May 10, 2023
A biopolymeric mesh enriched with PLGA microparticles loaded with AT101 for localized glioblastoma treatment
Current treatments for glioblastoma (GBM) face challenges due to rapidly occurring tumor recurrences. In response, researchers have developed localized drug delivery systems, notably AT101-GlioMesh - an alginate-based mesh embedded with AT101-loaded PLGA microspheres. Fabricated for high encapsulation efficiency, this system ensures a sustained release of AT101, demonstrating a significant cytotoxic effect on GBM cell lines. This promising development could potentially revolutionize GBM therapy and prevent tumor recurrence.
May 10, 2023
Carboxymethyl Cellulose-Agarose-Gelatin: A Thermoresponsive Triad Bioink Composition to Fabricate Volumetric Soft Tissue Constructs
Polysaccharide-based hydrogels offer great promise in 3D bioprinting due to their biocompatibility and cellular response, but their poor mechanical properties often require extensive crosslinking. The solution? Enter thermoresponsive bioinks. This study examines a triad of carboxymethyl cellulose, agarose, and gelatin as a potential thermoresponsive ink, demonstrating that specific blends can form stable hydrogels with desirable mechanical and physical properties. The bioinks' cytotoxicity was assessed on two cell lines according to ISO 10993-5 standards, and successful printing of complex 3D patterns confirmed their printability.
March 2, 2023
Effect of Fibrillization pH on Gelation Viscoelasticity and Properties of Biofabricated Dense Collagen Matrices via Gel Aspiration-Ejection
Dense collagen matrices, crafted through automated gel aspiration-ejection (GAE), offer exciting potential in the field of biofabrication. This study illuminates the crucial role fibrillization pH plays in both the real-time rheological changes during collagen hydrogel gelation and the properties of the resulting biofabricated matrices. Findings demonstrate a relative increase in hydrogel stiffness with higher gelation pH, with matrices demonstrating increased fibrillar density, alignment, and micro-compressive modulus at specific pH levels. Importantly, these matrices showed low cell mortality when seeded with fibroblasts. These findings may offer valuable insights applicable to other hydrogel systems and biofabrication techniques.
October 28, 2022
Facile fabrication of Bi-layered Perfusable Hydrogel Tubes as Biomimetic 3D arterial construct
Understanding the biomechanical properties of arteries is complex due to their cylindrical shape and waveguide behavior. This study provides valuable insights by utilizing three-dimensional measurements on an artery-mimicking tube in water, categorizing the tube wall motion into transient and steady state responses. The study's approach enables a more accurate estimation of the motion and improves our understanding of wave propagation in arterial walls, presenting significant opportunities for enhanced measurement of arterial mechanical properties.
September 23, 2022
Measurement of wave propagation through a tube using dual transducers for elastography in arteries
Researchers have devised a method called '3D wet writing' to create small-diameter arterial conduits. This technique uses ionic gelation for fabricating customizable constructs quickly and without a template. The constructs show mechanical properties similar to native blood vessels and demonstrate biocompatibility, indicating their potential use as vascular constructs.
September 13, 2022
In Situ Forming Chitosan-Alginate Interpolymer Complex Bioplatform for Wound Healing and Regeneration
User Cytocompatibility, biocompatibility, and biodegradability are amongst the most desirable qualities of wound dressings and can be tuned during the bioplatform fabrication steps to enhance wound healing capabilities. A three-stepped approach (partial-crosslinking, freeze-drying, and pulverisation) was employed in fabricating a particulate, partially crosslinked (PC), and transferulic acid (TFA)-loaded chitosan-alginate (CS-Alg) interpolymer complex (IPC) with enhanced wound healing capabilities.
May 5, 2022
Non-destructive mechanical assessment for optimization of 3D bioprinted soft tissue scaffolds
This study uses a non-destructive method to understand how 3D bioprinting affects the mechanical properties of hydrogel tissue scaffolds. It explores how parameters like fiber size, scaffold pattern, and bioink formulation impact these properties. The team also monitors real-time crosslinking, degradation, and the effect of cell growth on scaffold strength. This method may provide new insights and strategies for tissue engineering.
April 12, 2022
In Vitro Evaluation of Real-Time Viscoelastic and Coagulation Properties of Various Classes of Topical Hemostatic Agents Using a Novel Contactless Nondestructive Technology
A novel non-invasive technology is being studied for its potential in assessing the effectiveness of different types of hemostatic agents (HAs), which are used to manage bleeding in traumatic injuries. This technology measures how quickly clotting occurs and the stiffness of the formed clots, providing valuable insights into how different HAs impact coagulation. It can even identify HAs that work independently from the natural blood clotting process. This could pave the way for more precise predictions of in vivo outcomes and contribute to the development of optimal HAs for specific situations.