Polysaccharide-based hydrogels offer great promise in 3D bioprinting due to their biocompatibility and cellular response, but their poor mechanical properties often require extensive crosslinking. The solution? Enter thermoresponsive bioinks. This study examines a triad of carboxymethyl cellulose, agarose, and gelatin as a potential thermoresponsive ink, demonstrating that specific blends can form stable hydrogels with desirable mechanical and physical properties. The bioinks' cytotoxicity was assessed on two cell lines according to ISO 10993-5 standards, and successful printing of complex 3D patterns confirmed their printability.

Dense collagen matrices, crafted through automated gel aspiration-ejection (GAE), offer exciting potential in the field of biofabrication. This study illuminates the crucial role fibrillization pH plays in both the real-time rheological changes during collagen hydrogel gelation and the properties of the resulting biofabricated matrices. Findings demonstrate a relative increase in hydrogel stiffness with higher gelation pH, with matrices demonstrating increased fibrillar density, alignment, and micro-compressive modulus at specific pH levels. Importantly, these matrices showed low cell mortality when seeded with fibroblasts. These findings may offer valuable insights applicable to other hydrogel systems and biofabrication techniques.

Understanding the biomechanical properties of arteries is complex due to their cylindrical shape and waveguide behavior. This study provides valuable insights by utilizing three-dimensional measurements on an artery-mimicking tube in water, categorizing the tube wall motion into transient and steady state responses. The study's approach enables a more accurate estimation of the motion and improves our understanding of wave propagation in arterial walls, presenting significant opportunities for enhanced measurement of arterial mechanical properties.

Researchers have devised a method called '3D wet writing' to create small-diameter arterial conduits. This technique uses ionic gelation for fabricating customizable constructs quickly and without a template. The constructs show mechanical properties similar to native blood vessels and demonstrate biocompatibility, indicating their potential use as vascular constructs.

User Cytocompatibility, biocompatibility, and biodegradability are amongst the most desirable qualities of wound dressings and can be tuned during the bioplatform fabrication steps to enhance wound healing capabilities. A three-stepped approach (partial-crosslinking, freeze-drying, and pulverisation) was employed in fabricating a particulate, partially crosslinked (PC), and transferulic acid (TFA)-loaded chitosan-alginate (CS-Alg) interpolymer complex (IPC) with enhanced wound healing capabilities.

A study shows a new kind of superabsorbent hydrogels (SAHs) that remain ionized at all physiological pH levels. The optimized SAHs show improved absorbency and stronger mechanics when swollen, making them potential contenders for commercial hygiene products.

This study uses a non-destructive method to understand how 3D bioprinting affects the mechanical properties of hydrogel tissue scaffolds. It explores how parameters like fiber size, scaffold pattern, and bioink formulation impact these properties. The team also monitors real-time crosslinking, degradation, and the effect of cell growth on scaffold strength. This method may provide new insights and strategies for tissue engineering.

A novel non-invasive technology is being studied for its potential in assessing the effectiveness of different types of hemostatic agents (HAs), which are used to manage bleeding in traumatic injuries. This technology measures how quickly clotting occurs and the stiffness of the formed clots, providing valuable insights into how different HAs impact coagulation. It can even identify HAs that work independently from the natural blood clotting process. This could pave the way for more precise predictions of in vivo outcomes and contribute to the development of optimal HAs for specific situations.