{"id":70823,"date":"2026-09-29T11:43:48","date_gmt":"2026-09-29T15:43:48","guid":{"rendered":"https:\/\/rheolution.com\/?p=70823"},"modified":"2026-09-29T11:43:48","modified_gmt":"2026-09-29T15:43:48","slug":"viscoelasticidad-de-la-gelomica-lunagel-ecm-fotoreticulable","status":"publish","type":"post","link":"https:\/\/rheolution.com\/es\/notas-de-aplicacion\/viscoelasticidad-de-la-gelomica-lunagel-ecm-fotoreticulable\/","title":{"rendered":"Ajuste de la rigidez de los hidrogeles de ECM"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"70823\" class=\"elementor elementor-70823 elementor-19680\" data-elementor-post-type=\"post\">\n\t\t\t\t<div class=\"elementor-element elementor-element-9926633 e-flex e-con-boxed e-con e-parent\" data-id=\"9926633\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-2aa8b2e elementor-widget elementor-widget-heading\" data-id=\"2aa8b2e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h6 class=\"elementor-heading-title elementor-size-default\">Nota de aplicaci\u00f3n | ElastoSens\u2122 Bio<\/h6>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b490e4b elementor-widget elementor-widget-heading\" data-id=\"b490e4b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Ajuste de la rigidez de los hidrogeles de ECM con ElastoSens\u2122 Bio<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ed01f46 elementor-widget__width-initial elementor-widget elementor-widget-heading\" data-id=\"ed01f46\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">En colaboraci\u00f3n con<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-989a838 elementor-widget elementor-widget-image\" data-id=\"989a838\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.gelomics.com\">\n\t\t\t\t\t\t\t<img decoding=\"async\" width=\"300\" height=\"80\" src=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Gelomics_Logo_Horizontal_with_Claim_Full-colour_181002-01.png?fit=300%2C80&amp;ssl=1\" class=\"attachment-medium size-medium wp-image-70824\" alt=\"\" srcset=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Gelomics_Logo_Horizontal_with_Claim_Full-colour_181002-01.png?w=9178&amp;ssl=1 9178w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Gelomics_Logo_Horizontal_with_Claim_Full-colour_181002-01.png?resize=300%2C80&amp;ssl=1 300w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Gelomics_Logo_Horizontal_with_Claim_Full-colour_181002-01.png?resize=1024%2C272&amp;ssl=1 1024w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Gelomics_Logo_Horizontal_with_Claim_Full-colour_181002-01.png?resize=768%2C204&amp;ssl=1 768w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Gelomics_Logo_Horizontal_with_Claim_Full-colour_181002-01.png?resize=1536%2C407&amp;ssl=1 1536w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Gelomics_Logo_Horizontal_with_Claim_Full-colour_181002-01.png?resize=2048%2C543&amp;ssl=1 2048w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Gelomics_Logo_Horizontal_with_Claim_Full-colour_181002-01.png?resize=1200%2C318&amp;ssl=1 1200w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Gelomics_Logo_Horizontal_with_Claim_Full-colour_181002-01.png?resize=260%2C69&amp;ssl=1 260w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Gelomics_Logo_Horizontal_with_Claim_Full-colour_181002-01.png?resize=50%2C13&amp;ssl=1 50w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Gelomics_Logo_Horizontal_with_Claim_Full-colour_181002-01.png?resize=150%2C40&amp;ssl=1 150w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Gelomics_Logo_Horizontal_with_Claim_Full-colour_181002-01.png?w=2440&amp;ssl=1 2440w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Gelomics_Logo_Horizontal_with_Claim_Full-colour_181002-01.png?w=3660&amp;ssl=1 3660w\" sizes=\"(max-width:767px) 300px, 300px\" data-attachment-id=\"70824\" data-permalink=\"https:\/\/rheolution.com\/es\/notas-de-aplicacion\/viscoelasticidad-de-la-gelomica-lunagel-ecm-fotoreticulable\/attachment\/gelomics_logo_horizontal_with_claim_full-colour_181002-01-4\/\" data-orig-file=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Gelomics_Logo_Horizontal_with_Claim_Full-colour_181002-01.png?fit=9178%2C2434&amp;ssl=1\" data-orig-size=\"9178,2434\" data-comments-opened=\"1\" data-image-title=\"Gelomics_Logo_Horizontal_with_Claim_Full-colour_181002-01\" data-image-description=\"\" data-image-caption=\"\" data-large-file=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Gelomics_Logo_Horizontal_with_Claim_Full-colour_181002-01.png?fit=1024%2C272&amp;ssl=1\" \/>\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9026f26 elementor-widget__width-initial elementor-widget elementor-widget-heading\" data-id=\"9026f26\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Nota<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d3db1a2 elementor-widget__width-initial elementor-widget-mobile__width-inherit elementor-widget elementor-widget-text-editor\" data-id=\"d3db1a2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Este estudio fue fruto de una colaboraci\u00f3n conjunta entre <a href=\"https:\/\/rheolution.com\/life-sciences\/\">Rheolution<\/a> (QC, Canad\u00e1) y <a href=\"https:\/\/www.gelomics.com\/hydrogels\">Gelomics<\/a> (QLD, Australia).<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3ef1a56 elementor-widget elementor-widget-text-editor\" data-id=\"3ef1a56\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"raw_components--panel--3IcXg inspect_panels--inspectionPanel--3Wboz\" tabindex=\"-1\"><div class=\"inspect_panels--copyableRow--2_PiZ inspect_panels--highlightRow--21P9S\"><div class=\"inspect_panels--propertyRowContent--7Y-mu inspect_panels--copyableRow--2_PiZ inspect_panels--highlightRow--21P9S\"><div class=\"inspect_panels--contentProperty--2Z1QI text--fontPos11--RSei3 text--_fontBase--YWDo0 ellipsis--ellipsisAfter8Lines--2rn32 ellipsis--_ellipsisAfterNLines--26JkZ\"><p>por <a href=\"https:\/\/www.linkedin.com\/in\/gloriapinilla\/\" target=\"_blank\" rel=\"noopener\">Gloria Pinilla, M.Sc.<\/a>, especialista s\u00e9nior en aplicaciones de Rheolution Inc.<\/p><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-29c9a4e elementor-widget__width-initial elementor-widget elementor-widget-heading\" data-id=\"29c9a4e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Resumen<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-23a78fe elementor-widget__width-initial elementor-widget-mobile__width-inherit elementor-widget elementor-widget-text-editor\" data-id=\"23a78fe\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li>La rigidez inicial de los sistemas de cultivo en 3D se puede modificar para estudiar procesos fisiol\u00f3gicos y patol\u00f3gicos in vitro.<\/li><li>Los hidrogeles fotocrosslinkables son excelentes candidatos para los sistemas de cultivo en 3D, gracias a su similitud con la matriz extracelular natural y a lo f\u00e1cil que resulta controlar su rigidez final.<\/li><li>Los productos de matriz extracelular LunaGel\u2122 de Gelomics se reticularon con \u00e9xito mediante luz visible y se midi\u00f3 su cin\u00e9tica de reticulaci\u00f3n en tiempo real en el <a href=\"https:\/\/rheolution.com\/es\/productos\/elastosens-bio\/instrumento\/\" target=\"_blank\" rel=\"noopener\">ElastoSens\u2122 Bio<\/a>.<\/li><li>Las reacciones de reticulaci\u00f3n fotoqu\u00edmica se produjeron r\u00e1pidamente tanto en los kits LunaGel\u2122 de baja rigidez como en los de alta rigidez.<\/li><li>Los kits LunaGel\u2122 de alta rigidez dieron como resultado una mayor rigidez que los kits de baja rigidez.<\/li><li>La rigidez de las matrices de LunaGel\u2122 aument\u00f3 a medida que se prolongaba la duraci\u00f3n de la reticulaci\u00f3n por luz.<\/li><li>La capacidad invasiva de las c\u00e9lulas de c\u00e1ncer de mama aument\u00f3 significativamente al aumentar la rigidez de la MEC.<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-a11b72f e-flex e-con-boxed e-con e-parent\" data-id=\"a11b72f\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ff67a5f elementor-widget__width-initial elementor-widget-mobile__width-inherit elementor-widget elementor-widget-heading\" data-id=\"ff67a5f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">El papel de la rigidez del hidrogel en el comportamiento celular\n<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ddf558e elementor-widget elementor-widget-heading\" data-id=\"ddf558e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Introducci\u00f3n<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-dcef2a1 elementor-widget elementor-widget-text-editor\" data-id=\"dcef2a1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Todas las c\u00e9lulas del cuerpo humano est\u00e1n expuestas a fuerzas mec\u00e1nicas que regulan su funci\u00f3n y el desarrollo de los tejidos, y cada tipo de c\u00e9lula se adapta espec\u00edficamente a las propiedades mec\u00e1nicas del tejido en el que se encuentra. Las propiedades de la matriz de los tejidos humanos tambi\u00e9n pueden cambiar con la enfermedad y, a su vez, facilitar su progresi\u00f3n. Por ejemplo, el crecimiento, la supervivencia, la diferenciaci\u00f3n y la morfog\u00e9nesis de las c\u00e9lulas epiteliales mamarias normales se ven favorecidos por la interacci\u00f3n con una matriz blanda, similar a la rigidez del tejido mamario normal. Sin embargo, tras la transformaci\u00f3n que se produce en el c\u00e1ncer de mama, el tejido se vuelve cada vez m\u00e1s r\u00edgido [1] y las c\u00e9lulas tumorales se vuelven significativamente m\u00e1s contr\u00e1ctiles e hiperreactivas a las se\u00f1ales mec\u00e1nicas de la matriz, lo que, en \u00faltima instancia, provoca la transici\u00f3n epitelial a mesenquimal (EMT) y la met\u00e1stasis [2,3]. La investigaci\u00f3n de los mecanismos que subyacen a la compleja interacci\u00f3n entre las propiedades del sustrato y el comportamiento celular requiere metodolog\u00edas avanzadas de cultivo celular que superen las limitaciones asociadas a los enfoques de cultivo tradicionales [4].    <\/p><p>Las matrices extracelulares (MEC) LunaGel\u2122 de Gelomics son hidrogeles fotocrosslinkables que ofrecen un sistema de cultivo celular 3D controlado para estudiar procesos patol\u00f3gicos y fisiol\u00f3gicos <i>in vitro<\/i>. Basadas en componentes de la MEC como el col\u00e1geno de tipo I, III, IV y V, as\u00ed como en glicoprote\u00ednas y proteoglicanos del tejido conectivo, estas MEC imitan fielmente la matriz extracelular (MEC) natural que rodea a las c\u00e9lulas en el cuerpo humano y facilitan la adhesi\u00f3n, proliferaci\u00f3n, diferenciaci\u00f3n y migraci\u00f3n celular, as\u00ed como la degradaci\u00f3n proteol\u00edtica de la MEC. Adem\u00e1s, el proceso de reticulaci\u00f3n fotoinducida permite a los cient\u00edficos controlar mejor la rigidez final. Con solo variar la duraci\u00f3n de la reticulaci\u00f3n, se puede ajustar con precisi\u00f3n la rigidez del gel para imitar tejidos blandos y duros, como el cerebro, el h\u00edgado, la mama o el cart\u00edlago, entre otros, tanto en condiciones sanas como patol\u00f3gicas. Por estas razones, son sustratos ideales para el cultivo y la diferenciaci\u00f3n de una amplia gama de tipos celulares y facilitan el estudio de los cambios en el comportamiento celular provocados por la rigidez de la matriz.      <\/p><p><a href=\"https:\/\/rheolution.com\/es\/productos\/elastosens-bio\/instrumento\/\" target=\"_blank\" rel=\"noopener\">ElastoSens\u2122 Bio<\/a> mide sin contacto las propiedades viscoel\u00e1sticas de los materiales blandos. Al aplicar ligeras vibraciones a la muestra, el instrumento es capaz de registrar la cin\u00e9tica de reticulaci\u00f3n fotoqu\u00edmica en la longitud de onda deseada. En esta nota de aplicaci\u00f3n, se sometieron a fotoreticulaci\u00f3n los ECM LunaGel\u2122, basados en piel porcina modificada qu\u00edmicamente y gelatina de hueso bovino, mientras se evaluaba en tiempo real su cin\u00e9tica de reticulaci\u00f3n en el <a href=\"https:\/\/rheolution.com\/es\/productos\/elastosens-bio\/instrumento\/\" target=\"_blank\" rel=\"noopener\">ElastoSens\u2122 Bio<\/a>. Para investigar si las MEC LunaGel\u2122 son adecuadas para imitar los cambios fisiopatol\u00f3gicos en la rigidez de los tejidos y sus efectos en la progresi\u00f3n del c\u00e1ncer, se cultivaron esferoides de c\u00e1ncer de mama sobre sustratos de diferente rigidez y se observaron sus morfolog\u00edas.   <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-cc16549 elementor-widget__width-initial elementor-widget-mobile__width-inherit elementor-widget elementor-widget-heading\" data-id=\"cc16549\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Reticulaci\u00f3n por luz de los hidrogeles LunaGel\u2122 mediante Gelomics<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-cae21bc elementor-widget elementor-widget-heading\" data-id=\"cae21bc\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Materiales y m\u00e9todos<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-dfb4356 elementor-widget elementor-widget-text-editor\" data-id=\"dfb4356\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Los ECM LunaGel\u2122 a base de gelatina de piel porcina modificada qu\u00edmicamente, tipo A (<a href=\"https:\/\/www.gelomics.com\/product-page\/porcine-skin-gelatin\">LunaGel\u2122 \u2013 Gelatina de piel porcina \u2013 baja y alta rigidez, Gelomics<\/a>) y gelatina de hueso bovino, tipo B (<a href=\"https:\/\/www.gelomics.com\/product-page\/bovine-bone-gelatin\">LunaGel\u2122 \u2013 Gelatina de hueso bovino \u2013 baja y alta rigidez, Gelomics<\/a>), se prepararon siguiendo las instrucciones del fabricante. En resumen, se disolvieron los viales de fotoiniciador en PBS y se mezclaron con las soluciones de ECM fotocrosslinkables a 37 \u00b0C. Se pipetearon 2 ml de los productos en el portamuestras del <a href=\"https:\/\/rheolution.com\/es\/productos\/elastosens-bio\/instrumento\/\" target=\"_blank\" rel=\"noopener\">ElastoSens\u2122 Bio<\/a> y se inici\u00f3 inmediatamente el ensayo de viscoelasticidad a 37 \u00b0C utilizando las siguientes secuencias de medici\u00f3n:  <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3665319 elementor-widget__width-initial elementor-widget elementor-widget-image\" data-id=\"3665319\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"1024\" height=\"304\" src=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Screen-Shot-2021-11-18-at-10.26.59-AM.png?fit=1024%2C304&amp;ssl=1\" class=\"attachment-large size-large wp-image-70833\" alt=\"Table showing crossover of G\u2019 and G\u2019\u2019 indicating initial crosslinking in ElastoSens\u2122 Bio\" srcset=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Screen-Shot-2021-11-18-at-10.26.59-AM.png?w=2778&amp;ssl=1 2778w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Screen-Shot-2021-11-18-at-10.26.59-AM.png?resize=300%2C89&amp;ssl=1 300w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Screen-Shot-2021-11-18-at-10.26.59-AM.png?resize=1024%2C304&amp;ssl=1 1024w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Screen-Shot-2021-11-18-at-10.26.59-AM.png?resize=768%2C228&amp;ssl=1 768w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Screen-Shot-2021-11-18-at-10.26.59-AM.png?resize=1536%2C456&amp;ssl=1 1536w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Screen-Shot-2021-11-18-at-10.26.59-AM.png?resize=2048%2C607&amp;ssl=1 2048w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Screen-Shot-2021-11-18-at-10.26.59-AM.png?resize=1200%2C356&amp;ssl=1 1200w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Screen-Shot-2021-11-18-at-10.26.59-AM.png?resize=260%2C77&amp;ssl=1 260w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Screen-Shot-2021-11-18-at-10.26.59-AM.png?resize=50%2C15&amp;ssl=1 50w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Screen-Shot-2021-11-18-at-10.26.59-AM.png?resize=150%2C44&amp;ssl=1 150w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Screen-Shot-2021-11-18-at-10.26.59-AM.png?w=2440&amp;ssl=1 2440w\" sizes=\"(max-width:767px) 700px, (max-width:1024px) 100vw, 1024px\" data-attachment-id=\"70833\" data-permalink=\"https:\/\/rheolution.com\/es\/notas-de-aplicacion\/viscoelasticidad-de-la-gelomica-lunagel-ecm-fotoreticulable\/attachment\/screen-shot-2021-11-18-at-10-26-59-am-4\/\" data-orig-file=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Screen-Shot-2021-11-18-at-10.26.59-AM.png?fit=2778%2C824&amp;ssl=1\" data-orig-size=\"2778,824\" data-comments-opened=\"1\" data-image-title=\"crossover of G\u2019 and G\u2019\u2019\" data-image-description=\"\" data-image-caption=\"\" data-large-file=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Screen-Shot-2021-11-18-at-10.26.59-AM.png?fit=1024%2C304&amp;ssl=1\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-10b03f2 elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"10b03f2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>El m\u00f3dulo de elasticidad al cizallamiento (G\u2019) y tan(\u03b4) se obtuvieron directamente del ElastoSens\u2122 Bio. El tiempo inicial de reticulaci\u00f3n se determin\u00f3 a partir del punto de cruce entre G\u2019 y G\u2019\u2019 (tan(\u03b4) = 1). <\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0205664 elementor-widget__width-initial elementor-widget-mobile__width-inherit elementor-widget elementor-widget-heading\" data-id=\"0205664\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">La rigidez del hidrogel influye en el comportamiento celular<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d2fcdb2 elementor-widget elementor-widget-heading\" data-id=\"d2fcdb2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Resultados y discusi\u00f3n<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8b37e89 elementor-widget elementor-widget-text-editor\" data-id=\"8b37e89\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Las ECM LunaGel\u2122 reticulables por luz se evaluaron primero en cuanto a sus propiedades viscoel\u00e1sticas, que se pueden describir mediante el m\u00f3dulo de almacenamiento al cizallamiento (G\u2019 \u2014la parte el\u00e1stica del comportamiento viscoel\u00e1stico\u2014) y el m\u00f3dulo de p\u00e9rdida al cizallamiento (G\u2019\u2019 \u2014la parte viscosa del comportamiento viscoel\u00e1stico\u2014). Normalmente tambi\u00e9n se calcula la relaci\u00f3n entre G\u2019\u2019 y G\u2019 (factor de amortiguamiento o tan(\u03b4)) para ver qu\u00e9 comportamiento predomina.   <\/p><p><b>La fig. 1<\/b> muestra la evoluci\u00f3n del m\u00f3dulo de almacenamiento de cizallamiento (G\u2019) en funci\u00f3n del tiempo de reticulaci\u00f3n para las MEC fotoreticulables LunaGel\u2122 de baja y alta rigidez, tanto porcinas (izquierda) como bovinas (derecha). Las mediciones se realizaron sin exposici\u00f3n a la luz durante los primeros 2 minutos de la prueba. A continuaci\u00f3n, se program\u00f3 el encendido de la luz mediante el instrumento <a href=\"https:\/\/rheolution.com\/es\/productos\/elastosens-bio\/instrumento\/\" target=\"_blank\" rel=\"noopener\">ElastoSens\u2122 Bio<\/a> a los 2 minutos y su efecto se observ\u00f3 claramente con el aumento de G\u2019 a partir de ese momento y hasta los 12 minutos (cuando se apag\u00f3 la luz). Las mediciones continuaron durante unos 15 minutos para determinar las propiedades viscoel\u00e1sticas finales del gel. Las muestras quedaron reticuladas de forma homog\u00e9nea tras el ensayo (<b>fig. 2<\/b>).    <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e04bd87 elementor-widget__width-initial elementor-widget elementor-widget-image\" data-id=\"e04bd87\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"861\" height=\"426\" src=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Fig1_Gelomics_ECM.jpg?fit=861%2C426&amp;ssl=1\" class=\"attachment-large size-large wp-image-70826\" alt=\"G\u2019 over time for LunaGel\u2122 ECMs: porcine (left) &amp; bovine (right)\" srcset=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Fig1_Gelomics_ECM.jpg?w=861&amp;ssl=1 861w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Fig1_Gelomics_ECM.jpg?resize=300%2C148&amp;ssl=1 300w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Fig1_Gelomics_ECM.jpg?resize=768%2C380&amp;ssl=1 768w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Fig1_Gelomics_ECM.jpg?resize=260%2C129&amp;ssl=1 260w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Fig1_Gelomics_ECM.jpg?resize=50%2C25&amp;ssl=1 50w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Fig1_Gelomics_ECM.jpg?resize=150%2C75&amp;ssl=1 150w\" sizes=\"(max-width:767px) 700px, (max-width:861px) 100vw, 861px\" data-attachment-id=\"70826\" data-permalink=\"https:\/\/rheolution.com\/es\/notas-de-aplicacion\/viscoelasticidad-de-la-gelomica-lunagel-ecm-fotoreticulable\/attachment\/fig1_gelomics_ecm-4\/\" data-orig-file=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Fig1_Gelomics_ECM.jpg?fit=861%2C426&amp;ssl=1\" data-orig-size=\"861,426\" data-comments-opened=\"1\" data-image-title=\"G\u2019 over time\" data-image-description=\"\" data-image-caption=\"\" data-large-file=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Fig1_Gelomics_ECM.jpg?fit=861%2C426&amp;ssl=1\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d3a0f6a elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"d3a0f6a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Fig. 1:  <\/strong>M\u00f3dulo de almacenamiento al cizallamiento (G\u2019, Pa) en funci\u00f3n del tiempo para los productos de MEC LunaGel\u2122 de origen porcino (izquierda) y bovino (derecha).<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f58da9e elementor-widget__width-initial elementor-widget elementor-widget-image\" data-id=\"f58da9e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"825\" height=\"371\" src=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Image-2.jpg?fit=825%2C371&amp;ssl=1\" class=\"attachment-large size-large wp-image-70827\" alt=\"Crosslinked LunaGel\u2122 sample post-testing\" srcset=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Image-2.jpg?w=825&amp;ssl=1 825w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Image-2.jpg?resize=300%2C135&amp;ssl=1 300w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Image-2.jpg?resize=768%2C345&amp;ssl=1 768w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Image-2.jpg?resize=260%2C117&amp;ssl=1 260w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Image-2.jpg?resize=50%2C22&amp;ssl=1 50w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Image-2.jpg?resize=150%2C67&amp;ssl=1 150w\" sizes=\"(max-width:767px) 700px, (max-width:825px) 100vw, 825px\" data-attachment-id=\"70827\" data-permalink=\"https:\/\/rheolution.com\/es\/notas-de-aplicacion\/viscoelasticidad-de-la-gelomica-lunagel-ecm-fotoreticulable\/attachment\/image-2-6\/\" data-orig-file=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Image-2.jpg?fit=825%2C371&amp;ssl=1\" data-orig-size=\"825,371\" data-comments-opened=\"1\" data-image-title=\"Crosslinked LunaGel\u2122\" data-image-description=\"\" data-image-caption=\"\" data-large-file=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Image-2.jpg?fit=825%2C371&amp;ssl=1\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b3cbd35 elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"b3cbd35\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Fig. 2:  <\/strong>Ejemplo representativo de una muestra de LunaGel\u2122 tras la prueba.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ade62a3 elementor-widget elementor-widget-text-editor\" data-id=\"ade62a3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>La reticulaci\u00f3n por luz empez\u00f3 tras unos 0,5 min de exposici\u00f3n a la luz en el caso de los hidrogeles de alta rigidez y tras unos 1,5 min en los de baja rigidez (<b>fig. 3<\/b>). El valor final de G\u2019 fue aproximadamente 8 veces mayor en las formulaciones de alta rigidez que en las de baja rigidez. Las formulaciones de baja rigidez formaron geles blandos con un G\u2019 de ~550 Pa, mientras que los hidrogeles de alta rigidez alcanzaron ~4 500 Pa y no se observaron diferencias estad\u00edsticas entre las fuentes porcina y bovina. Sin embargo, se observaron diferencias significativas entre las formulaciones de baja y alta rigidez para ambos tipos de gelatina. De hecho, los productos LunaGel\u2122 de baja y alta rigidez contienen diferentes concentraciones de los componentes de gelatina modificada para permitir un control preciso sobre un amplio rango de rigidez. El valor final de tan(\u03b4) fue siempre inferior a 0,1, lo que demuestra que el comportamiento el\u00e1stico (relacionado con el m\u00f3dulo de almacenamiento de cizallamiento, G\u2019\u2019) es mucho m\u00e1s predominante que el comportamiento viscoso (relacionado con el m\u00f3dulo de p\u00e9rdida de cizallamiento, G\u2019\u2019) en estos hidrogeles.     <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f87206d elementor-widget__width-initial elementor-widget elementor-widget-image\" data-id=\"f87206d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"1020\" height=\"401\" src=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Fig3_Gelomics_ECM.jpg?fit=1020%2C401&amp;ssl=1\" class=\"attachment-large size-large wp-image-70828\" alt=\"Initial crosslinking time and final G\u2019\/tan(\u03b4) of LunaGel\u2122 gels\" srcset=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Fig3_Gelomics_ECM.jpg?w=1020&amp;ssl=1 1020w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Fig3_Gelomics_ECM.jpg?resize=300%2C118&amp;ssl=1 300w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Fig3_Gelomics_ECM.jpg?resize=768%2C302&amp;ssl=1 768w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Fig3_Gelomics_ECM.jpg?resize=260%2C102&amp;ssl=1 260w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Fig3_Gelomics_ECM.jpg?resize=50%2C20&amp;ssl=1 50w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Fig3_Gelomics_ECM.jpg?resize=150%2C59&amp;ssl=1 150w\" sizes=\"(max-width:767px) 700px, (max-width:1020px) 100vw, 1020px\" data-attachment-id=\"70828\" data-permalink=\"https:\/\/rheolution.com\/es\/notas-de-aplicacion\/viscoelasticidad-de-la-gelomica-lunagel-ecm-fotoreticulable\/attachment\/fig3_gelomics_ecm-4\/\" data-orig-file=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Fig3_Gelomics_ECM.jpg?fit=1020%2C401&amp;ssl=1\" data-orig-size=\"1020,401\" data-comments-opened=\"1\" data-image-title=\"crosslinking time\" data-image-description=\"\" data-image-caption=\"\" data-large-file=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Fig3_Gelomics_ECM.jpg?fit=1020%2C401&amp;ssl=1\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a66f9b4 elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"a66f9b4\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Fig. 3:<\/strong>  Tiempo inicial de reticulaci\u00f3n (min), G\u2019 final (Pa) y tan(\u03b4) final de los geles fotoreticulados.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-df11603 elementor-widget elementor-widget-text-editor\" data-id=\"df11603\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Tanto para las formulaciones de baja como de alta rigidez, se puede variar la duraci\u00f3n de la exposici\u00f3n a la luz para alcanzar las rigidezes deseadas, que sean inferiores o iguales al valor final de G\u2019. <b>La fig. 4<\/b> muestra la evoluci\u00f3n del m\u00f3dulo de almacenamiento al cizallamiento (G\u2019, Pa) en funci\u00f3n del tiempo para el LunaGel\u2122 porcino de alta rigidez reticulado con 9,0 mW\/cm\u00b2 durante 2, 4, 8 y 10 minutos, respectivamente. Del mismo modo, se program\u00f3 que la luz se encendiera tras 2 minutos de ensayo con la duraci\u00f3n mencionada. Como era de esperar, las curvas fueron pr\u00e1cticamente iguales durante los primeros 4 minutos. Pasado ese tiempo, el G\u2019 sigui\u00f3 aumentando considerablemente con el paso del tiempo en las muestras sometidas a una exposici\u00f3n a la luz m\u00e1s prolongada.   <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a255815 elementor-widget__width-initial elementor-widget elementor-widget-image\" data-id=\"a255815\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"431\" height=\"401\" src=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Fig4_Gelomics_ECM.jpg?fit=431%2C401&amp;ssl=1\" class=\"attachment-large size-large wp-image-70829\" alt=\"G\u2019 over time for high stiffness porcine LunaGel\u2122 with variable light exposure\" srcset=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Fig4_Gelomics_ECM.jpg?w=431&amp;ssl=1 431w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Fig4_Gelomics_ECM.jpg?resize=300%2C279&amp;ssl=1 300w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Fig4_Gelomics_ECM.jpg?resize=157%2C146&amp;ssl=1 157w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Fig4_Gelomics_ECM.jpg?resize=50%2C47&amp;ssl=1 50w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Fig4_Gelomics_ECM.jpg?resize=81%2C75&amp;ssl=1 81w\" sizes=\"(max-width:767px) 431px, 431px\" data-attachment-id=\"70829\" data-permalink=\"https:\/\/rheolution.com\/es\/notas-de-aplicacion\/viscoelasticidad-de-la-gelomica-lunagel-ecm-fotoreticulable\/attachment\/fig4_gelomics_ecm-4\/\" data-orig-file=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Fig4_Gelomics_ECM.jpg?fit=431%2C401&amp;ssl=1\" data-orig-size=\"431,401\" data-comments-opened=\"1\" data-image-title=\"G\u2019 over time\" data-image-description=\"\" data-image-caption=\"\" data-large-file=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Fig4_Gelomics_ECM.jpg?fit=431%2C401&amp;ssl=1\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0635d67 elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"0635d67\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Fig. 4:  <\/strong>M\u00f3dulo de almacenamiento de cizallamiento (G\u2019, Pa) en funci\u00f3n del tiempo para el LunaGel\u2122 porcino de alta rigidez reticulado con luz de 405 nm (9,0 mW\/cm\u00b2) durante 2, 4, 8 y 10 minutos.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9ca4a98 elementor-widget elementor-widget-text-editor\" data-id=\"9ca4a98\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Para analizar c\u00f3mo afecta la rigidez de la MEC de LunaGel al comportamiento de las c\u00e9lulas de c\u00e1ncer de mama, se sembraron esferoides de MDA-MB-231 en MEC con un m\u00f3dulo de almacenamiento de cizallamiento (G\u2019) de ~110, 220 y 440 kPa, respectivamente. Tras 7 d\u00edas de cultivo, se observaron diferencias sustanciales en las morfolog\u00edas celulares entre las diferentes rigidezes de la MEC (<b>fig. 5<\/b>). La capacidad invasiva de las c\u00e9lulas de c\u00e1ncer de mama aument\u00f3 en funci\u00f3n de la rigidez de la MEC, lo que corrobora los datos cl\u00ednicos que sugieren que la met\u00e1stasis se produce con mayor frecuencia en los c\u00e1nceres de mama con tejidos m\u00e1s r\u00edgidos. Se observ\u00f3 un cambio hacia morfolog\u00edas celulares m\u00e1s migratorias, asociadas a la met\u00e1stasis (fig. 5, recuadros ampliados), a medida que aumentaba la rigidez de la MEC de LunaGel.   <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-292155c elementor-widget__width-initial elementor-widget elementor-widget-image\" data-id=\"292155c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"355\" src=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Figure-5_web.jpg?fit=1024%2C355&amp;ssl=1\" class=\"attachment-large size-large wp-image-70830\" alt=\"Breast cancer cell behavior on LunaGel ECMs of varying stiffness\" srcset=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Figure-5_web.jpg?w=1415&amp;ssl=1 1415w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Figure-5_web.jpg?resize=300%2C104&amp;ssl=1 300w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Figure-5_web.jpg?resize=1024%2C355&amp;ssl=1 1024w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Figure-5_web.jpg?resize=768%2C266&amp;ssl=1 768w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Figure-5_web.jpg?resize=1200%2C416&amp;ssl=1 1200w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Figure-5_web.jpg?resize=260%2C90&amp;ssl=1 260w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Figure-5_web.jpg?resize=50%2C17&amp;ssl=1 50w, https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Figure-5_web.jpg?resize=150%2C52&amp;ssl=1 150w\" sizes=\"(max-width:767px) 700px, (max-width:1024px) 100vw, 1024px\" data-attachment-id=\"70830\" data-permalink=\"https:\/\/rheolution.com\/es\/notas-de-aplicacion\/viscoelasticidad-de-la-gelomica-lunagel-ecm-fotoreticulable\/attachment\/figure-5_web-4\/\" data-orig-file=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Figure-5_web.jpg?fit=1415%2C491&amp;ssl=1\" data-orig-size=\"1415,491\" data-comments-opened=\"1\" data-image-title=\"Breast cancer cell\" data-image-description=\"\" data-image-caption=\"\" data-large-file=\"https:\/\/i0.wp.com\/rheolution.com\/wp-content\/uploads\/2021\/11\/Figure-5_web.jpg?fit=1024%2C355&amp;ssl=1\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-201a0a6 elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"201a0a6\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Fig. 5:  <\/strong>La capacidad invasiva de las c\u00e9lulas de c\u00e1ncer de mama aumenta con la rigidez de la MEC. Las im\u00e1genes muestran esferoides de MDA-MB-231 sembrados en MEC de gelatina bovina LunaGel con un m\u00f3dulo de almacenamiento de cizallamiento de (A) 110 Pa, (B) 220 Pa y (C) 440 Pa, respectivamente, tras 7 d\u00edas de cultivo. Las c\u00e9lulas\/esferoides se ti\u00f1eron para visualizar los n\u00facleos celulares (azul), la integrina \u03b21 (verde), la membrana celular (naranja) y la actina (magenta).     <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-298788a elementor-widget elementor-widget-heading\" data-id=\"298788a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Conclusiones<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a5f8f67 elementor-widget elementor-widget-text-editor\" data-id=\"a5f8f67\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>La evoluci\u00f3n viscoel\u00e1stica de los productos ECM LunaGel\u2122 de Gelomics durante la reticulaci\u00f3n fotoqu\u00edmica se registr\u00f3 con \u00e9xito en tiempo real usando <a href=\"https:\/\/rheolution.com\/es\/?p=70823\">ElastoSens\u2122<\/a><a href=\"https:\/\/rheolution.com\/es\/?p=70823\"> Bio.<\/a> El valor final de G\u2019 fue aproximadamente 8 veces mayor en las formulaciones de alta rigidez en comparaci\u00f3n con las de baja rigidez. Las propiedades viscoel\u00e1sticas finales de estos hidrogeles se pudieron ajustar f\u00e1cilmente variando el tiempo de exposici\u00f3n a la luz durante la reticulaci\u00f3n (405 nm). La capacidad invasiva de las c\u00e9lulas de c\u00e1ncer de mama aument\u00f3 significativamente con la rigidez de la ECM, lo que demuestra que el sistema LunaGel\u2122 es capaz de imitar fielmente las condiciones fisiol\u00f3gicas y fisiopatol\u00f3gicas de los tejidos.  <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-afd817a elementor-widget elementor-widget-heading\" data-id=\"afd817a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Resumen<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d936ff2 elementor-widget elementor-widget-text-editor\" data-id=\"d936ff2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul class=\"bullets\"><li class=\"bullets\">Los productos LunaGel\u2122 facilitan el desarrollo de hidrogeles con la rigidez deseada.<\/li><li class=\"bullets\"><a href=\"https:\/\/rheolution.com\/es\/?p=70823\">ElastoSens\u2122 Bio<\/a> puede aplicar luz (a diferentes longitudes de onda) durante la medici\u00f3n de la viscoelasticidad de los hidrogeles, lo que permite conocer la cin\u00e9tica de su reticulaci\u00f3n fotoqu\u00edmica en tiempo real.<\/li><li class=\"bullets\">En el <a href=\"https:\/\/rheolution.com\/es\/?p=70823\">ElastoSens\u2122 Bio<\/a> se pueden combinar f\u00e1cilmente las intensidades de luz y los tiempos de exposici\u00f3n durante el fotoreticulado de los hidrogeles para alcanzar la viscoelasticidad deseada para cada aplicaci\u00f3n concreta.<\/li><li class=\"bullets\">Las ECM de LunaGel\u2122 facilitan el estudio del comportamiento celular en funci\u00f3n de la rigidez de la ECM.<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-650fa95 elementor-widget elementor-widget-heading\" data-id=\"650fa95\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Referencias<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ec1a35b elementor-widget elementor-widget-text-editor\" data-id=\"ec1a35b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>[1] Keely, P., &#038; Nain, A. (2015). <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4754037\/\" target=\"_blank\" rel=\"noopener\">Capturing relevant extracellular matrices for investigating cell migration<\/a>. F1000Research, 4.<\/p><p>[2] Wei, S. C., Fattet, L., Tsai, J. H., Guo, Y., Pai, V. H., Majeski, H. E., &#8230; &#038; Yang, J. (2015). <a href=\"https:\/\/www.nature.com\/articles\/ncb3157\" target=\"_blank\" rel=\"noopener\">Matrix stiffness drives epithelial\u2013mesenchymal transition and tumour metastasis through a TWIST1\u2013G3BP2 mechanotransduction pathway<\/a>. Nature cell biology, 17(5), 678-688.<\/p><p>[3] Paszek, M. J., Zahir, N., Johnson, K. R., Lakins, J. N., Rozenberg, G. I., Gefen, A., &#8230; &#038; Weaver, V. M. (2005). <a href=\"https:\/\/www.cell.com\/cancer-cell\/fulltext\/S1535-6108(05)00268-0\" target=\"_blank\" rel=\"noopener\">Tensional homeostasis and the malignant phenotype<\/a>. Cancer cell, 8(3), 241-254.<\/p><p>[4] Caliari, S. R., &#038; Burdick, J. A. (2016). <a href=\"https:\/\/www.nature.com\/articles\/nmeth.3839.pdf\" target=\"_blank\" rel=\"noopener\">A practical guide to hydrogels for cell culture<\/a>. Nature methods, 13(5), 405-414.<\/p><p> <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-93251b6 elementor-align-center elementor-widget elementor-widget-button\" data-id=\"93251b6\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/rheolution.com\/wp-content\/uploads\/Viscoelasticity-of-Gelomics-LunaGel-Photocrosslinkable-ECM.pdf\" target=\"_blank\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Accede a la nota completa de la aplicaci\u00f3n (PDF) <\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-55b7ef2 elementor-widget__width-initial elementor-widget-mobile__width-inherit elementor--h-position-center elementor--v-position-middle elementor-arrows-position-inside elementor-widget elementor-widget-slides\" data-id=\"55b7ef2\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;navigation&quot;:&quot;arrows&quot;,&quot;autoplay_speed&quot;:4000,&quot;transition_speed&quot;:4000,&quot;autoplay&quot;:&quot;yes&quot;,&quot;pause_on_hover&quot;:&quot;yes&quot;,&quot;pause_on_interaction&quot;:&quot;yes&quot;,&quot;infinite&quot;:&quot;yes&quot;,&quot;transition&quot;:&quot;slide&quot;}\" data-widget_type=\"slides.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-swiper\">\n\t\t\t\t\t<div class=\"elementor-slides-wrapper elementor-main-swiper swiper\" role=\"region\" aria-roledescription=\"carousel\" aria-label=\"Slides\" dir=\"ltr\" data-animation=\"fadeInUp\">\n\t\t\t\t<div class=\"swiper-wrapper elementor-slides\">\n\t\t\t\t\t\t\t\t\t\t<div class=\"elementor-repeater-item-c97f30c swiper-slide\" role=\"group\" aria-roledescription=\"slide\"><div class=\"swiper-slide-bg\" role=\"img\" aria-label=\"elastosens2\"><\/div><div class=\"swiper-slide-inner\" ><div class=\"swiper-slide-contents\"><\/div><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a31667a elementor-widget__width-initial elementor-widget-mobile__width-inherit elementor-widget elementor-widget-text-editor\" data-id=\"a31667a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Descubre c\u00f3mo nuestra tecnolog\u00eda mide de forma no destructiva las propiedades viscoel\u00e1sticas de los biomateriales blandos y los tejidos utilizando microvol\u00famenes de muestras<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ca42a8b elementor-align-center elementor-widget elementor-widget-button\" data-id=\"ca42a8b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/rheolution.com\/es\/contacto\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Ponte en contacto con nosotros para m\u00e1s informaci\u00f3n<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8418b6a elementor-widget elementor-widget-heading\" data-id=\"8418b6a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Art\u00edculos relacionados<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6c98ea9 premium-blog-cta-full-yes premium-floating-effects-yes premium-disable-fe-yes elementor-widget__width-initial premium-blog-align-left elementor-widget elementor-widget-premium-addon-blog\" data-id=\"6c98ea9\" data-element_type=\"widget\" data-e-type=\"widget\" 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class=\"premium-blog-thumbnail-overlay\">\n\t\t\t\t\t\t\t\t<a class=\"elementor-icon\" href=\"https:\/\/rheolution.com\/es\/notas-de-aplicacion\/viscoelasticidad-de-la-gelomica-lunagel-ecm-fotoreticulable\/\" target=\"_blank\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-screen-only\">Ajuste de la rigidez de los hidrogeles de ECM<\/span>\n\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"premium-blog-content-wrapper \">\n\n\t\t\t\t\t<div class=\"premium-blog-inner-container\">\n\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<h4 class=\"premium-blog-entry-title\">\n\t\t\t<a href=\"https:\/\/rheolution.com\/es\/notas-de-aplicacion\/viscoelasticidad-de-la-gelomica-lunagel-ecm-fotoreticulable\/\" target=\"_blank\">\n\t\t\t\tAjuste de la rigidez de los hidrogeles de ECM\t\t\t<\/a>\n\t\t<\/h4>\n\t\t\t\t<div class=\"premium-blog-entry-meta\">\n\t\t\t\n\t\t\t\n\t\t\t\n\t\t\t\t\t<\/div>\n\t\t\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t<div class=\"premium-blog-content-inner-wrapper\">\n\t\t<p class=\"premium-blog-post-content\">Todas las c\u00e9lulas del cuerpo humano est\u00e1n expuestas a fuerzas mec\u00e1nicas que regulan su funcionamiento y el desarrollo de los tejidos, y cada tipo de c\u00e9lula se adapta espec\u00edficamente a las propiedades mec\u00e1nicas del tejido en el que se encuentra. Las propiedades de la matriz de los tejidos humanos tambi\u00e9n pueden cambiar con la enfermedad y, a su vez, facilitar su progresi\u00f3n.<\/p><div class=\"premium-blog-excerpt-link-wrap\"><a href=\"https:\/\/rheolution.com\/es\/notas-de-aplicacion\/viscoelasticidad-de-la-gelomica-lunagel-ecm-fotoreticulable\/\" target=\"_blank\" class=\"premium-blog-excerpt-link elementor-button\">Leer m\u00e1s \u00bb<\/a><\/div>\t\t<\/div>\n\t\t\t\t\t\t\t\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\n\t\t\t\t\t\t\t<\/div>\n\n\t\t\n\t\t\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Todas las c\u00e9lulas del cuerpo humano est\u00e1n expuestas a fuerzas mec\u00e1nicas que regulan su funcionamiento y el desarrollo de los tejidos, y cada tipo de c\u00e9lula se adapta espec\u00edficamente a las propiedades mec\u00e1nicas del tejido en el que se encuentra. Las propiedades de la matriz de los tejidos humanos tambi\u00e9n pueden cambiar con la enfermedad y, a su vez, facilitar su progresi\u00f3n.   <\/p>\n","protected":false},"author":195401338,"featured_media":70832,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_wpcom_ai_launchpad_first_post":false,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_post_was_ever_published":false},"categories":[378,287,300,379],"tags":[89,92,94,91,124,88,146,99,105,87],"class_list":["post-70823","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-aplicaciones-de-la-ingenieria-de-tejidos","category-notas-de-aplicacion","category-application-formulation-of-hydrogels","category-reticulacion-por-luz","tag-elastosens-bio","tag-hydrogel-formation","tag-hydrogel-with-cells","tag-hydrogels","tag-life-sciences","tag-mechanical-testing","tag-natural-polymer","tag-photocrosslinking","tag-tissue-engineering","tag-viscoelasticity"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Ajuste de la Rigidez de los Hidrogeles de MEC para el Cultivo Celular<\/title>\n<meta name=\"description\" content=\"Mide la viscoelasticidad y la fotoreticulaci\u00f3n en tiempo real de los hidrogeles de la MEC con ElastoSens\u2122 Bio. 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