{"id":64834,"date":"2026-01-22T16:55:30","date_gmt":"2026-01-22T21:55:30","guid":{"rendered":"https:\/\/rheolution.com\/?p=64834"},"modified":"2026-08-14T10:11:44","modified_gmt":"2026-08-14T14:11:44","slug":"polymeres-pga","status":"publish","type":"post","link":"https:\/\/rheolution.com\/fr\/notes-application\/polymeres-pga\/","title":{"rendered":"Polym\u00e8res PGA"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"64834\" class=\"elementor elementor-64834 elementor-63282\" data-elementor-post-type=\"post\">\n\t\t\t\t<div class=\"elementor-element elementor-element-8fd4dcf e-flex e-con-boxed e-con e-parent\" data-id=\"8fd4dcf\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-8c770e2 elementor-widget elementor-widget-heading\" data-id=\"8c770e2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h6 class=\"elementor-heading-title elementor-size-default\">Note d\u2019application | ElastoSens\u2122 Bio<\/h6>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-760ae40 elementor-widget elementor-widget-heading\" data-id=\"760ae40\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Polym\u00e8res PGA&nbsp;: propri\u00e9t\u00e9s, applications et comportement m\u00e9canique<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-16057f6 elementor-widget elementor-widget-text-editor\" data-id=\"16057f6\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>par <a href=\"https:\/\/www.linkedin.com\/in\/mayasalame\/\">Maya Salame<\/a> et <a href=\"https:\/\/www.linkedin.com\/in\/dimitria-camas%C3%A3o-049002a2\/\">Dimitria Camasao<\/a><\/p><p>Scientifiques d\u2019application<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-97ac8de e-flex e-con-boxed e-con e-parent\" data-id=\"97ac8de\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-5fc8fde elementor-widget__width-initial elementor-widget-mobile__width-inherit elementor-widget elementor-widget-heading\" data-id=\"5fc8fde\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Qu'est-ce que le polym\u00e8re PGA&nbsp;?<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d61237b elementor-widget elementor-widget-text-editor\" data-id=\"d61237b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400\">L&rsquo;acide polyglycolique (PGA) est un polyester aliphatique synth\u00e9tique appartenant \u00e0 la famille des poly(\u03b1-hydroxyacides). Enti\u00e8rement produit par synth\u00e8se chimique industrielle, il est caract\u00e9ris\u00e9 par une unit\u00e9 d&rsquo;acide glycolique simple et r\u00e9p\u00e9titive, li\u00e9e par des liaisons ester. Le PGA est hautement cristallin et hydrophile, des caract\u00e9ristiques qui le distinguent des polyesters biod\u00e9gradables apparent\u00e9s tels que le PLA et le PLGA. Son produit de d\u00e9gradation, l&rsquo;acide glycolique, est un m\u00e9tabolite naturel pouvant \u00eatre m\u00e9tabolis\u00e9 par les voies physiologiques normales.   <\/span><\/p><p><span style=\"font-weight: 400\">Le PGA est synth\u00e9tis\u00e9 \u00e0 partir d&rsquo;acide glycolique ou de son dim\u00e8re cyclique, le glycolide. Du fait de sa tendance \u00e0 se d\u00e9grader et de sa faible solubilit\u00e9, la production de PGA de haut poids mol\u00e9culaire est techniquement complexe et a conduit au d\u00e9veloppement de multiples strat\u00e9gies de polym\u00e9risation adapt\u00e9es \u00e0 l&rsquo;obtention de performances m\u00e9caniques suffisantes pour les applications biom\u00e9dicales. <\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5703c6a elementor-widget__width-initial elementor-widget-mobile__width-inherit elementor-widget elementor-widget-heading\" data-id=\"5703c6a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Propri\u00e9t\u00e9s cl\u00e9s des polym\u00e8res PGA<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5a0b64a elementor-widget elementor-widget-heading\" data-id=\"5a0b64a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Caract\u00e9ristiques physico-chimiques<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-454b0e3 elementor-widget elementor-widget-text-editor\" data-id=\"454b0e3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400\">La formation du PGA repose sur des m\u00e9canismes de polym\u00e9risation par \u00e9tapes ou par ouverture de cycle, les propri\u00e9t\u00e9s finales d\u00e9pendant fortement du poids mol\u00e9culaire et de la cristallinit\u00e9.<\/span><\/p><p><b>Les voies de polym\u00e9risation et de synth\u00e8se comprennent&nbsp;:<\/b><\/p><ul><li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Polym\u00e9risation par ouverture de cycle du glycolide.<\/span><\/li><li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Polycondensation directe de l&rsquo;acide glycolique.<\/span><\/li><li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Polycondensation az\u00e9otropique pour \u00e9liminer l&rsquo;eau pendant la synth\u00e8se.<\/span><\/li><li style=\"font-weight: 400\">Polycondensation \u00e0 l&rsquo;\u00e9tat solide des halog\u00e9noac\u00e9tates.<\/li><li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Voies de polym\u00e9risation catalys\u00e9es par un acide ou une enzyme.<\/span><\/li><\/ul><p><span style=\"font-weight: 400\">Le PGA pr\u00e9sente une cristallinit\u00e9 \u00e9lev\u00e9e (g\u00e9n\u00e9ralement de 45 \u00e0 55 %), une temp\u00e9rature de transition vitreuse proche de la temp\u00e9rature physiologique et un point de fusion \u00e9lev\u00e9. Son empilement mol\u00e9culaire dense limite sa solubilit\u00e9 dans la plupart des solvants organiques courants, ce qui influe sur sa mise en \u0153uvre et sa caract\u00e9risation. <\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-30981bc elementor-widget elementor-widget-heading\" data-id=\"30981bc\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Propri\u00e9t\u00e9s m\u00e9caniques<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4476bec elementor-widget elementor-widget-text-editor\" data-id=\"4476bec\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400\">Le PGA est l&rsquo;un des polyesters biod\u00e9gradables les plus rigides utilis\u00e9s dans les applications biom\u00e9dicales. Son comportement m\u00e9canique est principalement d\u00e9termin\u00e9 par sa cristallinit\u00e9 et sa masse mol\u00e9culaire. <\/span><\/p><ul><li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Module de traction et r\u00e9sistance \u00e0 la traction \u00e9lev\u00e9s par rapport aux autres polym\u00e8res r\u00e9sorbables.<\/span><\/li><li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Faible allongement \u00e0 la rupture d\u00fb \u00e0 sa structure cristalline.<\/span><\/li><li style=\"font-weight: 400\"><span style=\"font-weight: 400\">La stabilit\u00e9 m\u00e9canique augmente avec le poids mol\u00e9culaire et la cristallinit\u00e9.<\/span><\/li><li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Perte rapide d&rsquo;int\u00e9grit\u00e9 m\u00e9canique lors de la d\u00e9gradation hydrolytique.<\/span><\/li><\/ul><p><span style=\"font-weight: 400\">\u00c0 mesure que la d\u00e9gradation progresse, le PGA subit une \u00e9rosion massive, entra\u00eenant une diminution rapide de sa rigidit\u00e9 et de sa r\u00e9sistance, souvent en quelques semaines dans des conditions physiologiques.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0959975 elementor-widget elementor-widget-heading\" data-id=\"0959975\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Interactions biologiques<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-62fefea elementor-widget elementor-widget-text-editor\" data-id=\"62fefea\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400\">Le PGA est g\u00e9n\u00e9ralement consid\u00e9r\u00e9 comme biocompatible et bior\u00e9sorbable.<\/span><\/p><ul><li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Se d\u00e9grade principalement par clivage hydrolytique des liaisons ester.<\/span><\/li><li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Peut \u00e9galement subir une d\u00e9gradation enzymatique en pr\u00e9sence d&rsquo;est\u00e9rases.<\/span><\/li><li style=\"font-weight: 400\"><span style=\"font-weight: 400\">La d\u00e9gradation produit de l&rsquo;acide glycolique, qui p\u00e9n\u00e8tre dans les voies m\u00e9taboliques.<\/span><\/li><li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Une d\u00e9gradation rapide peut localement diminuer le pH et d\u00e9clencher des r\u00e9actions inflammatoires.<\/span><\/li><\/ul><p><span style=\"font-weight: 400\">L&rsquo;adh\u00e9rence cellulaire au PGA est g\u00e9n\u00e9ralement limit\u00e9e sans modification de surface, et les r\u00e9ponses biologiques sont fortement influenc\u00e9es par l&rsquo;architecture de l&rsquo;\u00e9chafaudage, le taux de d\u00e9gradation et les sous-produits.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-28004d8 elementor-widget__width-initial elementor-widget-mobile__width-inherit elementor-widget elementor-widget-heading\" data-id=\"28004d8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Applications des polym\u00e8res PGA<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-06adff0 elementor-widget elementor-widget-heading\" data-id=\"06adff0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Ing\u00e9nierie tissulaire<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ba2f1b1 elementor-widget elementor-widget-text-editor\" data-id=\"ba2f1b1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400\">Le PGA est largement utilis\u00e9 comme mat\u00e9riau d&rsquo;\u00e9chafaudage temporaire en ing\u00e9nierie tissulaire en raison de sa r\u00e9sistance m\u00e9canique initiale \u00e9lev\u00e9e et de sa biod\u00e9gradation pr\u00e9visible. Il est employ\u00e9 dans la fabrication d&rsquo;\u00e9chafaudages pour les os, le cartilage, les tendons, les ligaments, les vaisseaux sanguins et les tissus mous, souvent sous forme de fibres ou de mailles non tiss\u00e9es. Les \u00e9chafaudages en PGA sont fr\u00e9quemment associ\u00e9s \u00e0 d&rsquo;autres polym\u00e8res ou rev\u00eatements afin de ralentir leur d\u00e9gradation et d&rsquo;am\u00e9liorer l&rsquo;adh\u00e9rence cellulaire, tout en pr\u00e9servant leur int\u00e9grit\u00e9 structurelle durant les premi\u00e8res phases de la r\u00e9g\u00e9n\u00e9ration tissulaire.  <\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d01f123 elementor-widget elementor-widget-heading\" data-id=\"d01f123\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Culture cellulaire 3D et mod\u00e8les de maladies<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-137d5ec elementor-widget elementor-widget-text-editor\" data-id=\"137d5ec\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400\">Dans les syst\u00e8mes de culture tridimensionnels, les mailles de fibres de PGA et les \u00e9chafaudages poreux ont \u00e9t\u00e9 utilis\u00e9s pour favoriser l&rsquo;organisation cellulaire et la formation de structures tissulaires. Sa d\u00e9gradation rapide rend le PGA particuli\u00e8rement adapt\u00e9 aux mod\u00e8les de culture \u00e0 court terme o\u00f9 le remplacement de l&rsquo;\u00e9chafaudage par une matrice extracellulaire nouvellement synth\u00e9tis\u00e9e est souhait\u00e9. Les structures \u00e0 base de PGA ont \u00e9t\u00e9 \u00e9tudi\u00e9es pour analyser le d\u00e9veloppement et le remodelage tissulaires dans des environnements m\u00e9caniques dynamiques.  <\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c1cb3eb elementor-widget elementor-widget-heading\" data-id=\"c1cb3eb\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">D\u00e9livrance de m\u00e9dicaments, de g\u00e8nes et de cellules<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ac87f2a elementor-widget elementor-widget-text-editor\" data-id=\"ac87f2a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400\">Le PGA est utilis\u00e9 dans les syst\u00e8mes de lib\u00e9ration contr\u00f4l\u00e9e, notamment comme sutures r\u00e9sorbables et vecteurs temporaires d&rsquo;agents bioactifs. La lib\u00e9ration du m\u00e9dicament \u00e0 partir des matrices de PGA est r\u00e9gie par la d\u00e9gradation du polym\u00e8re, sa cristallinit\u00e9 et la distribution des masses mol\u00e9culaires. Bien que son hydrolyse rapide limite les applications \u00e0 lib\u00e9ration prolong\u00e9e, le PGA demeure pr\u00e9cieux pour les lib\u00e9rations de courte dur\u00e9e et comme composant de syst\u00e8mes de lib\u00e9ration composites.  <\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-892f73a elementor-widget__width-initial elementor-widget-mobile__width-inherit elementor-widget elementor-widget-heading\" data-id=\"892f73a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Pourquoi la visco\u00e9lasticit\u00e9 des polym\u00e8res PGA est importante<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-05c6bea elementor-widget elementor-widget-text-editor\" data-id=\"05c6bea\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400\">Bien que le PGA soit souvent per\u00e7u comme un polym\u00e8re rigide, son comportement visco\u00e9lastique \u00e9volue consid\u00e9rablement au fil du temps en raison de sa d\u00e9gradation. Les variations de rigidit\u00e9, d&rsquo;amortissement et de relaxation m\u00e9canique influent directement sur le transfert de charge, la stabilit\u00e9 de l&rsquo;\u00e9chafaudage et la r\u00e9ponse tissulaire. Le suivi des propri\u00e9t\u00e9s visco\u00e9lastiques est essentiel pour comprendre le comportement des structures \u00e0 base de PGA lors de l&rsquo;implantation, de la r\u00e9g\u00e9n\u00e9ration tissulaire ou de la culture in vitro, d&rsquo;autant plus que leur int\u00e9grit\u00e9 m\u00e9canique diminue rapidement avec l&rsquo;hydrolyse.  <\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-851f298 elementor-widget__width-initial elementor-widget-mobile__width-inherit elementor-widget elementor-widget-heading\" data-id=\"851f298\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">M\u00e9thodes de caract\u00e9risation de la visco\u00e9lasticit\u00e9 des polym\u00e8res PGA<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-171be53 elementor-widget elementor-widget-text-editor\" data-id=\"171be53\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400\">La caract\u00e9risation m\u00e9canique du PGA repose g\u00e9n\u00e9ralement sur des techniques destructives ou bas\u00e9es sur le contact, telles que&nbsp;:<\/span><\/p><ul><li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Essais de traction<\/span><\/li><li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Essais de compression<\/span><\/li><li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Analyse m\u00e9canique dynamique<\/span><\/li><li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Rh\u00e9om\u00e9trie conventionnelle pour les formes fondues ou transform\u00e9es<\/span><\/li><\/ul><p><span style=\"font-weight: 400\">Ces m\u00e9thodes n\u00e9cessitent souvent la destruction de l&rsquo;\u00e9chantillon, offrent une r\u00e9solution temporelle limit\u00e9e et sont mal adapt\u00e9es au suivi de la d\u00e9gradation ou de l&rsquo;\u00e9volution m\u00e9canique en milieux hydrat\u00e9s ou st\u00e9riles. De ce fait, elles ne fournissent que des mesures ponctuelles, et non une vision continue du comportement au cours du temps. <\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1961b9f elementor-widget__width-initial elementor-widget-mobile__width-inherit elementor-widget elementor-widget-heading\" data-id=\"1961b9f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">ElastoSens\u2122 Bio&nbsp;: un outil non destructif pour mesurer les polym\u00e8res PGA souples<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-5a225c3 e-grid e-con-full e-con e-child\" data-id=\"5a225c3\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ce43e5b elementor-widget elementor-widget-text-editor\" data-id=\"ce43e5b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400\"><a href=\"https:\/\/rheolution.com\/instrument-elastosensbio\/\" target=\"_blank\" rel=\"noopener\"><strong>ElastoSens\u2122 Bio<\/strong><\/a><\/span> <span style=\"font-weight: 400\">est un instrument bas\u00e9 sur la r\u00e9sonance con\u00e7u pour la caract\u00e9risation visco\u00e9lastique non destructive des syst\u00e8mes polym\u00e8res souples et \u00e9volutifs.<\/span><\/p><ul><li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Mesure le module de cisaillement en temps r\u00e9el sans contact ni endommagement de l&rsquo;\u00e9chantillon.<\/span><\/li><li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Tr\u00e8s sensible et reproductible, elle convient \u00e0 la d\u00e9tection des changements m\u00e9caniques \u00e0 un stade pr\u00e9coce.<\/span><\/li><li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Permet une surveillance continue de l&rsquo;\u00e9volution m\u00e9canique du PGA pendant sa d\u00e9gradation.<\/span><\/li><li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Permet des mesures r\u00e9p\u00e9t\u00e9es sur le m\u00eame \u00e9chantillon dans des conditions hydrat\u00e9es ou st\u00e9riles.<\/span><\/li><li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Compatible avec les processus dynamiques tels que la polym\u00e9risation ou la relaxation structurale.<\/span><\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-045aef9 elementor-widget elementor-widget-image\" data-id=\"045aef9\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"968\" height=\"544\" src=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/elastosens2-1.webp?fit=968%2C544&amp;ssl=1\" class=\"attachment-large size-large wp-image-50364\" alt=\"\" srcset=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/elastosens2-1.webp?w=968&amp;ssl=1 968w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/elastosens2-1.webp?resize=300%2C169&amp;ssl=1 300w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/elastosens2-1.webp?resize=768%2C432&amp;ssl=1 768w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/elastosens2-1.webp?resize=133%2C75&amp;ssl=1 133w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/elastosens2-1.webp?resize=480%2C270&amp;ssl=1 480w\" sizes=\"(max-width:767px) 700px, (max-width:968px) 100vw, 968px\" data-attachment-id=\"50364\" data-permalink=\"https:\/\/rheolution.com\/fr\/elastosens2-4-2-2-2\/\" data-orig-file=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/elastosens2-1.webp?fit=968%2C544&amp;ssl=1\" data-orig-size=\"968,544\" data-comments-opened=\"1\" data-image-title=\"elastosens2\" data-image-description=\"\" data-image-caption=\"\" data-large-file=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/elastosens2-1.webp?fit=968%2C544&amp;ssl=1\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4c4f175 elementor-widget elementor-widget-text-editor\" data-id=\"4c4f175\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400\">Pour les syst\u00e8mes souples \u00e0 base de PGA, ElastoSens\u2122 Bio offre un moyen puissant de capturer la perte de rigidit\u00e9 en fonction du temps et les transitions visco\u00e9lastiques qui r\u00e9gissent les performances fonctionnelles dans les applications biom\u00e9dicales et de recherche.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8ad5968 elementor-widget elementor-widget-heading\" data-id=\"8ad5968\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Conclusions et perspectives<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b86e41a elementor-widget elementor-widget-text-editor\" data-id=\"b86e41a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400\">Les propri\u00e9t\u00e9s m\u00e9caniques du PGA, d\u00e9termin\u00e9es par sa cristallinit\u00e9, sa masse mol\u00e9culaire et sa d\u00e9gradation rapide, sont essentielles \u00e0 son utilisation dans les syst\u00e8mes biom\u00e9dicaux et les polym\u00e8res souples. Lorsqu&rsquo;il est transform\u00e9 en structures hydrat\u00e9es, poreuses ou composites, le PGA pr\u00e9sente une \u00e9volution visco\u00e9lastique en fonction du temps qui doit \u00eatre surveill\u00e9e sans alt\u00e9rer le mat\u00e9riau ni son environnement. La caract\u00e9risation visco\u00e9lastique non destructive avec l&rsquo;ElastoSens\u2122 Bio permet&nbsp;:  <\/span><\/p><ul><li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Mesures de haute sensibilit\u00e9 et r\u00e9p\u00e9tables, adapt\u00e9es aux syst\u00e8mes souples et \u00e9volutifs \u00e0 base de PGA.<\/span><\/li><li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Suivi en temps r\u00e9el de la formation des polym\u00e8res ou de la stabilisation structurale pr\u00e9coce.<\/span><\/li><li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Identification des transitions d&rsquo;un comportement de type liquide \u00e0 un comportement de type solide, le cas \u00e9ch\u00e9ant.<\/span><\/li><li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Quantification de la rigidit\u00e9 terminale et de la d\u00e9gradation m\u00e9canique au cours de la d\u00e9gradation.<\/span><\/li><li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Tests longitudinaux du m\u00eame \u00e9chantillon au fil du temps, y compris dans des conditions st\u00e9riles.<\/span><\/li><\/ul><p><span style=\"font-weight: 400\">Ensemble, ces capacit\u00e9s permettent une meilleure compr\u00e9hension des relations structure-propri\u00e9t\u00e9s du PGA et un meilleur contr\u00f4le de ses performances m\u00e9caniques dans la recherche et les applications biom\u00e9dicales.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-794c36a elementor-widget elementor-widget-heading\" data-id=\"794c36a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">R\u00e9f\u00e9rences<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-27340c7 elementor-widget elementor-widget-text-editor\" data-id=\"27340c7\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><a href=\"https:\/\/link.springer.com\/article\/10.1007\/s10965-020-02187-1\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400\">Budak, K., Sogut, O., &amp; Aydemir Sezer, U. (2020). A review on synthesis and biomedical applications of polyglycolic acid.  <\/span><i><span style=\"font-weight: 400\">Journal of polymer research<\/span><\/i><span style=\"font-weight: 400\">, <\/span><i><span style=\"font-weight: 400\">27<\/span><\/i><span style=\"font-weight: 400\">(8), 208.<\/span><\/a><\/p><p><a href=\"https:\/\/4spepublications.onlinelibrary.wiley.com\/doi\/10.1002\/pen.25508\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400\">Low, Y. J., Andriyana, A., Ang, B. C., &amp; Zainal Abidin, N. I. (2020). Bioresorbable and degradable behaviors of PGA: Current state and future prospects.  <\/span><i><span style=\"font-weight: 400\">Polymer Engineering &amp; Science<\/span><\/i><span style=\"font-weight: 400\">, <\/span><i><span style=\"font-weight: 400\">60<\/span><\/i><span style=\"font-weight: 400\">(11), 2657-2675.<\/span><\/a><\/p><p><a href=\"https:\/\/www.mdpi.com\/1996-1944\/17\/1\/15\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400\">Cai, M., Han, Y., Zheng, X., Xue, B., Zhang, X., Mahmut, Z., &#8230; &amp; Sun, J. (2024). Synthesis of poly-\u03b3-glutamic acid and its application in biomedical materials.  <\/span><i><span style=\"font-weight: 400\">Materials<\/span><\/i><span style=\"font-weight: 400\">, <\/span><i><span style=\"font-weight: 400\">17<\/span><\/i><span style=\"font-weight: 400\">(1), 15.<\/span><\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9383078 elementor-widget__width-initial elementor-widget-mobile__width-inherit elementor--h-position-center elementor--v-position-middle elementor-arrows-position-inside elementor-widget elementor-widget-slides\" data-id=\"9383078\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;navigation&quot;:&quot;arrows&quot;,&quot;autoplay_speed&quot;:4000,&quot;transition_speed&quot;:4000,&quot;autoplay&quot;:&quot;yes&quot;,&quot;pause_on_hover&quot;:&quot;yes&quot;,&quot;pause_on_interaction&quot;:&quot;yes&quot;,&quot;infinite&quot;:&quot;yes&quot;,&quot;transition&quot;:&quot;slide&quot;}\" data-widget_type=\"slides.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-swiper\">\n\t\t\t\t\t<div class=\"elementor-slides-wrapper elementor-main-swiper swiper\" role=\"region\" aria-roledescription=\"carousel\" aria-label=\"Slides\" dir=\"ltr\" data-animation=\"fadeInUp\">\n\t\t\t\t<div class=\"swiper-wrapper elementor-slides\">\n\t\t\t\t\t\t\t\t\t\t<div class=\"elementor-repeater-item-c97f30c swiper-slide\" role=\"group\" aria-roledescription=\"slide\"><div class=\"swiper-slide-bg\" role=\"img\" aria-label=\"elastosens2\"><\/div><div class=\"swiper-slide-inner\" ><div class=\"swiper-slide-contents\"><\/div><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8cce0c6 elementor-widget__width-initial elementor-widget-mobile__width-inherit elementor-widget elementor-widget-text-editor\" data-id=\"8cce0c6\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>D\u00e9couvrez comment notre technologie mesure de mani\u00e8re non destructive les propri\u00e9t\u00e9s visco\u00e9lastiques des biomat\u00e9riaux mous et des tissus en utilisant des micro-volumes d\u2019\u00e9chantillons<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c4ce1d0 elementor-align-center elementor-widget elementor-widget-button\" data-id=\"c4ce1d0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/rheolution.com\/contact\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Contactez-nous pour plus d'informations<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-efbb293 elementor-widget elementor-widget-heading\" data-id=\"efbb293\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Articles connexes<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element 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data-image-title=\"FIBRIN\" data-image-description=\"\" data-image-caption=\"\" data-large-file=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/FIBRIN.jpg?fit=1024%2C340&amp;ssl=1\" srcset=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/FIBRIN.jpg?w=7000&amp;ssl=1 7000w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/FIBRIN.jpg?resize=300%2C100&amp;ssl=1 300w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/FIBRIN.jpg?resize=1024%2C340&amp;ssl=1 1024w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/FIBRIN.jpg?resize=768%2C255&amp;ssl=1 768w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/FIBRIN.jpg?resize=1536%2C510&amp;ssl=1 1536w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/FIBRIN.jpg?resize=2048%2C679&amp;ssl=1 2048w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/FIBRIN.jpg?resize=150%2C50&amp;ssl=1 150w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/FIBRIN.jpg?resize=700%2C232&amp;ssl=1 700w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/FIBRIN.jpg?w=2440&amp;ssl=1 2440w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/FIBRIN.jpg?w=3660&amp;ssl=1 3660w\" sizes=\"(max-width:767px) 700px, (max-width:7000px) 100vw, 7000px\" \/>\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"premium-blog-thumbnail-overlay\">\n\t\t\t\t\t\t\t\t<a class=\"elementor-icon\" href=\"https:\/\/rheolution.com\/fr\/notes-application\/hydrogels-de-fibrine\/\" target=\"_blank\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-screen-only\">Hydrogels de fibrine<\/span>\n\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"premium-blog-content-wrapper \">\n\n\t\t\t\t\t<div class=\"premium-blog-inner-container\">\n\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<h4 class=\"premium-blog-entry-title\">\n\t\t\t<a href=\"https:\/\/rheolution.com\/fr\/notes-application\/hydrogels-de-fibrine\/\" target=\"_blank\">\n\t\t\t\tHydrogels de fibrine\t\t\t<\/a>\n\t\t<\/h4>\n\t\t\t\t<div class=\"premium-blog-entry-meta\">\n\t\t\t\n\t\t\t\n\t\t\t\n\t\t\t\t\t<\/div>\n\t\t\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t<div class=\"premium-blog-content-inner-wrapper\">\n\t\t<p class=\"premium-blog-post-content\">Les hydrogels de fibrine sont des biomat\u00e9riaux naturels \u00e0 base de prot\u00e9ines, form\u00e9s \u00e0 partir de la fibrine, ce polym\u00e8re insoluble g\u00e9n\u00e9r\u00e9 lors de la coagulation sanguine. La fibrine provient du fibrinog\u00e8ne, une glycoprot\u00e9ine plasmatique compos\u00e9e de trois paires de cha\u00eenes polypeptidiques qui s\u2019assemblent en un r\u00e9seau fibreux sous l\u2019effet d\u2019une activation enzymatique. Dans des conditions physiologiques, la formation de la fibrine est d\u00e9clench\u00e9e par le clivage du fibrinog\u00e8ne sous l\u2019action de la thrombine, ce qui expose des sites de polym\u00e9risation qui favorisent l\u2019auto-assemblage spontan\u00e9 en une matrice hydrat\u00e9e et poreuse.<\/p><div class=\"premium-blog-excerpt-link-wrap\"><a href=\"https:\/\/rheolution.com\/fr\/notes-application\/hydrogels-de-fibrine\/\" target=\"_blank\" class=\"premium-blog-excerpt-link elementor-button\">Lire la suite \u00bb<\/a><\/div>\t\t<\/div>\n\t\t\t\t\t\t\t\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\n\t\t\t\t<div class=\"premium-blog-post-outer-container\" data-total=\"3\">\n\t\t\t<div class=\"premium-blog-post-container premium-blog-skin-classic\">\n\t\t\t\t\t\t\t\t\t<div class=\"premium-blog-thumb-effect-wrapper\">\n\t\t\t\t\t\t<div class=\"premium-blog-thumbnail-container premium-blog-zoomin-effect\">\n\t\t\t\t\t\t\t<img decoding=\"async\" width=\"7000\" height=\"2322\" src=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/ALGINATE-1.jpg?fit=7000%2C2322&amp;ssl=1\" class=\"attachment-full size-full wp-image-63128\" alt=\"\" data-attachment-id=\"63128\" data-permalink=\"https:\/\/rheolution.com\/fr\/alginate-2-2\/\" data-orig-file=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/ALGINATE-1.jpg?fit=7000%2C2322&amp;ssl=1\" data-orig-size=\"7000,2322\" data-comments-opened=\"1\" data-image-title=\"ALGINATE\" data-image-description=\"\" data-image-caption=\"\" data-large-file=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/ALGINATE-1.jpg?fit=1024%2C340&amp;ssl=1\" srcset=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/ALGINATE-1.jpg?w=7000&amp;ssl=1 7000w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/ALGINATE-1.jpg?resize=300%2C100&amp;ssl=1 300w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/ALGINATE-1.jpg?resize=1024%2C340&amp;ssl=1 1024w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/ALGINATE-1.jpg?resize=768%2C255&amp;ssl=1 768w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/ALGINATE-1.jpg?resize=1536%2C510&amp;ssl=1 1536w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/ALGINATE-1.jpg?resize=2048%2C679&amp;ssl=1 2048w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/ALGINATE-1.jpg?resize=150%2C50&amp;ssl=1 150w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/ALGINATE-1.jpg?resize=700%2C232&amp;ssl=1 700w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/ALGINATE-1.jpg?w=2440&amp;ssl=1 2440w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/ALGINATE-1.jpg?w=3660&amp;ssl=1 3660w\" sizes=\"(max-width:767px) 700px, (max-width:7000px) 100vw, 7000px\" \/>\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"premium-blog-thumbnail-overlay\">\n\t\t\t\t\t\t\t\t<a class=\"elementor-icon\" href=\"https:\/\/rheolution.com\/fr\/notes-application\/hydrogels-dalginate\/\" target=\"_blank\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-screen-only\">Hydrogels d&rsquo;alginate<\/span>\n\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"premium-blog-content-wrapper \">\n\n\t\t\t\t\t<div class=\"premium-blog-inner-container\">\n\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<h4 class=\"premium-blog-entry-title\">\n\t\t\t<a href=\"https:\/\/rheolution.com\/fr\/notes-application\/hydrogels-dalginate\/\" target=\"_blank\">\n\t\t\t\tHydrogels d&rsquo;alginate\t\t\t<\/a>\n\t\t<\/h4>\n\t\t\t\t<div class=\"premium-blog-entry-meta\">\n\t\t\t\n\t\t\t\n\t\t\t\n\t\t\t\t\t<\/div>\n\t\t\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t<div class=\"premium-blog-content-inner-wrapper\">\n\t\t<p class=\"premium-blog-post-content\">Les hydrogels d'alginate sont des r\u00e9seaux polym\u00e8res tridimensionnels riches en eau, d\u00e9riv\u00e9s de l'alginate, un polysaccharide anionique d'origine naturelle. L'alginate est principalement extrait des parois cellulaires des algues brunes appartenant \u00e0 la classe des ph\u00e9ophyc\u00e9es, bien qu'il puisse \u00e9galement \u00eatre biosynth\u00e9tis\u00e9 par certaines esp\u00e8ces bact\u00e9riennes telles que les Azotobacter et les Pseudomonas. Sur le plan structurel, l\u2019alginate est un copolym\u00e8re lin\u00e9aire compos\u00e9 d\u2019acide \u03b2-D-mannuronique (unit\u00e9s M) et d\u2019acide \u03b1-L-guluronique (unit\u00e9s G), reli\u00e9s par des liaisons glycosidiques 1\u21924.<\/p><div class=\"premium-blog-excerpt-link-wrap\"><a href=\"https:\/\/rheolution.com\/fr\/notes-application\/hydrogels-dalginate\/\" target=\"_blank\" class=\"premium-blog-excerpt-link elementor-button\">Lire la suite \u00bb<\/a><\/div>\t\t<\/div>\n\t\t\t\t\t\t\t\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\n\t\t\t\t<div class=\"premium-blog-post-outer-container\" data-total=\"3\">\n\t\t\t<div class=\"premium-blog-post-container premium-blog-skin-classic\">\n\t\t\t\t\t\t\t\t\t<div class=\"premium-blog-thumb-effect-wrapper\">\n\t\t\t\t\t\t<div class=\"premium-blog-thumbnail-container premium-blog-zoomin-effect\">\n\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"7875\" height=\"2612\" src=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Gelatin-Methacrylate-1.jpg?fit=7875%2C2612&amp;ssl=1\" class=\"attachment-full size-full wp-image-63420\" alt=\"\" data-attachment-id=\"63420\" data-permalink=\"https:\/\/rheolution.com\/fr\/gelatin-methacrylate-2-2\/\" data-orig-file=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Gelatin-Methacrylate-1.jpg?fit=7875%2C2612&amp;ssl=1\" data-orig-size=\"7875,2612\" data-comments-opened=\"1\" data-image-title=\"Gelatin Methacrylate\" data-image-description=\"\" data-image-caption=\"\" data-large-file=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Gelatin-Methacrylate-1.jpg?fit=1024%2C340&amp;ssl=1\" srcset=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Gelatin-Methacrylate-1.jpg?w=7875&amp;ssl=1 7875w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Gelatin-Methacrylate-1.jpg?resize=300%2C100&amp;ssl=1 300w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Gelatin-Methacrylate-1.jpg?resize=1024%2C340&amp;ssl=1 1024w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Gelatin-Methacrylate-1.jpg?resize=768%2C255&amp;ssl=1 768w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Gelatin-Methacrylate-1.jpg?resize=1536%2C509&amp;ssl=1 1536w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Gelatin-Methacrylate-1.jpg?resize=2048%2C679&amp;ssl=1 2048w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Gelatin-Methacrylate-1.jpg?resize=150%2C50&amp;ssl=1 150w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Gelatin-Methacrylate-1.jpg?resize=700%2C232&amp;ssl=1 700w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Gelatin-Methacrylate-1.jpg?w=2440&amp;ssl=1 2440w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Gelatin-Methacrylate-1.jpg?w=3660&amp;ssl=1 3660w\" sizes=\"(max-width:767px) 700px, (max-width:7875px) 100vw, 7875px\" \/>\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"premium-blog-thumbnail-overlay\">\n\t\t\t\t\t\t\t\t<a class=\"elementor-icon\" href=\"https:\/\/rheolution.com\/fr\/notes-application\/gelma-hydrogels\/\" target=\"_blank\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-screen-only\">Hydrogels GelMA<\/span>\n\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"premium-blog-content-wrapper \">\n\n\t\t\t\t\t<div class=\"premium-blog-inner-container\">\n\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<h4 class=\"premium-blog-entry-title\">\n\t\t\t<a href=\"https:\/\/rheolution.com\/fr\/notes-application\/gelma-hydrogels\/\" target=\"_blank\">\n\t\t\t\tHydrogels GelMA\t\t\t<\/a>\n\t\t<\/h4>\n\t\t\t\t<div class=\"premium-blog-entry-meta\">\n\t\t\t\n\t\t\t\n\t\t\t\n\t\t\t\t\t<\/div>\n\t\t\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t<div class=\"premium-blog-content-inner-wrapper\">\n\t\t<p class=\"premium-blog-post-content\">La g\u00e9latine m\u00e9thacryloyle (GelMA) est un hydrogel photor\u00e9ticulable d\u00e9riv\u00e9 de la g\u00e9latine, elle-m\u00eame obtenue par hydrolyse partielle du collag\u00e8ne, la principale prot\u00e9ine structurelle de la matrice extracellulaire (MEC). Le GelMA est synth\u00e9tis\u00e9 par r\u00e9action de la g\u00e9latine avec de l'anhydride m\u00e9thacrylique, ce qui permet d'introduire des groupes fonctionnels m\u00e9thacryloyle sur les r\u00e9sidus d'acides amin\u00e9s de la g\u00e9latine tout en pr\u00e9servant la plupart de ses motifs bioactifs natifs.<\/p><div class=\"premium-blog-excerpt-link-wrap\"><a href=\"https:\/\/rheolution.com\/fr\/notes-application\/gelma-hydrogels\/\" target=\"_blank\" class=\"premium-blog-excerpt-link elementor-button\">Lire la suite \u00bb<\/a><\/div>\t\t<\/div>\n\t\t\t\t\t\t\t\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\n\t\t\t\t<div class=\"premium-blog-post-outer-container\" data-total=\"3\">\n\t\t\t<div class=\"premium-blog-post-container premium-blog-skin-classic\">\n\t\t\t\t\t\t\t\t\t<div class=\"premium-blog-thumb-effect-wrapper\">\n\t\t\t\t\t\t<div class=\"premium-blog-thumbnail-container premium-blog-zoomin-effect\">\n\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"7875\" height=\"2612\" src=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Polydimethylsiloxane-PDMS-1.jpg?fit=7875%2C2612&amp;ssl=1\" class=\"attachment-full size-full wp-image-63388\" alt=\"\" data-attachment-id=\"63388\" data-permalink=\"https:\/\/rheolution.com\/fr\/polydimethylsiloxane-pdms-2-2\/\" data-orig-file=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Polydimethylsiloxane-PDMS-1.jpg?fit=7875%2C2612&amp;ssl=1\" data-orig-size=\"7875,2612\" data-comments-opened=\"1\" data-image-title=\"Polydimethylsiloxane (PDMS)\" data-image-description=\"\" data-image-caption=\"\" data-large-file=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Polydimethylsiloxane-PDMS-1.jpg?fit=1024%2C340&amp;ssl=1\" srcset=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Polydimethylsiloxane-PDMS-1.jpg?w=7875&amp;ssl=1 7875w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Polydimethylsiloxane-PDMS-1.jpg?resize=300%2C100&amp;ssl=1 300w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Polydimethylsiloxane-PDMS-1.jpg?resize=1024%2C340&amp;ssl=1 1024w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Polydimethylsiloxane-PDMS-1.jpg?resize=768%2C255&amp;ssl=1 768w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Polydimethylsiloxane-PDMS-1.jpg?resize=1536%2C509&amp;ssl=1 1536w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Polydimethylsiloxane-PDMS-1.jpg?resize=2048%2C679&amp;ssl=1 2048w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Polydimethylsiloxane-PDMS-1.jpg?resize=150%2C50&amp;ssl=1 150w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Polydimethylsiloxane-PDMS-1.jpg?resize=700%2C232&amp;ssl=1 700w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Polydimethylsiloxane-PDMS-1.jpg?w=2440&amp;ssl=1 2440w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/Polydimethylsiloxane-PDMS-1.jpg?w=3660&amp;ssl=1 3660w\" sizes=\"(max-width:767px) 700px, (max-width:7875px) 100vw, 7875px\" \/>\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"premium-blog-thumbnail-overlay\">\n\t\t\t\t\t\t\t\t<a class=\"elementor-icon\" href=\"https:\/\/rheolution.com\/fr\/notes-application\/polymeres-pdms\/\" target=\"_blank\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-screen-only\">Polym\u00e8res PDMS<\/span>\n\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"premium-blog-content-wrapper \">\n\n\t\t\t\t\t<div class=\"premium-blog-inner-container\">\n\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<h4 class=\"premium-blog-entry-title\">\n\t\t\t<a href=\"https:\/\/rheolution.com\/fr\/notes-application\/polymeres-pdms\/\" target=\"_blank\">\n\t\t\t\tPolym\u00e8res PDMS\t\t\t<\/a>\n\t\t<\/h4>\n\t\t\t\t<div class=\"premium-blog-entry-meta\">\n\t\t\t\n\t\t\t\n\t\t\t\n\t\t\t\t\t<\/div>\n\t\t\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t<div class=\"premium-blog-content-inner-wrapper\">\n\t\t<p class=\"premium-blog-post-content\">Le polydim\u00e9thylsiloxane (PDMS) est un polym\u00e8re polysiloxane synth\u00e9tique compos\u00e9 d\u2019un squelette siloxane inorganique souple (\u2013Si\u2013O\u2013Si\u2013) comportant des groupes lat\u00e9raux m\u00e9thyle. Cette architecture inorganique-organique unique conf\u00e8re au PDMS une mobilit\u00e9 de cha\u00eene exceptionnelle, une tr\u00e8s basse temp\u00e9rature de transition vitreuse et un comportement \u00e9lastom\u00e8re stable sur une large plage de temp\u00e9ratures. Le PDMS est produit exclusivement par synth\u00e8se industrielle, impliquant g\u00e9n\u00e9ralement l\u2019hydrolyse et la condensation de chlorosilanes, suivies d\u2019une polym\u00e9risation par ouverture de cycle de siloxanes cycliques.<\/p><div class=\"premium-blog-excerpt-link-wrap\"><a href=\"https:\/\/rheolution.com\/fr\/notes-application\/polymeres-pdms\/\" target=\"_blank\" class=\"premium-blog-excerpt-link elementor-button\">Lire la suite \u00bb<\/a><\/div>\t\t<\/div>\n\t\t\t\t\t\t\t\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\n\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div class=\"premium-blog-footer\">\n\t\t\t\t\t\t\t<nav class=\"premium-blog-pagination-container\" role=\"navigation\" aria-label=\"Pagination\">\n\t\t\t\t<span aria-current=\"page\" class=\"page-numbers current\">1<\/span>\n<a class=\"page-numbers\" href=\"https:\/\/rheolution.com\/fr\/wp-json\/wp\/v2\/posts\/64834\/page\/2\/\">2<\/a>\n<a class=\"page-numbers\" href=\"https:\/\/rheolution.com\/fr\/wp-json\/wp\/v2\/posts\/64834\/page\/3\/\">3<\/a>\n<a class=\"next page-numbers\" href=\"https:\/\/rheolution.com\/fr\/wp-json\/wp\/v2\/posts\/64834\/page\/2\/\">Suivant \u00bb<\/a>\t\t\t<\/nav>\n\t\t\t\t\t\t<\/div>\n\t\t\n\t\t\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>L&rsquo;acide polyglycolique (PGA) est un polyester aliphatique synth\u00e9tique appartenant \u00e0 la famille des poly(\u03b1-hydroxyacides). Il est enti\u00e8rement produit par synth\u00e8se chimique industrielle et se caract\u00e9rise par une unit\u00e9 d&rsquo;acide glycolique simple et r\u00e9p\u00e9titive, li\u00e9e par des liaisons ester. Le PGA est hautement cristallin et hydrophile, des caract\u00e9ristiques qui le distinguent des polyesters biod\u00e9gradables apparent\u00e9s tels que le PLA et le PLGA.    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