Hemostatic Agents
& Blood Coagulation
Applications / Hemostatic Agents
hemostatic efficacy

Hemostatic agents (HA) such as powders, adhesives, gauze and sealants have been used for decades to control bleeding and their demand has recently grown by the expansion of minimally invasive surgery and complex reconstructive procedures. Evaluating with precision the efficacy of hemostatic agents is crucial for product development and production.  

Conventional testing instruments like rheometers, TEG, ROTEM, compression testers are not adapted for in vitro studies and do not provide a comprehensive evaluation of the effect of hemostatic agents on blood during clot formation. Therefore, visual inspection is often the only qualitative way to assess clot formation.

Drug delivery Sample pipette
Here, we introduce the ElastoSens™ Bio as the new state-of-the-art tool for quantitative measurement of the effect of hemostatic agents on blood. The instrument measures and displays the change in strength (shear elastic modulus, G’) and viscous behavior (shear loss modulus, G’’) of the blood/HA complex as a function of time during clot formation.

In this example, two commercially available HA were tested with whole blood at different concentrations. It clearly appears how increasing the HA dosage in the blood influences both the clot strength and the clot initiation time.

The ElastoSens Bio may be used in R&D to design more effective HA; in QC to improve the quality of products; and in preclinical studies to simulate in vivo conditions and better predict clinical outcomes.

 

Hemostatic agents Results
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