seaux polym\u00e8res secondaires.<\/span><span style=\"font-weight: 400\"><br><\/span><\/li><li style=\"font-weight: 400\"><b>Comportement visco\u00e9lastique :<\/b><span style=\"font-weight: 400\"> Le PDMS pr\u00e9sente une relaxation des contraintes et une dissipation d&rsquo;\u00e9nergie d\u00e9pendantes du temps sous une charge cyclique ou continue.<\/span><\/li><li style=\"font-weight: 400\"><b>Stabilit\u00e9 \u00e0 long terme :<\/b> la cha\u00eene principale en siloxane, qui ne se d\u00e9grade pas, offre une excellente durabilit\u00e9 m\u00e9canique par rapport \u00e0 de nombreux syst\u00e8mes d&rsquo;hydrogel.<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0959975 elementor-widget elementor-widget-heading\" data-id=\"0959975\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Interactions biologiques<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-90cc644 elementor-widget elementor-widget-text-editor\" data-id=\"90cc644\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400\">Le PDMS est g\u00e9n\u00e9ralement consid\u00e9r\u00e9 comme biocompatible et bioinerte.<\/span><\/p><ul><li style=\"font-weight: 400\"><b>Adh\u00e9rence cellulaire :<\/b><span style=\"font-weight: 400\"> Le PDMS natif est hydrophobe et emp\u00eache l\u2019adsorption des prot\u00e9ines ainsi que l\u2019adh\u00e9sion cellulaire ; on recourt couramment \u00e0 une modification de surface ou \u00e0 une hybridation avec des polym\u00e8res hydrophiles afin de favoriser des interactions cellulaires contr\u00f4l\u00e9es.<\/span><span style=\"font-weight: 400\"><br><\/span><\/li><li style=\"font-weight: 400\"><b>Immunog\u00e9nicit\u00e9 :<\/b><span style=\"font-weight: 400\"> Le PDMS ne provoque g\u00e9n\u00e9ralement qu\u2019une r\u00e9ponse inflammatoire minime dans les applications biom\u00e9dicales.<\/span><\/li><li style=\"font-weight: 400\"><b>D\u00e9gradation :<\/b><span> Le PDMS n\u2019est pas d\u00e9gradable par voie enzymatique, ce qui favorise son utilisation \u00e0 long terme mais limite les applications n\u00e9cessitant un renouvellement de la matrice.<\/span><\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-28004d8 elementor-widget__width-initial elementor-widget-mobile__width-inherit elementor-widget elementor-widget-heading\" data-id=\"28004d8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Applications des polym\u00e8res PDMS<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-06adff0 elementor-widget elementor-widget-heading\" data-id=\"06adff0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Ing\u00e9nierie tissulaire<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ba2f1b1 elementor-widget elementor-widget-text-editor\" data-id=\"ba2f1b1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400\">Le PDMS est largement utilis\u00e9 comme <\/span><b>substrat \u00e9lastique, composant de support et mat\u00e9riau structurel<\/b><span style=\"font-weight: 400\">  dans le domaine de l&rsquo;ing\u00e9nierie tissulaire. Sa rigidit\u00e9 modulable, sa transparence optique et sa compatibilit\u00e9 avec les techniques de micro- et nanofabrication permettent un contr\u00f4le pr\u00e9cis des signaux m\u00e9caniques et de la topographie de surface. Dans de nombreux syst\u00e8mes, le PDMS sert de support m\u00e9caniquement stable aux hydrogels qui offrent un environnement propice \u00e0 l&rsquo;interaction avec les cellules.  <\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d01f123 elementor-widget elementor-widget-heading\" data-id=\"d01f123\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Culture cellulaire 3D et mod\u00e8les de maladies<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-137d5ec elementor-widget elementor-widget-text-editor\" data-id=\"137d5ec\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400\">Le PDMS est un mat\u00e9riau essentiel pour <\/span><b>dispositifs microfluidiques et les plateformes organe sur puce<\/b><span style=\"font-weight: 400\">. Bien que le PDMS ne soit pas en soi un hydrogel, il est souvent associ\u00e9 \u00e0 des compartiments d&rsquo;hydrogel afin de cr\u00e9er des syst\u00e8mes de culture en 3D dans lesquels le transport des nutriments, le confinement m\u00e9canique et les gradients biochimiques peuvent \u00eatre contr\u00f4l\u00e9s avec pr\u00e9cision.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c1cb3eb elementor-widget elementor-widget-heading\" data-id=\"c1cb3eb\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">D\u00e9livrance de m\u00e9dicaments, de g\u00e8nes et de cellules<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ff74672 elementor-widget elementor-widget-text-editor\" data-id=\"ff74672\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400\">PDMS intervient dans <\/span><b>aux syst\u00e8mes \u00e0 base d&rsquo;hydrogel de silicone et aux r\u00e9seaux polym\u00e8res interp\u00e9n\u00e9trants<\/b><span style=\"font-weight: 400\">  utilis\u00e9s pour des applications de lib\u00e9ration contr\u00f4l\u00e9e. Dans ces mat\u00e9riaux hybrides, les phases polym\u00e8res hydrophiles permettent la fixation et la lib\u00e9ration du principe actif, tandis que le PDMS apporte \u00e9lasticit\u00e9, perm\u00e9abilit\u00e9 aux gaz et r\u00e9sistance m\u00e9canique. <\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-892f73a elementor-widget__width-initial elementor-widget-mobile__width-inherit elementor-widget elementor-widget-heading\" data-id=\"892f73a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Pourquoi la visco\u00e9lasticit\u00e9 des polym\u00e8res \u00e0 base de PDMS est-elle importante ?<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-05c6bea elementor-widget elementor-widget-text-editor\" data-id=\"05c6bea\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400\">Bien qu&rsquo;il soit souvent d\u00e9crit comme purement \u00e9lastique, le PDMS pr\u00e9sente un <\/span><b>comportement visco\u00e9lastique<\/b><span style=\"font-weight: 400\">  ce qui a un impact direct sur ses performances fonctionnelles. La relaxation des contraintes et l\u2019amortissement en fonction du temps influencent la mani\u00e8re dont les forces sont transmises et dissip\u00e9es sous une charge continue ou cyclique. Dans les applications biom\u00e9dicales et de m\u00e9canobiologie, ces propri\u00e9t\u00e9s visco\u00e9lastiques affectent la m\u00e9canosensation cellulaire, la stabilit\u00e9 m\u00e9canique \u00e0 long terme et la r\u00e9sistance \u00e0 la fatigue. Dans les syst\u00e8mes d\u2019hydrogel contenant du PDMS, la r\u00e9ponse visco\u00e9lastique de la phase PDMS joue un r\u00f4le cl\u00e9 dans la d\u00e9finition de l\u2019environnement m\u00e9canique composite auquel sont soumises les cellules.   <\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-851f298 elementor-widget__width-initial elementor-widget-mobile__width-inherit elementor-widget elementor-widget-heading\" data-id=\"851f298\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">M\u00e9thodes de caract\u00e9risation de la visco\u00e9lasticit\u00e9 des polym\u00e8res \u00e0 base de PDMS<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-171be53 elementor-widget elementor-widget-text-editor\" data-id=\"171be53\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400\">Les propri\u00e9t\u00e9s m\u00e9caniques et visco\u00e9lastiques du PDMS sont g\u00e9n\u00e9ralement caract\u00e9ris\u00e9es \u00e0 l\u2019aide d\u2019essais de traction, d\u2019essais de compression, de rh\u00e9om\u00e9trie et d\u2019analyse m\u00e9canique dynamique. Ces techniques permettent de mesurer le module d\u2019\u00e9lasticit\u00e9, les modules de stockage et de perte, ainsi que le comportement d\u2019amortissement. Cependant, les m\u00e9thodes conventionnelles n\u00e9cessitent souvent un contact direct, des d\u00e9formations importantes ou des essais destructifs, ce qui limite leur capacit\u00e9 \u00e0 suivre la cin\u00e9tique de g\u00e9lification dans les syst\u00e8mes hybrides ou \u00e0 surveiller l\u2019\u00e9volution m\u00e9canique au fil du temps sur un m\u00eame \u00e9chantillon.  <\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1961b9f elementor-widget__width-initial elementor-widget-mobile__width-inherit elementor-widget elementor-widget-heading\" data-id=\"1961b9f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">\u00c9tude de cas : Caract\u00e9risation m\u00e9canique de syst\u00e8mes polym\u00e8res souples \u00e0 base de PDMS \u00e0 l'aide d'ElastoSens\u2122 Bio<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4babf25 elementor-widget__width-initial elementor-widget-mobile__width-initial elementor-widget elementor-widget-heading\" data-id=\"4babf25\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">ElastoSens\u2122 Bio : un outil non destructif permettant de mesurer les mat\u00e9riaux souples \u00e0 base de PDMS\n<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-5a225c3 e-grid e-con-full e-con e-child\" data-id=\"5a225c3\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ce43e5b elementor-widget elementor-widget-text-editor\" data-id=\"ce43e5b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>L&rsquo; <a href=\"https:\/\/rheolution.com\/instrument-elastosensbio\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400\"><strong>ElastoSens\u2122 Bio<\/strong><\/span><\/a> est un  <span style=\"font-weight: 400\">Instrument sans contact, fonctionnant par r\u00e9sonance, con\u00e7u pour la caract\u00e9risation visco\u00e9lastique des mat\u00e9riaux souples. En surveillant les variations de la r\u00e9ponse vibratoire, il permet de mesurer avec pr\u00e9cision les propri\u00e9t\u00e9s m\u00e9caniques sans d\u00e9former physiquement l&rsquo;\u00e9chantillon. Cette approche est particuli\u00e8rement adapt\u00e9e aux polym\u00e8res souples \u00e0 base de PDMS et aux syst\u00e8mes d&rsquo;hydrogels contenant du PDMS.  <\/span><\/p><p><span style=\"font-weight: 400\">Parmi ses principaux avantages, on peut citer les essais non destructifs, la surveillance en temps r\u00e9el, une sensibilit\u00e9 et une r\u00e9p\u00e9tabilit\u00e9 \u00e9lev\u00e9es, ainsi que la compatibilit\u00e9 avec des flux de travail st\u00e9riles ou impliquant des cellules. Le syst\u00e8me permet un suivi continu de l&rsquo;\u00e9volution m\u00e9canique, l&rsquo;identification des transitions de l&rsquo;\u00e9tat liquide \u00e0 l&rsquo;\u00e9tat solide dans des syst\u00e8mes hybrides, ainsi que l&rsquo;analyse longitudinale d&rsquo;un m\u00eame \u00e9chantillon au fil du temps. <\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-045aef9 elementor-widget elementor-widget-image\" data-id=\"045aef9\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"968\" height=\"544\" src=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/elastosens2-1.webp?fit=968%2C544&amp;ssl=1\" class=\"attachment-large size-large wp-image-50364\" alt=\"\" srcset=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/elastosens2-1.webp?w=968&amp;ssl=1 968w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/elastosens2-1.webp?resize=300%2C169&amp;ssl=1 300w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/elastosens2-1.webp?resize=768%2C432&amp;ssl=1 768w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/elastosens2-1.webp?resize=133%2C75&amp;ssl=1 133w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/elastosens2-1.webp?resize=480%2C270&amp;ssl=1 480w\" sizes=\"(max-width:767px) 700px, (max-width:968px) 100vw, 968px\" data-attachment-id=\"50364\" data-permalink=\"https:\/\/rheolution.com\/fr\/elastosens2-4-2-2-2\/\" data-orig-file=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/elastosens2-1.webp?fit=968%2C544&amp;ssl=1\" data-orig-size=\"968,544\" data-comments-opened=\"1\" data-image-title=\"elastosens2\" data-image-description=\"\" data-image-caption=\"\" data-large-file=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/elastosens2-1.webp?fit=968%2C544&amp;ssl=1\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b87c673 elementor-widget elementor-widget-text-editor\" data-id=\"b87c673\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400\">Afin de d\u00e9montrer les capacit\u00e9s de l\u2019ElastoSens\u2122 Bio, nous avons r\u00e9alis\u00e9 une s\u00e9rie de tests sur des syst\u00e8mes polym\u00e8res souples \u00e0 base de PDMS. La section suivante pr\u00e9sente les mat\u00e9riaux et les m\u00e9thodes utilis\u00e9s, puis expose les r\u00e9sultats, offrant ainsi un exemple concret de la capacit\u00e9 de l\u2019instrument \u00e0 surveiller de mani\u00e8re non destructive les propri\u00e9t\u00e9s visco\u00e9lastiques au fil du temps. <\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ed23fc9 elementor-widget elementor-widget-heading\" data-id=\"ed23fc9\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Mat\u00e9riel et m\u00e9thodes<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d118051 elementor-widget elementor-widget-text-editor\" data-id=\"d118051\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400\">Le polydim\u00e9thylsiloxane (PDMS) a \u00e9t\u00e9 pr\u00e9par\u00e9 \u00e0 l&rsquo;aide du Sylgard 527, qui se compose d&rsquo;une base de PDMS \u00e0 terminaisons vinyliques (partie A) et d&rsquo;un agent de durcissement contenant de l&rsquo;hydrosilane et un catalyseur au platine (partie B). Les deux composants ont \u00e9t\u00e9 m\u00e9lang\u00e9s dans un rapport pond\u00e9ral de 1:1. Aucune \u00e9tape de d\u00e9gazage n\u2019a \u00e9t\u00e9 effectu\u00e9e avant les essais.    <\/span><\/p><p><span style=\"font-weight: 400\">Imm\u00e9diatement apr\u00e8s le m\u00e9lange, le PDMS non durci a \u00e9t\u00e9 vers\u00e9 directement dans le porte-\u00e9chantillon macro (volume total de 2,0 ml). Afin d&rsquo;\u00e9viter le s\u00e9chage de la surface et l&rsquo;\u00e9vaporation pendant les essais de longue dur\u00e9e, la surface de l&rsquo;\u00e9chantillon a \u00e9t\u00e9 recouverte d&rsquo;un liquide anti-\u00e9vaporation. <\/span><\/p><p><span style=\"font-weight: 400\">La cin\u00e9tique de durcissement et l&rsquo;\u00e9volution de la rigidit\u00e9 globale ont \u00e9t\u00e9 suivies pendant une p\u00e9riode de 24 heures \u00e0 70 \u00b0C \u00e0 l&rsquo;aide de l&rsquo;ElastoSens Bio. Les mesures ont \u00e9t\u00e9 enregistr\u00e9es toutes les 20 secondes, ce qui a permis de saisir \u00e0 la fois le comportement de durcissement en phase initiale et l&rsquo;approche de la rigidit\u00e9 finale au plateau. La configuration exp\u00e9rimentale est illustr\u00e9e \u00e0 la figure 1.  <\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-4133609 e-grid e-con-full e-con e-child\" data-id=\"4133609\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-5d093b9 e-con-full e-flex e-con e-child\" data-id=\"5d093b9\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-7f2302a elementor-widget elementor-widget-image\" data-id=\"7f2302a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"512\" height=\"331\" src=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/PDMS-in-holder.png?fit=512%2C331&amp;ssl=1\" class=\"attachment-large size-large wp-image-63249\" alt=\"\" srcset=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/PDMS-in-holder.png?w=512&amp;ssl=1 512w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/PDMS-in-holder.png?resize=300%2C194&amp;ssl=1 300w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/PDMS-in-holder.png?resize=116%2C75&amp;ssl=1 116w\" sizes=\"(max-width:767px) 512px, 512px\" data-attachment-id=\"63249\" data-permalink=\"https:\/\/rheolution.com\/fr\/pdms-in-holder-2\/\" data-orig-file=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/PDMS-in-holder.png?fit=512%2C331&amp;ssl=1\" data-orig-size=\"512,331\" data-comments-opened=\"1\" data-image-title=\"PDMS in holder\" data-image-description=\"\" data-image-caption=\"\" data-large-file=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/PDMS-in-holder.png?fit=512%2C331&amp;ssl=1\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e4e4608 elementor-widget elementor-widget-text-editor\" data-id=\"e4e4608\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>A<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-273e6e1 e-con-full e-flex e-con e-child\" data-id=\"273e6e1\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-bc9fe86 elementor-widget elementor-widget-image\" data-id=\"bc9fe86\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"512\" height=\"330\" src=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/PDMS.png?fit=512%2C330&amp;ssl=1\" class=\"attachment-large size-large wp-image-63257\" alt=\"\" srcset=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/PDMS.png?w=512&amp;ssl=1 512w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/PDMS.png?resize=300%2C193&amp;ssl=1 300w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/PDMS.png?resize=116%2C75&amp;ssl=1 116w\" sizes=\"(max-width:767px) 512px, 512px\" data-attachment-id=\"63257\" data-permalink=\"https:\/\/rheolution.com\/fr\/pdms-2\/\" data-orig-file=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/PDMS.png?fit=512%2C330&amp;ssl=1\" data-orig-size=\"512,330\" data-comments-opened=\"1\" data-image-title=\"PDMS\" data-image-description=\"\" data-image-caption=\"\" data-large-file=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/PDMS.png?fit=512%2C330&amp;ssl=1\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ae5abab elementor-widget elementor-widget-text-editor\" data-id=\"ae5abab\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>B<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-069025e elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"069025e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><em><b>Figure 1.<\/b><span style=\"font-weight: 400\">  PDMS dans un rapport 1:1 : (A) apr\u00e8s mise en place dans le support macro et (B) apr\u00e8s 24 heures d&rsquo;essai et retrait du support.  <\/span><\/em><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-aa24bd0 elementor-widget elementor-widget-heading\" data-id=\"aa24bd0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">R\u00e9sultats et discussion<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-54513af elementor-widget elementor-widget-text-editor\" data-id=\"54513af\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400\">La r\u00e9ponse visco\u00e9lastique en fonction du temps des \u00e9chantillons de Sylgard 527 PDMS dans un rapport de 1:1 est pr\u00e9sent\u00e9e \u00e0 la figure 2. Tout au long de la p\u00e9riode de durcissement de 24 heures, tant le module de stockage en cisaillement (G\u2032) que le module de perte en cisaillement (G\u2033) ont augment\u00e9, ce qui correspond \u00e0 une r\u00e9ticulation progressive et \u00e0 la formation d\u2019un r\u00e9seau. \u00c0 la fin de l\u2019exp\u00e9rience, G\u2032 a atteint 7 048 \u00b1 43 Pa, tandis que G\u2033 s\u2019est stabilis\u00e9 \u00e0 2 420 \u00b1 167 Pa. La valeur finale plus \u00e9lev\u00e9e de G\u2032 par rapport \u00e0 celle de G\u2033 indique que la r\u00e9ponse du mat\u00e9riau durci \u00e9tait principalement \u00e9lastique, c\u2019est-\u00e0-dire que le stockage d\u2019\u00e9nergie dans le r\u00e9seau r\u00e9ticul\u00e9 l\u2019emportait sur la dissipation d\u2019\u00e9nergie visqueuse.   <\/span><\/p><p><span style=\"font-weight: 400\">Le facteur d&rsquo;amortissement (tan \u03b4 = G\u2033\/G\u2032) a atteint en moyenne son maximum \u00e0 9,54 min. Ce pic correspond au point de transition, marquant le passage d&rsquo;une r\u00e9ponse de type essentiellement liquide (\u00e0 dominance visqueuse) \u00e0 un r\u00e9seau \u00e9lastique de type solide qui continue de se rigidifier \u00e0 mesure que le durcissement progresse. <\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4a7f0ab elementor-widget__width-initial elementor-widget elementor-widget-image\" data-id=\"4a7f0ab\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"691\" src=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/PDMS-G-kinetics.png?fit=1024%2C691&amp;ssl=1\" class=\"attachment-large size-large wp-image-63241\" alt=\"\" srcset=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/PDMS-G-kinetics.png?w=1396&amp;ssl=1 1396w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/PDMS-G-kinetics.png?resize=300%2C202&amp;ssl=1 300w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/PDMS-G-kinetics.png?resize=1024%2C691&amp;ssl=1 1024w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/PDMS-G-kinetics.png?resize=768%2C518&amp;ssl=1 768w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/PDMS-G-kinetics.png?resize=111%2C75&amp;ssl=1 111w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/PDMS-G-kinetics.png?resize=700%2C472&amp;ssl=1 700w\" sizes=\"(max-width:767px) 700px, (max-width:1024px) 100vw, 1024px\" data-attachment-id=\"63241\" data-permalink=\"https:\/\/rheolution.com\/fr\/pdms-g-kinetics-2\/\" data-orig-file=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/PDMS-G-kinetics.png?fit=1396%2C942&amp;ssl=1\" data-orig-size=\"1396,942\" data-comments-opened=\"1\" data-image-title=\"PDMS &amp;#8211; G&amp;rsquo; kinetics\" data-image-description=\"\" data-image-caption=\"\" data-large-file=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/PDMS-G-kinetics.png?fit=1024%2C691&amp;ssl=1\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-05790a9 elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"05790a9\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><em><b>Figure 2.<\/b><span style=\"font-weight: 400\">  Profil de durcissement en fonction du temps d&rsquo;un PDMS dans un rapport 1:1 sur 24 heures. Courbes repr\u00e9sentatives de G\u2019 (bleu), G\u2019\u2019 (orange) et tan\u03b4 (gris) illustrant l&rsquo;\u00e9volution des propri\u00e9t\u00e9s visco\u00e9lastiques \u00e0 70 \u00b0C (n = 3).   <\/span><\/em><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8ad5968 elementor-widget elementor-widget-heading\" data-id=\"8ad5968\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Conclusions et perspectives<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b7d7a98 elementor-widget elementor-widget-text-editor\" data-id=\"b7d7a98\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400\">Le comportement m\u00e9canique des <\/span><b>syst\u00e8mes polym\u00e8res souples \u00e0 base de PDMS<\/b><span style=\"font-weight: 400\">\u2014qui d\u00e9pendent de leur visco\u00e9lasticit\u00e9, de leur densit\u00e9 de r\u00e9ticulation et de leur r\u00e9ponse en fonction du temps\u2014jouent un r\u00f4le central dans leurs performances en microfluidique, en m\u00e9canobiologie et dans les plateformes hybrides \u00e0 base d\u2019hydrogel. Les mat\u00e9riaux PDMS \u00e9tant souples, \u00e9lastiques et souvent utilis\u00e9s au contact de syst\u00e8mes biologiques, leurs propri\u00e9t\u00e9s m\u00e9caniques doivent \u00eatre caract\u00e9ris\u00e9es sans alt\u00e9rer leur structure ni leur st\u00e9rilit\u00e9. <\/span><\/p><ul><li style=\"font-weight: 400\"><b>Technologie non destructive<\/b><span style=\"font-weight: 400\"> optimis\u00e9e pour les polym\u00e8res souples et les \u00e9lastom\u00e8res.<\/span><span style=\"font-weight: 400\"><br><\/span><\/li><li style=\"font-weight: 400\"><b>Haute sensibilit\u00e9 et r\u00e9p\u00e9tabilit\u00e9<\/b><span style=\"font-weight: 400\"> pour des mesures de rigidit\u00e9 fiables.<\/span><span style=\"font-weight: 400\"><br><\/span><\/li><li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Capacit\u00e9 \u00e0 surveiller <\/span><b>la cin\u00e9tique de durcissement et de g\u00e9lification<\/b><span style=\"font-weight: 400\">, y compris <\/span><b>la transition liquide-solide.<\/b><b><br><\/b><\/li><li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Mesure directe de la <\/span><b>la rigidit\u00e9 finale<\/b><span style=\"font-weight: 400\"> apr\u00e8s la formation du r\u00e9seau.<\/span><span style=\"font-weight: 400\"><br><\/span><\/li><li style=\"font-weight: 400\"><b>Essais longitudinaux<\/b><span style=\"font-weight: 400\"> du m\u00eame \u00e9chantillon au fil du temps, dans des conditions st\u00e9riles si n\u00e9cessaire.<\/span><span style=\"font-weight: 400\"><br><\/span><\/li><li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Module int\u00e9gr\u00e9 <\/span><b>module de photostimulation<\/b><span style=\"font-weight: 400\"> permettant <\/span><b>la surveillance en temps r\u00e9el de la photor\u00e9ticulation<\/b><span style=\"font-weight: 400\">, le cas \u00e9ch\u00e9ant.<\/span><span style=\"font-weight: 400\"><br><\/span><\/li><\/ul><p><span style=\"font-weight: 400\">Dans l&rsquo;ensemble, ElastoSens\u2122 Bio permet de mieux comprendre les relations entre la structure et les propri\u00e9t\u00e9s du PDMS et am\u00e9liore la reproductibilit\u00e9 tant dans le domaine de la recherche que dans les applications pratiques.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-794c36a elementor-widget elementor-widget-heading\" data-id=\"794c36a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">R\u00e9f\u00e9rences<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-27340c7 elementor-widget elementor-widget-text-editor\" data-id=\"27340c7\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400\">Gonz\u00e1lez Calder\u00f3n, J. A., Contreras L\u00f3pez, D., P\u00e9rez, E., &amp; Vallejo Montesinos, J. (2020). Polysiloxanes as polymer matrices in biomedical engineering: Their interesting properties as the reason for the use in medical sciences.  <\/span>Polymer Bulletin, 77(5), 2749-2817.<\/p><p><span style=\"font-weight: 400\">Shakeri, A., Khan, S., &amp; Didar, T. F. (2021). Conventional and emerging strategies for the fabrication and functionalization of PDMS-based microfluidic devices. Lab on a Chip, 21(16), 3053-3075. <\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9383078 elementor-widget__width-initial elementor-widget-mobile__width-inherit elementor--h-position-center elementor--v-position-middle elementor-arrows-position-inside elementor-widget elementor-widget-slides\" data-id=\"9383078\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;navigation&quot;:&quot;arrows&quot;,&quot;autoplay_speed&quot;:4000,&quot;transition_speed&quot;:4000,&quot;autoplay&quot;:&quot;yes&quot;,&quot;pause_on_hover&quot;:&quot;yes&quot;,&quot;pause_on_interaction&quot;:&quot;yes&quot;,&quot;infinite&quot;:&quot;yes&quot;,&quot;transition&quot;:&quot;slide&quot;}\" data-widget_type=\"slides.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-swiper\">\n\t\t\t\t\t<div class=\"elementor-slides-wrapper elementor-main-swiper swiper\" role=\"region\" aria-roledescription=\"carousel\" aria-label=\"Slides\" dir=\"ltr\" data-animation=\"fadeInUp\">\n\t\t\t\t<div class=\"swiper-wrapper elementor-slides\">\n\t\t\t\t\t\t\t\t\t\t<div class=\"elementor-repeater-item-c97f30c swiper-slide\" role=\"group\" aria-roledescription=\"slide\"><div class=\"swiper-slide-bg\" role=\"img\" aria-label=\"elastosens2\"><\/div><div class=\"swiper-slide-inner\" ><div class=\"swiper-slide-contents\"><\/div><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8cce0c6 elementor-widget__width-initial elementor-widget-mobile__width-inherit elementor-widget elementor-widget-text-editor\" data-id=\"8cce0c6\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>D\u00e9couvrez comment notre technologie mesure de mani\u00e8re non destructive les propri\u00e9t\u00e9s visco\u00e9lastiques des biomat\u00e9riaux mous et des tissus en utilisant des micro-volumes d\u2019\u00e9chantillons<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c4ce1d0 elementor-align-center elementor-widget elementor-widget-button\" data-id=\"c4ce1d0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/rheolution.com\/contact\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Contactez-nous pour plus d'informations<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-efbb293 elementor-widget elementor-widget-heading\" data-id=\"efbb293\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Articles connexes<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3f623a9 premium-blog-cta-full-yes premium-floating-effects-yes premium-disable-fe-yes elementor-widget__width-initial premium-blog-align-left elementor-widget elementor-widget-premium-addon-blog\" data-id=\"3f623a9\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;force_height&quot;:&quot;true&quot;,&quot;premium_blog_grid&quot;:&quot;yes&quot;,&quot;premium_blog_layout&quot;:&quot;even&quot;,&quot;premium_blog_columns_number&quot;:&quot;50%&quot;,&quot;premium_blog_columns_number_tablet&quot;:&quot;50%&quot;,&quot;premium_blog_columns_number_mobile&quot;:&quot;100%&quot;,&quot;scroll_to_offset&quot;:&quot;yes&quot;,&quot;premium_fe_trigger&quot;:&quot;load&quot;,&quot;premium_fe_direction&quot;:&quot;alternate&quot;,&quot;premium_fe_loop&quot;:&quot;default&quot;,&quot;premium_fe_easing&quot;:&quot;easeInOutSine&quot;}\" data-widget_type=\"premium-addon-blog.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\n\t\t\n\n\t\t\t\t<div class=\"premium-blog-wrap  premium-blog-even\" data-page=\"65395\" data-pagination=\"true\">\n\t\t\t\t\t\t\t\t\t<div class=\"premium-blog-post-outer-container\" data-total=\"3\">\n\t\t\t<div class=\"premium-blog-post-container premium-blog-skin-classic\">\n\t\t\t\t\t\t\t\t\t<div class=\"premium-blog-thumb-effect-wrapper\">\n\t\t\t\t\t\t<div class=\"premium-blog-thumbnail-container premium-blog-zoomin-effect\">\n\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"7000\" height=\"2322\" src=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/FIBRIN.jpg?fit=7000%2C2322&amp;ssl=1\" class=\"attachment-full size-full wp-image-63000\" alt=\"\" data-attachment-id=\"63000\" data-permalink=\"https:\/\/rheolution.com\/fr\/fibrin-2\/\" data-orig-file=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/FIBRIN.jpg?fit=7000%2C2322&amp;ssl=1\" data-orig-size=\"7000,2322\" data-comments-opened=\"1\" data-image-title=\"FIBRIN\" data-image-description=\"\" data-image-caption=\"\" data-large-file=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/FIBRIN.jpg?fit=1024%2C340&amp;ssl=1\" srcset=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/FIBRIN.jpg?w=7000&amp;ssl=1 7000w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/FIBRIN.jpg?resize=300%2C100&amp;ssl=1 300w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/FIBRIN.jpg?resize=1024%2C340&amp;ssl=1 1024w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/FIBRIN.jpg?resize=768%2C255&amp;ssl=1 768w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/FIBRIN.jpg?resize=1536%2C510&amp;ssl=1 1536w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/FIBRIN.jpg?resize=2048%2C679&amp;ssl=1 2048w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/FIBRIN.jpg?resize=150%2C50&amp;ssl=1 150w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/FIBRIN.jpg?resize=700%2C232&amp;ssl=1 700w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/FIBRIN.jpg?w=2440&amp;ssl=1 2440w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/FIBRIN.jpg?w=3660&amp;ssl=1 3660w\" sizes=\"(max-width:767px) 700px, (max-width:7000px) 100vw, 7000px\" \/>\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"premium-blog-thumbnail-overlay\">\n\t\t\t\t\t\t\t\t<a class=\"elementor-icon\" href=\"https:\/\/rheolution.com\/fr\/notes-application\/hydrogels-de-fibrine\/\" target=\"_blank\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-screen-only\">Hydrogels de fibrine<\/span>\n\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"premium-blog-content-wrapper \">\n\n\t\t\t\t\t<div class=\"premium-blog-inner-container\">\n\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<h4 class=\"premium-blog-entry-title\">\n\t\t\t<a href=\"https:\/\/rheolution.com\/fr\/notes-application\/hydrogels-de-fibrine\/\" target=\"_blank\">\n\t\t\t\tHydrogels de fibrine\t\t\t<\/a>\n\t\t<\/h4>\n\t\t\t\t<div class=\"premium-blog-entry-meta\">\n\t\t\t\n\t\t\t\n\t\t\t\n\t\t\t\t\t<\/div>\n\t\t\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t<div class=\"premium-blog-content-inner-wrapper\">\n\t\t<p class=\"premium-blog-post-content\">Les hydrogels de fibrine sont des biomat\u00e9riaux naturels \u00e0 base de prot\u00e9ines, form\u00e9s \u00e0 partir de la fibrine, ce polym\u00e8re insoluble g\u00e9n\u00e9r\u00e9 lors de la coagulation sanguine. La fibrine provient du fibrinog\u00e8ne, une glycoprot\u00e9ine plasmatique compos\u00e9e de trois paires de cha\u00eenes polypeptidiques qui s\u2019assemblent en un r\u00e9seau fibreux sous l\u2019effet d\u2019une activation enzymatique. Dans des conditions physiologiques, la formation de la fibrine est d\u00e9clench\u00e9e par le clivage du fibrinog\u00e8ne sous l\u2019action de la thrombine, ce qui expose des sites de polym\u00e9risation qui favorisent l\u2019auto-assemblage spontan\u00e9 en une matrice hydrat\u00e9e et poreuse.<\/p><div class=\"premium-blog-excerpt-link-wrap\"><a href=\"https:\/\/rheolution.com\/fr\/notes-application\/hydrogels-de-fibrine\/\" target=\"_blank\" class=\"premium-blog-excerpt-link elementor-button\">Lire la suite \u00bb<\/a><\/div>\t\t<\/div>\n\t\t\t\t\t\t\t\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\n\t\t\t\t<div class=\"premium-blog-post-outer-container\" data-total=\"3\">\n\t\t\t<div class=\"premium-blog-post-container premium-blog-skin-classic\">\n\t\t\t\t\t\t\t\t\t<div class=\"premium-blog-thumb-effect-wrapper\">\n\t\t\t\t\t\t<div class=\"premium-blog-thumbnail-container premium-blog-zoomin-effect\">\n\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"7000\" height=\"2322\" src=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/ALGINATE-1.jpg?fit=7000%2C2322&amp;ssl=1\" class=\"attachment-full size-full wp-image-63128\" alt=\"\" data-attachment-id=\"63128\" data-permalink=\"https:\/\/rheolution.com\/fr\/alginate-2-2\/\" data-orig-file=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/ALGINATE-1.jpg?fit=7000%2C2322&amp;ssl=1\" data-orig-size=\"7000,2322\" data-comments-opened=\"1\" data-image-title=\"ALGINATE\" data-image-description=\"\" data-image-caption=\"\" data-large-file=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/ALGINATE-1.jpg?fit=1024%2C340&amp;ssl=1\" srcset=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/ALGINATE-1.jpg?w=7000&amp;ssl=1 7000w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/ALGINATE-1.jpg?resize=300%2C100&amp;ssl=1 300w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/ALGINATE-1.jpg?resize=1024%2C340&amp;ssl=1 1024w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/ALGINATE-1.jpg?resize=768%2C255&amp;ssl=1 768w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/ALGINATE-1.jpg?resize=1536%2C510&amp;ssl=1 1536w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/ALGINATE-1.jpg?resize=2048%2C679&amp;ssl=1 2048w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/ALGINATE-1.jpg?resize=150%2C50&amp;ssl=1 150w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/ALGINATE-1.jpg?resize=700%2C232&amp;ssl=1 700w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/ALGINATE-1.jpg?w=2440&amp;ssl=1 2440w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/ALGINATE-1.jpg?w=3660&amp;ssl=1 3660w\" sizes=\"(max-width:767px) 700px, (max-width:7000px) 100vw, 7000px\" \/>\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"premium-blog-thumbnail-overlay\">\n\t\t\t\t\t\t\t\t<a class=\"elementor-icon\" href=\"https:\/\/rheolution.com\/fr\/notes-application\/hydrogels-dalginate\/\" target=\"_blank\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-screen-only\">Hydrogels d&rsquo;alginate<\/span>\n\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"premium-blog-content-wrapper \">\n\n\t\t\t\t\t<div class=\"premium-blog-inner-container\">\n\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<h4 class=\"premium-blog-entry-title\">\n\t\t\t<a href=\"https:\/\/rheolution.com\/fr\/notes-application\/hydrogels-dalginate\/\" target=\"_blank\">\n\t\t\t\tHydrogels d&rsquo;alginate\t\t\t<\/a>\n\t\t<\/h4>\n\t\t\t\t<div class=\"premium-blog-entry-meta\">\n\t\t\t\n\t\t\t\n\t\t\t\n\t\t\t\t\t<\/div>\n\t\t\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t<div class=\"premium-blog-content-inner-wrapper\">\n\t\t<p class=\"premium-blog-post-content\">Les hydrogels d'alginate sont des r\u00e9seaux polym\u00e8res tridimensionnels riches en eau, d\u00e9riv\u00e9s de l'alginate, un polysaccharide anionique d'origine naturelle. L'alginate est principalement extrait des parois cellulaires des algues brunes appartenant \u00e0 la classe des ph\u00e9ophyc\u00e9es, bien qu'il puisse \u00e9galement \u00eatre biosynth\u00e9tis\u00e9 par certaines esp\u00e8ces bact\u00e9riennes telles que les Azotobacter et les Pseudomonas. Sur le plan structurel, l\u2019alginate est un copolym\u00e8re lin\u00e9aire compos\u00e9 d\u2019acide \u03b2-D-mannuronique (unit\u00e9s M) et d\u2019acide \u03b1-L-guluronique (unit\u00e9s G), reli\u00e9s par des liaisons glycosidiques 1\u21924.<\/p><div class=\"premium-blog-excerpt-link-wrap\"><a href=\"https:\/\/rheolution.com\/fr\/notes-application\/hydrogels-dalginate\/\" target=\"_blank\" class=\"premium-blog-excerpt-link elementor-button\">Lire la suite \u00bb<\/a><\/div>\t\t<\/div>\n\t\t\t\t\t\t\t\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\n\t\t\t\t<div class=\"premium-blog-post-outer-container\" data-total=\"3\">\n\t\t\t<div class=\"premium-blog-post-container premium-blog-skin-classic\">\n\t\t\t\t\t\t\t\t\t<div class=\"premium-blog-thumb-effect-wrapper\">\n\t\t\t\t\t\t<div class=\"premium-blog-thumbnail-container premium-blog-zoomin-effect\">\n\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"7875\" height=\"2612\" src=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Gelatin-Methacrylate-1.jpg?fit=7875%2C2612&amp;ssl=1\" class=\"attachment-full size-full wp-image-63420\" alt=\"\" data-attachment-id=\"63420\" data-permalink=\"https:\/\/rheolution.com\/fr\/gelatin-methacrylate-2-2\/\" data-orig-file=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Gelatin-Methacrylate-1.jpg?fit=7875%2C2612&amp;ssl=1\" data-orig-size=\"7875,2612\" data-comments-opened=\"1\" data-image-title=\"Gelatin Methacrylate\" data-image-description=\"\" data-image-caption=\"\" data-large-file=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Gelatin-Methacrylate-1.jpg?fit=1024%2C340&amp;ssl=1\" srcset=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Gelatin-Methacrylate-1.jpg?w=7875&amp;ssl=1 7875w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Gelatin-Methacrylate-1.jpg?resize=300%2C100&amp;ssl=1 300w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Gelatin-Methacrylate-1.jpg?resize=1024%2C340&amp;ssl=1 1024w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Gelatin-Methacrylate-1.jpg?resize=768%2C255&amp;ssl=1 768w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Gelatin-Methacrylate-1.jpg?resize=1536%2C509&amp;ssl=1 1536w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Gelatin-Methacrylate-1.jpg?resize=2048%2C679&amp;ssl=1 2048w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Gelatin-Methacrylate-1.jpg?resize=150%2C50&amp;ssl=1 150w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Gelatin-Methacrylate-1.jpg?resize=700%2C232&amp;ssl=1 700w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Gelatin-Methacrylate-1.jpg?w=2440&amp;ssl=1 2440w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Gelatin-Methacrylate-1.jpg?w=3660&amp;ssl=1 3660w\" sizes=\"(max-width:767px) 700px, (max-width:7875px) 100vw, 7875px\" \/>\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"premium-blog-thumbnail-overlay\">\n\t\t\t\t\t\t\t\t<a class=\"elementor-icon\" href=\"https:\/\/rheolution.com\/fr\/notes-application\/gelma-hydrogels\/\" target=\"_blank\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-screen-only\">Hydrogels GelMA<\/span>\n\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"premium-blog-content-wrapper \">\n\n\t\t\t\t\t<div class=\"premium-blog-inner-container\">\n\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<h4 class=\"premium-blog-entry-title\">\n\t\t\t<a href=\"https:\/\/rheolution.com\/fr\/notes-application\/gelma-hydrogels\/\" target=\"_blank\">\n\t\t\t\tHydrogels GelMA\t\t\t<\/a>\n\t\t<\/h4>\n\t\t\t\t<div class=\"premium-blog-entry-meta\">\n\t\t\t\n\t\t\t\n\t\t\t\n\t\t\t\t\t<\/div>\n\t\t\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t<div class=\"premium-blog-content-inner-wrapper\">\n\t\t<p class=\"premium-blog-post-content\">La g\u00e9latine m\u00e9thacryloyle (GelMA) est un hydrogel photor\u00e9ticulable d\u00e9riv\u00e9 de la g\u00e9latine, elle-m\u00eame obtenue par hydrolyse partielle du collag\u00e8ne, la principale prot\u00e9ine structurelle de la matrice extracellulaire (MEC). Le GelMA est synth\u00e9tis\u00e9 par r\u00e9action de la g\u00e9latine avec de l'anhydride m\u00e9thacrylique, ce qui permet d'introduire des groupes fonctionnels m\u00e9thacryloyle sur les r\u00e9sidus d'acides amin\u00e9s de la g\u00e9latine tout en pr\u00e9servant la plupart de ses motifs bioactifs natifs.<\/p><div class=\"premium-blog-excerpt-link-wrap\"><a href=\"https:\/\/rheolution.com\/fr\/notes-application\/gelma-hydrogels\/\" target=\"_blank\" class=\"premium-blog-excerpt-link elementor-button\">Lire la suite \u00bb<\/a><\/div>\t\t<\/div>\n\t\t\t\t\t\t\t\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\n\t\t\t\t<div class=\"premium-blog-post-outer-container\" data-total=\"3\">\n\t\t\t<div class=\"premium-blog-post-container premium-blog-skin-classic\">\n\t\t\t\t\t\t\t\t\t<div class=\"premium-blog-thumb-effect-wrapper\">\n\t\t\t\t\t\t<div class=\"premium-blog-thumbnail-container premium-blog-zoomin-effect\">\n\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"7875\" height=\"2612\" src=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Polydimethylsiloxane-PDMS-1.jpg?fit=7875%2C2612&amp;ssl=1\" class=\"attachment-full size-full wp-image-63388\" alt=\"\" data-attachment-id=\"63388\" data-permalink=\"https:\/\/rheolution.com\/fr\/polydimethylsiloxane-pdms-2-2\/\" data-orig-file=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Polydimethylsiloxane-PDMS-1.jpg?fit=7875%2C2612&amp;ssl=1\" data-orig-size=\"7875,2612\" data-comments-opened=\"1\" data-image-title=\"Polydimethylsiloxane (PDMS)\" data-image-description=\"\" data-image-caption=\"\" data-large-file=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Polydimethylsiloxane-PDMS-1.jpg?fit=1024%2C340&amp;ssl=1\" srcset=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Polydimethylsiloxane-PDMS-1.jpg?w=7875&amp;ssl=1 7875w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Polydimethylsiloxane-PDMS-1.jpg?resize=300%2C100&amp;ssl=1 300w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Polydimethylsiloxane-PDMS-1.jpg?resize=1024%2C340&amp;ssl=1 1024w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Polydimethylsiloxane-PDMS-1.jpg?resize=768%2C255&amp;ssl=1 768w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Polydimethylsiloxane-PDMS-1.jpg?resize=1536%2C509&amp;ssl=1 1536w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Polydimethylsiloxane-PDMS-1.jpg?resize=2048%2C679&amp;ssl=1 2048w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Polydimethylsiloxane-PDMS-1.jpg?resize=150%2C50&amp;ssl=1 150w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Polydimethylsiloxane-PDMS-1.jpg?resize=700%2C232&amp;ssl=1 700w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Polydimethylsiloxane-PDMS-1.jpg?w=2440&amp;ssl=1 2440w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Polydimethylsiloxane-PDMS-1.jpg?w=3660&amp;ssl=1 3660w\" sizes=\"(max-width:767px) 700px, (max-width:7875px) 100vw, 7875px\" \/>\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"premium-blog-thumbnail-overlay\">\n\t\t\t\t\t\t\t\t<a class=\"elementor-icon\" href=\"https:\/\/rheolution.com\/fr\/notes-application\/polymeres-pdms\/\" target=\"_blank\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-screen-only\">Polym\u00e8res PDMS<\/span>\n\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"premium-blog-content-wrapper \">\n\n\t\t\t\t\t<div class=\"premium-blog-inner-container\">\n\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<h4 class=\"premium-blog-entry-title\">\n\t\t\t<a href=\"https:\/\/rheolution.com\/fr\/notes-application\/polymeres-pdms\/\" target=\"_blank\">\n\t\t\t\tPolym\u00e8res PDMS\t\t\t<\/a>\n\t\t<\/h4>\n\t\t\t\t<div class=\"premium-blog-entry-meta\">\n\t\t\t\n\t\t\t\n\t\t\t\n\t\t\t\t\t<\/div>\n\t\t\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t<div class=\"premium-blog-content-inner-wrapper\">\n\t\t<p class=\"premium-blog-post-content\">Le polydim\u00e9thylsiloxane (PDMS) est un polym\u00e8re polysiloxane synth\u00e9tique compos\u00e9 d\u2019un squelette siloxane inorganique souple (\u2013Si\u2013O\u2013Si\u2013) comportant des groupes lat\u00e9raux m\u00e9thyle. Cette architecture inorganique-organique unique conf\u00e8re au PDMS une mobilit\u00e9 de cha\u00eene exceptionnelle, une tr\u00e8s basse temp\u00e9rature de transition vitreuse et un comportement \u00e9lastom\u00e8re stable sur une large plage de temp\u00e9ratures. Le PDMS est produit exclusivement par synth\u00e8se industrielle, impliquant g\u00e9n\u00e9ralement l\u2019hydrolyse et la condensation de chlorosilanes, suivies d\u2019une polym\u00e9risation par ouverture de cycle de siloxanes cycliques.<\/p><div class=\"premium-blog-excerpt-link-wrap\"><a href=\"https:\/\/rheolution.com\/fr\/notes-application\/polymeres-pdms\/\" target=\"_blank\" class=\"premium-blog-excerpt-link elementor-button\">Lire la suite \u00bb<\/a><\/div>\t\t<\/div>\n\t\t\t\t\t\t\t\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\n\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div class=\"premium-blog-footer\">\n\t\t\t\t\t\t\t<nav class=\"premium-blog-pagination-container\" role=\"navigation\" aria-label=\"Pagination\">\n\t\t\t\t<span aria-current=\"page\" class=\"page-numbers current\">1<\/span>\n<a class=\"page-numbers\" href=\"https:\/\/rheolution.com\/fr\/wp-json\/wp\/v2\/posts\/65395\/page\/2\/\">2<\/a>\n<a class=\"page-numbers\" href=\"https:\/\/rheolution.com\/fr\/wp-json\/wp\/v2\/posts\/65395\/page\/3\/\">3<\/a>\n<a class=\"next page-numbers\" href=\"https:\/\/rheolution.com\/fr\/wp-json\/wp\/v2\/posts\/65395\/page\/2\/\">Suivant \u00bb<\/a>\t\t\t<\/nav>\n\t\t\t\t\t\t<\/div>\n\t\t\n\t\t\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Le polydim\u00e9thylsiloxane (PDMS) est un polym\u00e8re polysiloxane synth\u00e9tique compos\u00e9 d\u2019un squelette siloxane inorganique souple (\u2013Si\u2013O\u2013Si\u2013) comportant des groupes lat\u00e9raux m\u00e9thyle. Cette architecture inorganique-organique unique conf\u00e8re au PDMS une mobilit\u00e9 de cha\u00eene exceptionnelle, une tr\u00e8s basse temp\u00e9rature de transition vitreuse et un comportement \u00e9lastom\u00e8re stable sur une large plage de temp\u00e9ratures. Le PDMS est produit exclusivement par synth\u00e8se industrielle, impliquant g\u00e9n\u00e9ralement l\u2019hydrolyse et la condensation de chlorosilanes, suivies d\u2019une polym\u00e9risation par ouverture de cycle de siloxanes cycliques.  <\/p>\n","protected":false},"author":195401359,"featured_media":63388,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_wpcom_ai_launchpad_first_post":false,"_jetpack_hide_featured_image":false,"_jetpack_featured_image_duplicate_dismissed":0,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_post_was_ever_published":false},"categories":[285,333],"tags":[89,124,88,261],"class_list":["post-65395","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-notes-application","category-polymer-library","tag-elastosens-bio","tag-life-sciences","tag-mechanical-testing","tag-polymer"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.7 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